J. Rohlena

发表

Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2.

Johan Kuiper, M. Daemen, T. V. van Berkel, 2007, Blood.

Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes.

Jurgen Seppen, J. Seppen, T. V. van Berkel, 2005, The American journal of pathology.

Mitochondrial complex II and reactive oxygen species in disease and therapy

J. Neuzil, J. Rohlena, Katerina Hadrava Vanova, 2020, Redox report : communications in free radical research.

Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death.

H. Zischka, J. Neuzil, Katerina Rohlenova, 2017, Free radical biology & medicine.

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

M. Molloy, M. Kubista, J. Neuzil, 2018, Nature Communications.

Mitochondrial respiration supports autophagy to provide stress resistance during quiescence

P. Carmeliet, A. Benda, J. Neuzil, 2022, Autophagy.

Limited contribution of claudin-5-dependent tight junction strands to endothelial barrier function.

J. van Marle, A. Horrevoets, H. Pannekoek, 2006, European journal of cell biology.

Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.

T. Obsil, E. Bouřa, J. Neuzil, 2011, Cancer research.

Molecular and Cellular Pathobiology Hippo / Mst 1 Stimulates Transcription of the Proapoptotic Mediator NOXA in a FoxO 1-Dependent Manner

T. Obsil, E. Bouřa, J. Neuzil, 2011 .

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

H. Ditzel, L. Andĕra, J. Neuzil, 2018, Cell Death & Differentiation.

Germline SUCLG2 Variants in Patients with Pheochromocytoma and Paraganglioma.

Jun Zhu, J. Černý, J. Neuzil, 2021, Journal of the National Cancer Institute.

Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene

M. Vrbacký, C. Bařinka, J. Truksa, 2022, Scientific Reports.

High Molecular Weight Forms of Mammalian Respiratory Chain Complex II

K. Hejzlarová, M. Vrbacký, J. Houštěk, 2013, PloS one.

MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma

J. Neuzil, Katerina Rohlenova, P. Hozák, 2016, Oncotarget.

Shikonin impairs mitochondrial activity to selectively target leukemia cells

M. Minden, Nawaz Ahmed, P. Spagnuolo, 2022, Phytomedicine Plus.

Mitochondrial Complex II in Cancer

J. Neuzil, J. Rohlena, K. Kľučková, 2014 .

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

Yaoqi Zhou, M. Ricchetti, T. Cunha-Oliveira, 2019, Cell metabolism.

Suppression of Tumor Growth In vivo by the Mitocan α-tocopheryl Succinate Requires Respiratory Complex II

R. Moreno-Sánchez, S. Rodríguez-Enríquez, P. Witting, 2009, Clinical Cancer Research.

Mitochondrial complex II, a novel target for anti-cancer agents.

J. Neuzil, Lan-feng Dong, J. Rohlena, 2013, Biochimica et biophysica acta.

Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization.

N. Kootstra, R. Dekker, A. Horrevoets, 2006, Cardiovascular research.

Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming.

J. Neuzil, A. Schmitt, B. Hersant, 2020, Cell metabolism.

Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer.

P. Ježek, J. Černý, J. Neuzil, 2017, Antioxidants & redox signaling.

Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer.

J. Neuzil, J. Rohlena, S. Hubackova, 2020, Biochimica et biophysica acta. Molecular basis of disease.

Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.

David A. Eccles, L. Haupt, L. Griffiths, 2015, Cell metabolism.

Mitochondria on the move: Horizontal mitochondrial transfer in disease and health

J. Neuzil, M. Berridge, J. Rohlena, 2023, The Journal of cell biology.

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

P. Stopka, Ana Coelho, P. Oliveira, 2017, eLife.

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors

H. Ditzel, Ana Coelho, J. Neuzil, 2020, Cell Death & Disease.

Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments

S. Diez, J. Neuzil, C. Bařinka, 2020, bioRxiv.

Miro proteins connect mitochondrial function and intercellular transport

J. Neuzil, J. Rohlena, R. Zobalova, 2021, Critical reviews in biochemistry and molecular biology.

Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II*

R. Moreno-Sánchez, S. Rodríguez-Enríquez, J. Černý, 2010, The Journal of Biological Chemistry.

Effects of metabolic cancer therapy on tumor microenvironment

Katerina Rohlenova, J. Rohlena, J. Škoda, 2022, Frontiers in Oncology.

in a FoxO 1-Dependent Manner NOXA Mediator Hippo / Mst 1 Stimulates Transcription of the Proapoptotic

T. Obsil, E. Bouřa, J. Neuzil, 2011 .

Mitochondria-driven elimination of cancer and senescent cells

J. Neuzil, J. Rohlena, S. Hubackova, 2018, Biological chemistry.

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

M. Molloy, M. Kubista, J. Neuzil, 2018, Nature Communications.

Classification of mitocans, anti-cancer drugs acting on mitochondria.

J. Neuzil, J. Truksa, S. Ralph, 2013, Mitochondrion.

Mitocans, Mitochondria-Targeting Anticancer Drugs

J. Neuzil, J. Rohlena, Lan-Feng Dong, 2012 .

Anticancer drugs targeting the mitochondrial electron transport chain.

