W. H. Pearson

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Solid-phase synthesis of pyrrolidines via 2-azaallyl anion cycloadditions with alkenes

W. H. Pearson, R. Clark, 1997 .

Formal synthesis of aspidosperma alkaloids via the intramolecular [3 + 2] cycloaddition of 2-azapentdienyllithiums.

W. H. Pearson, A. Aponick, 2006, Organic letters.

A Schmidt route to 1-azabicyclo[x.y.0]alkanes: a comparison of carbocation stabilizing groups

W. H. Pearson, R. Walavalkar, 2001 .

Intramolecular Schmidt reactions of azides with carbocations: synthesis of bridged-bicyclic and fused-bicyclic tertiary amines

W. H. Pearson, J. Schkeryantz, R. Walavalkar, 1993 .

The intramolecular Schmidt reaction of azides with tertiary alcohols: Synthesis of 5-(α-naphthyl)- and 5-(β-naphthyl)indolizidines as potential dopamine analogs and non-opiate antinociceptive agents

B. Gallagher, W. H. Pearson, 1996 .

Aliphatic azides as lewis bases. Application to the synthesis of heterocyclic compounds

W. H. Pearson, W. Pearson, 1996 .

Total synthesis of (.+-.)-3-deoxy-D-manno-2-octulopyranosate

B. Segmuller, S. Danishefsky, W. H. Pearson, 1985 .

Advances in heterocyclic natural product synthesis

W. H. Pearson, W. Pearson, 1990 .

Preparation of immobilized swainsonine analogs on solid support

W. H. Pearson, Luyi Guo, T. Jewell, 2002 .

Synthesis and mannosidase inhibitory activity of 6- and 7-substituted analogs of swainsonine

E. Hembre, W. H. Pearson, W. Pearson, 2001 .

The Synthesis of Triazole Analogues of Antitumor Dehydropyrrolizidine Alkaloids

W. H. Pearson, S. Bergmeier, Jayne A. Chytra, 1990 .

Chelation-controlled facially selective cyclocondensation reactions of chiral alkoxy aldehydes: syntheses of a mouse androgen and of a carbon-linked disaccharide

J. Springer, S. Danishefsky, W. H. Pearson, 1985 .

Cycloadditions of nonstabilized 2-azaallyllithiums (2-azaallyl anions) and azomethine ylides with alkenes: [3+2] Approaches to pyrrolidines and application to alkaloid total synthesis

W. H. Pearson, P. Stoy, 2003 .

Formation and cycloaddition of nonstabilized N-unsubstituted azomethine ylides from (2-azaallyl)stannanes and (2-azaallyl)silanes

W. H. Pearson, R. Clark, 1999 .

Assembly of the gephyrotoxin ring system via a [4+1] approach to 3-pyrrolines

Y. Poon, W. H. Pearson, 1989 .

Synthetic applications of 1,3-dipolar cycloaddition chemistry toward heterocycles and natural products

A. Padwa, W. H. Pearson, W. Pearson, 2002 .

The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase.

M. Marletta, W. H. Pearson, J. Artz, 2006, Bioorganic & medicinal chemistry letters.

A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum alpha-mannosidase I.

K. Moremen, K. Karaveg, W. H. Pearson, 2005, The Journal of organic chemistry.

Total synthesis of (.+-.)-3-deoxy-D-manno-2-octulopyranosate

B. Segmuller, S. Danishefsky, W. H. Pearson, 1985 .

Total synthesis of the Kopsia lapidilecta alkaloid (+/-)-lapidilectine B.

W. H. Pearson, Y. Mi, P. Stoy, 2001, Journal of the American Chemical Society.

The generation and cycloaddition of 2-azaallyl anions and azomethine ylides from a common precursor. A novel synthesis of indolizidines and other heterocycles

W. H. Pearson, Y. Mi, 1997 .

Azidomethyl phenyl sulfide. A synthon for NH2

B. Trost, W. H. Pearson, W. Pearson, 1981 .

Sulfur activation of azides toward addition of organometallics. Amination of aliphatic carbanions

B. Trost, W. H. Pearson, W. Pearson, 1983 .

Synthesis and mannosidase inhibitory activity of 3-benzyloxymethyl analogs of swainsonine

Luyi Guo, W. H. Pearson, William H. Pearson, 2001 .

The intramolecular cycloaddition of azides with ω-chloroalkenes. A facile route to (-)-swainsonine and other indolizidine alkaloids

W. H. Pearson, K. Lin, 1990 .

On the relationship of topological and diastereofacial control in the Lewis acid catalyzed cyclocondensation reaction of alkoxyaldehydes with activated dienes: metal tunable asymmetric induction

S. Danishefsky, W. H. Pearson, D. Harvey, 1984 .

Total synthesis of (+)-cocaine via desymmetrization of a meso-dialdehyde.

