H. Kirst

发表

Developing new antibacterials through natural product research

H. Kirst, 2013, Expert opinion on drug discovery.

Recent derivatives from smaller classes of fermentation-derived antibacterials

H. Kirst, 2012, Expert opinion on therapeutic patents.

Novel fermentation products from Streptomyces fradiae: X-ray crystal structure of 5-O-mycarosyltylactone and proof of the absolute configuration of tylosin.

R. H. Baltz, N. D. Jones, H. Kirst, 1982, The Journal of antibiotics.

Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.

K. Willard, H. Kirst, J. Ott, 1988, Journal of medicinal chemistry.

Protein Synthesis Inhibitors from Smaller Antibiotic Classes

H. Kirst, 2014 .

The Application of Artificial Neural Networks to the Identification of New Spinosoids with Improved Biological Activity toward Larvae of Heliothis virescens

J. Gifford, T. Sparks, H. Kirst, 2000 .

Discovery, Isolation, and Structure Elucidation of a Family of Structurally Unique, Fermentation-Derived Tetracyclic Macrolides

K. Michel, J. Deeter, R. C. Yao, 1992 .

Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides.

K. Willard, H. Kirst, J. Ott, 1989, The Journal of antibiotics.

Semi-synthetic derivatives of 16-membered macrolide antibiotics.

H. Kirst, 1994, Progress in medicinal chemistry.

Semi-synthetic derivatives of erythromycin.

H. Kirst, 1993, Progress in medicinal chemistry.

Preparation and evaluation of 3,4''-ester derivatives of 16-membered macrolide antibiotics related to tylosin.

K. Willard, H. Kirst, J. Toth, 1986, The Journal of antibiotics.

Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli

W. Alborn, H. Kirst, N. E. Allen, 1983, Antimicrobial Agents and Chemotherapy.

Introduction to the macrolide antibiotics

H. Kirst, 2002 .

Circumventing resistance to anti-infective agents

H. Kirst, 2015, Expert opinion on pharmacotherapy.

Synthesis and in vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol 3‐Kinase.

R. Schultz, C. Vlahos, H. Kirst, 1997 .

The antibacterial and NMDA receptor activating properties of aminoglycosides are dissociable.

P. Skolnick, H. Kirst, X. Li, 2000, European journal of pharmacology.

Comparative activity of macrolides against Toxoplasma gondii demonstrating utility of an in vitro microassay

H. Kirst, W. Current, S. Chamberland, 1991, Antimicrobial Agents and Chemotherapy.

Comparative Activity of Macrolides against Toxoplasma gondii

H. Kirst, S. Chamberland, 2022 .

Evaluation and development of spinosyns to control ectoparasites on cattle and sheep.

D. Snyder, T. Sparks, H. Kirst, 2002, Current topics in medicinal chemistry.

Branched-chain fatty acids produced by mutants of Streptomyces fradiae, putative precursors of the lactone ring of tylosin

J. Turner, H. Kirst, J. W. Paschal, 1990, Antimicrobial Agents and Chemotherapy.

Biological Activity of the Spinosyns, New Fermentation Derived Insect Control Agents, on Tobacco Budworm (Lepidoptera: Noctuidae) Larvae

S. Thibault, L. Larson, G. Thompson, 1998 .

Chapter 13. Macrolide Antibiotics

H. Kirst, 1990 .

Structure elucidation of A58365A and A58365B, angiotensin converting enzyme inhibitors produced by Streptomyces chromofuscus.

N. D. Jones, J. K. Swartzendruber, H. Kirst, 1988, The Journal of antibiotics.

The spinosyn family of insecticides: realizing the potential of natural products research

H. Kirst, 2010, The Journal of Antibiotics.

A Mild Single-Step Reduction of Oximes to Amines1

H. Kirst, J. P. Leeds, 1988 .

Structural Modification of Macrolide Antibiotics

H. Kirst, 1990 .

Synthesis, antimicrobial evaluation and structure-activity relationships within 23-modified derivatives of 5-O-mycaminosyltylonolide.

R. Molloy, K. Willard, H. Kirst, 1987, The Journal of antibiotics.

Recent developments with macrolide antibiotics

H. Kirst, 1998 .

Structure of the spiroketal-macrolide ossamycin.

J. Clardy, P. Baker, E. Lobkovsky, 1996, The Journal of antibiotics.

The structure of A201A, a novel nucleoside antibiotic.

N. D. Jones, H. Kirst, J. Paschal, 1985, The Journal of antibiotics.

7.21 – Aminoglycosides Antibiotics

H. Kirst, 2007 .

Macrolide antibiotics in food-animal health.

H. Kirst, 1997, Expert opinion on investigational drugs.

13th International Conference on the Chemistry of Antibiotics and Other Bioactive Compounds (ICCA-13)

H. Kirst, 2013, The Journal of Antibiotics.

Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives.

K. Willard, H. Kirst, J. Ott, 1989, The Journal of antibiotics.

Elucidation of structure of novel macrolide antibiotics produced by mutant strains of Streptomyces fradiae.

R. H. Baltz, H. Kirst, G. M. Wild, 1983, The Journal of antibiotics.

Structure-activity studies among 16-membered macrolide antibiotics related to tylosin.

R. H. Baltz, H. Kirst, J. Ott, 1982, The Journal of antibiotics.

Structure of the new spiroketal-macrolide A82548A.

J. Clardy, S. Larsen, E. Lobkovsky, 1995, The Journal of antibiotics.

Position-specific alkylation of lithio-1-trimethylsilylpropyne, a useful new route to acetylenes and 1, 5-dienes

E. Corey, H. Kirst, 1968 .

A Stereospecific Total Synthesis of α-Santalol

E. Corey, J. Katzenellenbogen, H. Kirst, 1970 .

The stereochemical outcome of electrophilic addition reactions on the 5,6-double bond in the spinosyns.

