J. Hesselgesser

发表

An Orphan Seven-Transmembrane Domain Receptor Expressed Widely in the Brain Functions as a Coreceptor for Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus

R. Doms, D. Kolson, Benhur Lee, 1998, Journal of Virology.

Ad26/MVA Therapeutic Vaccination with TLR7 Stimulation in SIV-Infected Rhesus Monkeys

Jeffrey M. Gerold, Jerome H. Kim, H. Schuitemaker, 2016, Nature.

CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons

J. Hoxie, D. Taub, M. Halks-Miller, 1997, Current Biology.

CXCR3 expression in human central nervous system diseases

D. Kolson, E. Lavi, F. González-Scarano, 2001, Neuropathology and applied neurobiology.

A Phase 1/2 Randomized, Placebo-Controlled Trial of Romidespin in Persons With HIV-1 on Suppressive Antiretroviral Therapy.

J. Karn, J. Mellors, E. Acosta, 2020, Journal of Infectious Diseases.

CD4-independent association between HIV-1 gp120 and CXCR4: Functional chemokine receptor expression in human neurons

J. Hoxie, D. Taub, M. Halks-Miller, 1997 .

The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor

R. Horuk, Zi-Xuan Wang, S. Peiper, 1995, The Journal of experimental medicine.

Identification and Characterization of a Potent, Selective, and Orally Active Antagonist of the CC Chemokine Receptor-1*

D. Taub, S. Harvey, R. Horuk, 2000, The Journal of Biological Chemistry.

Species selectivity of a small molecule antagonist for the CCR1 chemokine receptor.

R. Horuk, P. Kretschmer, M. Morrissey, 2000, European journal of pharmacology.

Noncompetitive, Chemokine-mediated Inhibition of Basic Fibroblast Growth Factor-induced Endothelial Cell Proliferation*

A. Mantovani, M. Presta, R. Horuk, 1998, The Journal of Biological Chemistry.

The role of CXC chemokines in the regulation of angiogenesis in non‐small cell lung cancer

R. Strieter, S. Kunkel, D. Arenberg, 1997, Journal of leukocyte biology.

Transendothelial Migration of Megakaryocytes in Response to Stromal Cell-derived Factor 1 (SDF-1) Enhances Platelet Formation

S. Rafii, J. Hoxie, R. Möhle, 1998, The Journal of experimental medicine.

The role of CXC chemokines in the regulation of angiogenesis in non-small cell lung cancer.

R. Strieter, S. Kunkel, D. Arenberg, 1999, Journal of leukocyte biology.

Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity.

J. Hoxie, L. Brass, R. Horuk, 1998, Journal of immunology.

Expression of the Duffy antigen in K562 cells. Evidence that it is the human erythrocyte chemokine receptor.

R. Horuk, A. Pogo, A. Chaudhuri, 1994, The Journal of biological chemistry.

Modulation of Feline Immunodeficiency Virus Infection by Stromal Cell-Derived Factor

J. Hoxie, J. Neil, B. Willett, 1998, Journal of Virology.

PD-1 Blockade and TLR7 Activation Lack Therapeutic Benefit in Chronic Simian Immunodeficiency Virus-Infected Macaques on Antiretroviral Therapy

J. Lifson, B. Carr, R. Geleziunas, 2019, Antimicrobial Agents and Chemotherapy.

HIV-1 Infectivity Lines: Ligand Binding, Biological Activity, and CXCR4 Chemokine Receptor in Human T Cell Identification and Characterization of the

D. Taub, L. Brass, R. Horuk, 1998 .

Alanine scan mutagenesis of chemokines.

R. Horuk, J. Hesselgesser, 1997, Methods in enzymology.

A Non-peptide Functional Antagonist of the CCR1 Chemokine Receptor Is Effective in Rat Heart Transplant Rejection*

C. Weber, A. Krensky, H. Gröne, 2001, The Journal of Biological Chemistry.

CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis.

R. Ransohoff, H. Lassmann, P. Kivisäkk, 2001, The American journal of pathology.

CCR1-specific non-peptide antagonist: efficacy in a rabbit allograft rejection model.

R. Horuk, M. Morrissey, H. Perez, 2001, Immunology letters.

Preclinical Evaluation of GS-9160, a Novel Inhibitor of Human Immunodeﬁciency Virus Type 1 Integrase (cid:1) †

R. Geleziunas, Xiaowu Chen, M. Tsiang, 2009 .

Preclinical Evaluation of GS-9160, a Novel Inhibitor of Human Immunodeficiency Virus Type 1 Integrase

R. Geleziunas, Xiaowu Chen, M. Tsiang, 2008, Antimicrobial Agents and Chemotherapy.

The solution structure of melanoma growth stimulating activity.

