M. Reese

发表

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Malina A. Bakowski, Chunlong Ma, Jun Wang, 2021, Nature Communications.

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19

Malina A. Bakowski, R. Obach, Chunlong Ma, 2020, bioRxiv.

Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide.

Tara B. Manion, A. Vaz, R. Robinson, 2011, Bioorganic & medicinal chemistry letters.

C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization.

T. Maurer, M. Leininger, C. Steppan, 2010, Bioorganic & medicinal chemistry letters.

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19

K. Gajiwala, A. Kalgutkar, P. Verhoest, 2021, Science.

2-Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as potent dissociated glucocorticoid receptor agonists.

L. Buckbinder, R. Robinson, Y. Abramov, 2015, Journal of medicinal chemistry.

Ru/Ni Dual Catalytic Desulfinative Photoredox Csp2-Csp3 Cross-Coupling of Alkyl Sulfinate Salts and Aryl Halides.

N. Sach, R. Chandrasekaran, J. Chen, 2017, Organic letters.

Octahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration.

E. Laird, L. Buckbinder, M. Wessel, 2009, Journal of medicinal chemistry.

Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.

I. Otterness, R. Robinson, J. Liras, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of α,α-difluoroethyl aryl and heteroaryl ethers.

J. Humphrey, M. Reese, Eddie Yang, 2012, Organic letters.

Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides.

Mark Rusznak, Christopher W. am Ende, J. Humphrey, 2018, Organic letters.

High-Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates.

Rory M. McDonald, N. Sach, D. Hall, 2019, Angewandte Chemie.

High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates

N. Sach, D. Hall, W. Farrell, 2019, Angewandte Chemie.

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.

J. Pandit, Ji-Young Kim, M. Hayward, 2012, ACS medicinal chemistry letters.

Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors.

E. Laird, R. Robinson, M. Reese, 2001, Bioorganic & medicinal chemistry letters.

Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors

B. L. Kormos, P. Sahasrabudhe, R. Sommese, 2023, The Journal of biological chemistry.

Syntheses of C-5-spirocyclic C-glycoside SGLT2 inhibitors

M. Leininger, C. Steppan, R. Robinson, 2010 .

Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss.

Jeonifer M. Garren, Martin R. M. Koos, J. Fortin, 2023, Journal of medicinal chemistry.

Catalytic Enantioselective Synthesis of a cis-β-Boronyl Cyclobutylcarboxyester Scaffold and Its Highly Diastereoselective Nickel/Photoredox Dual-Catalyzed Csp3–Csp2 Cross-Coupling to Access Elusive trans-β-Aryl/Heteroaryl Cyclobutylcarboxyesters

N. Sach, D. Hall, W. Farrell, 2020, ACS Catalysis.

Correction to “Catalytic Enantioselective Synthesis of a cis-β-Boronyl Cyclobutylcarboxyester Scaffold and Its Highly Diastereoselective Nickel/Photoredox Dual-Catalyzed Csp3–Csp2 Cross-Coupling to Access Elusive trans-β-Aryl/Heteroaryl Cyclobutylcarboxyesters”

N. Sach, D. Hall, M. Reese, 2021, ACS Catalysis.

Discovery of a novel Kv7 channel opener as a treatment for epilepsy.

Lei Zhang, R. J. Mather, Christopher R Butler, 2015, Bioorganic & medicinal chemistry letters.

Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.

J. Cianfrogna, A. Stepan, Daniel P. Walker, 2014, Journal of medicinal chemistry.

Structure-based design and synthesis of a potent matrix metalloproteinase-13 inhibitor based on a pyrrolidinone scaffold.

J. Blake, E. Laird, R. Robinson, 2000, Journal of medicinal chemistry.

Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.

J. Cianfrogna, A. Stepan, Daniel P. Walker, 2017, Journal of medicinal chemistry.

Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels

Jake E. Delmore, A. Kalgutkar, B. L. Kormos, 2023, Nature communications.

Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.

I. Otterness, R. Robinson, J. Liras, 2004, Bioorganic & medicinal chemistry letters.

Title: Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19

Chunlong Ma, Jun Wang, A. Mesecar, 2021 .

Rapid Multikilogram Scale-Up of Di- and Trifluoromethoxy Proline Derivatives

M. Reese, Joel T. Arcari, E. McInturff, 2024, Organic Process Research & Development.

Highly Potent , Selective , and E ffi cacious Metabotropic Glutamate Receptor 5 ( mGluR 5 ) Negative Allosteric Modulator

Ey, J. Cianfrogna, A. Stepan, 2014 .