P. Fanwick, J. Erickson, H. Kirst, 2001, The Journal of organic chemistry.

New method for the synthesis of macrolides

E. Corey, H. Kirst, 1972 .

Structure of althiomycin.

N. D. Jones, H. Kirst, M. Chaney, 1975, The Journal of antibiotics.

Fermentation-Derived Insect Control Agents

G. Thompson, T. Sparks, J. Turner, 1999 .

New directions for macrolide antibiotics: pharmacokinetics and clinical efficacy

K., G. Sides, H. Kirst, 1989, Antimicrobial Agents and Chemotherapy.

Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin

H. Kirst, J. W. Paschal, F. T. Counter, 1991, Antimicrobial Agents and Chemotherapy.

New directions for macrolide antibiotics: structural modifications and in vitro activity

G. Sides, H. Kirst, 1989, Antimicrobial Agents and Chemotherapy.

A83543A-D, unique fermentation-derived tetracyclic macrolides

K. Michel, J. Deeter, W. Nakatsukasa, 1991 .

Synthesis and in vitro evaluation of new wortmannin esters: potent inhibitors of phosphatidylinositol 3-kinase.

R. Schultz, C. Vlahos, H. Kirst, 1996, Journal of medicinal chemistry.

7-Hydroxytropolone: an inhibitor of aminoglycoside-2"-O-adenylyltransferase

W. Alborn, H. Kirst, N. Allen, 1982, Antimicrobial Agents and Chemotherapy.

Effects of LY267108, an erythromycin analogue derivative, on lower esophageal sphincter function in the cat.

J. Gidda, D. Dieckman, H. Kirst, 1994, Gastroenterology.

In vitro and in vivo evaluation of C-20- and C-23-modified derivatives of tylosin against veterinary pathogens.

K. Willard, H. Kirst, J. Toth, 1988, The Journal of antibiotics.

Enzyme technologies for pharmaceutical and biotechnological applications

H. Kirst, M. Zmijewski, Yeh Wu-Kuang, 2001 .

Conversion of spinosyn A and spinosyn D to their respective 9- and 17-pseudoaglycones and their aglycones.

H. Kirst, J. W. Paschal, L. C. Creemer, 1998, The Journal of antibiotics.

Synthesis and insecticidal activity of spinosyn analogs functionally altered at the 2'-,3'- and 4'-positions of the rhamnose moiety.

H. Kirst, J. W. Paschal, T. Worden, 2000, Journal of antibiotics (Tokyo. 1968).

Chemistry of A83543A Derivatives. 1. Oxidations and Reductions of A83543A Aglycon

H. Kirst, J. Martynow, 1994 .

Control of site-specific substitution of aminoglycosides by transition metal cations

H. Kirst, J. Toth, B. A. Truedell, 1981 .

Synthesis and in vitro antimicrobial activity of 3-keto 16-membered macrolides derived from tylosin.

H. Kirst, J. Toth, L. C. Creemer, 2002, The Journal of antibiotics.

Synthesis and characterization of a novel inhibitor of an aminoglycoside-inactivating enzyme.

N. D. Jones, H. Kirst, J. Toth, 1982, The Journal of antibiotics.

New macrolide, lincosaminide and streptogramin B antibiotics

Herbert A Kirst, H. Kirst, 2010, Expert opinion on therapeutic patents.

Synthesis and Insecticidal Activity of Spinosyn Analogues Functionally Altered at the 2′‐, 3′‐, and 4′‐Positions of the Rhamnose Moiety.

H. Kirst, J. Paschal, T. Worden, 2000 .

Chemistry and Insecticidal Activity of the Spinosyns

H. Kirst, Carl V. DeAmicis, J. Martynow, 1999 .

Chemistry of A83543A Derivatives. Part 1. Oxidations and Reductions of A83543A Aglycon.

H. Kirst, J. Martynow, 1994 .

New macrolides: expanded horizons for an old class of antibiotics.

H. Kirst, 1991, The Journal of antimicrobial chemotherapy.

Synthesis of ring-contracted derivatives of erythromycin

H. Kirst, J. Paschal, J. A. Wind, 1987 .

Introduction and historical development

H. Kirst, 1995 .

Structure-Activity Relationships Among 9-N-Alkyl Derivatives of Erythromycylamine and Their Effect on the Oxidative Burst of Human Neutrophils In Vitro

H. Kirst, M. Labro, A. Soukri, 2002, Journal of chemotherapy.

Historical Yearly Usage of Vancomycin

D. Thompson, T. Nicas, H. Kirst, 1998, Antimicrobial Agents and Chemotherapy.

12th International Conference on the Chemistry of Antibiotics and other Bioactive Compounds (ICCA-12)

H. Kirst, 2011, The Journal of Antibiotics.

Genetic engineering of aminodeoxyhexose biosynthesis in Streptomyces fradiae

N. Bate, A. Butler, D. Kiehl, 2002, Nature Biotechnology.

Comparison of aminoglycoside antibiotics with respect to uptake and lethal activity in Escherichia coli.

W. Alborn, H. Kirst, N. E. Allen, 1987, Journal of medicinal chemistry.

Synthesis, antimicrobial activity and in vivo fluorine NMR of a hexafluorinated derivative of tilmicosin.

A. Webb, H. Kirst, J. Campbell, 1995, Journal of antibiotics (Tokyo. 1968).

Identification and Synthesis of Products Isolated during Metabolism Studies of Tilmicosin

H. Kirst, J. Paschal, D. M. Berry, 1994 .