H. Lamb

发表

A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.

J. Otero, A. Hawkins, C. González‐Bello, 2011, Journal of medicinal chemistry.

The molecular biology of multidomain proteins

A. Hawkins, Alastair R. Hawkins, H. Lamb, 1995 .

The molecular biology of multidomain proteins. Selected examples.

H K Lamb, A. Hawkins, H. Lamb, 1995, European journal of biochemistry.

Evolution of transcription-regulating proteins by enzyme recruitment: molecular models for nitrogen metabolite repression and ethanol utilisation in eukaryotes.

J. Moore, A. Hawkins, A. Radford, 1994, Gene.

Crystal structure of NucB, a biofilm-degrading endonuclease

A. Hawkins, R. Lewis, H. Murray, 2017, Nucleic acids research.

PDZ Domains Facilitate Binding of High Temperature Requirement Protease A (HtrA) and Tail-specific Protease (Tsp) to Heterologous Substrates through Recognition of the Small Stable RNA A (ssrA)-encoded Peptide*

I. Charles, M. Pallen, D. Maskell, 2002, The Journal of Biological Chemistry.

Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78

B. Lefkove, S. Martin, J. Arbiser, 2013, British Journal of Cancer.

Molecular organisation of the quinic acid utilization (QUT) gene cluster in Aspergillus nidulans

A. Hawkins, H. Lamb, Melanie Smith, 1988, Molecular and General Genetics MGG.

2‐Substituted‐3‐Dehydroquinic Acids as Potent Competitive Inhibitors of Type II Dehydroquinase

A. Hawkins, C. González‐Bello, L. Castedo, 2009, ChemMedChem.

Structural characterization of Salmonella typhimurium YeaZ, an M22 O‐sialoglycoprotein endopeptidase homolog

Ian G. Charles, I. Charles, D. Stammers, 2006, Proteins.

Isolation and partial cloning of ryanodine‐sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle

G. Meissner, H. Lamb, J. Morgan, 1995, FEBS letters.

The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases

A. Hawkins, Christopher L. Johnson, J. Gray, 2010, Protein science : a publication of the Protein Society.

Dinucleotide-Sensing Proteins: Linking Signaling Networks and Regulating Transcription

D. Stammers, A. Hawkins, H. Lamb, 2008, Science Signaling.

Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium.

W. Dunlop, H. Lamb, J. Morgan, 1997, The Biochemical journal.

A second gene (qutH) within the Aspergillus nidulans-quinic-acid utilisation gene cluster encodes a protein with a putative zinc-cluster motif.

A. Hawkins, H. Lamb, C. Roberts, 1992, Gene.

Spatial and biological characterisation of the complete quinic acid utilisation gene cluster in Aspergillus nidulans

G. Turner, A. Hawkins, John L. Brown, 1990, Molecular and General Genetics MGG.

Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium

Clive R. Bagshaw, I. Charles, D. Stammers, 2007, Protein science : a publication of the Protein Society.

Matriptase Induction of Metalloproteinase‐Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms

C. Craik, R. Leduc, A. Hawkins, 2017, Arthritis & rheumatology.

Expression, purification and crystallization of Aspergillus nidulans NmrA, a negative regulatory protein involved in nitrogen-metabolite repression.

D. Stammers, A. Hawkins, C. Nichols, 2001, Acta crystallographica. Section D, Biological crystallography.

In vivo overproduction of the pentafunctional arom polypeptide in Aspergillus nidulans affects metabolic flux in the quinate pathway

Clive R. Bagshaw, A. Hawkins, H. Lamb, 1991, Molecular and General Genetics MGG.

Modulation of the ligand binding properties of the transcription repressor NmrA by GATA‐containing DNA and site‐directed mutagenesis

D. Stammers, A. Hawkins, K. Leslie, 2004, Protein science : a publication of the Protein Society.

Deletion of the 389 N-Terminal Residues of the Transcriptional Activator AREA Does Not Result in Nitrogen Metabolite Derepression in Aspergillus nidulans

H. Lamb, A. Dodds, D. R. Swatman, 1998 .

Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases

I. Charles, D. Stammers, A. Hawkins, 2007, Proteins.

Mycobacterium tuberculosis shikimate kinase inhibitors: design and simulation studies of the catalytic turnover.

J. Otero, A. Hawkins, C. González‐Bello, 2013, Journal of the American Chemical Society.

Synthesis of 3-alkyl enol mimics inhibitors of type II dehydroquinase: factors influencing their inhibition potency.

A. Hawkins, C. González‐Bello, B. Blanco, 2012, Organic & biomolecular chemistry.

Understanding the Key Factors that Control the Inhibition of Type II Dehydroquinase by (2R)‐2‐Benzyl‐3‐dehydroquinic Acids

J. Otero, F. Gago, A. Hawkins, 2010, ChemMedChem.

Inducible overproduction of the Aspergillus nidulans pentafunctional AROM protein and the type-I and -II 3-dehydroquinases from Salmonella typhi and Mycobacterium tuberculosis.

I. Charles, G. Dougan, J. Moore, 1992, The Biochemical journal.

The Negative Transcriptional Regulator NmrA Discriminates between Oxidized and Reduced Dinucleotides*

D. Stammers, A. Hawkins, K. Leslie, 2003, Journal of Biological Chemistry.

A thermodynamic study of the reactions: {2-dehydro-3-deoxy-d-arabino-heptanoate 7-phosphate(aq)=3-dehydroquinate(aq) + phosphate(aq)} and {3-dehydroquinate(aq)=3-dehydroshikimate(aq) + H2O(l)}

A. Hawkins, R. Goldberg, Y. B. Tewari, 2002 .

The Affinity of a Major Ca2+ Binding Site on GRP78 Is Differentially Enhanced by ADP and ATP*

I. Charles, A. Hawkins, Weiming Xu, 2006, Journal of Biological Chemistry.

Isolation, characterization and nucleotide sequences of the aroC genes encoding chorismate synthase from Salmonella typhi and Escherichia coli.

