J. Skokowa

发表

NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD+–sirtuin-1–dependent pathway

A. Schambach, M. Gaestel, B. K. Thakur, 2009, Nature Medicine.

LEF‐1 Is a Decisive Transcription Factor in Neutrophil Granulopoiesis

K. Welte, J. Skokowa, 2007, Annals of the New York Academy of Sciences.

Severe congenital neutropenia: inheritance and pathophysiology

K. Welte, M. Germeshausen, J. Skokowa, 2007, Current opinion in hematology.

LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.

K. Welte, C. Gloeckner, Yun Xu, 2019, Blood.

Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF–triggered granulopoiesis

A. Ganser, R. Grosschedl, K. Welte, 2012, Nature Medicine.

Dysregulation of Myeloid‐specific Transcription Factors in Congenital Neutropenia

K. Welte, J. Skokowa, 2009, Annals of the New York Academy of Sciences.

Ultra-Sensitive CSF3R Deep Sequencing in Patients With Severe Congenital Neutropenia

K. Welte, J. Skokowa, M. Klimiankou, 2019, Front. Immunol..

Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis.

D. Steinemann, R. Beekman, A. Kohlmann, 2013, Blood.

Heterogeneous expression pattern of pro‐ and anti‐apoptotic factors in myeloid progenitor cells of patients with severe congenital neutropenia treated with granulocyte colony‐stimulating factor

M. Schrappe, Z. Wang, K. Welte, 2005, British journal of haematology.

Macrophages Induce the Inflammatory Response in the Pulmonary Arthus Reaction through Gαi2 Activation That Controls C5aR and Fc Receptor Cooperation1

L. Birnbaumer, J. Köhl, B. Nürnberg, 2005, The Journal of Immunology.

Severe congenital neutropenias

K. Welte, I. Touw, D. Dale, 2017, Nature Reviews Disease Primers.

Role of CSF3R mutations in the pathomechanism of congenital neutropenia and secondary acute myeloid leukemia

K. Welte, J. Skokowa, M. Klimiankou, 2016, Annals of the New York Academy of Sciences.

Two cases of cyclic neutropenia with acquired CSF3R mutations, with 1 developing AML.

K. Welte, J. Skokowa, M. Klimiankou, 2016, Blood.

NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells

K. Welte, Yun Xu, J. Skokowa, 2020, Stem Cell Research & Therapy.

A topological refactoring design strategy yields highly stable granulopoietic proteins

A. Lupas, K. Welte, P. Müller, 2022, Nature Communications.

Design of novel granulopoietic proteins by topological rescaffolding

A. Lupas, K. Welte, Laura Weidmann, 2020, PLoS biology.

NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression.

B. K. Thakur, Tino Dittrich, P. Chandra, 2012, Biochemical and biophysical research communications.

NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD+-sirtuin-1-dependent pathway.

B. K. Thakur, K. Welte, M. Stanulla, 2009 .

The Regulatory FcγR System in Antibody-Mediated Autoimmune Diseases

R. Schmidt, J. E. Gessner, J. Skokowa, 2004, Transfusion Medicine and Hemotherapy.

Opposite Regulation of Type II and III Receptors for Immunoglobulin G in Mouse Glomerular Mesangial Cells and in the Induction of Anti-glomerular Basement Membrane (GBM) Nephritis*

P. Heeringa, R. Schmidt, H. Radeke, 2002, The Journal of Biological Chemistry.

FcγRIII-Mediated Production of TNF-α Induces Immune Complex Alveolitis Independently of CXC Chemokine Generation1

B. Nieswandt, R. Schmidt, U. Baumann, 2001, The Journal of Immunology.

In Vivo Effects of a Synthetic 2-Kilodalton Macrophage-Activating Lipopeptide of Mycoplasma fermentans after Pulmonary Application

R. Pabst, P. Mühlradt, J. E. Gessner, 2002, Infection and Immunity.

Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1.

