C. Dinsmore

发表

Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders.

Jongwon Lim, Michael D Altman, Craig Rosenstein, 2011, Journal of medicinal chemistry.

P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes.

C. Tang, J. Lin, J. Wai, 2001, Biochemical pharmacology.

Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth

A. Burkhardt, N. Kohl, R. Lobell, 1997, BioFactors.

Preparation of Ethyl 5-Iodo-1H-indole- 2-carboxylate

D. Beshore, C. Dinsmore, 2003 .

Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.

K. K. Nanda, C. Lindsley, R. Spencer, 2017, Bioorganic & medicinal chemistry letters.

Biochemical and structural characterization of a novel class of inhibitors of the type 1 insulin-like growth factor and insulin receptor kinases.

S. Stirdivant, L. Kuo, P. Darke, 2005, Biochemistry.

Parallel synthesis of ureas and carbamates from amines and CO2 under mild conditions.

C. Dinsmore, S. Peterson, Sabrina Stucka, 2010, Organic letters.

2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.

N. Kohl, R. Lobell, C. Buser, 2001, Bioorganic & medicinal chemistry letters.

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Elizabeth C. Townsend, Claire Heride, D. Komander, 2017, Nature.

Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor

Irena Ivanovska, C. Chiu, I. Kariv, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors.

H. Su, Sangita Patel, H. Gunaydin, 2016, Bioorganic & medicinal chemistry letters.

Atrial Antifibrillatory Effects of Structurally Distinct IKur Blockers 3-[(Dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-Phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in Dogs with Underlying Heart Failure

N. Liverton, L. Kiss, C. Regan, 2008, Journal of Pharmacology and Experimental Therapeutics.

Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase.

J. Davide, N. Kohl, R. Lobell, 2001, Bioorganic & medicinal chemistry letters.

Preclinical Models Geranylgeranyl : Protein Transferase Inhibitor Combinations in Evaluation of Farnesyl : Protein Transferase and Updated

A. Kral, D. Heimbrook, J. Davide, 2001 .

Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase.

T. Ciccarone, N. Kohl, J. Gibbs, 1999, Bioorganic & medicinal chemistry letters.

Recent advances in the synthesis of diketopiperazines

D. Beshore, C. Dinsmore, 2002 .

Abstract #1751: MK-8033, a selective c-Met / Ron inhibitor, suppresses tumor cell growth in vitro and in vivo

P. Majumder, W. Lu, K. Kunii, 2009 .

Alkyne insertion reactions of metal-carbenes derived from enynyl-.alpha.-diazoketones [R'CN2COCR2CH2C.tplbond.C(CH2)n-2CH:CH2]

T. Hoye, Douglas S. Johnson, C. Dinsmore, 1990 .

Arylmethanesulfonates are convenient latent phenols in the nucleophilic aromatic substitution reaction

C. Dinsmore, C. B. Zartman, 1999 .

Discovery and Optimization of Quinolinone Derivatives as Potent, Selective and Orally Bioavailable mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors.

Mark T. Kershaw, S. Ashwell, K. Bair, 2019, Journal of medicinal chemistry.

Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation.

Kenneth D Anderson, K. K. Nanda, N. Liverton, 2006, Journal of medicinal chemistry.

Carboxylation and Mitsunobu reaction of amines to give carbamates: retention vs inversion of configuration is substituent-dependent.

C. Dinsmore, Christopher J Dinsmore, Swati P Mercer, 2004, Organic letters.

Nonconventional Stereochemical Issues in the Design of the Synthesis of the Vancomycin Antibiotics: Challenges Imposed by Axial and Nonplanar Chiral Elements in the Heptapeptide Aglycons.

T. I. Richardson, Davidr . Evans, C. Dinsmore, 1998, Angewandte Chemie.

Double (internal/external) alkyne insertion reactions of α-diazoketones

T. Hoye, C. Dinsmore, 1991 .

SYNTHESES AND TRANSFORMATIONS OF PIPERAZINONE RINGS. A REVIEW

D. Beshore, C. Dinsmore, 2002 .

Efficient synthesis of unsymmetrical 1,4-disubstituted-2,3-diketopiperazines via tandem reductive amination–cyclization

D. Beshore, C. Dinsmore, 2000 .

Preparation of substituted piperazinones via tandem reductive amination-(N,N'-acyl transfer)-cyclization.

D. Beshore, C. Dinsmore, 2002, Organic letters.

Mild nitrosation and hydrolysis of polyfunctional amides

J. Barrow, Davidr . Evans, P. Carter, 1997 .

TANDEM REDUCTIVE ALKYLATION-CYCLIZATION FOR THE PREPARATION OF UNSYMMETRICAL 1,4-DISUBSTITUTED 2,3-DIKETOPIPERAZINES

C. Dinsmore, J. Bergman, 1998 .

Oxidative macrocyclizations for the vancomycin antibiotics. Unexpected transannular effects in the thallium(III)-mediated M(2–4) macrocyclic ring closure

Davidr . Evans, C. Dinsmore, A. M. Ratz, 1997 .

Kinetic and thermodynamic atropdiastereoselection in the synthesis of the M(5–7) tripeptide portion of vancomycin

Davidr . Evans, C. Dinsmore, D. A. Evans, 1993 .

Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.

