K. Quirk

发表

Photoaffinity labeling of the benzodiazepine binding site of alpha1beta3gamma2 gamma-aminobutyric acidA receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the alpha subunit and predicts orientation of these within the benzodiazepine pharmacophore.

R. Mckernan, I. Collins, A. Asuni, 1998, Molecular pharmacology.

The pharmacology of the benzodiazepine site of the GABA-A receptor is dependent on the type of gamma-subunit present.

R. Mckernan, P. Whiting, C. Ragan, 1995, Journal of receptor and signal transduction research.

THE PHARMACOLOGY OF THE BENZODIAZEPINE SITE OF SUBUNIT PRESENT. THE GABA-A RECEPTOR IS DEPENDENT ON THE TYPE OF y-

R. Mckernan, K. Wafford, K. Quirk, 1995 .

Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.

G. Kennett, C. Dourish, D. Adams, 2006, Bioorganic & medicinal chemistry letters.

Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites.

J. Kemp, R. Mckernan, P. Whiting, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Solubilisation and immunoprecipitation of rat striatal adenosine A(2A) receptors.

K. Quirk, A. R. Knight, V. Harvey, 2001, European journal of pharmacology.

Model of Subunit Composition of y-Aminobutyric Acid A Receptor Subtypes Expressed in Rat Cerebellum with Respect to Their a and

P. Whiting, C. Ragan, K. Quirk, 1994 .

[3H]L-655,708, a Novel Ligand Selective for the Benzodiazepine Site of GABAA Receptors which Contain the α5 Subunit

P. Leeson, R. Mckernan, C. Ragan, 1996, Neuropharmacology.

Solubilisation of the 5‐Hydroxytryptamine3 Receptor from Pooled Rat Cortical and Hippocampal Membranes

R. Mckernan, C. Ragan, R. Jackson, 1990, Journal of neurochemistry.

Characterisation of agonist binding on human 5-HT2C receptor isoforms.

A. Lawrence, R. Porter, K. Quirk, 2001, European journal of pharmacology.

Rat and Human Hippocampal a 5 Subunit-Containing g-Aminobutyric AcidA Receptors Have a 5 b 3 g 2 Pharmacological Characteristics

R. Mckernan, J. Atack, D. Dewar, 1998 .

gamma-Aminobutyric acid type A receptors in the rat brain can contain both gamma 2 and gamma 3 subunits, but gamma 1 does not exist in combination with another gamma subunit.

R. Mckernan, P. Whiting, C. Ragan, 1994, Molecular pharmacology.

Purification of the 5-hydroxytryptamine 5-HT3 receptor from NCB20 cells.

R. Mckernan, C. Ragan, C. Swain, 1990, The Journal of biological chemistry.

Anticonvulsant Activity of Azirino[1,2-d] [1,4]Benzodiazepines and Related 1,4-Benzodiazepines in Mice

R. Mckernan, A. Chimirri, G. Sarro, 1997, Pharmacology Biochemistry and Behavior.

Characterisation of δ-subunit containing GABAA receptors from rat brain

R. Mckernan, P. Whiting, C. Ragan, 1995 .

CHARACTERIZATION OF DELTA-SUBUNIT CONTAINING GABA(A) RECEPTORS FROM RAT-BRAIN

R. Mckernan, P. Whiting, C. Ragan, 1995 .

Characterisation of delta-subunit containing GABAA receptors from rat brain.

R. Mckernan, P. Whiting, C. Ragan, 1995, European journal of pharmacology.

3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1

G. Dawson, P. Leeson, R. Mckernan, 2004 .

3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.

G. Dawson, P. Leeson, R. Mckernan, 2004, Journal of medicinal chemistry.

Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors

G. Kennett, Guy Kennett, Anil Misra, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Rat and Human Hippocampal α5 Subunit-Containing γ-Aminobutyric AcidA Receptors Have α5β3γ2 Pharmacological Characteristics

Deborah Dewar, R. Mckernan, J. Atack, 1998 .

Rat and human hippocampal alpha5 subunit-containing gamma-aminobutyric AcidA receptors have alpha5 beta3 gamma2 pharmacological characteristics.

R. Mckernan, J. Atack, D Dewar, 1998, Molecular pharmacology.

Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers.

R. Mckernan, J. Atack, C. Ragan, 1994, The Journal of pharmacology and experimental therapeutics.

7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.

G. Dawson, R. Mckernan, A. Pike, 2005, Journal of medicinal chemistry.

A novel allosteric modulatory site on the GABAA receptor β subunit

J. Kemp, R. Mckernan, P. Whiting, 1994, Neuron.

A novel allosteric modulatory site on the GABAA receptor beta subunit.

J. Kemp, R. Mckernan, P. Whiting, 1994, Neuron.

Model of subunit composition of gamma-aminobutyric acid A receptor subtypes expressed in rat cerebellum with respect to their alpha and gamma/delta subunits.

R. Mckernan, P. Whiting, C. Ragan, 1994, The Journal of biological chemistry.

3-Heteroaryl-2-pyridones: Benzodiazepine Site Ligands with Functional Selectivity for α2/α3-Subtypes of Human GABAA Receptor-Ion Channels

G. Dawson, R. Mckernan, A. Pike, 2002 .

GABAA receptor subtypes immunopurified from rat brain with α subunit-specific antibodies have unique pharmacological properties

R. Mckernan, P. Whiting, C. Ragan, 1991, Neuron.

Indoline derivatives as 5-HT(2C) receptor agonists.

G. Kennett, C. Dourish, D. Adams, 2004, Bioorganic & medicinal chemistry letters.

Molecular size of the 5-HT3 receptor solubilized from NCB 20 cells.

R. Mckernan, C. Ragan, K. Quirk, 1990, The Biochemical journal.

Characterization of the solubilized NMDA receptor complex from rat brain with [3H]L-689,560, a glycine site antagonist.

R. Mckernan, K. Quirk, A. C. Foster, 1994, Molecular membrane biology.

[125I]iodoclonazepam, a specific high affinity radioligand for the identification of BZ1 and BZ2 sites in rat brain.

R. Mckernan, C. Ragan, K. Quirk, 1991, European Journal of Pharmacology.