Naoya Matsunaga

发表

Solubility and Dissolution Properties of Generic Versions of Gemcitabine Hydrochloride Preparation for Injection

S. Ohdo, S. Koyanagi, T. Akamine, 2013 .

Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches

S. Ohdo, S. Koyanagi, T. Akamine, 2020, Genes to cells : devoted to molecular & cellular mechanisms.

A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson’s Disease

S. Ohdo, S. Koyanagi, Keisuke Kakimoto, 2013, NeuroMolecular Medicine.

Influence of Feeding Schedule on 24-h Rhythm of Hepatotoxicity Induced by Acetaminophen in Mice

S. Higuchi, S. Ohdo, H. Terazono, 2004, Journal of Pharmacology and Experimental Therapeutics.

Bezafibrate Induces Plasminogen Activator Inhibitor-1 Gene Expression in a CLOCK-Dependent Circadian Manner

K. Kadota, K. Oishi, S. Ohdo, 2010, Molecular Pharmacology.

Intestinal Expression of Mouse Abcg2/Breast Cancer Resistance Protein (BCRP) Gene Is under Control of Circadian Clock-activating Transcription Factor-4 Pathway*

S. Ohdo, S. Koyanagi, Yuichi Murakami, 2012, The Journal of Biological Chemistry.

Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2022, Molecular cancer research : MCR.

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease

A. Ojida, T. Ueda, S. Ohdo, 2022, bioRxiv.

Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system.

S. Ohdo, S. Koyanagi, Keisuke Kakimoto, 2018, Biochemical and biophysical research communications.

Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain

M. Tsuda, Kazuhide Inoue, S. Ohdo, 2010, Molecular pain.

Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice.

S. Ohdo, K. Maruyama, R. Suzuki, 2010, Cancer research.

Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting platelet-derived growth factor signaling.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2008, Journal of pharmacological sciences.

Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs.

S. Ohdo, S. Koyanagi, T. Akamine, 2019, Biochemical and biophysical research communications.

Circadian Modulation in the Intestinal Absorption of P-Glycoprotein Substrates in Monkeys

S. Ohdo, N. Suzuki, T. Izumi, 2015, Molecular Pharmacology.

Ozagrel hydrochloride, a selective thromboxane A2 synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice

S. Ohdo, M. Irikura, T. Irie, 2013, BMC Gastroenterology.

Renal Circadian Clock Regulates the Dosing-Time Dependency of Cisplatin-Induced Nephrotoxicity in Mice

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2014, Molecular Pharmacology.

PROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-α MEDIATES HIGH-FAT, DIET-ENHANCED DAILY OSCILLATION OF PLASMINOGEN ACTIVATOR INHIBITOR-1 ACTIVITY IN MICE

K. Oishi, S. Ohdo, S. Koyanagi, 2010, Chronobiology international.

Glucocorticoid-Dependent Expression of O6-Methylguanine-DNA Methyltransferase Gene Modulates Dacarbazine-Induced Hepatotoxicity in Mice

S. Ohdo, T. Egawa, S. Koyanagi, 2010, Journal of Pharmacology and Experimental Therapeutics.

Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the anti-tumor effects of aldehyde dehydrogenase

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2018 .

Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model.

S. Ohdo, S. Koyanagi, T. Akamine, 2018, Biochemical and biophysical research communications.

Chronopharmacology of immune-related diseases.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2022, Allergology international : official journal of the Japanese Society of Allergology.

Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study.

T. Shimazoe, T. Kubota, S. Ohdo, 2016, Biological & pharmaceutical bulletin.

RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2022, The Journal of biological chemistry.

Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice.

S. Ohdo, Takashi Matsunaga, S. Koyanagi, 2018, Biochemical and biophysical research communications.

Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2017, The Journal of Biological Chemistry.

Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light-dark cycle in mice.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2017, Journal of pharmacological sciences.

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease.

A. Ojida, T. Ueda, S. Ohdo, 2022, Journal of medicinal chemistry.

Bile Acid-regulated Peroxisome Proliferator-activated Receptor-α (PPARα) Activity Underlies Circadian Expression of Intestinal Peptide Absorption Transporter PepT1/Slc15a1*

S. Shibata, S. Ohdo, S. Koyanagi, 2014, The Journal of Biological Chemistry.

Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins.

A. Ojida, S. Ohdo, S. Koyanagi, 2020, Journal of the American Chemical Society.

Influence of Dosing Schedule on Toxicity and Antitumor Effects of a Combination of Adriamycin and Docetaxel in Mice

S. Higuchi, S. Ohdo, H. To, 2004, Clinical Cancer Research.

Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2021, Biochemical pharmacology.

Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: a possible mechanism of chemotherapy-induced circadian rhythm disturbances.

Y. Shigeyoshi, S. Ohdo, T. Egawa, 2008, Biochemical pharmacology.

Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors.

Satoshi O. Suzuki, S. Ohdo, S. Koyanagi, 2012, Cancer research.

