H. Hayashi

发表

Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

S. Dan, H. Miyoshi, E. Kodama, 2020, Nature Communications.

A ribonucleopeptide module for effective conversion of an RNA aptamer to a fluorescent sensor.

T. Morii, Eiji Nakata, F. Liew, 2011, Bioorganic & medicinal chemistry.

Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance

Arun K. Ghosh, H. Mitsuya, Y. Takamatsu, 2019, Antimicrobial Agents and Chemotherapy.

Raltegravir blocks the infectivity of red‐fluorescent‐protein (mCherry)‐labeled HIV‐1JR‐FL in the setting of post‐exposure prophylaxis in NOD/SCID/Jak3−/− mice transplanted with human PBMCs

Hisataka Kobayashi, H. Mitsuya, S. Okada, 2018, Antiviral research.

Antiviral Activity and Resistance Profile of the Novel HIV-1 Non-Catalytic Site Integrase Inhibitor JTP-0157602

E. Kodama, K. Kimura, H. Hayashi, 2022, Journal of virology.

Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants

Arun K. Ghosh, H. Mitsuya, H. Bulut, 2019, Antimicrobial Agents and Chemotherapy.

Disseminated tuberculosis with paradoxical reactions caused by a Mycobacterium tuberculosis strain belonging to the Indo-Oceanic lineage: An imported case in Japan.

T. Aoyagi, K. Tokuda, M. Kaku, 2022, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Development of A Fluorescent Ribonucleopeptide Sensor for Histamine

T. Morii, H. Hayashi, M. Fukuda, 2009 .

Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors

M. Shirouzu, K. Murayama, E. Kodama, 2022, Communications Biology.

Potent and biostable inhibitors of the main protease of SARS-CoV-2

N. Kishimoto, K. Nakano, T. Okamura, 2022, iScience.

Pyrimidine analogs as a new class of Gram-positive antibiotics, mainly targeting thymineless-death related proteins.

M. Kaku, E. Kodama, C. Nakajima, 2020, ACS infectious diseases.

A Modular Strategy for Development of RNA-Based Fluorescent Sensors

T. Morii, H. Hayashi, M. Fukuda, 2009 .

The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase.

S. Sarafianos, H. Mitsuya, K. Maeda, 2018, Cell chemical biology.

HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir

H. Mitsuya, K. Maeda, Y. Yasutake, 2018, Scientific Reports.

Application of human lymphoid cells for the evaluation of antivirals against human adenovirus type 19: Zalcitabine has superior activity compared to cidofovir

E. Kodama, Kumi Kawaji, H. Hayashi, 2020, Antiviral chemistry & chemotherapy.

Early phase dynamics of traceable mCherry fluorescent protein‐carrying HIV‐1 infection in human peripheral blood mononuclear cells‐transplanted NOD/SCID/Jak3‐/‐ mice

Hisataka Kobayashi, H. Mitsuya, S. Okada, 2017, Antiviral research.

Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure-Activity Studies and Biological and X-ray Structural Studies.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2018, Journal of medicinal chemistry.

Establishing an accurate and sensitive in vitro drug screening system for human adenovirus infection with human corneal cells.

Kumi Kawaji, H. Hayashi, Eiichi Kodama, 2023, Virology.

Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir

Arun K. Ghosh, H. Mitsuya, Y. Koh, 2014, Proceedings of the National Academy of Sciences.

A connecter-like factor, CacA, links RssB/RpoS and the CpxR/CpxA two-component system in Salmonella

R. Utsumi, Wataru Nomura, 加藤明宣, 2012, BMC Microbiology.

Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

M. Kiso, Y. Kawaoka, N. Kishimoto, 2023, Nature Communications.

A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection.

S. Steinberg, H. Mitsuya, B. Nguyen, 1999, Antiviral research.

Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib‐sensitive and ‐resistant multiple myeloma cells

Y. Okuno, M. Matsuoka, H. Mitsuya, 2019, Cancer science.

Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

S. Dan, H. Miyoshi, E. Kodama, 2020, Nature Communications.

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

Arun K. Ghosh, A. Wlodawer, H. Mitsuya, 2021, Nature Communications.

Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance

Arun K. Ghosh, H. Mitsuya, Y. Takamatsu, 2018, mBio.

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

Arun K. Ghosh, H. Mitsuya, H. Jono, 2017, eLife.

Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2015, Journal of medicinal chemistry.

JE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1.

J. Falloon, H. Masur, H. Mitsuya, 1999, Proceedings of the National Academy of Sciences of the United States of America.

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir

Arun K. Ghosh, H. Mitsuya, Teruya Nakamura, 2015, Journal of Virology.

Design Strategies of Fluorescent Biosensors Based on Biological Macromolecular Receptors

Hironori Hayashi, Takashi Morii, Shun Nakano, 2010, Sensors.

Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study

Y. Ohashi, N. Masuda, M. Toi, 2013, Current nutrition and food science.

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

Arun K. Ghosh, H. Mitsuya, D. Davis, 2020, Scientific Reports.

Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.

Irene T Weber, Yuan-Fang Wang, Debananda Das, 2017, Journal of medicinal chemistry.

Removal of human immunodeficiency virus type 1 (HIV-1) protease inhibitors from preparations of immature HIV-1 virions does not result in an increase in infectivity or the appearance of mature morphology

H. Mitsuya, S. Höglund, D. Davis, 1997, Antimicrobial agents and chemotherapy.

Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2016, Journal of medicinal chemistry.

GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants

Arun K. Ghosh, H. Mitsuya, Y. Takamatsu, 2018, Antimicrobial Agents and Chemotherapy.

Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro

Arun K. Ghosh, H. Mitsuya, H. Hayashi, 2022, Antimicrobial agents and chemotherapy.

Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications

Arun K. Ghosh, H. Mitsuya, H. Hayashi, 2019, Antimicrobial Agents and Chemotherapy.

HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir

H. Mitsuya, K. Maeda, Y. Yasutake, 2018, Scientific Reports.

GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants

Arun K. Ghosh, N. Kishimoto, K. Murayama, 2023, Science advances.