B. K. Thakur, K. Welte, J. Skokowa, 2009, Blood.

Transcriptional regulation of granulopoiesis

J. Skokowa, 2019, Reactome - a curated knowledgebase of biological pathways.

The Association Between STAT5a Activation, LEF-1 Down Regulation and Leukemic Transformation in Patients with Severe Congenital Neutropenia

K. Welte, Kshama Gupta, J. Skokowa, 2008 .

Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34+ cells preceding leukemic transformation.

L. Kanz, K. Schulze-Osthoff, K. Welte, 2019, Experimental hematology.

Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche

J. Skokowa, M. Klimiankou, M. Nasri, 2022, Cell reports. Medicine.

Identification of GFI1 mutations in adult patients with congenital neutropenia

E. Drakos, H. Papadaki, J. Skokowa, 2022, Annals of Hematology.

SRP54 mutations induce Congenital Neutropenia via dominant-negative effects on XBP1 splicing.

M. Konantz, C. Lengerke, T. Schaefer, 2020, Blood.

Release of the pre-assembled naRNA-LL37 composite DAMP re-defines neutrophil extracellular traps (NETs) as intentional DAMP webs

K. Hipp, Yu Wang, A. Weber, 2022, bioRxiv.

naRNA is a canonical neutrophil extracellular trap (NET) component and novel inflammation-amplifying composite DAMP

K. Hipp, Yu Wang, Jule Focken, 2022, bioRxiv.

Cooperating, congenital neutropenia–associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs

A. Schambach, L. Kanz, D. Link, 2020, Annals of Hematology.

Defective G-CSFR signaling pathways in congenital neutropenia.

K. Welte, J. Skokowa, 2013, Hematology/oncology clinics of North America.

Chronische Neutropenien im Kindesalter

J. Skokowa, C. Zeidler, K. Welte, 2018, Monatsschrift Kinderheilkunde.

Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization

H. Gohlke, A. Borkhardt, Lukas Spanier, 2021, ACS central science.

Old drug revisited: disulfiram, NETs, and sepsis.

J. Skokowa, M. Klimiankou, 2021, Blood.

C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease.

R. Schmidt, U. Baumann, J. E. Gessner, 2002, The Journal of clinical investigation.

Lentiviral gene therapy and vitamin B3 treatment enable granulocytic differentiation of G6PC3-deficient induced pluripotent stem cells

D. Steinemann, A. Schambach, C. Klein, 2020, Gene Therapy.

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Dirk Roos, Charaf Benarafa, Dominik Hartl, 2015, PLoS pathogens.

ELANE mutant–specific activation of different UPR pathways in congenital neutropenia

K. Welte, Inna S. Kuznetsova, J. Skokowa, 2016, British journal of haematology.

iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia.

M. Konantz, C. Lengerke, D. Steinemann, 2021, Cell stem cell.

Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies

Gesine Hansen, Axel Schambach, Nico Lachmann, 2015, Stem cell reports.

CRISPR/Cas9-mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients

K. Welte, K. Hipp, Yun Xu, 2019, Haematologica.

The diversity of mutations and clinical outcomes for ELANE-associated neutropenia

P. Rosenberg, P. Newburger, D. Link, 2015, Current opinion in hematology.

New insights into the pathomechanism of cyclic neutropenia

K. Welte, J. Skokowa, M. Klimiankou, 2020, Annals of the New York Academy of Sciences.

GM-CSF stimulates granulopoiesis in a congenital neutropenia patient with loss-of-function biallelic heterozygous CSF3R mutations.

K. Welte, J. Skokowa, M. Klimiankou, 2015, Blood.

The chemokine CXCL14 mediates platelet function and migration via direct interaction with CXCR4.

O. Borst, M. Gawaz, D. Rath, 2020, Cardiovascular research.

Low platelet counts after induction therapy for childhood acute lymphoblastic leukemia are strongly associated with poor early response to treatment as measured by minimal residual disease and are prognostic for treatment outcome

B. Meissner, A. Teigler‐Schlegel, M. Schrappe, 2012, Haematologica.

High interleukin-15 expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNS.

