M. Lanier

发表

Selection, synthesis, and structure-activity relationship of tetrahydropyrido[4,3-d]pyrimidine-2,4-diones as human GnRH receptor antagonists.

C. J. Loweth, M. Feher, D. Slee, 2007, Bioorganic & medicinal chemistry.

Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists.

Zhiqian Guo, S. Betz, Xin-jun Liu, 2007, Bioorganic & medicinal chemistry letters.

A Chemical Biology Approach to Myocardial Regeneration

J. Cashman, M. Mercola, E. Willems, 2011, Journal of cardiovascular translational research.

Small-Molecule Inhibitors of the Wnt Pathway Potently Promote Cardiomyocytes From Human Embryonic Stem Cell–Derived Mesoderm

J. Cashman, M. Mercola, M. Dawson, 2011, Circulation research.

A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).

K. Saikatendu, Louise M. Walsh, G. Ambrus, 2014, Journal of medicinal chemistry.

Design and Synthesis of Molecular Umbrellas

S. Regen, M. Lanier, V. Janout, 1997 .

Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling.

J. Cashman, M. Mercola, D. Schade, 2012, Journal of medicinal chemistry.

Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties.

D. Grigoriadis, S. Hoare, D. Slee, 2010, Bioorganic & medicinal chemistry letters.

2-Amino-N-pyrimidin-4-ylacetamides as A2A receptor antagonists: 2. Reduction of hERG activity, observed species selectivity, and structure-activity relationships.

J. Díaz, S. Lechner, D. Slee, 2008, Journal of medicinal chemistry.

STEREOSELECTIVE SYNTHESIS OF Z AND E 3-F-ALKYL 2-PROPENOATES AND DERIVATIVES

M. Lanier, R. Pastor, 1995 .

Design and Synthesis of Tricyclic Imidazo[4,5- b ]pyridin-2-ones as Corticotropin-Releasing Factor-1 Antagonists

Zhiqian Guo, D. Grigoriadis, B. Dyck, 2005 .

Design and synthesis of selective inhibitors of placental alkaline phosphatase.

T. Chung, J. Cashman, J. Millán, 2010, Bioorganic & medicinal chemistry.

Ring-opening of - F-alkyl a,-epoxyesters with NaBH 4 in alcoholic media

M. Lanier, R. Pastor, 1995 .

Nucleophilic ring opening of 3-F-alkyl 2,3-epoxypropanoates. Access to α,β-difunctional β-F-alkylpropanoates

M. Lanier, M. Blanc, R. Pastor, 1996 .

Stereoselective synthesis of F-alkyl α,β-unsaturated esters and their epoxidation

M. Haddach, J. Riess, M. Lanier, 1993 .

2-Amino-N-pyrimidin-4-ylacetamides as A2A receptor antagonists: 1. Structure-activity relationships and optimization of heterocyclic substituents.

J. Díaz, S. Lechner, D. Slee, 2008, Journal of medicinal chemistry.

Sterol−Polyamine Conjugates as Synthetic Ionophores

S. Regen, M. Lanier, and Gang Deng, 1998 .

SYNTHESIS OF NEW PERFLUOROALKYLATED ZWITTERIONIC CARBOXYBETAINES. INFLUENCE OF THE PRESENCE AND POSITION OF A HYDROXYL GROUP ON THEIR SOLUBILITY AND B IOCOMPATIBILITY

M. Haddach, J. Riess, M. Lanier, 1994 .

Evidence for highly cooperative binding between molecular umbrella-spermine conjugates and DNA.

S. Regen, M. Lanier, V. Janout, 1997, Bioconjugate chemistry.

Structure-activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor.

Beth A. Fleck, Joe A. Tran, A. Foster, 2004, Bioorganic & medicinal chemistry letters.

Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure-activity relationship study based on inhibitors for the Wnt response.

Erik Willems, Marion Lanier, J. Cashman, 2012, Journal of medicinal chemistry.

Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells.

Wenqing Cai, J. I. Izpisúa Belmonte, T. Kirchhausen, 2012, Cell Stem Cell.

Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes

M. Klein, R. Tjhen, M. Hixon, 2017, Journal of medicinal chemistry.

Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists.

J. Díaz, S. Lechner, D. Slee, 2008, Bioorganic & medicinal chemistry letters.

Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists.

Zhiqian Guo, D. Grigoriadis, B. Dyck, 2005, Journal of Medicinal Chemistry.

1,5-Disubstituted benzimidazoles that direct cardiomyocyte differentiation from mouse embryonic stem cells.

J. Cashman, M. Mercola, P. Bushway, 2015, Bioorganic & medicinal chemistry.

Evaluation in vitro of synthetic curcumins as agents promoting monocytic gene expression related to β-amyloid clearance.

K. Abel, J. Cashman, M. Lanier, 2012, Chemical research in toxicology.

Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines.

Beth A. Fleck, Joe A. Tran, A. Foster, 2005, Bioorganic & medicinal chemistry letters.

Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor.

Beth A. Fleck, Joe A. Tran, A. Foster, 2004, Bioorganic & medicinal chemistry letters.

A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice.

S. Hoare, Beth A. Fleck, M. Joppa, 2005, Bioorganic & medicinal chemistry letters.

Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor.

Beth A. Fleck, Joe A. Tran, A. Foster, 2006, Bioorganic & medicinal chemistry letters.

Small molecule corticotropin-releasing factor antagonists

M. Lanier, J. Williams, 2002 .

Curcumins Promote Monocytic Gene Expression Related to β-Amyloid and Superoxide Dismutase Clearance

K. Abel, J. Cashman, M. Lanier, 2011, Neurodegenerative Diseases.

Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure.

A. Ivetac, E. Bradshaw-Pierce, Petro Halkowycz, 2017, ACS medicinal chemistry letters.

Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells.

J. I. Izpisúa Belmonte, T. Kirchhausen, J. Cashman, 2012, Cell stem cell.

A Chemical Biology Approach to Myocardial Regeneration

J. Cashman, M. Mercola, E. Willems, 2011, Journal of cardiovascular translational research.

Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease.

J. Díaz, S. Lechner, D. Slee, 2008, Journal of medicinal chemistry.

MRGPRX2 Antagonist EP262 Potently Inhibits Agonist-Induced Mast Cell Degranulation In Vitro and In Vivo

V. Viswanath, M. Lanier, G. Timony, 2023, Journal of Allergy and Clinical Immunology.