I. Charles, G. Dougan, A. Hawkins, 1990, Journal of general microbiology.

Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium.

Ian G. Charles, I. Charles, D. Stammers, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural analysis of the recognition of the negative regulator NmrA and DNA by the zinc finger from the GATA-type transcription factor AreA.

D. Stammers, A. Hawkins, Christopher L. Johnson, 2008, Journal of molecular biology.

Comparative analysis of the QUTR transcription repressor protein and the three C-terminal domains of the pentafunctional AROM enzyme.

J. Coggins, J. Moore, A. Hawkins, 1996, The Biochemical journal.

Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD–YeaZ–YjeE complex

I. Charles, D. Stammers, A. Hawkins, 2013, Protein science : a publication of the Protein Society.

Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: An unusual Type II glyoxalase

I. Charles, D. Stammers, A. Hawkins, 2010, Protein science : a publication of the Protein Society.

GTP Cyclohydrolase II Structure and Mechanism*

D. Stammers, A. Hawkins, M. Lockyer, 2005, Journal of Biological Chemistry.

The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short‐chain dehydrogenase/reductases

D. Stammers, A. Hawkins, C. Nichols, 2001, The EMBO journal.

Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase: Synthesis, Biological Evaluation, and NMR Studies

A. Hawkins, C. González‐Bello, S. Suh, 2008, ChemMedChem.

Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase.

D. Stammers, A. Hawkins, C. Nichols, 2001, Acta crystallographica. Section D, Biological crystallography.

Genetic regulation of the quinic acid utilization (QUT) gene cluster in Aspergillus nidulans.

A. Hawkins, H. Lamb, S. Grant, 1988, Journal of general microbiology.

Deletion of the N-terminal region of the AREA protein is correlated with a derepressed phenotype with respect to nitrogen metabolite repression

A. Hawkins, H. Lamb, A. Dodds, 1997, Journal of bacteriology.

The QUTA activator and QUTR repressor proteins of Aspergillus nidulans interact to regulate transcription of the quinate utilization pathway genese.

A. Hawkins, H. Lamb, C. Roberts, 1996, Microbiology.

The pre-chorismate (shikimate) and quinate pathways in filamentous fungi: theoretical and practical aspects.

I. Charles, J. Moore, A. Hawkins, 1993, Journal of general microbiology.

Identification and isolation of a putative permease gene in the quinic acid utilization (QUT) gene cluster of Aspergillus nidulans

A. Hawkins, H. Lamb, S. Grant, 2004, Current Genetics.

Determination of the Bound Conformation of a Competitive Nanomolar Inhibitor of Mycobacterium tuberculosis Type II Dehydroquinase by NMR Spectroscopy

A. Hawkins, C. González‐Bello, F. Cañada, 2006, ChemMedChem.

Interaction between relaxase MbeA and accessory protein MbeC of the conjugally mobilizable plasmid ColE1

C. Drainas, A. Hawkins, F. de la Cruz, 2012, FEBS letters.

Genesis of eukaryotic transcriptional activator and repressor proteins by splitting a multidomain anabolic enzyme.

J. Moore, A. Hawkins, H. Lamb, 1993, Gene.

Domain structure and function within the QUTA protein of Aspergillus nidulans: implications for the control of transcription.

R. Dalgleish, A. Hawkins, E. V. van Schothorst, 1996, Microbiology.

Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases.

F. Gago, A. Hawkins, C. González‐Bello, 2014, The Biochemical journal.

Mechanistic basis of the inhibition of type II dehydroquinase by (2S)- and (2R)-2-benzyl-3-dehydroquinic acids.

J. Otero, A. Hawkins, C. González‐Bello, 2013, ACS chemical biology.

Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase

J. Coggins, A. Hawkins, C. González‐Bello, 2007, ChemMedChem.

Structure-based design, synthesis, and biological evaluation of inhibitors of Mycobacterium tuberculosis type II dehydroquinase.

A. Hawkins, C. González‐Bello, L. Castedo, 2005, Journal of medicinal chemistry.

Identification of domains responsible for signal recognition and transduction within the QUTR transcription repressor protein.

J. Coggins, A. Hawkins, H. Lamb, 2000, The Biochemical journal.

Kinetic analysis of the interaction between the QutA and QutR transcription‐regulating proteins

J. Coggins, A. Hawkins, H. Lamb, 2002, Proteins.

Ligand-induced conformational changes and a mechanism for domain closure in Aspergillus nidulans dehydroquinate synthase.

D. Stammers, A. Hawkins, C. Nichols, 2003, Journal of molecular biology.

Biophysical and kinetic analysis of wild‐type and site‐directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein

I. Charles, D. Stammers, J. Moore, 2004, Protein science : a publication of the Protein Society.

Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of Type II Dehydroquinase

J. Otero, A. Hawkins, C. González‐Bello, 2011, ChemMedChem.

Differential flux through the quinate and shikimate pathways. Implications for the channelling hypothesis.

A. Hawkins, H. Lamb, G. H. Newton, 1992, The Biochemical journal.

Structure of the Aspergillus nidulans qut repressor-encoding gene: implications for the regulation of transcription initiation.

H. Lamb, Alastair R. Hawkins, Clive F. Roberts, 1992, Gene.