Samuele Maramai

发表

Disease‐Modifying Anti‐Alzheimer's Drugs: Inhibitors of Human Cholinesterases Interfering with β‐Amyloid Aggregation

Simone Brogi, Stefania Lamponi, Ettore Novellino, 2014, CNS neuroscience & therapeutics.

Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization.

E. Novellino, J. Kastrup, M. Brindisi, 2011, Journal of medicinal chemistry.

A stereoselective approach to peptidomimetic BACE1 inhibitors.

E. Novellino, Simone Brogi, M. Brindisi, 2013, European journal of medicinal chemistry.

Development of a practical and scalable route for the preparation of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and analogs

E. Novellino, Simone Brogi, M. Brindisi, 2016 .

Development of novel cyclic peptides as pro-apoptotic agents.

E. Novellino, P. Campiglia, Simone Brogi, 2016, European journal of medicinal chemistry.

Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor

G. Giannini, S. Mangani, E. Cini, 2022, International journal of molecular sciences.

Macroreticular POLITAG-Pd(0) for the waste minimized hydrogenation/reductive amination of phenols using formic acid as hydrogen source

F. Valentini, L. Vaccaro, M. Taddei, 2022, Catalysis Today.

Inhibition of Monoacylglycerol Lipase by NSD1819 as an Effective Strategy for the Endocannabinoid System Modulation against Neuroinflammation-Related Disorders

C. Ghelardini, L. Micheli, L. di Cesare Mannelli, 2022, International journal of molecular sciences.

Subtype selective γ-Aminobutyric Acid Type A Receptor (GABAAR) Modulators Acting at the Benzodiazepine Binding Site: An Update.

S. Ward, J. Atack, M. Benchekroun, 2019, Journal of medicinal chemistry.

An Intramolecular Hydroaminomethylation-Based Approach to Pyrrolizidine Alkaloids under Microwave-Assisted Heating

M. Taddei, C. Matassini, F. Cardona, 2022, Molecules.

Micellar Catalysis for Sustainable Hydroformylation

F. Migliorini, Samuele Maramai, M. Calamante, 2021 .

( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.

Simone Brogi, Ettore Novellino, Mikko Gynther, 2018, Journal of medicinal chemistry.

Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties.

Simone Brogi, C. Ghelardini, C. Bigogno, 2022, European journal of medicinal chemistry.

Multitarget-directed ligands for neurodegenerative diseases: real opportunity or blurry mirage?

M. Benchekroun, Samuele Maramai, 2019, Future medicinal chemistry.

Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.

E. Novellino, V. Andrisano, M. Bartolini, 2013, ACS medicinal chemistry letters.

Targeting Endocannabinoid Metabolism: an Arrow with Multiple Tips Against Multiple Sclerosis

M. Brindisi, Samuele Maramai, 2020, ChemMedChem.

Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.

M. Brindisi, S. Gemma, G. Campiani, 2012, Journal of medicinal chemistry.

Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases

H. Stark, Simone Brogi, M. Brindisi, 2016, Front. Neurosci..

Quinolines and Oxazino-quinoline Derivatives as Small Molecule GLI1 Inhibitors Identified by Virtual Screening.

G. Giannini, Snigdha Singh, P. Governa, 2022, ACS medicinal chemistry letters.

2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: Synthesis, In Silico Analysis and In Vitro Pharmacological Evaluation

F. Fusi, O. Spiga, S. Saponara, 2021, Molbank.

Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress

M. C. Baratto, Marco Paolino, L. De Petrocellis, 2022, International journal of molecular sciences.

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.

A. Pittaluga, D. Piomelli, Simone Brogi, 2016, Journal of medicinal chemistry.

Activation of the Wnt Pathway by Small Peptides: Rational Design, Synthesis and Biological Evaluation

E. Novellino, Simone Brogi, M. Brindisi, 2017, ChemMedChem.

Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors.

A. Prasse, L. Altucci, E. Bargagli, 2021, Journal of medicinal chemistry.

Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies.

E. Novellino, L. Altucci, A. Nebbioso, 2016, Future medicinal chemistry.

Multitarget Therapeutic Strategies for Alzheimer's Disease: Review on Emerging Target Combinations

M. Gabr, M. Benchekroun, Samuele Maramai, 2020, BioMed research international.

Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain

Simone Brogi, M. Brindisi, S. Gemma, 2018, ChemMedChem.

Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition

E. Novellino, V. Marzo, Simone Brogi, 2016 .

Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.

M. Brindisi, S. Gemma, G. Campiani, 2013, Bioorganic & medicinal chemistry letters.

Title Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain Permalink

A. Pittaluga, D. Piomelli, V. Marzo, 2016 .

In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists.

M. Frosini, V. Di Marzo, L. De Petrocellis, 2023, Journal of medicinal chemistry.

Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization.

S. Gemma, G. Campiani, S. Butini, 2024, Journal of medicinal chemistry.