T. Lukas

S. Ajroud‐Driss, T. Siddique, T. Lukas, 2008, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

ACTH (Acthar Gel) Reduces Toxic SOD1 Protein Linked to Amyotrophic Lateral Sclerosis in Transgenic Mice: A Novel Observation

T. Siddique, T. Lukas, Hasan Arrat, 2015, PloS one.

Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS

S. Ajroud‐Driss, J. Armstrong, S. Heller, 2007, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

The Intermediate Filament Protein, Vimentin, in the Lens Is a Target for Cross-linking by Transglutaminase*

S. N. Murthy, L. Lorand, S. Clément, 1998, The Journal of Biological Chemistry.

Identification of calcium binding sites in the trypanosome flagellar calcium-acyl switch protein.

S. Goldenberg, D. Engman, L. Godsel, 1999, Molecular and biochemical parasitology.

Site-specific amino acid alterations in Ca2+ binding domains in calmodulin impair activation of RBC Ca(2+)-ATPase.

A. Wawrzynów, D. Kosk-Kosicka, T. Bzdȩga, 1992, Biophysical journal.

CHAPTER 31 – Immobilized Drugs in Protein and Peptide Isolation

D. Marshak, D. Watterson, T. Lukas, 1985 .

An in vitro model for testing drugs to treat tinnitus.

G. Gross, Calvin Wu, T. Lukas, 2011, European journal of pharmacology.

Amino acid sequence of a novel calmodulin from Paramecium tetraurelia that contains dimethyllysine in the first domain.

I. Blair, D. Watterson, J. Schultz, 1987, The Journal of biological chemistry.

Trimethyllysine and protein function. Effect of methylation and mutagenesis of lysine 115 of calmodulin on NAD kinase activation.

D. Watterson, D. M. Roberts, T. Lukas, 1986, The Journal of biological chemistry.

Amino Acid sequence of a novel calmodulin from the unicellular alga chlamydomonas.

D. Watterson, T. Lukas, M. E. Wiggins, 1985, Plant Physiology.

Analysis of the molecular basis of calmodulin defects that affect ion channel-mediated cellular responses: site-specific mutagenesis and microinjection

T. Craig, R. Hinrichsen, J. Schultz, 1990, The Journal of cell biology.

Compound heterozygote mutations in SPG7 in a family with adult-onset primary lateral sclerosis

K. Ahmeti, N. Siddique, T. Siddique, 2016, Neurology: Genetics.

Phosphorylation of kinase-related protein (telokin) in tonic and phasic smooth muscles

A. Vorotnikov, D. Watterson, V. Shirinsky, 2004, Journal of Muscle Research & Cell Motility.

Direct identification of residues of the epidermal growth factor receptor in close proximity to the amino terminus of bound epidermal growth factor.

R. Woltjer, J. V. Staros, T. Lukas, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Drug-protein interactions: isolation and characterization of covalent adducts of phenoxybenzamine and calmodulin.

D. Marshak, D. Watterson, T. Lukas, 1985, Biochemistry.

Astrocytes in glaucomatous optic neuropathy.

M. Hernandez, M Rosario Hernandez, Haixi Miao, 2008, Progress in brain research.

Pharmacodynamics of potassium channel openers in cultured neuronal networks.

Guenter W Gross, G. Gross, Calvin Wu, 2014, European journal of pharmacology.

Tumor-suppressive Maspin Functions as a Reactive Oxygen Species Scavenger

N. Mahajan, T. Lukas, Ming Zhang, 2013, The Journal of Biological Chemistry.

RESIDUES IMPORTANCE OF CYSTEINE Reactive Oxygen Species Scavenger : Tumor-suppressive Maspin Functions as a Cell Biology :

M. Zhang, N. Mahajan, T. Lukas, 2013 .

Autophagy, exosomes and drusen formation in age-related macular degeneration

M. Tso, A. Neufeld, T. Lukas, 2009, Autophagy.

Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/kinase.

