D. Kyle

发表

Computational screening of combinatorial libraries via multicopy sampling

Q. Zheng, D. Kyle, Qiang Zheng, 1997 .

Multiple copy sampling: Rigid versus flexible protein

D J Kyle, Q Zheng, Q. Zheng, 1994, Proteins.

NMR and computational evidence that high-affinity bradykinin receptor antagonists adopt C-terminal beta-turns.

D J Kyle, M. Summers, P. Blake, 1993, Journal of medicinal chemistry.

A Systematic Study of the Sar in Second Generation Bradykinin Antagonists Leads to the Design of the First High Affinity Cyclic Peptide Antagonists

S. Chakravarty, D. Kyle, B. Mavunkel, 1994 .

Synthesis and characterization of pseudopeptide bradykinin B2 receptor antagonists containing the 1,3,8-triazaspiro[4.5]decan-4-one ring system.

E. Novotny, S. Chakravarty, D. Kyle, 1996, Journal of medicinal chemistry.

Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7‐selective peptide – protoxin II

K. Carlin, Gang Wu, D. Kyle, 2012, Journal of peptide science : an official publication of the European Peptide Society.

A Review of the NOP (ORL-1)-Nociceptin/Orphanin FQ System Covering Receptor Structure, Distribution, Role in Analgesia and Reward and Interactions with Other Receptors

D. Kyle, G. Whiteside, 2013 .

Roles of Mu Opioid Receptors and Nociceptin/Orphanin FQ Peptide Receptors in Buprenorphine-Induced Physiological Responses in Primates

D. Kyle, M. Ko, Colette M Cremeans, 2012 .

Recent developments in the understanding of bradykinin receptors.

D. Kyle, R. Burch, Ronald M. Burch, 1992, Life sciences.

Molecular biology and pharmacology of bradykinin receptors

T. Stormann, D. Kyle, R. Burch, 1993 .

Functionally Biased Agonism of Mu and Kappa Opioid Receptors

D. Kyle, 2013 .

N-Aryl azacycles as novel sodium channel blockers.

K. Carlin, S. Lynch, D. Kyle, 2015, Bioorganic & medicinal chemistry letters.

Solid-phase synthesis of 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones

Qun Sun, D. Kyle, Xiaoming Zhou, 2001 .

d‐Arg[Hyp3‐Thi5‐d‐Tic7‐Tic8]‐bradykinin, a potent antagonist of smooth muscle BK2 receptors and BK3 receptors

S. Meeker, D. Kyle, J. A. Martin, 1991, British journal of pharmacology.

Antioedematogenic and antinociceptive actions of NPC 18521, a novel bradykinin B2 receptor antagonist.

J. Calixto, S. Chakravarty, D. Kyle, 1996, European journal of pharmacology.

Antinociceptive profile of the pseudopeptide B2 bradykinin receptor antagonist NPC 18688 in mice

J. Calixto, D. Kyle, C. R. Corrêa, 1996, British journal of pharmacology.

High-affinity binding of peptide agonists to the human B1 bradykinin receptor depends on interaction between the peptide N-terminal L-lysine and the fourth extracellular domain of the receptor.

L. M. Leeb-Lundberg, D. Kyle, D. Fathy, 2000, Molecular pharmacology.

Oral anti-inflammatory action of NPC 18884, a novel bradykinin B2 receptor antagonist.

J. Calixto, S. Chakravarty, D. Kyle, 1998, European journal of pharmacology.

Mass Receptor Screening for New Drugs

D. Kyle, R. Burch, 1991, Pharmaceutical Research.

Computational screening of combinatorial libraries.

D J Kyle, Q Zheng, Q. Zheng, 1996, Bioorganic & medicinal chemistry.

Design and conformational analysis of several highly potent bradykinin receptor antagonists.

D. Kyle, J. A. Martin, S. G. Farmer, 1991, Journal of medicinal chemistry.

Recent Developments in Theoretical Studies of Proteins Edited by Ron Elber. World Scientific Publishing Co. Pte. Ltd., Singapore. 1996. viii + 399 pp. 16 × 22 cm. ISBN 981-02-2196-7. $78.00.

D. Kyle, 1998 .

Bradykinin Receptor Antagonists

D. Kyle, 2018 .

The N Terminus of Bradykinin When Bound to the Human Bradykinin B2 Receptor Is Adjacent to Extracellular Cys20 and Cys277 in the Receptor*

N. Nash, L. M. Leeb-Lundberg, D. Kyle, 1996, The Journal of Biological Chemistry.

Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist

J. Calixto, S. Chakravarty, J. Ferreira, 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.

Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor.

