G. Henson

发表

Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor.

B Clotet, E. De Clercq, B. Clotet, 1999, Molecular pharmacology.

Shift of Clinical Human Immunodeficiency Virus Type 1 Isolates from X4 to R5 and Prevention of Emergence of the Syncytium-Inducing Phenotype by Blockade of CXCR4

E. De Clercq, B. Clotet, J. Blanco, 1999, Journal of Virology.

Pharmacokinetics of antiviral polyoxometalates in rats

S. Fricker, G. Bossard, F. D. Boudinot, 1992, Antimicrobial Agents and Chemotherapy.

Interleukin-3 supports growth of mouse pre-B-cell clones in vitro

M. Steinmetz, G. Henson, R. Palacios, 1984, Nature.

Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist.

B. Wood, H. Broxmeyer, G. Bridger, 2003, Blood.

Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.

E. Gorovits, A. Kolykhalov, Srinivas K. Battina, 2011, Journal of medicinal chemistry.

Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines.

J. Balzarini, C. Mcguigan, G. Andrei, 2007, Journal of Medicinal Chemistry.

Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4

E. Clercq, D. Schols, J. Esté, 1997, The Journal of experimental medicine.

Pharmacokinetics and Safety of FV-100, a Novel Oral Anti-Herpes Zoster Nucleoside Analogue, Administered in Single and Multiple Doses to Healthy Young Adult and Elderly Adult Volunteers

B. Boehlecke, A. Morris, G. Henson, 2011, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics ofAntiviral Polyoxometalates inRats

G. Bossard, F. D. Boudinot, P. Ash, 1994 .

Synthesis and Structure−Activity Relationships of Phenylenebis(methylene)- Linked Bis-tetraazamacrocycles That Inhibit Human Immunodeficiency Virus Replication. 2. Effect of Heteroaromatic Linkers on the Activity of Bicyclams

E. De Clercq, R. Pauwels, M. Witvrouw, 1996 .

Quantitative structural activity relationship study of bis-tetraazacyclic compounds. A novel series of HIV-1 and HIV-2 inhibitors.

E. De Clercq, R. Pauwels, G. Bridger, 1995, Journal of medicinal chemistry.

In vitro Activity of a Novel Series of Polyoxosilicotungstates against Human Myxo-, Herpes- and Retroviruses

E. De Clercq, S. Ikeda, J. Neyts, 1993 .

Leukocytosis and Mobilization of CD34+ Hematopoietic Progenitor Cells by AMD3100, a CXCR4 Antagonist.

B. Wood, H. Broxmeyer, G. Bridger, 2004, Supportive cancer therapy.

10 – Mapping of Novel B Lymphocyte Differentiation Antigens

G. Henson, J. Mckearn, 1985 .

INX-08189, a Phosphoramidate Prodrug of 6-O-Methyl-2′-C-Methyl Guanosine, Is a Potent Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic and Pharmacodynamic Properties

E. Gorovits, Yule Liu, A. Kolykhalov, 2011, Antimicrobial Agents and Chemotherapy.

Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.

E. Gorovits, Yule Liu, A. Kolykhalov, 2010, Journal of medicinal chemistry.

Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.

E. Gorovits, A. Brancale, A. Kolykhalov, 2010, Bioorganic & medicinal chemistry letters.

Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.

A. Kolykhalov, Srinivas K. Battina, J. Vernachio, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker.

R. Pauwels, G. Bridger, M. Abrams, 1995, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4.

E. De Clercq, D. Schols, M. Witvrouw, 1999, Journal of medicinal chemistry.

Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4.

E. De Clercq, E. Clercq, D. Schols, 1997, Antiviral research.

Safety, Pharmacokinetics, and Antiviral Activity of AMD3100, a Selective CXCR4 Receptor Inhibitor, in HIV-1 Infection

Dominique Schols, M. Lederman, C. Flexner, 2004, Journal of acquired immune deficiency syndromes.

Pharmacokinetics and Safety of AMD-3100, a Novel Antagonist of the CXCR-4 Chemokine Receptor, in Human Volunteers

Edward J. Fuchs, Craig W. Hendrix, Charles Flexner, 2000, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics of Polyoxometalates after Multiple‐dose Administration in Rats

G. Bossard, F. D. Boudinot, M. Darkes, 1996 .

2'-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743.

J. Balzarini, Marco Derudas, C. Mcguigan, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2'-C-methyl-6-O-methyl guanosine nucleoside and L-Alanine ester phosphoramidates.

E. Gorovits, A. Brancale, A. Kolykhalov, 2013, Bioorganic & medicinal chemistry letters.

Bicyclams, Selective Antagonists of the Human Chemokine Receptor CXCR4, Potently Inhibit Feline Immunodeficiency Virus Replication

E. De Clercq, Marian C. Horzinek, J. Balzarini, 1999, Journal of Virology.

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

J. Moore, T. Sakmar, D. Schols, 1998, Nature Medicine.

Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1.

E. De Clercq, A. Vandamme, M. Witvrouw, 1996, Antiviral research.

Pharmacodynamic Properties Replication with Excellent Pharmacokinetic Potent Inhibitor of Hepatitis C Virus-Methyl Guanosine , Is a C-′-Methyl-2 O 6-INX-08189 , a Phosphoramidate Prodrug of

E. Gorovits, Yule Liu, A. Kolykhalov, 2011 .

460 A STUDY OF THE SAFETY AND PHARMACOKINETICS OF SINGLE ASCENDING ORAL DOSES OF INX-08189, A NUCLEOTIDE POLYMERASE INHIBITOR, IN HEALTHY SUBJECTS

B. Boehlecke, G. Henson, J. Patti, 2011 .

Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus.

L. Naesens, A. Jones, E. Verbeken, 2007, The Journal of antimicrobial chemotherapy.

Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.

E. De Clercq, C. Pannecouque, L. Naesens, 1999, International journal of pharmaceutics.

The CXCR4 Antagonist AMD3100 Efficiently Inhibits Cell-Surface-Expressed Human Immunodeficiency Virus Type 1 Envelope-Induced Apoptosis

J. Barretina, E. De Clercq, B. Clotet, 2000, Antimicrobial Agents and Chemotherapy.

AMD3100, a Potent and Specific Antagonist of the Stromal Cell-Derived Factor-1 Chemokine Receptor CXCR4, Inhibits Autoimmune Joint Inflammation in IFN-γ Receptor-Deficient Mice1

Dominique Schols, E. De Clercq, A. Billiau, 2001, The Journal of Immunology.

The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding.

I. De Clercq, A. Steinkasserer, W. James, 1996, Antiviral research.

Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.

E. De Clercq, T. Schwartz, E. Clercq, 2001, Molecular pharmacology.

A comparison of cleavable and noncleavable hydrazinopyridine linkers for the 99mTc labeling of Fab' monoclonal antibody fragments.

G. Bridger, M. Abrams, C B Longley, 1996, Bioconjugate chemistry.

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

E. De Clercq, R. Pauwels, M. Baba, 1992, Proceedings of the National Academy of Sciences of the United States of America.

7 – The HPLC of Immunoglobulins

G. Henson, 1985 .

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

E. De Clercq, R. Pauwels, B. Rosenwirth, 1994, Antimicrobial Agents and Chemotherapy.