J. V. Staros, S. Cohen, T. Lukas, 1985, The Journal of biological chemistry.

Purification of calmodulin and preparation of immobilized calmodulin.

D. Watterson, T. Lukas, D. Watterson, 1988, Methods in enzymology.

A cysteine-functionalized micellar catalyst

R. Moss, T. Lukas, Robert C. Nahas, 1978 .

New amino acid-functionalized surfactants; preparation and catalytic properties

R. Moss, T. Lukas, Robert C. Nahas, 1977 .

Identification of Residues of the Epidermal Growth Factor Receptor Proximal to Residue 45 of Bound Epidermal Growth Factor*

C. A. Guyer, J. V. Staros, T. Lukas, 1996, The Journal of Biological Chemistry.

3 – Calmodulin-Regulated Protein Kinases

S. Mirzoeva, D. Watterson, T. Lukas, 1998 .

Calmodulin and calmodulin-regulated protein kinases as transducers of intracellular calcium signals.

T. Craig, W. Zimmer, J. Haiech, 1988, Cold Spring Harbor symposia on quantitative biology.

Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins.

D. Marshak, D. Watterson, T. Lukas, 1985, Biochemistry.

Site-directed antibodies to vertebrate and plant calmodulins.

L. V. Van Eldik, T. Lukas, 1987, Methods in enzymology.

Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene

L. V. Van Eldik, W. Zimmer, D. Watterson, 1992, Molecular and cellular biology.

The heterodimer calmodulin: myosin light-chain kinase as a prototype vertebrate calcium signal transduction complex.

J. Haiech, M. Kilhoffer, T. Lukas, 1992, Biochimica et biophysica acta.

Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity

L. V. Van Eldik, L. Guerra-Santos, D. Watterson, 1990, The Journal of cell biology.

Mutant analysis approaches to understanding calcium signal transduction through calmodulin and calmodulin regulated enzymes.

T. Craig, J. Haiech, L. Guerra-Santos, 1990, Advances in experimental medicine and biology.

Computational and site‐specific mutagenesis analyses of the asymmetric charge distribution on calmodulin

T. A. Craig, M. King, P. Weber, 1989, Proteins.

Calmodulin binding domains: characterization of a phosphorylation and calmodulin binding site from myosin light chain kinase.

F G Prendergast, D. Watterson, W H Burgess, 1986, Biochemistry.

An antigenically related polypeptide family is a major structural constituent of a stable acrosomal matrix assembly in bovine spermatozoa.

J. Neff, S. Nagdas, V. Winfrey, 1997, Biology of reproduction.

Purification and characterization of epidermal growth factor (beta-urogastrone) and epidermal growth factor fragments from large volumes of human urine.

D. Orth, T. Lukas, C. D. Mount, 1985, Archives of biochemistry and biophysics.

Dysfunction of the retinal pigment epithelium with age: increased iron decreases phagocytosis and lysosomal activity.

Hui-yi Chen, A. Neufeld, T. Lukas, 2009, Investigative ophthalmology & visual science.

A Novel FK506 Binding Protein Can Mediate the Immunosuppressive Effects of FK506 and Is Associated with the Cardiac Ryanodine Receptor (*)

E. A. O'neill, S. O'keefe, R. Abraham, 1995, The Journal of Biological Chemistry.

Using LC3 to monitor autophagy flux in the retinal pigment epithelium

M. Boulton, A. Neufeld, Jun Cai, 2009, Autophagy.

A calcium-dependent 35-kilodalton substrate for epidermal growth factor receptor/kinase isolated from normal tissue.

B. Mroczkowski, K. Misono, S. Cohen, 1986, The Journal of biological chemistry.

Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the gamma chain.

S. Timmons, J. Hawiger, T. Lukas, 1984, Biochemistry.

Fluorescence analysis of calmodulin mutants containing tryptophan: conformational changes induced by calmodulin-binding peptides from myosin light chain kinase and protein kinase II.

