Yinghong Gao

发表

The use of ligand-based de novo design for scaffold hopping and sidechain optimization: two case studies.

Miklos Feher, John Saunders, J Christian Baber, 2008, Bioorganic & medicinal chemistry.

Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: Selectivity between voltage‐gated and Maxi‐K channels

M. Garcia, Yinghong Gao, Maria L. Garcia, 2003, Proteins.

Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain.

Richard E Middleton, Ying-Duo Gao, R. Middleton, 2004, Biochemistry.

(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

G. Scapin, Suresh B. Singh, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

Fluoroalkyl substituted (Z)-dehydro α-amino ester as a building block for the fluorine-containing cyclopropyl α-amino esters and dihydrooxazole

Yinghong Gao, J. Hao, Haizhen Jiang, 2008 .

Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected].

Ping Chen, G. Scapin, R. S. Roy, 2013, Bioorganic & medicinal chemistry letters.

Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.

Youwei Yan, Ping Chen, J. Metzger, 2015, Bioorganic & medicinal chemistry letters.

Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis.

T. Fischmann, K. Maloney, C. Garlisi, 2017, Bioorganic & medicinal chemistry letters.

Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.

K. Lyons, A. Weber, G. Kaczorowski, 2009, Bioorganic & medicinal chemistry letters.

Binding of Correolide to the Kv1.3 Potassium Channel: Characterization of the Binding Domain by Site-Directed Mutagenesis†

G. Kaczorowski, A. Linde, M. Matyskiela, 2001 .

(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.

A. Blackburn, I. Gaidarov, S. H. Kim, 2014, ACS medicinal chemistry letters.

Fused tricyclic indoles as S1P₁ agonists with robust efficacy in animal models of autoimmune disease.

D. Sengupta, Michael E. Morgan, K. Whelan, 2012, Bioorganic & medicinal chemistry letters.

Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.

Jinsong Hao, A. Stamford, G. Scapin, 2016, ACS medicinal chemistry letters.

Determination of the binding mode of thienopyrimidinedione antagonists to the human gonadotropin releasing hormone receptor using structure-activity relationships, site-directed mutagenesis, and homology modeling.

Zhiqian Guo, S. Betz, M. Mesleh, 2006, Journal of medicinal chemistry.

Glycine 30 in iberiotoxin is a critical determinant of its specificity for maxi‐K versus KV channels

N. Schroeder, Yinghong Gao, W. Schmalhofer, 2002, FEBS letters.

Discovery of novel BTK inhibitors with carboxylic acids.

T. Fischmann, K. Maloney, C. Garlisi, 2017, Bioorganic & medicinal chemistry letters.

Succinic Acids as Potent Inhibitors of Plasmid-borne IMP-1 Metallo-β-lactamase*

N. Sharma, P. Fitzgerald, S. Olson, 2001, The Journal of Biological Chemistry.

A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Martin Augustin, Yinghong Gao, M. Augustin, 2013, The Biochemical journal.

Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.

V. Hornak, T. Fischmann, K. Maloney, 2016, ACS medicinal chemistry letters.

Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists.

Zhiqian Guo, Chen Chen, Yinghong Gao, 2004, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists.

Zhiqian Guo, Chen Chen, Yinghong Gao, 2003, Bioorganic & medicinal chemistry letters.

Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists.

Zhiqian Guo, Chen Chen, Yinghong Gao, 2003, Journal of medicinal chemistry.

Quinoline-carboxylic acids are potent inhibitors that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins.

N. Ling, K. Wilcoxen, Chen Chen, 2003, Bioorganic & medicinal chemistry letters.

Two tarantula peptides inhibit activation of multiple sodium channels.

V. Garsky, M. Bogusky, V. Warren, 2002, Biochemistry.

4-{(2R)-[3-Aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thienyl)ethylaminomethyl]phenyl}piperazine as a potent and selective melanocortin-4 receptor antagonist--design, synthesis, and characterization.