J. Neuzil, S. Ralph, J. Rohlena, 2011, Antioxidants & redox signaling.

The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria

J. Neuzil, Katerina Rohlenova, J. Rohlena, 2016, Biological chemistry.

K-Ras and mitochondria: Dangerous liaisons

J. Neuzil, Jiri Neuzil, J. Rohlena, 2011, Cell Research.

Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression

J. Neuzil, Jin-Mo Kim, J. Rohlena, 2023, Theranostics.

Targeting the mitochondrial electron transport chain complexes for the induction of apoptosis and cancer treatment.

J. Neuzil, J. Rohlena, Lan-Feng Dong, 2013, Current pharmaceutical biotechnology.

Mitochondrially targeted tamoxifen in patients with metastatic solid tumours: an open-label, phase I/Ib single-centre trial.

J. Neuzil, Katerina Rohlenova, V. Bobek, 2023, EClinicalMedicine.

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors

H. Ditzel, Ana Coelho, J. Neuzil, 2020, Cell Death & Disease.

SMAD4 loss limits the vulnerability of pancreatic cancer cells to complex I inhibition via promotion of mitophagy

J. Neuzil, M. Berridge, J. Štursa, 2021, Oncogene.

Powerhouse down: Complex II dissociation in the respiratory chain.

S. Grimm, J. Neuzil, J. Rohlena, 2014, Mitochondrion.

Mitochondrial Complex II: At the Crossroads.

J. Neuzil, K. Pacak, J. Rohlena, 2017, Trends in biochemical sciences.

Mitochondrial respiratory states and rates

Sharma, Whiejong M. Han, Duchen, 2019 .

Endothelial CD81 is a marker of early human atherosclerotic plaques and facilitates monocyte adhesion.

P. Hordijk, J. V. van Buul, J. Post, 2009, Cardiovascular research.

Mitocans: Mitochondrially Targeted Anti-cancer Drugs

J. Neuzil, Katerina Rohlenova, J. Rohlena, 2018 .

Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis.

J. Neuzil, M. Zoratti, J. Štursa, 2015, Antioxidants & redox signaling.

The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells*

J. Neuzil, J. Rohlena, Ayenachew Bezawork‐Geleta, 2016, The Journal of Biological Chemistry.

Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming.

J. Neuzil, A. Schmitt, B. Hersant, 2021, Cell metabolism.

Nuclear Receptor Nurr1 Is Expressed In and Is Associated With Human Restenosis and Inhibits Vascular Lesion Formation In Mice Involving Inhibition of Smooth Muscle Cell Proliferation and Inflammation

R. D. de Winter, K. Koch, I. Bot, 2010, Circulation.

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapy.

B. Zhivotovsky, P. Witting, B. Salvatore, 2011, Free radical biology & medicine.

Residues Phe342–Asn346 of Activated Coagulation Factor IX Contribute to the Interaction with Low Density Lipoprotein Receptor-related Protein*

P. Lenting, J. Kolkman, K. Mertens, 2003, The Journal of Biological Chemistry.

Mitochondrially targeted α-tocopheryl succinate is antiangiogenic: potential benefit against tumor angiogenesis but caution against wound healing.

C. Sen, J. Houštěk, J. Neuzil, 2011, Antioxidants & redox signaling.

Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents.

J. Neuzil, J. Rohlena, K. Kľučková, 2015, Methods in molecular biology.

Functional duplication of ligand-binding domains within low-density lipoprotein receptor-related protein for interaction with receptor associated protein, alpha2-macroglobulin, factor IXa and factor VIII.

P. Lenting, A. V. van Zonneveld, K. Mertens, 2007, Biochimica et biophysica acta.

Corrigendum to: "Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy" [Free Radic Biol Med. 50 (2011) 1546-1555].

B. Zhivotovsky, P. Witting, B. Salvatore, 2013, Free radical biology & medicine.

Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation

E. Gottlieb, J. Černý, J. Neuzil, 2015, Cell Death and Disease.

UvA-DARE ( Digital Academic Repository ) The transcription factor KLF 2 in vascular biology

M. Daemen, J. Kuiper, R. Dekker, 2008 .

Mitochondrial Complex II: At the Crossroads.

J. Neuzil, K. Pacak, J. Rohlena, 2017, Trends in biochemical sciences.

Limited contribution of claudin-5-dependent tight junction strands to endothelial barrier function.

J. van Marle, A. Horrevoets, H. Pannekoek, 2006, European journal of cell biology.

Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer.

P. Ježek, J. Černý, J. Neuzil, 2017, Antioxidants and Redox Signaling.

Mitochondrial HER2 stimulates respiration and promotes tumorigenicity.

Katerina Rohlenova, J. Brábek, J. Rohlena, 2024, European journal of clinical investigation.

Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners

G. Cecchini, K. Vanova, T. Mráček, 2024, Nature communications.

MitoTam-01 Trial: Mitochondrial Targeting as Plausible Approach to Cancer Therapy. Comment on Yap et al. Complex I Inhibitor of Oxidative Phosphorylation in Advanced Solid Tumors and Acute Myeloid Leukemia: Phase I Trials. Nat. Med. 2023, 29, 115–126

J. Rohlena, L. Werner, Z. Bielcikova, 2023, Cancers.