P. Lacombe

发表

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.

Chun Xing Li, R. Young, S. Charleson, 2005, Bioorganic & medicinal chemistry letters.

The discovery and synthesis of potent zwitterionic inhibitors of renin.

J. Falgueyret, M. Percival, S. Gagné, 2011, Bioorganic & medicinal chemistry letters.

L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition.

L. Zhang, R. Young, J. Mancini, 2007, Biochemical pharmacology.

Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.

Yongxin Han, S. Gagné, Y. Ducharme, 2011, Bioorganic & medicinal chemistry letters.

3,4-Diarylpiperidines as potent renin inhibitors.

J. Falgueyret, Yongxin Han, E. Cauchon, 2012, Bioorganic & medicinal chemistry letters.

Identification of a new biaryl scaffold generating potent renin inhibitors.

C. Bayly, D. McKay, R. Aspiotis, 2010, Bioorganic & medicinal chemistry letters.

Structure-activity relationship of biaryl acylsulfonamide analogues on the human EP(3) prostanoid receptor.

D. Denis, R. Ruel, K. Metters, 2002, Bioorganic & medicinal chemistry letters.

Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study.

S. Gagné, D. McKay, E. Grimm, 2010, Bioorganic & medicinal chemistry letters.

Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.

R. Young, J. Mancini, D. Nicholson, 2009, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors.

R. Young, J. Mancini, H. Perrier, 2008, Bioorganic & medicinal chemistry letters.

Design and synthesis of potent, isoxazole-containing renin inhibitors.

J. Falgueyret, M. Percival, Yongxin Han, 2012, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension.

C. Bayly, S. Gagné, S. Soisson, 2010, Bioorganic & medicinal chemistry letters.

Samarium(II) Iodide-Mediated Synthesis of Chlorohydrins†

R. Ruel, P. Lacombe, Bastien Castagner, 1998 .

Reduction of olefins on solid support using diimide

R. Ruel, Y. Gareau, P. Lacombe, 1998 .

A ring closing metathesis-osmylation approach to oxygenated oxepanes as carbohydrate surrogates

P. Lacombe, C. Sturino, Jerome C. Y. Wong, 1999 .

Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors.

S. Charleson, J. Mancini, H. Perrier, 2006, Bioorganic & medicinal chemistry letters.

Structure–Activity Relationship of Biaryl Acylsulfonamide Analogues on the Human EP3 Prostanoid Receptor

D. Denis, R. Ruel, K. Metters, 2002 .

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.

R. Young, J. Mancini, R. Friesen, 2010, Bioorganic & medicinal chemistry letters.

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.

R. Young, J. Mancini, R. Friesen, 2010, Bioorganic & medicinal chemistry letters.