W. H. Pearson, Douglas Mans, W. Pearson, 2004, Organic letters.

Azidomethyl phenyl sulfide. A synthon for NH2

B. Trost, W. H. Pearson, 1981 .

Azomethine ylides from tin-substituted cyclic carbinol amides: a new route to highly substituted pyrrolizidines.

W. H. Pearson, P. Stoy, Amber L. Dietz, 2004, Organic Letters.

Total synthesis of the Kopsia lapidilecta alkaloid (+/-)-lapidilectine B.

W. H. Pearson, I. Lee, Y. Mi, 2004, The Journal of organic chemistry.

Synthesis of benzo-fused 1-azabicyclo[m.n.0]alkanes via the Schmidt reaction: a formal synthesis of gephyrotoxin.

W. H. Pearson, W. Fang, 2000, The Journal of organic chemistry.

1.01 – Aziridines and Azirines: Monocyclic

B. Lian, W. H. Pearson, W. Pearson, 1996 .

Synthesis of N,N-bis(3-butenyl)amines from 2-azaallyl dication synthetic equivalents and conversion to 2,3,6,7-tetrahydroazepines by ring-closing metathesis.

W. H. Pearson, A. Aponick, Amber L. Dietz, 2006, The Journal of organic chemistry.

Generation and cycloaddition of heteroatom-substituted 2-azaallyl anions with alkenes and alkynes. Synthesis of 1-pyrrolines and pyrroles

W. H. Pearson, E. Stevens, 1994 .

The synthesis of pyrrolizidines and indolizidines by the intramolecular cycloaddition of azides with electron-rich 1,3-dienes. A synthetic equivalent of a nitrene-diene cycloaddition

Y. Poon, W. H. Pearson, J. Schkeryantz, 1990 .

Azidomercurations of alkenes: mercury-promoted Schmidt reactions.

W. H. Pearson, W. Fang, D. A. Hutta, 2000, The Journal of organic chemistry.

Synthesis of benzo-fused 1-azabicyclo[m.n.0]alkanes via the Schmidt reaction: a formal synthesis of gephyrotoxin.

W. H. Pearson, W. Fang, 2000, The Journal of organic chemistry.

A three-component, one-pot synthesis of indolizidines and related heterocycles via the [3+2] cycloaddition of nonstabilized azomethine ylides.

W. H. Pearson, Y. Mi, P. Stoy, 2004, The Journal of organic chemistry.

Alkaloid synthesis via [3+2] cycloadditions

W. H. Pearson, 2002 .

Nonstabilized N-unsubstituted azomethine ylides: a synthesis of indolizidine 239CD.

W. H. Pearson, R. Clark, 1999, Organic letters.

A Practical Synthesis of (-)-Swainsonine.

E. Hembre, W. H. Pearson, 1996, The Journal of organic chemistry.

Synthesis of Novel Glycosidase-Inhibitory Hydroxymethyl-Substituted Polyhydroxylated Indolizidines: Ring-Expanded Analogs of the Pyrrolizidine Alkaloids Alexine and Australine

E. Hembre, W. H. Pearson, 1996 .

Synthetic Studies on Lepadiformine Using the 2-Azaallyl Anion Method.

Yi Ren, W. H. Pearson, 1999, The Journal of organic chemistry.

Synthetic studies on the perhydropyrrolo[2,1-j]quinoline marine alkaloids lepadiformine and cylindricine C using a 2-azapentadienyl anion cycloaddition. Synthesis of 2,13-diepilepadiformine (or 2-epi-11-deoxycylindricine C)

J. Kampf, N. Barta, W. H. Pearson, 1997 .

Generation and Cycloaddition of Heteroatom-Substituted 2-Azaallyl Anions with Alkenes and Alkynes. Synthesis of 1-Pyrrolines and Pyrroles.

W. H. Pearson, E. Stevens, 1994 .

Configurational stability of chiral, nonconjugated nitrogen-substituted organolithium compounds generated by tin-lithium exchange of N-[(1-tri-n-butylstannyl)alkyl]imidazolidin-2-ones and -oxazolidin-2-ones

J. Kampf, W. H. Pearson, A. Lindbeck, 1993 .

Stereochemical studies on chiral, nonconjugated nitrogen-substituted carbanions generated by tin-lithium exchange

W. H. Pearson, A. Lindbeck, 1991 .

Synthesis of (±)tylophorine by the intramolecular cycloaddition of an azide with an ω-chloroalkene

W. H. Pearson, R. Walavalkar, W. Pearson, 1994 .

Application of the 2-Azaallyl Anion Cycloaddition Method to an Enantioselective Total Synthesis of (+)-Coccinine.