P. Axelsen, M. Chabbert, D. Watterson, 1991, Biochemistry.

Autophagy and Exosomes in the Aged Retinal Pigment Epithelium: Possible Relevance to Drusen Formation and Age-Related Macular Degeneration

M. Tso, A. Neufeld, T. Lukas, 2009, PloS one.

Isolation and characterization of calmodulin from the motile green alga Chlamydomonas reinhardtii.

M. Schleicher, D. Watterson, T. Lukas, 1984, Archives of biochemistry and biophysics.

Molecular Mechanisms of Calmodulin Action

D. Watterson, D. M. Roberts, T. Lukas, 1986 .

Amino acid sequence of the phosphorylation site of bovine cardiac myosin light chain.

D. Watterson, W. Burgess, T. Lukas, 1985, Archives of biochemistry and biophysics.

Further Characterization of Calmodulin from the Monocotyledon Barley (Hordeum vulgare).

M. Schleicher, D. Watterson, T. Lukas, 1983, Plant physiology.

Amino Acid Sequence of a Novel Calmodulin from the

D. Watterson, T. Lukas, M. E. Wiggins, 1985 .

Further Characterization of Calmodulin from the Monocotyledon

M. Schleicher, D. Watterson, T. Lukas, 1983 .

Structural Characterization of a Higher Plant Calmodulin'

M. Schleicher, T. Lukas, D. Iverson, 2022 .

AN INTERDISCIPLINARY APPROACH TO THE MOLECULAR MECHANISMS OF CALMODULIN ACTION: COMPARATIVE BIOCHEMISTRY, SITE-SPECIFIC MUTAGENESIS, AND PROTEIN ENGINEERING

T. Craig, J. Haiech, D. Watterson, 1987 .

Smooth muscle myosin filament assembly under control of a kinase-related protein (KRP) and caldesmon

A. Vorotnikov, J. Sellers, D. Watterson, 2004, Journal of Muscle Research & Cell Motility.

A. Vorotnikov, J. Sellers, K. Birukov, 1993, The Journal of biological chemistry.

Transglutaminase-catalyzed crosslinking of the Aα and γ constituent chains in fibrinogen

S. N. Murthy, L. Lorand, J. Weisel, 2000 .

The Aged Retinal Pigment Epithelium/Choroid: A Potential Substratum for the Pathogenesis of Age-Related Macular Degeneration

Thomas J. Lukas, Bin Liu, B. Liu, 2008, PloS one.

Characterization of a Low Molecular Mass Autophosphorylating Protein in Cultured Sugarcane Cells and Its Identification as a Nucleoside Diphosphate Kinase

S. Dharmasiri, S. Moisyadi, T. Lukas, 1994, Plant physiology.

Gene Expression and Functional Studies of the Optic Nerve Head Astrocyte Transcriptome from Normal African Americans and Caucasian Americans Donors

Sean M. Riordan, Simon M. Lin, Pan Du, 2008, PloS one.

Informatics-assisted Protein Profiling in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis*S

T. Siddique, T. Lukas, N. Cole, 2006, Molecular & Cellular Proteomics.

Micellar stereoselectivity. Cleavage of diastereomeric substrates by functional surfactant micelles

R. Moss, T. Lukas, Y. Lee, 1979 .

and PKC Afterpotential in Rat Jaw-Closing Motoneurons by PKA Serotonergic Modulation of the Hyperpolarizing Spike

C. Heckman, Masayuki Kobayashi, S. H. Chandler, 2013 .

Unique sequence of a high molecular weight myosin light chain kinase is involved in interaction with actin cytoskeleton

J. Sellers, K. Birukov, L. V. Van Eldik, 1999, FEBS letters.

Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets

T. Petrova, L. J. Eldik, T. Koppal, 1999, Brain Research.

Adult Rats Motoneurons of the Sacrocaudal Spinal Cord of Persistent Sodium Currents and Repetitive Firing in

W. Rymer, C. Heckman, S. Waxman, 2015 .

Effect of fluoxetine on disease progression in a mouse model of ALS.