W. Fairbrother, D. Reilly, R. Horuk, 1994, Journal of molecular biology.

Functional expression of the seven-transmembrane HIV-1 co-receptor APJ in neural cells.

P. Crino, D. Kolson, E. Lavi, 2000, Journal of neurovirology.

The Duffy antigen receptor for chemokines: structural analysis and expression in the brain

Zhaohua Lu, Wang, R. Horuk, 1996, Journal of leukocyte biology.

Chemokine and chemokine-receptor expression in human glial elements: induction by the HIV protein, Tat, and chemokine autoregulation.

S. Woodman, C. Mcmanus, J. Berman, 2000, The American journal of pathology.

Mechanisms of leukocyte traf ® cking into the CNS

J. Weiss, E. Major, S. Woodman, 2000 .

Functional expression of the seven-transmembrane

P. Crino, D. Kolson, E. Lavi, 2000 .

Short Communication: Comparative Evaluation of Coformulated Injectable Combination Antiretroviral Therapy Regimens in Simian Immunodeficiency Virus-Infected Rhesus Macaques.

J. Lifson, B. Keele, M. Piatak, 2016, AIDS research and human retroviruses.

Binding of Human Immunodeficiency Virus Type 1 to CD4 and CXCR4 Receptors Differentially Regulates Expression of Inflammatory Genes and Activates the MEK/ERK Signaling Pathway

P. Pitha, J. Hesselgesser, W. Popik, 1998, Journal of Virology.

Identification and optimization of pteridinone Toll-like receptor 7 (TLR7) agonists for the oral treatment of viral hepatitis.

Hong Yang, R. Halcomb, B. Gallagher, 2013, Journal of medicinal chemistry.

The CC Chemokine I-309 Inhibits CCR8-dependent Infection by Diverse HIV-1 Strains*

R. Doms, D. Taub, M. Halks-Miller, 1998, The Journal of Biological Chemistry.

Identification and Characterization of Small Molecule Functional Antagonists of the CCR1 Chemokine Receptor*

D. Taub, Wei Zheng, R. Horuk, 1998, The Journal of Biological Chemistry.

Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4

Michael Greenberg, J. Hoxie, D. Taub, 1998, Current Biology.

CXCR4 on human endothelial cells can serve as both a mediator of biological responses and as a receptor for HIV-2.

J. Hoxie, D. Praticò, N. Prévost, 2000, Biochimica et biophysica acta.

Postcapillary venule endothelial cells in kidney express a multispecific chemokine receptor that is structurally and functionally identical to the erythroid isoform, which is the Duffy blood group antigen.

R. Horuk, K. Waśniowska, S. Peiper, 1994, The Journal of clinical investigation.

Identification and characterization of a promiscuous chemokine-binding protein in a human erythroleukemic cell line.

R. Horuk, S. Peiper, J. Hesselgesser, 1994, The Journal of biological chemistry.

A His19 to Ala mutant of melanoma growth-stimulating activity is a partial antagonist of the CXCR2 receptor.

C. Kotts, L. Simmons, W. Fairbrother, 1998, Journal of immunology.

The Promiscuous Chemokine Binding Profile of the Duffy Antigen/Receptor for Chemokines Is Primarily Localized to Sequences in the Amino-terminal Domain (*)

R. Horuk, S. Peiper, J. Hesselgesser, 1995, The Journal of Biological Chemistry.

Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model.

R. Strieter, M. Kaufhold, R. Horuk, 1998, The Journal of clinical investigation.

A role for CXCL12 (SDF-1α) in the pathogenesis of multiple sclerosis: Regulation of CXCL12 expression in astrocytes by soluble myelin basic protein

J. Berman, T. Calderon, E. Eugenin, 2006, Journal of Neuroimmunology.

Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy

J. Lifson, W. Alvord, B. Keele, 2015, Antimicrobial Agents and Chemotherapy.

Chemokine and chemokine receptor expression in the central nervous system.

R. Horuk, J. Hesselgesser, 1999, Journal of neurovirology.

Mechanisms of leukocyte trafficking into the CNS.