D. Kyle, K. Valenzano, Zhengming Chen, 2004, Bioorganic & medicinal chemistry letters.

TRPV1 antagonists: a survey of the patent literature

D. Kyle, Laykea Tafesse, 2006 .

Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis.

A. A. Romanovsky, Y. Shimansky, P. Hegyi, 2020, Pharmacology & therapeutics.

Pharmacological profile of novel cyclic analogs of 2-amino-7-phosphonoheptanoic acid.

R. Patch, B. Narayanan, J. Ferkany, 1992, Epilepsy research. Supplement.

Alkylation of DNA with aziridine produced during the hydrolysis of N,N',N''-triethylenethiophosphoramide.

M. Egorin, S. Musser, P. Callery, 1992, Chemical research in toxicology.

A proposed model of bradykinin bound to the rat B2 receptor and its utility for drug design.

D J Kyle, T. Stormann, S. Chakravarty, 1994, Journal of medicinal chemistry.

Display of somatostatin-related peptides in the complementarity determining regions of an antibody light chain.

Baiyang Wang, D. Kyle, D. Soltis, 2005, Archives of biochemistry and biophysics.

Pharmacological profile of NPC 12626, a novel, competitive N-methyl-D-aspartate receptor antagonist.

L. Snell, Susan M. Jones, J. Ferkany, 1989, The Journal of pharmacology and experimental therapeutics.

4-(2-pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists.

Qun Sun, M. Hachicha, Y. Rotshteyn, 2003, Bioorganic & medicinal chemistry letters.

Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management

Y. Yamaguchi, Gang Wu, D. Kyle, 2014, Journal of medicinal chemistry.

1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones as ligands for the NOP receptor.

J. Whitehead, D. Kyle, K. Valenzano, 2004, Bioorganic & medicinal chemistry letters.

8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors.

P. Gharagozloo, A. Gehrig, M. Hachicha, 2005, Journal of medicinal chemistry.

Stable Expression of the Human Kinin B1 Receptor in Chinese Hamster Ovary Cells

D. Proud, J. Bathon, S. Chakravarty, 1997, The Journal of Biological Chemistry.

Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists.

Qun Sun, Y. Rotshteyn, D. Kyle, 2004, Bioorganic & medicinal chemistry letters.

Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells.

L. M. Leeb-Lundberg, D. Kyle, Chong Zhang, 2002, Biochemistry.

Probing the bradykinin receptor: mapping the geometric topography using ethers of hydroxyproline in novel peptides.

J. Sullivan, S. Meeker, D. Kyle, 1991, Agents and actions. Supplements.

Probing the bradykinin receptor: mapping the geometric topography using ethers of hydroxyproline in novel peptides.

J. Sullivan, S. Meeker, D. Kyle, 1991, Journal of medicinal chemistry.

Dibenzazepines and dibenzoxazepines as sodium channel blockers.

K. Carlin, S. Lynch, D. Kyle, 2015, Bioorganic & medicinal chemistry letters.

Multiple copy sampling in protein loop modeling: Computational efficiency and sensitivity to dihedral angle perturbations

C DeLisi, D J Kyle, C. DeLisi, 1994, Protein science : a publication of the Protein Society.

Accuracy and reliability of the scaling‐relaxation method for loop closure: An evaluation based on extensive and multiple copy conformational samplings

D J Kyle, Q Zheng, Q. Zheng, 1996, Proteins.

Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints.

D. Kyle, K. Valenzano, Chong Zhang, 2002, Journal of medicinal chemistry.

Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294.

D. Cavalla, P. Halushka, C. Page, 2003, Pulmonary pharmacology & therapeutics.

Structure-Based Drug Design: Progress Toward the Discovery of the Elusive Bradykinin Receptor Antagonists

D. Kyle, 1995, Current Pharmaceutical Design.

Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.

K. Carlin, P. Blake, Gang Wu, 2014, Journal of medicinal chemistry.

An efficient parallel synthesis of capsazepine and capsazepine analogs.

D. Kyle, Laykea Tafesse, 2004, Combinatorial chemistry & high throughput screening.

A randomized, double-blind, positive-controlled, 3-way cross-over human experimental pain study of a TRPV1 antagonist (V116517) in healthy volunteers and comparison with preclinical profile

L. Arendt-Nielsen, R. Kapil, D. Kyle, 2016, Pain.

Theoretical analysis of the multicopy sampling method in molecular modeling

Rakefet Rosenfeld, R. Rosenfeld, Q. Zheng, 1993 .

Design and synthesis of novel small molecule N/OFQ receptor antagonists.

D. Kyle, K. Valenzano, R. Goehring, 2004, Bioorganic & medicinal chemistry letters.