K. Kunii, M. Altman, A. Szewczak, 2011, Journal of medicinal chemistry.

Oxidative coupling of arylglycine-containing peptides. A biomimetic approach to the synthesis of the macrocyclic actinoidinic-containing vancomycin subunit

Davidr . Evans, C. Dinsmore, D. Evrard, 1993 .

Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase.

N. Kohl, R. Lobell, J. Gibbs, 1999, Bioorganic & medicinal chemistry letters.

Synthesis and conformational properties of the M(4-6)(5-7) bicyclic tetrapeptide common to the vancomycin antibiotics

J. Barrow, Davidr . Evans, C. Dinsmore, 1997 .

Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.

J. Davide, N. Kohl, R. Lobell, 2001, Bioorganic & medicinal chemistry letters.

Preparation of a stable trifluoroborate salt for the synthesis of 1-aryl-2,2-difluoro-enolethers and/or 2,2-difluoro-1-aryl-ketones via palladium-mediated cross-coupling.

C. Dinsmore, J. Katz, Blair T. Lapointe, 2009, The Journal of organic chemistry.

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.

A. Kral, D. Heimbrook, J. Davide, 2001, Cancer research.

Inhibitors of farnesyltransferase and geranylgeranyltransferase-I for antitumor therapy: substrate-based design, conformational constraint and biological activity.

I. M. Bell, C. Dinsmore, 2003, Current topics in medicinal chemistry.

Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

J. Davide, N. Kohl, R. Lobell, 2001, Bioorganic & medicinal chemistry letters.

3,8-Diazabicyclo[3.2.1]octan-2-one peptide mimetics: synthesis of a conformationally restricted inhibitor of farnesyltransferase.

M. Bogusky, J. Culberson, C. Dinsmore, 2001, Organic letters.

Approaches to the Synthesis of the Vancomycin Antibiotics. Synthesis of Orienticin C (Bis-dechlorovancomycin) Aglycon

J. Barrow, Davidr . Evans, J. Ellman, 1997 .

Approaches to the Synthesis of the Vancomycin Antibiotics. Synthesis of Orienticin C (Bis-dechlorovancomycin) Aglycon (I).

J. Barrow, Davidr . Evans, J. Ellman, 1997 .

Anions Modulate the Potency of Geranylgeranyl-Protein Transferase I Inhibitors*

D. Heimbrook, R. Lobell, C. Buser, 2001, The Journal of Biological Chemistry.

Structure-based design and identification of FT-2102 (olutasidenib), a potent mutant-selective IDH1 inhibitor.

Mark T. Kershaw, S. Ashwell, D. Walker, 2020, Journal of medicinal chemistry.

The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: hit to lead.

T. Rush, M. Altman, Joon Jung, 2010, Bioorganic & medicinal chemistry letters.

N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.

J. Huff, J. Davide, N. Kohl, 1999, Journal of medicinal chemistry.

Farnesyl transferase inhibitors: Design of a new class of cancer chemotherapeutic agents

T. Williams, C. Dinsmore, 1999 .

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

C. Paweletz, K. Kunii, I. Kariv, 2010, Cancer research.

Rhodium(II) acetate catalyzed alkyne insertion reactions of .alpha.-diazo ketones: mechanistic inferences

T. Hoye, C. Dinsmore, 1991 .

Efficient synthesis of substituted piperazinones via tandem reductive amination–cyclization

C. Dinsmore, C. B. Zartman, 2000 .

Synthesis of conformationally constrained 5,6,7, 8-Tetrahydroimidazo[1,5-a]pyridine inhibitors of farnesyltransferase.

J. Huff, T. Olah, I. Chen, 2000, Organic letters.

USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

Andreas C. Damianou, A. Damianou, Claire Heride, 2020, bioRxiv.

The deubiquitylase USP9X controls ribosomal stalling

Claire Heride, D. Komander, A. Behrens, 2020, bioRxiv.

Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel.

N. Liverton, C. Claiborne, R. Spencer, 2010, Bioorganic & medicinal chemistry letters.

Potent antagonists of the Kv1.5 potassium channel: synthesis and evaluation of analogous N,N-diisopropyl-2-(pyridine-3-yl)acetamides.

K. K. Nanda, C. Lindsley, R. Spencer, 2006, Bioorganic & medicinal chemistry letters.

Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.

Wei Lu, Michael D Altman, Craig Rosenstein, 2013, Journal of medicinal chemistry.

High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123.

C. Buser, C. Fernandes, K. Koblan, 2001, Analytical biochemistry.

The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.

Duan Liu, J. Klappenbach, X. Fradera, 2017, Journal of medicinal chemistry.

Conformational restriction of flexible ligands guided by the transferred noe experiment: potent macrocyclic inhibitors of farnesyltransferase.

J. Huff, M. Bogusky, S. Graham, 2001, Journal of the American Chemical Society.

Tandem alkyne insertion and allyl sulfonium ylide rearrangement of γ,δ-alkynyl-α′-diazoketones

T. Hoye, C. Dinsmore, 1992 .

Tandem Alkyne Insertion and Allyl Sulfonium Ylide Rearrangement of . gamma.,δ-Alkynyl α′-Diketones.

T. Hoye, C. Dinsmore, 1992 .

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

C. Paweletz, K. Kunii, I. Kariv, 2010, Cancer research.