Pia A. Thommes

发表

Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity.

G. Hofmann, G. Burton, R. Sarisky, 2007, Bioorganic & medicinal chemistry letters.

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.

X. Jacq, J. Nissink, I. Hickson, 2013, Journal of medicinal chemistry.

Abstract 1823: AZ20, a novel potent and selective inhibitor of ATR kinase with in vivo antitumour activity

Lisa L. Smith, P. Caie, X. Jacq, 2012 .

Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin

A. Sattar, A. Therien, L. Hernandez, 2016, Antimicrobial Agents and Chemotherapy.

Identification and Evaluation of Improved 4′-O-(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics

H. Boukari, J. Schacht, A. Vasella, 2014, mBio.

Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

R. Hamatake, Z. Hong, Shawn P. Williams, 2014, Journal of medicinal chemistry.

Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.

Z. Ni, P. Rowland, S. Baker, 2010, Bioorganic & medicinal chemistry letters.

Intermittent micafungin for prophylaxis in a rat model of chronic Candida albicans gut colonization.

A. Sattar, N. Undre, P. Warn, 2020, The Journal of antimicrobial chemotherapy.

SMT19969 for Clostridium difficile infection (CDI): in vivo efficacy compared with fidaxomicin and vancomycin in the hamster model of CDI

A. Sattar, P. Warn, R. Vickers, 2015, The Journal of antimicrobial chemotherapy.

Development of Cell-Based Assays for In Vitro Characterization of Hepatitis C Virus NS3/4A Protease Inhibitors

A. Carroll, N. Parry, Pia A. Thommes, 2005, Antimicrobial Agents and Chemotherapy.

Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives.

I. Hardcastle, R. Griffin, B. Golding, 2012, Organic & biomolecular chemistry.

Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.

David Haigh, Malcolm Ellis, George Burton, 2007, Journal of medicinal chemistry.

4′-O-substitutions determine selectivity of aminoglycoside antibiotics

H. Boukari, V. Ramakrishnan, A. Vasella, 2014, Nature Communications.

Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K

N. Curtin, R. Griffin, Yan Zhao, 2011, Molecular Cancer Therapeutics.

1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.

N. Curtin, I. Hardcastle, R. Griffin, 2013, Journal of medicinal chemistry.

Chimeric GB virus B genomes containing hepatitis C virus p7 are infectious in vivo☆

D. Rowlands, N. Parry, S. Griffin, 2008, Journal of hepatology.

Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation

J. Jaeger, A. Baron, Pia A. Thommes, 2014, Journal of Virology.

HYDROPHOBIC AND CHARGED RESIDUES IN THE C-TERMINAL ARM OF 1 HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE REGULATE 2

J. Jaeger, A. Baron, Pia A. Thommes, 2014 .

Time‐kill kinetics of cadazolid and comparator antibacterial agents against different ribotypes of Clostridium difficile

H. Locher, D. Corbett, Kirsty Skinner, 2018, Journal of medical microbiology.

Chimeric bacteriocin S5-PmnH engineered by domain swapping efficiently controls Pseudomonas aeruginosa infection in murine keratitis and lung models

Y. Gleba, A. Ražanskienė, A. Misiūnas, 2022, Scientific reports.

Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa.

Christoph E. Dumelin, A. Keefe, S. Evans, 2021, Journal of medicinal chemistry.

Abstract 2348: Discovery of AZD6738, a potent and selective inhibitor with the potential to test the clinical efficacy of ATR kinase inhibition in cancer patients.

S. Guichard, P. Jewsbury, R. Odedra, 2013 .

[594] GSK625433; A NOVEL AND HIGHLY POTENT INHIBITOR OF THE HCV NS5B POLYMERASE

Stephen A. Smith, F. Nerozzi, M. Slater, 2007 .

Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates.

William McDowell, Yang Liu, Dazhong Fan, 2010, Bioorganic & medicinal chemistry letters.

Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K

N. Curtin, R. Griffin, Yan Zhao, 2012, Molecular Cancer Therapeutics.

Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin

A. Sattar, A. Therien, L. Hernandez, 2016, Antimicrobial Agents and Chemotherapy.

Time‐kill kinetics of cadazolid and comparator antibacterial agents against different ribotypes of Clostridium difficile

H. Locher, D. Corbett, Kirsty Skinner, 2018, Journal of medical microbiology.