F. Emms

发表

Photoaffinity labeling of the benzodiazepine binding site of alpha1beta3gamma2 gamma-aminobutyric acidA receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the alpha subunit and predicts orientation of these within the benzodiazepine pharmacophore.

R. Mckernan, I. Collins, A. Asuni, 1998, Molecular pharmacology.

Substituted pyrazoles as novel selective ligands for the human dopamine D4 receptor.

P. Leeson, I. Collins, M. Rowley, 1998, Bioorganic & medicinal chemistry.

Stable expression of human D3 dopamine receptors in GH4C1 pituitary cells

G. Mcallister, G. Seabrook, S. Freedman, 1992, FEBS letters.

Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands.

P. Leeson, S. Freedman, S. Patel, 1999, Bioorganic & medicinal chemistry letters.

4-Heterocyclyl tetrahydropyridines as selective ligands for the human dopamine D4 receptor

P. Leeson, S. Patel, R. Marwood, 1997 .

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

P D Leeson, P. Leeson, C. Ragan, 1996, Journal of medicinal chemistry.

4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.

P D Leeson, P. Leeson, C. Ragan, 1997, Journal of medicinal chemistry.

5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.

P. Leeson, C. Ragan, H. Broughton, 1996, Journal of medicinal chemistry.

Binding of 2,4-disubstituted morpholines at human D4 dopamine receptors.

P D Leeson, P. Leeson, D. O'connor, 1998, Bioorganic & medicinal chemistry.

Expression and pharmacological characterization of the human D3 dopamine receptor.

M. Knowles, G. Mcallister, G. Seabrook, 1994, The Journal of pharmacology and experimental therapeutics.

4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors.

P. Leeson, M. Rowley, S. Patel, 1999, Bioorganic & medicinal chemistry letters.

Functional coupling of human D2, D3, and D4 dopamine receptors in HEK293 cells.

M. Knowles, G. Mcallister, G. Seabrook, 1995, Journal of receptor and signal transduction research.

1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.

P. Leeson, A. Pike, C. Moyes, 1999, Journal of medicinal chemistry.

Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.

P. Leeson, M. Knowles, G. Mcallister, 1997, The Journal of pharmacology and experimental therapeutics.

Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.

R. Mckernan, F. Emms, A. Smith, 1999, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

Antagonism of the effects of (+)‐PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L‐741,626

L. Bristow, G. Seabrook, S. Freedman, 1996, British journal of pharmacology.

Regional Differences in the Inhibition of Mouse In Vivo [3H]Ro 15-1788 Binding Reflect Selectivity for α1 versus α2 and α3 Subunit-Containing GABAA Receptors

R. Mckernan, J. Atack, F. Emms, 1999, Neuropsychopharmacology.

3-(1-piperazinyl)-4,5-dihydro-1H-benzo[g]indazoles: high affinity ligands for the human dopamine D4 receptor with improved selectivity over ion channels.

P. Leeson, I. Collins, M. Rowley, 1998, Bioorganic & medicinal chemistry.

Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor.

P. Leeson, S. Freedman, S. Patel, 1996, Molecular pharmacology.

Characterisation of a chimeric hD3/D2 dopamine receptor expressed in CHO cells

G. Mcallister, G. Seabrook, S. Freedman, 1993, FEBS letters.

Antagonism oftheeffects of(+)-PD128907 on midbrain dopamine neuronesinratbrain slices byaselective D2receptor antagonist L-741,626

L. Bristow, G. Seabrook, S. Freedman, 1996 .