Cell-cycle-dependent pharmacology of methotrexate in HL-60.

H. Aramaki, T. Fukagawa, S. Higuchi, 2005, Journal of pharmacological sciences.

Vancomycin induces reactive oxygen species‐dependent apoptosis via mitochondrial cardiolipin peroxidation in renal tubular epithelial cells

T. Yano, S. Ohdo, S. Masuda, 2017, European journal of pharmacology.

A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson’s Disease

S. Ohdo, S. Koyanagi, Keisuke Kakimoto, 2013, NeuroMolecular Medicine.

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

M. Tsuda, Kazuhide Inoue, S. Ohdo, 2016, Nature Communications.

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

H. Aramaki, A. Ojida, M. Tsuda, 2016, EBioMedicine.

Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells

Y. Fukada, S. Ohdo, Hideki Terajima, 2021, eLife.

Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2017, Scientific Reports.

Hypoxia-response plasmid vector producing bcl-2 shRNA enhances the apoptotic cell death of mouse rectum carcinoma.

S. Ohdo, T. Fujioka, S. Koyanagi, 2010, Journal of pharmacological sciences.

Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis

S. Ohdo, S. Koyanagi, H. Kurose, 2021, Nature Communications.

Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2020, Scientific Reports.

Different Roles of Negative and Positive Components of the Circadian Clock in Oncogene-induced Neoplastic Transformation*

S. Shibata, S. Shimba, S. Ohdo, 2016, The Journal of Biological Chemistry.

Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse primary hepatocytes.

S. Ohdo, S. Koyanagi, Keisuke Kakimoto, 2011, Toxicology.

Dosing schedule-dependent change in the disruptive effects of interferon-alpha on the circadian clock function.

H. Aramaki, S. Ohdo, S. Koyanagi, 2008, Life sciences.

Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction*

H. Aramaki, S. Ohdo, Y. Yokota, 2016, The Journal of Biological Chemistry.

Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function

Y. Tahara, S. Ohdo, S. Koyanagi, 2018, Scientific Reports.

Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2009, Biochemical pharmacology.

Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene

S. Ohdo, S. Koyanagi, T. Akamine, 2018, The Journal of Biological Chemistry.

Role of glucocorticoid receptor in the regulation of cellular sensitivity to irinotecan hydrochloride.

T. Ikemura, H. Iba, H. Aramaki, 2009, Journal of pharmacological sciences.

Ibudilast attenuates doxorubicin‐induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

M. Nishida, S. Ohdo, Y. Ibuki, 2019, British journal of pharmacology.

Chronopharmacological strategies focused on chrono-drug discovery.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2019, Pharmacology & therapeutics.

RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2021, The Journal of biological chemistry.

Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2019, Biological & pharmaceutical bulletin.

Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma.

M. Kuwano, M. Ono, S. Ohdo, 2014, Cancer research.

Time-Dependent Interaction between Differentiated Embryo Chondrocyte-2 and CCAAT/Enhancer-Binding Protein α Underlies the Circadian Expression of CYP2D6 in Serum-Shocked HepG2 Cells

K. Fujimoto, F. Sato, S. Ohdo, 2012, Molecular Pharmacology.

[Dosing time based on molecular mechanism of biological clock of hepatic drug metabolic enzyme].

Naoya Matsunaga, 2009, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

The molecular mechanism regulating 24‐hour rhythm of CYP2E1 expression in the mouse liver

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2008, Hepatology.

Mitomycin C modulates the circadian oscillation of clock gene period 2 expression through attenuating the glucocorticoid signaling in mouse fibroblasts.

S. Ohdo, S. Koyanagi, T. Kubota, 2015, Biochemical and biophysical research communications.

Role of Activating Transcription Factor-4 in 24-Hour Rhythm of Serotonin Transporter Expression in the Mouse Midbrain

Satoru Koyanagi, Akio Fujimura, Naoya Matsunaga, 2012, Molecular Pharmacology.

Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice.

S. Ohdo, S. Koyanagi, Yuichi Murakami, 2008, Gastroenterology.

Aryl hydrocarbon receptor-mediated Cyp1a1 expression is modulated in a CLOCK-dependent circadian manner.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2011, Toxicology.

Fluorescence-Based Detection of Fatty Acid β-Oxidation in Cells and Tissues Using Quinone Methide-Releasing Probes.

A. Ojida, S. Ohdo, S. Koyanagi, 2023, Journal of the American Chemical Society.

Administering xCT Inhibitors Based on Circadian Clock Improves Antitumor Effects.

H. To, M. Kutsukake, Naoya Matsunaga, 2017, Cancer research.

Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells.

A. Ojida, S. Ohdo, Naoya Matsunaga, 2020, Chemical communications.

Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2018, Journal of pharmacological sciences.

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

M. Ono, A. Ojida, I. Hamachi, 2019, Nature Chemical Biology.

24-hour rhythm of aquaporin-3 function in the epidermis is regulated by molecular clocks.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2014, The Journal of investigative dermatology.

Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2007, Pharmacogenetics and genomics.

