Y. Ishihara

发表

Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.

J. Kunitomo, Masaharu Nakayama, Koki Kato, 2012, Journal of medicinal chemistry.

T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist.

Yuji Ishihara, Masahiko Fujino, Osamu Nishimura, 2002, European journal of pharmacology.

The MCH1 receptor, an anti‐obesity target, is allosterically inhibited by 8‐methylquinoline derivatives possessing subnanomolar binding and long residence times

K. Ogawa, S. Kasai, Y. Ishihara, 2014, British journal of pharmacology.

Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.

Koki Kato, Y. Nakano, Toshio Tanaka, 2012, Journal of medicinal chemistry.

Neurochemical effects of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-b enzazepin-8-yl)-1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, in rats.

M. Miyamoto, K. Hirai, K. Kato, 1997, Journal of Pharmacology and Experimental Therapeutics.

Synthesis of isoindolo[2,1-a]quinoline derivatives and their effects on N2-induced hypoxia.

Y. Ishihara, Y. Kiyota, G. Goto, 1990, Chemical & pharmaceutical bulletin.

TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons

Koki Kato, M. Miyamoto, Y. Ishihara, 1999, Neuroscience Letters.

Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (TAK-802) and related compounds.

M. Sasaki, T. Doi, T. Tsukamoto, 2005, Bioorganic & medicinal chemistry.

Stereo- and regiocontrol of acyclic systems via the lewis acid mediated reaction of allylic stannanes with aldehydes

K. Maruyama, Yoshinori Yamamoto, Y. Ishihara, 1984 .

Central Cholinergic Agents. Part 6. Synthesis and Evaluation of 3‐(1‐( Phenylmethyl)‐4‐piperidinyl)‐1‐(2,3,4,5‐tetrahydro‐1H‐1‐benzazepin‐8‐ yl)‐1‐propanones and Their Analogues as Central Selective Acetylcholinesterase Inhibitors.

M. Miyamoto, K. Hirai, Y. Ishihara, 1994 .

Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors.

M. Miyamoto, K. Hirai, Y. Ishihara, 1994, Journal of medicinal chemistry.

Nad(P)+-nad(p)h models. 57

Y. Ishihara, A. Ohno, S. Ushida, 1986 .

NAD(P)+-NAD(P)H model. 38. Reduction of aldehyde by 1,4-dihydroquinolin derivative

Y. Ishihara, A. Ohno, S. Ushida, 1982 .

A short and stereoselective synthesis of the (±) Prelog-Djerassi lactonic acid

K. Maruyama, Yoshinori Yamamoto, Y. Ishihara, 1981 .

Lewis acid-catalyzed, high pressure, stereospecific, regiospecific, Diels-Alder cycloaddition of unsubstituted 2-pyrone: Short synthesis of a racemic A-ring precursor to physiologically active 1-hydroxyvitamin D3 steroids

G. Posner, Y. Ishihara, 1994 .

Lewis Acid-Promoted, Stereocontrolled, Gram Scale, Diels-Alder Cycloadditions of Electronically Matched 2-Pyrones and Vinyl Ethers: The Critical Importance of Molecular Sieves and the Temperature of Titanium Coordination with the Pyrone.

G. Posner, Y. Ishihara, F. Eydoux, 1996, The Journal of organic chemistry.

Lewis acid mediated reactions of organocopper reagents. Entrainment in the conjugate addition to .alpha.,.beta.-unsaturated ketones, esters, and acids via the RCu.cntdot.BF3 system

K. Maruyama, Yoshinori Yamamoto, Y. Ishihara, 1982 .

Regioselective Friedel–Crafts acylation of 2,3,4,5-tetrahydro-1H-2-benzazepine and related nitrogen heterocycles

A. Fujishima, Toshimasa Tanaka, Seiji Miwatashi, 1994 .

Regioselective Friedel–Crafts acylation of 1,2,3,4-tetrahydroquinoline and related nitrogen heterocycles: effects of NH protective groups and ring size

Toshimasa Tanaka, Y. Ishihara, G. Goto, 1992 .

Effects of TAK-802, a novel acetylcholinesterase inhibitor, on distension-induced rhythmic bladder contractions in rats and guinea pigs.

T. Doi, Y. Ishichi, Y. Ishihara, 2004, European journal of pharmacology.

CCR5 antagonists as anti-HIV-1 agents. 1. Synthesis and biological evaluation of 5-oxopyrrolidine-3-carboxamide derivatives.

Yuji Ishihara, Yoshihiro Matsushita, M. Baba, 2004, Chemical & pharmaceutical bulletin.

Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.

Koki Kato, Y. Nakano, M. Tawada, 2011, Bioorganic & medicinal chemistry.

Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists.

Koki Kato, Y. Nakano, S. Endo, 2011, Bioorganic & Medicinal Chemistry.

Liquid-crystalline Phthalocyanine with Short Intercolumnar Distance and Variation of the Liquid Crystallinity Induced by Square-planar Metal Ions

Kentaro Tanaka, Shin‐ichiro Kawano, Y. Ishihara, 2018, Chemistry Letters.

Thermal stability of photochromic bis[(trifluoromethyl)thiazolyl]ethene derivatives

Kiyoshi Tanaka, Y. Ishihara, C. Qian, 1992 .

Effects of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1 -H-1-benzazepin-8-yl)-1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, on impaired learning and memory in animal models.

M. Miyamoto, K. Hirai, K. Kato, 1996, The Journal of pharmacology and experimental therapeutics.

Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.

Koki Kato, Y. Nakano, M. Tawada, 2011, Bioorganic & Medicinal Chemistry.