Shih‐Hsien Chuang

发表

Synthesis and structure-activity relationship of 3-O-acylated (-)-epigallocatechins as 5α-reductase inhibitors.

Young-Sun Lin, R. Hiipakka, Chu-Bin Liao, 2010, European journal of medicinal chemistry.

Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy.

Mengyu Chen, Yu-Hsiang Lin, Kuan-Pin Huang, 2020, European journal of medicinal chemistry.

Discovery of 4-aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 inhibitors. Part I: optimization of in vitro potencies and pharmacokinetic properties.

Yu-Hsiang Lin, Shih‐Hsien Chuang, Jia-Ming Chang, 2014, Journal of medicinal chemistry.

D‐420720, A novel orally active sulfonamide compound dipeptidyl peptidase IV inhibitor: structure and activity relationship of arylsulfonamide to dipeptidyl peptidase IV inhibition

Chien-Cheng Chen, F. Hsu, H. J. Tsai, 2008 .

Selective and predicable amine conjugation sites by kinetic characterization under excess reagents

Tzu-Fan Wang, Shu-Hui Chen, Chao-pin Lee, 2021, Scientific Reports.

Aminyl and iminyl radicals from arylhydrazones in the photo-induced DNA cleavage.

J. Hwu, K. King, Shih‐Hsien Chuang, 2004, Bioorganic & medicinal chemistry.

Inhibition of Hec1 as a novel approach for treatment of primary liver cancer

R. Gish, K. Kao, G. M. Lau, 2014, Cancer Chemotherapy and Pharmacology.

Activity of a Novel Hec1-Targeted Anticancer Compound against Breast Cancer Cell Lines In Vitro and In Vivo

K. Kao, G. M. Lau, Shih‐Hsien Chuang, 2014, Molecular Cancer Therapeutics.

Protective effect of a sesamin derivative, 3-bis (3-methoxybenzyl) butane-1, 4-diol on ischemic and hypoxic neuronal injury

K. Jeng, Shih‐Hsien Chuang, Yi-ling Chen, 2014, Journal of Biomedical Science.

Discovery of pyrrole-indoline-2-ones as Aurora kinase inhibitors with a different inhibition profile.

Weilin Chi, Chu-Bin Liao, Yu-Hsiang Lin, 2010, Journal of medicinal chemistry.

One-pot ethynylation and catalytic desilylation in synthesis of mestranol and levonorgestrel

Yu-Hsiang Lin, Shih‐Hsien Chuang, Sheng-chuan Yang, 2010 .

Michael addition of chiral Fischer aminocarbene complexes to nitroolefins: study on the effect of the Michael acceptor structure on diastereoselectivity

A. Albinati, A. Papagni, J. Hwu, 2001 .

Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6H-indolo[3,2-c]quinolin-6-ones as Potent Topoisomerase-I Inhibitors.

Chin‐Hung Lai, Yu-Hsiang Lin, S. Lin, 2021, Journal of medicinal chemistry.

Di- and Trinuclear Ruthenium and Osmium Bis(2-pyridyl) Ketone Oximate Derivatives

C. Alvarez-Rúa, S. García‐Granda, J. Hwu, 2003 .

Photochemical cleavage of single- and double-stranded oligonucleotides by 3-(p-tolylamino)-1,5-azulenequinone

L. Kan, J. Hwu, F. Tsai, 2001 .

Targeting cancer stemness mediated by BMI1 and MCL1 for non‐small cell lung cancer treatment

M. Hsiao, Cheng-Wen Wu, Tsung-Hsien Lin, 2022, Journal of cellular and molecular medicine.

Targeting BMI1 and MCL1 for Lung Adenocarcinoma Treatment

Chi-Ying F. Huang, M. Hsiao, Cheng-Wen Wu, 2018, bioRxiv.

Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1

K. Kao, Shih‐Hsien Chuang, Jia-Ming Chang, 2014, Journal of Experimental & Clinical Cancer Research.

The inhibition profiles of 4'‐acylpyrrole–5‐fluoroindolin‐2‐ones with a C‐3' side chain for VEGFR2, PDGFR‐β, and FGFR‐1 protein kinases

Chu-Bin Liao, Yu-Hsiang Lin, Chao-Cheng Chiang, 2020 .

Design, synthesis, and in vitro/vivo anticancer activity of 4‐substituted 7‐(3‐fluoro‐4‐methoxybenzyl)‐ 7 H ‐pyrrolo[2,3‐ d ]pyrimidines

Shih‐Hsien Chuang, Jiann‐Jyh Huang, P. Tsai, 2021 .

Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1

K. Kao, Shih‐Hsien Chuang, Chia-wei Liu, 2014, Journal of experimental & clinical cancer research : CR.

Design and synthesis of pyrrole–5-(2,6-dichlorobenzyl)sulfonylindolin-2-ones with C-3′ side chains as potent Met kinase inhibitors

Yu-Hsiang Lin, Chao-Cheng Chiang, S. Lin, 2014 .

PROCESSES FOR PREPARING GLYCOPROTEIN-DRUG CONJUGATES

Yi-Jen Chen, Chun-chung Lee, Shih‐Hsien Chuang, 2018 .

Design and synthesis of 4-anilinoquinazolines as Raf kinase inhibitors. Part 1. Selective B-Raf/B-RafV600E and potent EGFR/VEGFR2 inhibitory 4-(3-hydroxyanilino)-6-(1H-1,2,3-triazol-4-yl)quinazolines.

Shih‐Hsien Chuang, Jiann‐Jyh Huang, Hsin‐Yi Huang, 2021, Bioorganic chemistry.

New benzo[b]furans as electroluminescent materials for emitting blue light.

J. Hwu, Shih‐Hsien Chuang, S. Tsay, 2005, Organic letters.

Discovery of pyrrole-indoline-2-ones as Aurora kinase inhibitors with a different inhibition profile.

Weilin Chi, Yu-Hsiang Lin, Chao-Cheng Chiang, 2010, Journal of medicinal chemistry.