C. Hegadorn

发表

Cell type-specific regulation of von Willebrand factor expression by the E4BP4 transcriptional repressor.

D. Lillicrap, C. Hough, C. Notley, 2005, Blood.

Cell type – specific regulation of von Willebrand factor expression by the E 4 BP 4 transcriptional repressor

D. Lillicrap, C. Hough, C. Notley, 2005 .

Use of a mouse model to elucidate the phenotypic effects of the von Willebrand factor cleavage mutants, Y1605A/M1606A and R1597W

D. Lillicrap, C. Hegadorn, S. Haberichter, 2012, Journal of thrombosis and haemostasis : JTH.

Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response.

M. Ozelo, V. Arruda, A. Winterborn, 2014, Blood.

circulating FVIII antigen and a complex immune response Omental implantation of BOECs in hemophilia dogs results in

M. Ozelo, V. Arruda, A. Winterborn, 2014 .

Ex Vivo Gene Therapy for Hemophilia A That Enhances Safe Delivery and Sustained In Vivo Factor VIII Expression from Lentivirally Engineered Endothelial Progenitors

R. Hebbel, B. Brown, J. Galipeau, 2007, Stem cells.

Quantitative and qualitative changes of von Willebrand factor and their impact on mortality in patients with end-stage kidney disease

P. James, R. Holden, A. Tuttle, 2013, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

The mutational spectrum of type 1 von Willebrand disease: Results from a Canadian cohort study.

L. O'Brien, J. Leggo, M. Othman, 2007, Blood.

Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division

P. Greer, J. Elce, J. Arthur, 2000, Molecular and Cellular Biology.

Comprehensive analysis of the role of von Willebrand factor and platelet glycoprotein VI-and α 2 β 1-mediated collagen binding in thrombus formation

B. Nieswandt, D. Lillicrap, Kate Sponagle, 2014 .

THROMBOSIS AND HEMOSTASIS Analysis of the role of von Willebrand factor , platelet glycoprotein VI-, and a 2 b 1-mediated collagen binding in thrombus formation

B. Nieswandt, D. Lillicrap, Kate Sponagle, 2014 .

A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells.

B. Brown, C. Miao, T. VandenDriessche, 2009, Blood.

Challenges in defining type 2M von Willebrand disease: results from a Canadian cohort study

P. James, D. Lillicrap, M. Poon, 2007, Journal of thrombosis and haemostasis : JTH.

Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease.

J. Sutherland, L. O'Brien, M. Othman, 2003, Blood.

The effects of truncations of the small subunit on m-calpain activity and heterodimer formation.

P. Davies, J. Elce, D. Maurice, 1997, The Biochemical journal.

Autolysis, Ca2+ Requirement, and Heterodimer Stability in m-Calpain*

J. Elce, J. Arthur, C. Hegadorn, 1997, The Journal of Biological Chemistry.

Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation.

B. Nieswandt, D. Lillicrap, Kate Sponagle, 2014, Blood.

The effect of exercise on von Willebrand factor and ADAMTS‐13 in individuals with type 1 and type 2B von Willebrand disease

P. Lenting, P. James, D. Lillicrap, 2007, Journal of thrombosis and haemostasis : JTH.

ADAMTS13 cleavage efficiency is altered by mutagenic and, to a lesser extent, polymorphic sequence changes in the A1 and A2 domains of von Willebrand factor

L. O'Brien, D. Lillicrap, C. Notley, 2008, British journal of haematology.

Genetic linkage and association analysis in type 1 von Willebrand disease: results from the Canadian Type 1 VWD Study

A. Paterson, L. O'Brien, J. Leggo, 2006, Journal of thrombosis and haemostasis : JTH.

A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A.

L. Naldini, M. Ozelo, B. Brown, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Thromboelastography reflects global hemostatic variation among severe haemophilia A dogs at rest and following acute exercise

M. Othman, W. Hopman, D. Lillicrap, 2009, Haemophilia : the official journal of the World Federation of Hemophilia.

Genetically-Engineered Endothelial Cells Implanted Into the Omentum of Hemophilia A Dogs Provides Long-Term Circulating FVIII Resulting From Sustained FVIII Expression and Persistent Cell Viability.

M. Ozelo, J. Hulvat, A. Winterborn, 2009 .

Transgene-host cell interactions mediate significant influences on the production, stability, and function of recombinant canine FVIII

M. Ozelo, D. Lillicrap, C. Hough, 2015, Molecular therapy. Methods & clinical development.

A novel type 2A (Group II) von Willebrand disease mutation (L1503Q) associated with loss of the highest molecular weight von Willebrand factor multimers

J. Sutherland, L. O'Brien, D. Lillicrap, 2004, Journal of thrombosis and haemostasis : JTH.

A novel type 2A von Willebrand factor mutation located at the last nucleotide of exon 26 (3538G>A) causes skipping of 2 nonadjacent exons.

L. O'Brien, P. James, D. Lillicrap, 2004, Blood.

Mutation-specific hemostatic variability in mice expressing common type 2B von Willebrand disease substitutions.

D. Lillicrap, Kate Sponagle, J. Mewburn, 2010, Blood.

Crystallization and X-ray crystallographic analysis of m-calpain, a Ca2+-dependent protease.

Z. Jia, Q. Ye, J. Elce, 1999, Acta crystallographica. Section D, Biological crystallography.

Biosynthesis of CDP-diacylglycerol in hog mesenteric lymph node lymphocytes.

C. Hegadorn, M. Sribney, 1982, Canadian Journal of Biochemistry.

Pathologic mechanisms of type 1 VWD mutations R1205H and Y1584C through in vitro and in vivo mouse models.

D. Lillicrap, Kate Sponagle, C. Notley, 2011, Blood.

Recombinant calpain II: improved expression systems and production of a C105A active-site mutant for crystallography.

P. Davies, J. Elce, S. Gauthier, 1995, Protein engineering.

Human von Willebrand Disease Mutations in Mouse von Willebrand Factor Alter Its Cleavage by ADAMTS13.

D. Lillicrap, C. Notley, C. Hegadorn, 2007 .

Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation.

B. Nieswandt, D. Lillicrap, Kate Sponagle, 2014, Blood.

C. Miao, T. VandenDriessche, M. Chuah, 2009, Blood.