J. Lau

发表

Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides.

K. Rimvall, J. Lau, C. B. Jeppesen, 2006, Bioorganic & medicinal chemistry letters.

Small-molecule agonists for the glucagon-like peptide 1 receptor

Jeppe Sturis, Jarek Kostrowicki, Carsten Behrens, 2007, Proceedings of the National Academy of Sciences.

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.

T. Kruse, H. Strauss, S. M. Knudsen, 2015, Journal of medicinal chemistry.

Transmembrane α-Helix 2 and 7 Are Important for Small Molecule-Mediated Activation of the GLP-1 Receptor

G. Peters, L. B. Knudsen, H. Bräuner‐Osborne, 2011, Pharmacology.

Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain.

R. Rudolph, S. M. Knudsen, K. Madsen, 2007, Biochemistry.

Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selective α-melanocyte-stimulating hormone (α-MSH) analogues.

K. Conde-Frieboes, K. Raun, H. Thøgersen, 2012, Journal of medicinal chemistry.

The synthesis and biochemical evaluation of new A1 selective adenosine receptor agonists containing 6-hydrazinopurine moieties

C. Thomsen, M. Sheardown, J. Lau, 1993 .

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

C. Kahn, U. V. von Andrian, R. Mrsny, 2018, eLife.

Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls

T. Kruse, K. Raun, P. Sauerberg, 2022, PloS one.

New β-Alanine Derivatives Are Orally Available Glucagon Receptor Antagonists

C. Behrens, L. B. Knudsen, C. L. Brand, 2007 .

Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor.

J. Holst, J. D. de Jong, Michael D. Johnson, 2007, Bioorganic & medicinal chemistry letters.

Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.

A. Kuki, Michael D. Johnson, D. Murphy, 2002, Journal of medicinal chemistry.

New beta-alanine derivatives are orally available glucagon receptor antagonists.

C. Behrens, L. B. Knudsen, C. L. Brand, 2007, Journal of medicinal chemistry.

Human glucagon receptor antagonists based on alkylidene hydrazides.

A. Kuki, D. Murphy, A. Polinsky, 2002, Bioorganic & medicinal chemistry letters.

Long acting analogue of the calcitonin gene-related peptide induces positive metabolic effects and secretion of the glucagon-like peptide-1.

B. Hartmann, K. Raun, C. Nilsson, 2016, European journal of pharmacology.

Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.

M. J. Newman, O. Olsen, L. Iversen, 2002, Journal of medicinal chemistry.

Versatile strategies for the solid phase synthesis of small heterocyclic scaffolds: [1,3,4]-thiadiazoles and [1,3,4]-oxadiazoles

J. Kilburn, J. Lau, R. Severinsen, 2005 .

Pharmacological characterisation of a new oral GH secretagogue, NN703.

K. Raun, T. Hansen, M. Ankersen, 1999, European journal of endocrinology.

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

Chris de Graaf, Suwen Zhao, Raymond C. Stevens, 2017, Nature.

Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells

J. Holst, T. Kruse, N. J. Wewer Albrechtsen, 2022, iScience.

New highly potent dipeptidic growth hormone secretagogues with low molecular weight.

K. Raun, T. Hansen, M. Ankersen, 2000, European journal of medicinal chemistry.

A new series of highly potent growth hormone-releasing peptides derived from ipamorelin.

K. Raun, K. Madsen, H. Thøgersen, 1998, Journal of medicinal chemistry.

Structure of the full-length glucagon class B G protein-coupled receptor

Hualiang Jiang, R. Stevens, R. Sierra, 2017, Nature.

Parallel solid-phase synthesis of disubstituted (5-biphenyltetrazolyl) hydantoins and thiohydantoins targeting the growth hormone secretagogue receptor.

K. Bondensgaard, M. Ankersen, B. S. Hansen, 2004, Bioorganic & medicinal chemistry letters.

The Discovery and Development of Liraglutide and Semaglutide

L. B. Knudsen, J. Lau, 2019, Front. Endocrinol..

Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties.

