R. Middleton

发表

SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).

C. Kenific, Melissa Chenard, A. Kral, 2008, Bioorganic & medicinal chemistry letters.

Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain.

Richard E Middleton, Ying-Duo Gao, R. Middleton, 2004, Biochemistry.

Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).

Joshua Close, Sriram Tyagarajan, C. Kenific, 2008, Bioorganic & medicinal chemistry letters.

Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.

C. Kenific, Melissa Chenard, A. Kral, 2014, ACS medicinal chemistry letters.

Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).

J. Grimm, Melissa Chenard, A. Kral, 2009, Bioorganic & medicinal chemistry letters.

Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A₁ receptor ligands

L. May, S. Hill, S. Briddon, 2010 .

Oral Treatment with a (cid:1) -Secretase Inhibitor Improves Long-Term Potentiation in a Mouse Model of Alzheimer’s Disease

A. Gray, M. Shearman, R. Middleton, 2010 .

Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization.

C. Kenific, Melissa Chenard, A. Kral, 2009, Bioorganic & Medicinal Chemistry Letters.

Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile.

O. McManus, Amrita Ghosh, M. J. Staruch, 2003, Biochemistry.

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

Christopher J. Ott, Kwok-Kin Wong, J. Bradner, 2014, Science.

Triazoloamides as potent γ-secretase modulators with reduced hERG liability.

A. Szewczak, C. Moxham, Hua Zhou, 2012, Bioorganic & medicinal chemistry letters.

Triazoles as γ-secretase modulators.

C. Kenific, A. Szewczak, Hua Zhou, 2011, Bioorganic & medicinal chemistry letters.

Quinazolinones as γ-secretase modulators.

A. Szewczak, J. Crispino, B. Muñoz, 2011, Bioorganic & medicinal chemistry letters.

Identification of tryptophan 55 as the primary site of [3H]nicotine photoincorporation in the γ‐subunit of the Torpedo nicotinic acetylcholine receptor

J. B. Cohen, D. C. Chiara, Jonathan B. Cohen, 1998, FEBS letters.

Purine derivatives as potent gamma-secretase modulators.

C. Kenific, A. Szewczak, J. Crispino, 2010, Bioorganic & medicinal chemistry letters.

Two tarantula peptides inhibit activation of multiple sodium channels.

V. Garsky, M. Bogusky, V. Warren, 2002, Biochemistry.

A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.

V. Warren, Y. S. Tang, K. Wafford, 2004, Biochemistry.

Functional Properties of the High-Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist (4-Hydroxy-5-iodo-3-methoxyphenylacetate ester) Iodo-Resiniferatoxin

S. Teague, S. Boyce, Z. Ali, 2002, Journal of Pharmacology and Experimental Therapeutics.

Evaluating TBK1 as a Therapeutic Target in Cancers with Activated IRF3

H. Hirsch, Kwok-Kin Wong, P. Janne, 2014, Molecular Cancer Research.

Identi ﬁ cation and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis

J. Radich, N. Gray, Xianming Deng, 2022 .

The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.

A. Kral, A. Szewczak, A. Hitz, 2007, Bioorganic & medicinal chemistry letters.

Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label.

R. Middleton, J. Cohen, Jonathan B. Cohen, 1991, Biochemistry.

Homodimeric architecture of a CIC-type chloride ion channel

Christopher Miller, Christopher Miller, R. Middleton, 1996, Nature.

Purification, reconstitution, and subunit composition of a voltage-gated chloride channel from Torpedo electroplax.

Christopher Miller, R. Middleton, C. Miller, 1994, Biochemistry.

Delay of intracellular calcium transients using a calcium chelator: application to high-throughput screening of the capsaicin receptor ion channel and G-protein-coupled receptors.

S. Feighner, S. Grant, G. Kaczorowski, 2001, Analytical biochemistry.

Signal Transduction Evaluating TBK 1 as a Therapeutic Target in Cancers with Activated IRF 3

Kwok-Kin Wong, L. Zawel, P. Kirschmeier, 2015 .

Functional Mapping of the Transient Receptor Potential Vanilloid 1 Intracellular Binding Site

T. Bonnert, R. Middleton, Yinghong Gao, 2006, Molecular Pharmacology.

Oral Treatment with a γ-Secretase Inhibitor Improves Long-Term Potentiation in a Mouse Model of Alzheimer's Disease

M. Hutton, Zhenhua Wu, A. Gray, 2010, Journal of Pharmacology and Experimental Therapeutics.

Fluorinated piperidine acetic acids as gamma-secretase modulators.

C. Kenific, A. Szewczak, J. Crispino, 2010, Bioorganic & medicinal chemistry letters.

Photoaffinity labeling the torpedo nicotinic acetylcholine receptor with [(3)H]tetracaine, a nondesensitizing noncompetitive antagonist.

R. Middleton, N. P. Strnad, J. Cohen, 1999, Molecular pharmacology.

Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators.

Alexey Rivkin, Chaomin Li, A. Szewczak, 2010, Bioorganic & Medicinal Chemistry Letters.

Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1).

J. Grimm, A. Kral, A. Szewczak, 2008, Bioorganic & medicinal chemistry letters.

A high-capacity membrane potential FRET-based assay for NaV1.8 channels.

G. Kaczorowski, B. Priest, H. Knaus, 2006, Assay and drug development technologies.