Chronopharmacological strategies: Intra- and inter-individual variability of molecular clock.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2010, Advanced drug delivery reviews.

Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression*

H. Aramaki, S. Ohdo, H. To, 2016, The Journal of Biological Chemistry.

Molecular basis of chronopharmaceutics.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2011, Journal of pharmaceutical sciences.

Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines.

M. Ono, A. Ojida, S. Ohdo, 2020, ACS medicinal chemistry letters.

cAMP-response Element (CRE)-mediated Transcription by Activating Transcription Factor-4 (ATF4) Is Essential for Circadian Expression of the Period2 Gene*

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2011, The Journal of Biological Chemistry.

Modulation of Peroxisome Proliferator-Activated Receptor-α Activity by Bile Acids Causes Circadian Changes in the Intestinal Expression of Octn1/Slc22a4 in Mice

S. Ohdo, S. Koyanagi, T. Akamine, 2015, Molecular Pharmacology.

Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells

S. Yoshida, Yoshiyuki Kobayashi, S. Ohdo, 2018, Japanese Journal of Ophthalmology.

Optimized Dosing Schedule Based on Circadian Dynamics of Mouse Breast Cancer Stem Cells Improves the Antitumor Effects of Aldehyde Dehydrogenase Inhibitor.

S. Ohdo, Takahiro Tanaka, S. Koyanagi, 2018, Cancer research.

Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function

S. Shibata, Y. Tahara, S. Ohdo, 2018, Scientific Reports.

Dosing Time-Dependent Changes in the Analgesic Effect of Pregabalin on Diabetic Neuropathy in Mice

S. Ohdo, S. Koyanagi, T. Akamine, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Molecular Mechanism Regulating 24-Hour Rhythm of Dopamine D3 Receptor Expression in Mouse Ventral Striatum

S. Ohdo, S. Koyanagi, Keisuke Kakimoto, 2013, Molecular Pharmacology.

Rhythmic control of the ARF-MDM2 pathway by ATF4 underlies circadian accumulation of p53 in malignant cells.

S. Ohdo, S. Koyanagi, Keisuke Kakimoto, 2013, Cancer research.

Hepatocyte growth factor increases uptake of estradiol 17beta-D-glucuronide and Oatp1 protein level in rat hepatocytes.

H. Kai, K. Arimori, Naoya Matsunaga, 2008, European journal of pharmacology.

IL-6 Receptor Is a Possible Target against Growth of Metastasized Lung Tumor Cells in the Brain

S. Ohdo, M. Noda, H. Iguchi, 2012, International journal of molecular sciences.

Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines.

A. Ojida, Naoya Matsunaga, Yuya Yoshida, 2023, Journal of medicinal chemistry.

Oral administration of vancomycin alleviates heart failure triggered by chronic kidney disease

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2023, Biochemical and Biophysical Research Communications.

Modulation of cell physiology by bispecific nanobodies enabling changes in the intracellular localization of organelle proteins.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2023, Biochemical pharmacology.

Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2009, Biochemical pharmacology.

Effect of Haloperidol on mPer1 Gene Expression in Mouse Suprachiasmatic Nuclei*

J. Viyoch, S. Higuchi, S. Ohdo, 2005, Journal of Biological Chemistry.

Population Pharmacodynamic Analysis for Exploration of the Factors Affecting Serum Uric Acid Levels in Hyperuricemic Patients who are Switched from Allopurinol to Febuxostat

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2018 .

Population Pharmacodynamic Analysis of Allopurinol Based on Electronic Medical Records

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2017 .

cAMP-response Element (CRE)-mediated Transcription by Activating Transcription Factor-4 (ATF4) Is Essential for Circadian Expression of the Period2 Gene*

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2011, The Journal of Biological Chemistry.

Microcurrent stimulation activates the circadian machinery in mice.

S. Ohdo, S. Koyanagi, A. Shiraishi, 2019, Biochemical and biophysical research communications.

Bezafibrate Induces Plasminogen Activator Inhibitor-1 Gene Expression in a CLOCK-Dependent Circadian Manner

K. Kadota, K. Oishi, S. Ohdo, 2010, Molecular Pharmacology.

Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2010 .

Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner

K. Oishi, S. Ohdo, S. Koyanagi, 2010 .

Suppression of neuropathic pain in the circadian clock–deficient Per2m/m mice involves up-regulation of endocannabinoid system

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2023, PNAS nexus.

Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2024, Cancer & metabolism.

Hematopoietic Prostaglandin D Synthase Is Increased in Mast Cells and Pericytes in Autopsy Myocardial Specimens from Patients with Duchenne Muscular Dystrophy

Naoya Matsunaga, Kengo Hamamura, Yuya Yoshida, 2024, International journal of molecular sciences.

Circadian rhythms in CYP2A5 expression underlie the time-dependent effect of tegafur on breast cancer.

S. Ohdo, S. Koyanagi, Naoya Matsunaga, 2024, Biochemical and biophysical research communications.