L. Trimble

发表

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.

Chun Xing Li, R. Young, S. Charleson, 2005, Bioorganic & medicinal chemistry letters.

On the use of double‐quantum coherence from an AX3 system (protons in lactate) for spectral editing

P. Allen, L. Trimble, W. Nosel, 1989, Magnetic resonance in medicine.

Biosynthetic origin of the tetrahydropyranyl side chain of verucopeptin

Y. Tsantrizos, L. Trimble, Jianhua Shen, 1997 .

Characterization of verlukast metabolites arising from an epoxide intermediate produced with hepatic microsomes from beta-naphthoflavone-treated rodents (P-4501A1).

R. Zamboni, J. Yergey, L. Favreau, 1993, Drug metabolism and disposition: the biological fate of chemicals.

Identification of 5-keto-(7E,9E,11Z,14Z)-eicosatetraenoic acid as a novel nonenzymatic rearrangement product of leukotriene A4.

J. Falgueyret, D. Riendeau, J. Yergey, 1993, Archives of biochemistry and biophysics.

NMR structural studies of the tight complex between a trifluoromethyl ketone inhibitor and the 85-kDa human phospholipase A2.

M. Bernstein, H. Perrier, I. Street, 1993, Biochemistry.

Verlukast (MK-0679) conjugation with glutathione by rat liver and kidney cytosols and excretion in the bile.

J. Yergey, L. Trimble, D. Nicoll-Griffith, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Lactate editing by means of selective-pulse filtering of both zero-and double-quantum coherence signals

A. Wilman, P. Allen, L. Trimble, 1990 .

In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites.

R. Young, R. Zamboni, Y. Aubin, 2007, Bioorganic & medicinal chemistry letters.

An acid metabolite of cyclosporine.

J. Vederas, L. Trimble, I. Jardine, 1985, Biochemical and biophysical research communications.

Characterization of the in vitro oxidative metabolites of the COX-2 selective inhibitor L-766,112

J. Yergey, C. Li, L. Trimble, 1997 .

Integrated application of capillary HPLC/continuous-flow liquid secondary ion mass spectrometry to discovery stage metabolism studies.

J. Yergey, Y. Ducharme, L. Trimble, 1995, Analytical chemistry.

Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization.

H. Perrier, J. Yergey, J. Silva, 2001, Drug metabolism and disposition: the biological fate of chemicals.

ortho-Hydroxyalkylation of Aminopyridines: A Novel Approach to Heterocycles

C. K. Lau, L. Trimble, Peter A. Zakrzewski, 1999 .

Syntheses of quinolines, dihydro- and tetrahydroquinolines via ortho-quinone methide imine intermediate

C. K. Lau, A. Caillé, L. Trimble, 1996 .

SITE SELECTIVITY IN THE ALPHA -SILYL LITHIATION OF 3,4,6-TRIS-O-(TERT-BUTYLDIMETHYLSILYL)-D-GLUCAL AND 3,4-BIS-O-(TERT-BUTYLDIMETHYLSILYL)-6-DEOXY-L-G LUCAL WITH TERT-BUTYLLITHIUM

R. Friesen, L. Trimble, 1996 .

Comparison of the Suzuki cross-coupling reactions of 4,7-dichloroquinoline and 7-chloro-4-iodoquinoline with arylboronic acids using phosphine-free palladium catalysis in water

R. Friesen, L. Trimble, 2004 .

Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).

D. Riendeau, R. Young, P. Prasit, 2000, Bioorganic & medicinal chemistry letters.

Amination of chiral enolates by dialkyl azodiformates. Synthesis of .alpha.-hydrazino acids and .alpha.-amino acids

J. Vederas, L. Trimble, 1986 .

Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).

R. Young, D. Denis, S. Kargman, 2007, Journal of medicinal chemistry.

Biosynthesis of monocerin. Incorporation of 2H-, 13C-, and 18O-labelled acetates by Drechslera ravenelii

J. Vederas, T. J. Simpson, L. Trimble, 1984 .

Synthesis and reactivity of N-hydroxy-2-aminoindoles

P. Duspara, L. Trimble, Daniel Beaudoin, 2006 .

Total synthesis of (+)-cyanthiwigin AC.

L. Trimble, G. Bordeau, T. Reddy, 2006, Organic letters.

Synthesis and Reactivity of N-Hydroxy-2-Amino-3-Arylindoles

P. Duspara, L. Trimble, Daniel Beaudoin, 2007 .

Facile construction of the bicyclo[6.4.0]dodecane ring system via intramolecular cyclization of a sulfone stabilized carbanion

E. Grimm, L. Trimble, Michel L. Coutu, 1993 .

Total synthesis of (±)-Heliannuol A

E. Grimm, L. Trimble, Sylvain Levac, 1994 .

ORTHO-QUINONE METHIDE IMINE : GENERATION AND DIELS-ALDER REACTION AT ROOM TEMPERATURE

C. K. Lau, A. Caillé, L. Trimble, 1996 .

Discovery, biosynthesis, and structure elucidation of metabolites of a doping agent and a direct analogue, tetrahydrogestrinone and gestrinone, using human hepatocytes.