C. Heckman, T. Siddique, J. Koschnitzky, 2014, Journal of neurophysiology.

Selectivity in the post-translational, transglutaminase-dependent acylation of lysine residues.

S. N. Murthy, L. Lorand, T. Jardetzky, 2009, Biochemistry.

Differential Effects of Elevated Hydrostatic Pressure on Gene Expression and Protein Phosphorylation in Optic Nerve Head Astrocytes

Simon M. Lin, Pan Du, T. Lukas, 2011 .

A thiocholine surfactant: Preparation and kinetic properties

R. Moss, T. Lukas, G. Bizzigotti, 1979 .

Changes in Retinal Pigment Epithelium Related to Cigarette Smoke: Possible Relevance to Smoking as a Risk Factor for Age-Related Macular Degeneration

J. Handa, A. Neufeld, T. Lukas, 2009, PloS one.

Solid-phase peptide synthesis under continuous-flow conditions.

B. W. Erickson, M. Prystowsky, T. Lukas, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Modulation of factors affecting optic nerve head astrocyte migration.

M. Hernandez, T. Lukas, H. Miao, 2010, Investigative ophthalmology & visual science.

A signal transduction pathway model prototype II: Application to Ca2+-calmodulin signaling and myosin light chain phosphorylation.

Thomas J Lukas, T. Lukas, 2004, Biophysical journal.

model of ALS Effect of fluoxetine on disease progression in a mouse

C. Heckman, T. Lukas, K. Quinlan, 2014 .

Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge.

S. Mirzoeva, D. Watterson, U. Słomczyńska, 1999, Journal of medicinal chemistry.

Kcnq1-5 (Kv7.1-5) potassium channel expression in the adult zebrafish

C. Torres, Calvin Wu, T. Lukas, 2014, BMC Physiology.

Preparation and kinetic properties of cysteine surfactants

R. Moss, T. Lukas, Robert C. Nahas, 1978 .

Interaction of smooth muscle caldesmon with calmodulin mutants

N. Gusev, D. Watterson, V. Shirinsky, 1995, FEBS Letters.

Inositol polyphosphate receptor and clathrin assembly protein AP-2 are related proteins that form potassium-selective ion channels in planar lipid bilayers.

S. Fleischer, H. Schindler, D. Watterson, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Features of calmodulin that are important in the activation of the catalytic subunit of phosphorylase kinase.

T. Craig, D. Watterson, T. Lukas, 1993, The Journal of biological chemistry.

Gain of function mutations for yeast calmodulin and calcium dependent regulation of protein kinase activity.

J. Haiech, D. Watterson, M. Collinge, 1994, Biochimica et biophysica acta.

Phosphorylation regulates interaction of 210-kDa myosin light chain kinase N-terminal domain with actin cytoskeleton

D. Watterson, V. Shirinsky, T. Lukas, 2015, Biochemistry (Moscow).

Multiple gene products are produced from a novel protein kinase transcription region

K. Birukov, L. V. Van Eldik, M. Collinge, 1995, FEBS letters.

Tumor suppressive maspin functions as a ROS scavenger : Importance of cysteine residues

N. Mahajan, T. Lukas, Heidi Y. Shi, 2013 .

Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression.

T. Siddique, K. Scheidt, T. Lukas, 2014, Bioorganic & medicinal chemistry letters.

AUTOMATED SOLID-PHASE PEPTIDE SYNTHESIS

B. W. Erickson, M. Prystowsky, T. Lukas, 1981 .

Isolation and culture of astrocytes from the retina and optic nerve.

T. Lukas, A. Wang, 2012, Methods in molecular biology.

In vivo mutations of calmodulin: a mutant Paramecium with altered ion current regulation has an isoleucine-to-threonine change at residue 136 and an altered methylation state at lysine residue 115.

D. Watterson, T. Lukas, M. Wallen-Friedman, 1989, Proceedings of the National Academy of Sciences of the United States of America.