J. Weiss, E. Major, S. Woodman, 2000, Journal of neurovirology.

Rapid Seeding of the Viral Reservoir Prior to SIV Viremia in Rhesus Monkeys

Jinyan Liu, Merlin L. Robb, Alison L. Hill, 2014, Nature.

Antibody and TLR7 Agonist Delay Viral Rebound in SHIV-Infected Monkeys

G. Alter, R. Geleziunas, D. Barouch, 2018, Nature.

A mutant of melanoma growth stimulating activity does not activate neutrophils but blocks erythrocyte invasion by malaria

L. Miller, C. Kotts, R. Horuk, 1995, The Journal of Biological Chemistry.

TLR7 Agonist GS-9620 Is a Potent Inhibitor of Acute HIV-1 Infection in Human Peripheral Blood Mononuclear Cells

S. Yant, T. Cihlar, C. Frey, 2016, Antimicrobial Agents and Chemotherapy.

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy

Jeffrey M. Gerold, William A. Lee, P. Hraber, 2018, Science Translational Medicine.

Expression of chemokine receptors by subsets of neurons in the central nervous system.

L. Schweitzer, R. Horuk, H. Perez, 1997, Journal of immunology.

Interleukin-1β induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors

A. Krensky, P. Nelson, H. Perez, 2000, Journal of Neuroimmunology.

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

C. Spina, J. Mellors, Helen Yu, 2014, PLoS pathogens.

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

L. Picker, J. Lifson, Y. Fukazawa, 2018, Nature Medicine.

A B cell follicle sanctuary permits persistent productive SIV infection in elite controllers

L. Picker, J. Lifson, M. Piatak, 2014, Nature Medicine.

Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation

B. Keele, R. Geleziunas, D. Barouch, 2020, Nature Communications.

TLR7 agonist administration to SIV-infected macaques receiving early initiated cART does not induce plasma viremia.

J. Lifson, W. Alvord, R. Kiser, 2019, JCI insight.

Safety, Pharmacokinetics and Pharmacodynamics of Gs-9620, An Oral Toll-Like Receptor 7 Agonist

B. Kearney, J. McHutchison, G. Subramanian, 2013, Antiviral therapy.

Anti‐CD81 antibodies can prevent a hepatitis C virus infection in vivo

G. Leroux-Roels, H. Reiser, I. Desombere, 2008, Hepatology.

Discovery of novel non-peptide CCR1 receptor antagonists.

R. Horuk, M. Morrissey, H. Perez, 1999, Journal of medicinal chemistry.

Pharmacokinetic and Pharmacodynamic Properties of GS-9620, a Novel Toll-Like Receptor 7 Agonist, Demonstrate Interferon-Stimulated Gene Induction without Detectable Serum Interferon at Low Oral Doses

R. Halcomb, S. Pflanz, C. Frey, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Chemokine receptors on mononuclear phagocytes in the central nervous system of patients with multiple sclerosis.

H. Lassmann, P. Kivisäkk, R. Horuk, 2002, Ernst Schering Research Foundation workshop.

Publisher Correction: Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

R. Geleziunas, D. Barouch, S. Fischinger, 2018, Nature.

Chemokine receptors in developing human brain.

M. Halks-Miller, R. Horuk, J. Hesselgesser, 1997, Methods in enzymology.

Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons

R. Doms, Wei Chen, V. Lee, 2000, Neuroscience.

Chemokines and Chemokine Receptors in the Brain

R. Horuk, J. Hesselgesser, 1999 .

Activation of HIV-Specific CD8+ T-cells from HIV+ Donors by Vesatolimod

R. Geleziunas, J. Hesselgesser, M. Abram, 2020, Antiviral therapy.

Publisher Correction: Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

G. Alter, R. Geleziunas, D. Barouch, 2018, Nature.

Search for small molecule activators of latent HIV

Helen Yu, R. Geleziunas, G. Stepan, 2012, Retrovirology.

Pharmacokinetic and Pharmacodynamic Properties of GS-9620 , a Novel Toll-Like Receptor 7 Agonist , Demonstrate Interferon-Stimulated Gene Induction without Detectable Serum Interferon at Low Oral Doses s

R. Halcomb, S. Pflanz, C. Frey, 2013 .

Identiﬁcation and Characterization of the CXCR4 Chemokine Receptor in Human T Cell Lines: Ligand Binding, Biological Activity, and HIV-1 Infectivity 1

J. Hoxie, L. Brass, R. Horuk, 2022 .