L. Trimble, N. Chauret, Jean-François Lévesque, 2005, Analytical chemistry.

Syntheses of Quinolines, Dihydro‐ and Tetrahydroquinolines via ortho‐ Quinone Methide Imine Intermediates.

A. Caillé, L. Trimble, Lau Cheuk-Kun, 1996 .

Isolation and structure elucidation by LC-MS-SPE/NMR: PR toxin- and cuspidatol-related eremophilane sesquiterpenes from Penicillium roqueforti.

J. Miller, M. Sumarah, B. Blackwell, 2007, Journal of natural products.

Biosynthesis of the meroterpenoid, austin, by Aspergillus ustus: incorporation of 18O2, sodium [1-13C, 18O2]acetate, and [Me-13C, 2H3]methionine

Richard N. Moore, J. Vederas, T. J. Simpson, 1984 .

NMR method to detect stereospecific deuterium labeling at diastereotopic methylene hydrogens: selective proton, carbon-13 heteronuclear shift correlation

J. Vederas, P. Reese, L. Trimble, 1985 .

Application of stable isotope labelling methodology to the biosynthesis of the mycotoxin, terretonin, by aspergillus terreus: incorporation of 13C-labelled acetates and methionine, 2H- and 13C, 18O-labelled ethyl 3,5-dimethylorsellinate and oxygen-18 gas

J. Vederas, T. J. Simpson, L. Trimble, 1989 .

Studies on the biosynthesis of the mycotoxin austin, a meroterpenoid metabolite of Aspergillus ustus

Richard N. Moore, J. Vederas, K. Arai, 1989 .

Biosynthesis of the meroterpenoid austin, by Aspergillus ustus: synthesis and incorporation of 13C,18O-labelled ethyl 3,5-dimethylorsellinate

J. Vederas, T. J. Simpson, L. Trimble, 1986 .

Structure–activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists

D. Denis, R. Gordon, R. Zamboni, 2005 .

Identification of Novel Metabolites of Colchicine in Rat Bile Facilitated by Enhanced Online Radiometric Detection

Valentina V Jeliazkova-Mecheva, G. Kwei, A. Harsch, 2008, Drug Metabolism and Disposition.

In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).

D. Riendeau, C. Brideau, J. Mancini, 2001, Bioorganic & medicinal chemistry letters.

Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560.

H. Perrier, K. Bateman, Y. Girard, 2006, Journal of mass spectrometry : JMS.

Biosynthesis and full NMR assignment of Fungichromin, a polyene antibiotic from Streptomyces cellulosae

J. Vederas, H. Noguchi, K. Arai, 1988 .

High‐resolution NMR experiments which use frequency‐selective R.F. Pulses in combination with magnetic field gradients

M. Bernstein, L. Trimble, 1994 .

Oxidative bioactivation of the lactol prodrug of a lactone cyclooxygenase-2 inhibitor.

J. Falgueyret, D. Riendeau, Z. Wang, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Detection of deuterium labelling by two-dimensional 1H,13C nuclear magnetic resonance shift correlation with 2H decoupling

J. Vederas, P. Reese, L. Trimble, 1986 .

In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.

Chun Xing Li, J. Yergey, J. Silva, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis and Reactivity of N-Hydroxy-2-aminoindoles.

P. Duspara, L. Trimble, Daniel Beaudoin, 2006 .

Studies on the Dimerization of 2-Benzylidene-1-indanone.

Y. Leblanc, N. Tsou, L. Trimble, 1997, The Journal of organic chemistry.

Nuclear magnetic resonance spectroscopy and sensitizer-adduct measurements of photodynamic therapy-induced ischemia in solid tumors.

P. Allen, M. Arnfield, M. Chetner, 1991, Journal of the National Cancer Institute.

Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: impacts of glutathione trapping and glucuronide conjugation on covalent binding.

R. Young, R. Zamboni, K. Bateman, 2007, Bioorganic & medicinal chemistry letters.

Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones.

M. Gresser, C. Ramachandran, Qingping Wang, 2004, Biochemistry.

Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.

J. Lacaille, R. Mckernan, G. O'neill, 2001, Molecular pharmacology.

Automation of protein 2D proton NMR assignment by means of fuzzy mathematics and graph theory

Jun Xu, Bryan C. Sanctuary, Suzana K. Straus, 1993, J. Chem. Inf. Comput. Sci..

Use of fuzzy mathematics for complete automated assignment of peptide 1H 2D NMR spectra.

S. Straus, J Xu, S K Straus, 1994, Journal of Magnetic Resonance - Series B.