S. Takekawa

发表

Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.

J. Kunitomo, Masaharu Nakayama, Koki Kato, 2012, Journal of medicinal chemistry.

T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist.

Yuji Ishihara, Masahiko Fujino, Osamu Nishimura, 2002, European journal of pharmacology.

Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.

Koki Kato, Y. Nakano, Toshio Tanaka, 2012, Journal of medicinal chemistry.

Inhibition of MGAT2 modulates fat‐induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high‐fat diet

Kazumi Take, Kenjiro Sato, S. Takekawa, 2019, FEBS open bio.

Identification and characterization of a novel human cortistatin-like peptide.

S. Hinuma, C. Kitada, M. Fujino, 1997, Biochemical and biophysical research communications.

Live attenuated SARS-CoV-2 vaccine candidate: Protective immunity without serious lung lesions in Syrian hamsters

W. Kamitani, K. Yamanishi, Hirotaka Ebina, 2021 .

Potent antiobesity effect of a short-length peptide YY-analogue continuously administered in mice.

Y. Adachi, N. Amano, H. Hirabayashi, 2017, Bioorganic & medicinal chemistry letters.

Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization

Kazumi Take, Kenjiro Sato, N. Amano, 2016, PloS one.

A potent and selective natriuretic peptide receptor-3 blocker 11-mer peptide created by hybridization of musclin and atrial natriuretic peptide.

Masaharu Nakayama, Hideyuki Nakagawa, S. Takekawa, 2017, Bioorganic & medicinal chemistry letters.

A novel and selective melanin‐concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet‐induced obese rodent models

Masaharu Nakayama, A. Ando, S. Okuda, 2017, European journal of pharmacology.

Discovery of an artificial peptide agonist to the fibroblast growth factor receptor 1c/βKlotho complex from random peptide T7 phage display.

Takashi Ito, Kotaro Sakamoto, S. Takekawa, 2016, Biochemical and biophysical research communications.

Highly potent antiobesity effect of a short-length peptide YY analog in mice.

N. Amano, H. Hirabayashi, S. Takekawa, 2017, Bioorganic & medicinal chemistry.

Identification and Characterization of a New Series of Ghrelin O-Acyl Transferase Inhibitors

Tsuyoshi Ishii, Y. Nakano, Ikumi Chisaki, 2018, SLAS discovery : advancing life sciences R & D.

Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.

Koki Kato, Y. Nakano, M. Tawada, 2011, Bioorganic & medicinal chemistry.

Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists.

Koki Kato, Y. Nakano, S. Endo, 2011, Bioorganic & Medicinal Chemistry.

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.

P. B. Jensen, G. Weir, C. Newgard, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.

M. Yoshikawa, T. Kawamoto, K. Okada, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.

Tsuyoshi Ishii, Kenjiro Sato, N. Amano, 2015, Journal of medicinal chemistry.

Differential effects of selective agonists of neuromedin U1 and U2 receptors in obese and diabetic mice

J. Noguchi, T. Kaisho, S. Takekawa, 2018, British journal of pharmacology.

Effects of peripheral administration of a Neuromedin U receptor 2-selective agonist on food intake and body weight in obese mice

T. Kaisho, S. Takekawa, H. Fujita, 2017, International Journal of Obesity.

Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.

H. Hirabayashi, T. Kaisho, S. Takekawa, 2017, Journal of medicinal chemistry.

A PEGylated analog of short-length Neuromedin U with potent anorectic and anti-obesity effects.

T. Shinohara, J. Noguchi, Kotaro Sakamoto, 2017, Bioorganic & medicinal chemistry.

A potent neuromedin U receptor 2-selective alkylated peptide.

S. Takekawa, T. Asami, H. Fujita, 2017, Bioorganic & medicinal chemistry letters.

Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity

W. Kamitani, Y. Matsuura, K. Yamanishi, 2022, bioRxiv.

Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities.

Kazumi Take, Kenjiro Sato, N. Amano, 2015, Bioorganic & medicinal chemistry.

Antiobesity and emetic effects of a short-length peptide YY analog and its PEGylated and alkylated derivatives.

H. Hirabayashi, S. Takekawa, T. Asami, 2017, Bioorganic & medicinal chemistry.

Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.

Koki Kato, Y. Nakano, M. Tawada, 2011, Bioorganic & Medicinal Chemistry.