Susana Liu

发表

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.

Chun Xing Li, R. Young, S. Charleson, 2005, Bioorganic & medicinal chemistry letters.

The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors.

R. Young, D. Nicholson, Y. Girard, 2010, Bioorganic & medicinal chemistry letters.

Preferential inhibition of human phosphodiesterase 4 by ibudilast.

Y. Natsumeda, M. Salem, Zheng Huang, 2006, Life sciences.

Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors

M. Percival, D. Riendeau, W. Cromlish, 2011, Journal of the renin-angiotensin-aldosterone system : JRAAS.

Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.

R. Young, J. Mancini, D. Nicholson, 2009, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors.

R. Young, J. Mancini, H. Perrier, 2008, Bioorganic & medicinal chemistry letters.

In vitro PKA phosphorylation‐mediated human PDE4A4 activation

M. Gresser, Zheng Huang, F. Laliberté, 2002, FEBS letters.

Dynamic Activation of Cystic Fibrosis Transmembrane Conductance Regulator by Type 3 and Type 4D Phosphodiesterase Inhibitors

M. Tota, A. Veilleux, R. Friesen, 2005, Journal of Pharmacology and Experimental Therapeutics.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Interaction of vanadium (V) complexes with rabbit muscle phosphoglycerate mutase studies by 1H and 51V nuclear magnetic resonance

Susana Liu, 1989 .

Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis.

S. Jin, M. Conti, D. Macdonald, 2002, The Journal of clinical investigation.

Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate*

M. Gresser, C. Ramachandran, P. Payette, 1997, The Journal of Biological Chemistry.

Interaction of vanadate with uridine and adenosine monophosphate. Formation of ADP and ATP analogs

A. Tracey, M. Gresser, Susana Liu, 1988 .

Development of a homogeneous immunoassay for the detection of angiotensin I in plasma using AlphaLISA acceptor beads technology.

J. Falgueyret, M. Percival, Steve Rowland, 2009, Analytical biochemistry.

Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors.

S. Charleson, J. Mancini, H. Perrier, 2006, Bioorganic & medicinal chemistry letters.

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.

R. Young, J. Mancini, R. Friesen, 2010, Bioorganic & medicinal chemistry letters.

Conformational difference between PDE4 apoenzyme and holoenzyme.

A. Govindarajan, Yongxin Han, M. Gresser, 2000, Biochemistry.

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.

R. Young, J. Mancini, R. Friesen, 2010, Bioorganic & medicinal chemistry letters.