H. Schünemann, M. Schrappe, S. Izraeli, 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia

A. Schambach, R. Grosschedl, K. Welte, 2006, Nature Medicine.

GM-CSF treatment is not effective in congenital neutropenia patients due to its inability to activate NAMPT signaling

L. Kanz, K. Welte, J. Skokowa, 2017, Annals of Hematology.

Thrombopoietin Regulates Differentiation of Rhesus Monkey Embryonic Stem Cells to Hematopoietic Cells

M. Ballmaier, K. Welte, Z. Wang, 2005, Annals of the New York Academy of Sciences.

TCIRG1‐Associated Congenital Neutropenia

D. Nickerson, Joshua D. Smith, M. Bamshad, 2014, Human mutation.

CLPB in neutropenia: 1 gene with many faces.

C. Lengerke, J. Skokowa, 2022, Blood.

Nicotinamide (vitamin B3) treatment improves response to G‐CSF in severe congenital neutropenia patients

K. Welte, A. Shcherbina, G. Novichkova, 2021, British journal of haematology.

Mutations in the TNFRSF1A, CEBPE and ELANE genes in a Congenital Cyclic Neutropenia Patient: A New Syndrome?

K. Welte, J. Skokowa, M. Klimiankou, 2012 .

Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response.

K. Schulze-Osthoff, K. Welte, Yun Xu, 2019, Blood advances.

Congenital and Acquired Chronic Neutropenias: Challenges, Perspectives and Implementation of the EuNet-INNOCHRON Action

J. Palmblad, K. Stamatopoulos, C. Mecucci, 2020, HemaSphere.

G-CSF receptor mutations in patients with congenital neutropenia

M. Ballmaier, K. Welte, M. Germeshausen, 2008, Current opinion in hematology.

RUNX1 Mutations Are the Most Frequent Leukemia Associated Mutations in Congenital Neutropenia Patients

D. Steinemann, A. Kohlmann, S. Schnittger, 2012 .

Clinical Outcomes for Patients with Severe Chronic Neutropenia Due to Mutations in the Gene for Neutrophil Elastase, ELANE

Repository, P. Newburger, K. Welte, 2012 .

A zebrafish model for HAX1-associated congenital neutropenia

K. Welte, B. Bajoghli, N. Aghaallaei, 2020, Haematologica.

The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells

D. Reinhardt, K. Welte, M. V. D. van den Heuvel-Eibrink, 2012, Haematologica.

Gene expression profile of the infective murine model for biliary atresia

J. Kübler, R. Wasielewski, B. Ure, 2005, Pediatric Surgery International.

Analysis of Leukemogenic Effects of RUNX1 and CSF3R Mutations Using Congenital Neutropenia (CN)/AML Patient-Derived Induced Pluripotent Stem Cells (iPSCs)

L. Kanz, K. Welte, J. Skokowa, 2016 .

Chronic neutropenic colitis with complete colonic obstruction in a patient with severe congenital neutropenia associated with G6PC3 mutations

M. Tzardi, H. Papadaki, T. Nikolouzakis, 2022, Annals of Hematology.

High-content cytometry and transcriptomic biomarker profiling of human B-cell activation.

C. Pignata, C. Klein, I. Caragol, 2014, The Journal of allergy and clinical immunology.

Thrombopoietin induces hematopoiesis from mouse ES cells via HIF‐1α–dependent activation of a BMP4 autoregulatory loop

K. Welte, J. Skokowa, D. Lan, 2016, Annals of the New York Academy of Sciences.

miR-155 Is Associated with the Leukemogenic Potential of the Class IV Granulocyte Colony-Stimulating Factor Receptor in CD34+ Progenitor Cells

A. Schambach, R. Blasczyk, B. Eiz-Vesper, 2014, Molecular medicine.

The European Guidelines on Diagnosis and Management of Neutropenia in Adults and Children: A Consensus Between the European Hematology Association and the EuNet-INNOCHRON COST Action

J. Palmblad, P. Newburger, A. Warren, 2023, HemaSphere.

Neutrophil Extracellular Traps (NETs) in Patients with Congenital Neutropenia

K. Welte, M. Germeshausen, C. Happle, 2011 .

PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS A lack of secretory leukocyte protease inhibitor ( SLPI ) causes defects in granulocytic differentiation

K. Welte, K. Hussein, J. Skokowa, 2014 .

NAMPT signaling is critical for the proangiogenic activity of tumor‐associated neutrophils

D. Schadendorf, C. Franklin, B. K. Thakur, 2018, International journal of cancer.

A unique role of p53 haploinsufficiency or loss in the development of acute myeloid leukemia with FLT3-ITD mutation

A. Ganser, K. Welte, O. Dittrich‐Breiholz, 2021, Leukemia.

Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34(+) cells.