C. Behrens, L. B. Knudsen, E. Nishimura, 2009, Journal of medicinal chemistry.

Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.

C. Behrens, L. B. Knudsen, E. Nishimura, 2008, Journal of medicinal chemistry.

Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.

P. Suzdak, Michael D B Swedberg, J. Lau, 2001, Bioorganic & medicinal chemistry.

1,3,4-oxadiazole formation; a novel solid support strategy

J. Kilburn, Raymond C. F. Jones, J. Lau, 2001 .

Solid-phase synthesis of substituted 1,3,4-thiadiazoles

J. Kilburn, Raymond C. F. Jones, J. Lau, 2003 .

A convenient large-scale chiral synthesis of protected 2-substituted 4-oxo-piperidine derivatives

J. Kilburn, H. Andersen, T. Hansen, 2002 .

Substituted 2-amino-1,3,4-thiadiazines: a novel solid-phase approach

J. Kilburn, Raymond C. F. Jones, J. Lau, 2002 .

A novel facile solid-phase strategy for the synthesis of N, N', N -substituted guanidines

J. Kilburn, Raymond C. F. Jones, J. Lau, 2002 .

The synthesis of novel GABA uptake inhibitors. Part 2. Synthesis of 5-hydroxytiagabine, a human metabolite of the GABA reuptake inhibitor tiagabine

Elaine C. Lee, H. Thøgersen, M. Chorghade, 1994 .

Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

P. Sexton, D. Donnelly, C. de Graaf, 2016, Pharmacological Reviews.

Anticonvulsant Actions of Novel and Reference Adenosine Agonists

M. Judge, J. Weis, C. Thomsen, 1995 .

Synthesis of substituted 10,11‐dihydro‐5H‐dibenz[b,f]azepines; key synthons in syntheses of pharmaceutically active compounds

J. Lau, P. Madsen, K. Andersen, 1999 .

Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain*

Kjeld Madsen, R. Rudolph, K. Madsen, 2008, Journal of Biological Chemistry.

Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.

P. Suzdak, Michael D B Swedberg, R. Henry, 1999, Journal of medicinal chemistry.

Solid-phase synthesis of 1,2,4-oxadiazoles

J. Lau, C. Sams, 1999 .

Structure of the human glucagon class B G-protein-coupled receptor

Chris de Graaf, Raymond C. Stevens, Dehua Yang, 2013, Nature.

N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects.

M. Judge, A. Hansen, J. Weis, 1999, Journal of medicinal chemistry.

Structure of the glucagon receptor in complex with a glucagon analogue

Hualiang Jiang, R. Stevens, M. Hanson, 2018, Nature.

Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice

J. Holst, M. Rosenkilde, T. Kruse, 2022, Molecular metabolism.

A Facile Synthesis of Racemic 2-Aminomethyl-4-oxo-piperidine Intermediates

T. Hansen, D. Holsworth, J. Lau, 2003 .

Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates.

P. Suzdak, Michael D B Swedberg, J. Sorensen, 1999, Journal of medicinal chemistry.

Synthesis of Novel γ-Aminobutyric Acid (GABA) Uptake Inhibitors. Part 5. Preparation and Structure—Activity Studies of Tricyclic Analogues of Known GABA Uptake Inhibitors.

P. Suzdak, Michael D B Swedberg, J. Lau, 2001 .

Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.

P. Suzdak, Michael D B Swedberg, J. Sorensen, 2001, Journal of medicinal chemistry.

Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases.

M. J. Newman, O. Olsen, G. Peters, 2001, Biochemistry.

Investigation into reversed phase chromatography peptide separation systems part I: Development of a protocol for column characterisation.

H. Thøgersen, P. Petersson, J. Lau, 2019, Journal of chromatography. A.

Synthesis of Substituted 10,11‐Dihydro‐5H‐dibenz[b,f]azepines; Key Synthons in Syntheses of Pharmaceutically Active Compounds.

J. Lau, P. Madsen, K. Andersen, 1999 .