Lihu Yang

发表

Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists.

M. Struthers, J. Demartino, S. Mills, 2008, Bioorganic & medicinal chemistry letters.

Design and syntheses of melanocortin subtype-4 receptor agonists: evolution of the pyridazinone archetype.

F. Ujjainwalla, L. V. D. van der Ploeg, C. Rosenblum, 2003, Bioorganic & medicinal chemistry letters.

Impacting Global Health Through Equipment Repurposing: Measurable Progress Through the Accumulation of Many Tiny Victories.

K. Young, Lihu Yang, E. Minnihan, 2017, Journal of pharmaceutical sciences.

Synthesis, characterization and photophysical properties of rhenium(I)-containing polyfluorene-based copolymers

Bai Yang, Hong Xia, Yuguang Ma, 2005 .

Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice

Yun-ping Zhou, J. Berger, N. Thornberry, 2008, Diabetes.

Synthesis of 2′-β-C-methyl-neplanocin derivatives as anti-HCV agents

M. Maccoss, G. Butora, D. Olsen, 2008 .

Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist.

Margaret S. Wu, Yun-ping Zhou, A. Howard, 2012, ACS medicinal chemistry letters.

Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase.

Peter S. Kutchukian, M. Glick, M. Altman, 2017, ACS chemical biology.

Antidiabetic activity of a highly potent and selective nonpeptide somatostatin receptor subtype-2 agonist.

Roy G. Smith, A. Patchett, J. Schaeffer, 2006, Endocrinology.

An expeditious synthesis of 3-(difluoromethoxy)- and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines

M. Maccoss, D. Guiadeen, S. Kothandaraman, 2008 .

Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists.

Yun-ping Zhou, J. Berger, N. Thornberry, 2010, Bioorganic & medicinal chemistry letters.

3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists.

A. Howard, Carina P. Tan, G. Eiermann, 2011, Bioorganic & medicinal chemistry letters.

Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.

A. Swensen, G. Kaczorowski, B. Priest, 2016, Bioorganic & medicinal chemistry letters.

Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.

A. Swensen, G. Kaczorowski, B. Priest, 2016, Bioorganic & medicinal chemistry letters.

Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.

J. Metzger, A. Swensen, M. Forrest, 2016, ACS medicinal chemistry letters.

A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production.

Erica M. Stec, M. Ferrer, B. Strulovici, 2008, Assay and drug development technologies.

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.

J. Chen, R. Bentley, J. Metzger, 2015, ACS medicinal chemistry letters.

Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists.

M. Tota, A. Howard, S. Feighner, 2009, Bioorganic & medicinal chemistry letters.

Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.

Kenny K. Wong, Shirly Pinto, R. S. Roy, 2010, Journal of medicinal chemistry.

Chapter 21. Non-peptide Somatostatin Receptor Ligands

Lihu Yang, 1999 .

Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.

M. Struthers, M. Maccoss, J. Demartino, 2009, Bioorganic & medicinal chemistry letters.

Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.

Margaret S. Wu, Michael E. Lassman, J. Berger, 2010, Bioorganic & medicinal chemistry letters.

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.

G. Kaczorowski, B. Priest, Haifeng Tang, 2012, ACS medicinal chemistry letters.

Solid phase synthesis of ‘head-to-tail’ cyclic peptides using a sulfonamide ‘safety-catch’ linker: the cleavage by cyclization approach

G. Morriello, Lihu Yang, 1999 .

Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists.

M. Struthers, J. Demartino, G. Butora, 2008, Bioorganic & medicinal chemistry letters.

The design and synthesis of non-peptide somatostatin receptor agonists

A. Patchett, J. Schaeffer, G. Morriello, 2002 .

Facile cleavage of the carbamate linker of hydroxymethyl resin and its application in syntheses requiring strongly acidic conditions

Lihu Yang, 2000 .

A simple and efficient procedure for the synthesis of benzimidazoles using air as the oxidant

Lihu Yang, Songnian Lin, 2005 .

4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties.

M. Maccoss, G. Butora, D. Guiadeen, 2006, Bioorganic & medicinal chemistry letters.

Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists.

M. Maccoss, W. Hanlon, G. Butora, 2006, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

K. Chapman, James E. Thompson, J. Hale, 2015, Bioorganic & medicinal chemistry letters.

Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists.

M. Maccoss, G. Butora, W. Parsons, 2007, Journal of medicinal chemistry.

Total synthesis of (.+-.)-saframycin A

R. Sachleben, T. Fukuyama, Lihu Yang, 1990 .

Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

K. Chapman, James E. Thompson, J. Hale, 2009, Bioorganic & medicinal chemistry letters.

A Simple and Efficient Procedure for the Synthesis of Benzimidazoles Using Air as the Oxidant.

Lihu Yang, Songnian Lin, 2005 .

A general method for the preparation of 3-acyl-4-cyano-5-amino-pyrazoles

E. Cline, Lihu Yang, M. Ge, 2006 .

A General Method for the Preparation of 3‐Acyl‐4‐cyano‐5‐amino‐pyrazoles.

E. Cline, Lihu Yang, M. Ge, 2006 .

α-Aminothiazole-γ-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists

M. Maccoss, W. Parsons, Changyou Zhou, 2007 .

Synthetic approaches toward mitomycins. I. Stereoselective synthesis of a tetracyclic intermediate.

T. Fukuyama, Lihu Yang, 1986 .

Practical total synthesis of (.+-.)-mitomycin C

T. Fukuyama, Lihu Yang, 1989 .

Total synthesis of (.+-.)-mitomycins via isomitomycin A

T. Fukuyama, Lihu Yang, 1987 .

Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist

M. Struthers, J. Demartino, R. Kilburn, 2010 .

Solid phase synthesis of Fmoc N-methyl amino acids: Application of the Fukuyama amine synthesis☆

Lihu Yang, K. Chiu, 1997 .

The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.

Margaret S. Wu, Rebecca T. Ruck, M. Reibarkh, 2012, ACS medicinal chemistry letters.

Alkylation and Crosslinking of DNA by the Unnatural Enantiomer of Mitomycin C: Mechanism of the DNA-Sequence Specificity of Mitomycins

M. Tomasz, T. Fukuyama, Lihu Yang, 1995 .

Concise preparation of 8-trifluoromethyltetrahydro-6H-pyrido [1,2-a] pyrazine-6-one

M. Maccoss, G. Butora, D. Guiadeen, 2009 .

3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2.

G. Butora, W. Parsons, Hong Jin, 2007, Bioorganic & medicinal chemistry letters.

Novel, Orally Bioavailable γ-Aminoamide CC Chemokine Receptor 2 (CCR2) Antagonists

M. Maccoss, W. Parsons, S. Mills, 2006 .

Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.

A. Swensen, G. Kaczorowski, B. Priest, 2013, Bioorganic & medicinal chemistry letters.

Macrocyclic renin inhibitors : synthesis of a subnanomolar, orally active cysteine derived inhibitor

W. Greenlee, A. Patchett, A. Weber, 1993 .

Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.

D. Macneil, H. Iwaasa, A. Kanatani, 2009, Bioorganic & Medicinal Chemistry Letters.

Practical Total Synthesis of (.+-.)-Mitomycin C.

T. Fukuyama, Lihu Yang, 1990 .

Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.

R G Smith, A. Patchett, J. Schaeffer, 1998, Science.

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.

G. Kaczorowski, B. Priest, Haifeng Tang, 2012, ACS medicinal chemistry letters.

Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists.

M. Maccoss, W. Parsons, S. Mills, 2006, Journal of medicinal chemistry.