K. Welte, Johann Meyer, M. Moore, 2014, Blood.

PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS Bortezomib inhibits STAT 5-dependent degradation of LEF-1 , inducing granulocytic differentiation in congenital neutropenia CD 34 1 cells

K. Welte, Johann Meyer, M. Moore, 2014 .

Bortezomib Induces Granulocytic Differentiation of CD34 Cells from Congenital Neutropenia Patients by Reversing Hyperactivate-STAT5a- Dependent Downregulation of LEF-1

K. Welte, Johann Meyer, M. Moore, 2014 .

Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1 alpha-dependent activation of a BMP4 autoregulatory loop

K. Welte, J. Skokowa, Azadeh Zahabi, 2016 .

Clinical trio genome sequencing facilitates the interpretation of variants in cancer predisposition genes in paediatric tumour patients

C. Schroeder, M. Sturm, A. Dufke, 2023, European Journal of Human Genetics.

Fc gamma RIII-mediated production of TNF-alpha induces immune complex alveolitis independently of CXC chemokine generation.

B. Nieswandt, R. Schmidt, U. Baumann, 2001, Journal of immunology.

Release of the Pre-Assembled naRNA-LL37 Composite DAMP Re-Defines Neutrophil Extracellular Traps (NETs) as Intentional DAMP Webs

K. Hipp, Yu Wang, A. Weber, 2022, SSRN Electronic Journal.

LEF-1 Transcription Factor Regulates Proliferation and Differentiation of Myeloid Progenitors in Healthy Individuals and in Patients with Severe Congenital Neutropenia (CN).

A. Schambach, K. Welte, C. Baum, 2005 .

J. Palmblad, K. Welte, M. Bartels, 2023, British journal of haematology.

The design of functional proteins using tensorized energy calculations

T. Dijkstra, A. Lupas, N. Aghaallaei, 2023, Cell reports methods.

Cooperativity of RUNX1 and CSF3R Mutations in the Development of Leukemia in Severe Congenital Neutropenia: A Unique Pathway in Myeloid Leukemogenesis

D. Steinemann, J. Skokowa, 2014 .

Is Associated with the Leukemogenic Potential of the Class IV Granulocyte Colony-Stimulating Factor Receptor in CD 34 + Progenitor Cells

A. Schambach, R. Blasczyk, B. Eiz-Vesper, 2015 .

Differential transcriptional control of hematopoiesis in congenital and cycling neutropenia patients harboring ELANE mutations.

J. Skokowa, Azadeh Zahabi, M. Klimiankou, 2023, Haematologica.

Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1.

B. K. Thakur, K. Welte, J. Skokowa, 2009, Blood.

Circumventing Mutation to Nix Neutropenia.

J. Skokowa, 2021, The New England journal of medicine.

Two cases of cyclic neutropenia with acquired CSF3R mutations, with 1 developing AML.

K. Welte, J. Skokowa, M. Klimiankou, 2016, Blood.

CRISPR/Cas9 Genome Editing of Human-Induced Pluripotent Stem Cells Followed by Granulocytic Differentiation.

K. Welte, J. Skokowa, M. Nasri, 2020, Methods in molecular biology.

Role of CSF3R mutations in the pathomechanism of congenital neutropenia and secondary acute myeloid leukemia

K. Welte, J. Skokowa, M. Klimiankou, 2016, Annals of the New York Academy of Sciences.

Co-Acquisition of RUNX1 and CSF3R Mutations Transforms Hematopoietic Progenitor Cells of CN Patients into More Primitive Highly Proliferative Blasts: Evidence in CN Patients and in a Mouse Model

D. Link, K. Welte, C. Stocking, 2014 .