V. Hosagrahara

发表

Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis.

Christopher B. Cooper, Amit K. Gupta, D. Murray, 2017, Journal of medicinal chemistry.

Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway

Amit K. Gupta, G. Balakrishnan, A. Narayan, 2016 .

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.

M. Blanar, Rongan Zhang, S. Krystek, 2016, ACS medicinal chemistry letters.

Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.

Wei Wang, Jonathan Lippy, Arthur M Doweyko, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.

Weiqi Wang, A. Doweyko, T. Harrity, 2015, Bioorganic & medicinal chemistry letters.

Effect of repeated dosing on rifampin exposure in BALB/c mice.

Vijay T. Ahuja, S. Ganguly, J. Reddy, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Functional analysis of human microsomal epoxide hydrolase genetic variants.

A. Rettie, V. Hosagrahara, C. Hassett, 2004, Chemico-biological interactions.

Induction of the metabolism of midazolam by rifampin in cultured porcine hepatocytes: preliminary evidence for CYP3A isoforms in pigs.

R. Remmel, L. Hansen, V. Hosagrahara, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Epoxide hydrolase--polymorphism and role in toxicology.

V. Hosagrahara, C. Hassett, C. Omiecinski, 2000, Toxicology letters.

3,5-diarylazoles as novel and selective inhibitors of protein kinase D.

I. Enyedy, T. McKinsey, N. Pagratis, 2011, Bioorganic & medicinal chemistry letters.

Identification of orally available naphthyridine protein kinase D inhibitors.

I. Enyedy, T. McKinsey, Margaret R Pancost, 2010, Journal of medicinal chemistry.

Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.

A. Doweyko, T. Harrity, Litao Zhang, 2008, Bioorganic & medicinal chemistry letters.

Title Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

J. Sivak, Fupeng Ma, P. Tarsa, 2018 .

Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration.

J. Sivak, B. Jaffee, Fupeng Ma, 2015, Journal of medicinal chemistry.

Identification of a Novel N-Carbamoyl Glucuronide: In Vitro, In Vivo, and Mechanistic Studies

U. Argikar, V. Hosagrahara, Suzie Ferreira, 2010, Drug Metabolism and Disposition.

Evaluation of pharmaceutical excipients as cosolvents in 4-methyl umbelliferone glucuronidation in human liver microsomes: applications for compounds with low solubility.

U. Argikar, V. Hosagrahara, Wendy Lee, 2011, Drug Metabolism and Pharmacokinetics.

Preclinical investigations and a first-in-human phase I trial of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2, in patients with advanced solid tumors

K. Papadopoulos, A. Naing, S. Piha-Paul, 2020, Journal for ImmunoTherapy of Cancer.

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

D. Wirth, D. Fidock, Pavithra Viswanath, 2015, Nature Communications.

Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator Published, JLR Papers in Press, June 1, 2004. DOI 10.1194/jlr.M300450-JLR200

T. Kirchgessner, J. Billheimer, Jeffrey Billheimer, 2004, Journal of Lipid Research.

4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity.

J. Mckinney, L. Chiarelli, N. Dhar, 2014, Journal of medicinal chemistry.

Discovery of pyrazolopyridones as a novel class of noncovalent DprE1 inhibitor with potent anti-mycobacterial activity.

A. Narayan, V. Ramachandran, V. Sambandamurthy, 2014, Journal of medicinal chemistry.

Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.

Vijay T. Ahuja, A. Srivastava, A. Narayan, 2013, Journal of medicinal chemistry.

Concise review of the cytochrome P450s and their roles in toxicology.

R. Remmel, V. Hosagrahara, C. Omiecinski, 1999, Toxicological sciences : an official journal of the Society of Toxicology.

N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds.

D. Fidock, F. Gamo, A. Srivastava, 2014, Journal of medicinal chemistry.

Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.

D. Wirth, F. Gamo, Pavithra Viswanath, 2014, Journal of medicinal chemistry.

317 Characterization of pharmacokinetics, pharmacodynamics, tolerability and clinical activity in phase I studies of the novel allosteric tyrosine kinase 2 (TYK2) inhibitor NDI-034858

J. McElwee, V. Hosagrahara, S. Carreiro, 2022, Journal of Investigative Dermatology.

Microsoft Word-18199777-file00

U. Argikar, V. Hosagrahara, Suzie Ferreira, 2009 .

Single-Dose Pharmacokinetics, Excretion, and Metabolism of Zoliflodacin, a Novel Spiropyrimidinetrione Antibiotic, in Healthy Volunteers

K. Vishwanathan, V. Hosagrahara, J. O’Donnell, 2018, Antimicrobial Agents and Chemotherapy.

Challenges and opportunities in tuberculosis drug discovery: an industry perspective.

Pravin S. Shirude, V. Hosagrahara, Sreekanth A. Ramachandran, 2013, Future medicinal chemistry.

Identification of potent and selective amidobipyridyl inhibitors of protein kinase D.

I. Enyedy, T. McKinsey, D. Lemon, 2010, Journal of medicinal chemistry.

Comparative Metabolism of Radiolabeled Muraglitazar in Animals and Humans by Quantitative and Qualitative Metabolite Profiling

W. Humphreys, Haiying Zhang, Litao Zhang, 2007, Drug Metabolism and Disposition.

Reactivity of mefenamic acid 1-o-acyl glucuronide with proteins in vitro and ex vivo.

B. Burchell, D. Tosh, K. McGurk, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).

Wei Wang, Jun Li, Ying Wang, 2010, Journal of medicinal chemistry.

The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.

J. Sivak, B. Jaffee, Fupeng Ma, 2018, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.

Daniel Meyers, Jonathan Lippy, Rongan Zhang, 2010, Bioorganic & medicinal chemistry letters.

Identification and mitigation of a reactive metabolite liability associated with aminoimidazoles.

Vijay T. Ahuja, A. Srivastava, V. Hosagrahara, 2014, Chemical research in toxicology.

Lipid Peroxide–Mediated Oxidative Rearrangement of the Pyrazinone Carboxamide Core of Neutrophil Elastase Inhibitor AZD9819 in Blood Plasma Samples

A. Wells, R. Lewis, V. Hosagrahara, 2015, Drug Metabolism and Disposition.

DMD065136 1441..1449

A. Wells, R. Lewis, V. Hosagrahara, 2015 .

Pharmacokinetics of muraglitazar (BMS-298585), a dual peroxisome proliferator-activated receptors (PPAR) alpha and gamma activator, in mice, rats, dogs, and monkeys.

W. Humphreys, B. Koplowitz, V. Hosagrahara, 2006, Xenobiotica; the fate of foreign compounds in biological systems.

Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.

J. McElwee, Phani Ghanakota, Wenyan Miao, 2023, Journal of Medicinal Chemistry.

Evaluation of the effect of culture matrices on induction of CYP3A isoforms in cultured porcine hepatocytes.

G. Beilman, R. Remmel, L. Hansen, 2000, Chemico-biological interactions.