Beth A. Fleck, Joe A. Tran, A. Foster, 2004, Journal of medicinal chemistry.

The synthesis of sialylated oligosaccharides using a CMP-Neu5Ac synthetase/sialyltransferase fusion

Yinghong Gao, M. Gilbert, W. Wakarchuk, 1998, Nature Biotechnology.

Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.

Zhiqian Guo, Chen Chen, Yinghong Gao, 2003, Journal of medicinal chemistry.

3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization.

N. Ling, Zhiqian Guo, Xin-jun Liu, 2005, Journal of medicinal chemistry.

Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.

Kathy Lyons, Ping Chen, Dennis Feng, 2014, Journal of medicinal chemistry.

Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.

T. Fischmann, K. Maloney, C. Garlisi, 2020, Bioorganic & medicinal chemistry letters.

The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization.

V. Hornak, W. Schafer, C. Welch, 2012, Bioorganic & Medicinal Chemistry.

Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality.

V. Hornak, W. Schafer, C. Welch, 2011, ACS medicinal chemistry letters.

Functional Mapping of the Transient Receptor Potential Vanilloid 1 Intracellular Binding Site

T. Bonnert, R. Middleton, Yinghong Gao, 2006, Molecular Pharmacology.

Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.

D. Macneil, H. Iwaasa, A. Kanatani, 2009, Bioorganic & Medicinal Chemistry Letters.

Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P₁ agonists.

C. Sage, Robert M. Jones, Yinghong Gao, 2011, Bioorganic & medicinal chemistry letters.

Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor.

S. H. Kim, Robert M. Jones, Yinghong Gao, 2015, Bioorganic & medicinal chemistry letters.

A comparative study of the binding properties, dipeptidyl peptidase‐4 (DPP‐4) inhibitory activity and glucose‐lowering efficacy of the DPP‐4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice

G. Scapin, J. Berger, N. Thornberry, 2017, Endocrinology, diabetes & metabolism.

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.

A. Blackburn, David Mills, I. Gaidarov, 2014, ACS medicinal chemistry letters.

The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors.

J. Metzger, G. Scapin, S. Xu, 2016, Bioorganic & medicinal chemistry letters.

Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists.

John Saunders, Yinghong Gao, N. Ling, 2002, Bioorganic & medicinal chemistry letters.

Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.

G. Scapin, Suresh B. Singh, N. Thornberry, 2008, Bioorganic & medicinal chemistry letters.

Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors.

R. Sheridan, G. Scapin, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

A point mutation in the human melanin concentrating hormone receptor 1 reveals an important domain for cellular trafficking.

R. Maki, Jun Fan, S. Perry, 2005, Molecular endocrinology.

Attenuating pregnane X receptor (PXR) activation: A molecular modelling approach

R. Evers, J. Yabut, R. Mosley, 2007, Xenobiotica; the fate of foreign compounds in biological systems.

The Use of Consensus Scoring in Ligand-Based Virtual Screening

Miklos Feher, J. Christian Baber, Yinghong Gao, 2006, J. Chem. Inf. Model..

Fused tricyclic indoles as S1P₁ agonists with robust efficacy in animal models of autoimmune disease.

D. Sengupta, Michael E. Morgan, K. Whelan, 2012, Bioorganic & medicinal chemistry letters.

Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.

K. Lyons, A. Weber, G. Kaczorowski, 2009, Bioorganic & medicinal chemistry letters.

Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.

K. Lyons, A. Weber, G. Kaczorowski, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics.

Beth A. Fleck, T. Ewing, Yinghong Gao, 2008, Bioorganic & Medicinal Chemistry Letters.

Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).

Yinghong Gao, Beth A. Fleck, Dongpei Wu, 2008, Bioorganic & medicinal chemistry letters.

A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonists.

Zhiqian Guo, K. Wilcoxen, Chen Chen, 2002, Bioorganic & medicinal chemistry letters.