B. Lian, W. H. Pearson, 1998, Angewandte Chemie.

Spiro asymmetric induction. Synthesis of optically pure .alpha.-hydroxy acid derivatives by alkylation of a chiral glycolate enolate

W. H. Pearson, M.-C. Cheng, 1986 .

A new strategy for the synthesis of spiroketals

S. Danishefsky, W. H. Pearson, 1983 .

Spiro asymmetric induction. 3. Synthesis of optically pure syn- or anti-.alpha.,.beta.-dihydroxy esters by the aldol condensation of chiral glycolate enolates

W. H. Pearson, M.-C. Cheng, 1987 .

Total syntheses of (+)-australine and (-)-7-epialexine.

W. H. Pearson, J. Hines, W. Pearson, 2000, The Journal of organic chemistry.

Synthesis of 1,3,dioxolan-4-ones. An improved procedure

W. H. Pearson, M.-C. Cheng, 1987 .

Synthesis of (-)-slaframine and related indolizidines

W. H. Pearson, S. Bergmeier, John P. Williams, 1992 .

Synthesis of indolidines by the 1,3-dipolar cycloaddition of azides with methylenecyclopropanes followed by cyclopropyumine rearrangement

W. H. Pearson, S. Bergmeier, P. Heidt, 1990 .

Studies on the asymmetric cycloaddition of 2-azaallyl anions with alkenes

W. H. Pearson, A. Aponick, E. Stevens, 2001 .

A synthesis of (+)-7-Epiaustraline and (−)-7-Epialexine

W. H. Pearson, J. Hines, 1991 .

Azidomethyl Phenyl Sulfide

W. H. Pearson, P. Ramamoorthy, E. M. Schuster, 2011 .

A stereoselective route to 2-(phenylthio)-1,3-butadienes

Y. Poon, W. H. Pearson, K. Lin, 1989 .

An efficient synthesis of (±)-crinane using an intramolecular azide-olefin cycloaddition

W. H. Pearson, J. Schkeryantz, 1996 .

Synthesis of .beta.-amino-.alpha.-hydroxy acids via aldol condensation of a chiral glycolate enolate. A synthesis of (-)-bestatin

W. H. Pearson, J. Hines, 1989 .

Synthesis of fused pyrrolines by the intramolecular cycloadition of azides application to the pyrrolizidine alkaloids.

W. H. Pearson, W. Pearson, 1985 .

Approach to the homoerythrina alkaloids using a tandem N-alkylation/azomethine ylide cycloaddition.

J. Kampf, J. Kropf, W. H. Pearson, 2007, The Journal of organic chemistry.

The Synthesis of 9,10‐Dihydro‐9,10‐(Methaniminomethano)Anthracene and N‐Protected Derivatives Via Double Reductive Amination

W. H. Pearson, P. Stoy, J. Rush, 2004 .

Diastereofacial control in the Lewis acid catalyzed cyclocondensation reaction of aldehydes with activated dienes: a synthesis of the Mus musculus pheromone

S. Danishefsky, W. H. Pearson, D. Harvey, 1984 .

Synthesis of novel polyhydroxylated quinolizidines: Ring expanded analogs of glycosidase inhibitory indolizidines

E. Hembre, W. H. Pearson, 1993 .

A synthesis of the naphthalene core of streptovaricin D via A synthon of NH2

B. Trost, W. H. Pearson, W. Pearson, 1983 .

Sulfur activation of azides toward addition of organometallics. Amination of aliphatic carbanions

B. Trost, W. H. Pearson, 1983 .

Synthesis of the novel mannosidase inhibitors (3R)- and (3S)-3-(hydroxymethyl)swainsonine

E. Hembre, W. H. Pearson, W. Pearson, 1997 .

Assembly of 3a-Arylperhydroindoles by the Intramolecular Cycloaddition of 2-Azaallyl Anions with Alkenes. Total Syntheses of (±)-Crinine, (±)-6-Epicrinine, (−)-Amabiline, and (−)-Augustamine

F. Lovering, W. H. Pearson, 1998 .

Short, Efficient Syntheses of the Amaryllidaceae Alkaloids (-)-Amabiline and (-)-Augustamine via Intramolecular 2-Azaallyl Anion Cycloadditions

F. Lovering, W. H. Pearson, 1995 .

Application of the 2-azaallyl anion cycloaddition method to syntheses of (±)-crinine and (±)-6-epicrinine

F. Lovering, W. H. Pearson, 1994 .

Lithium perchlorate-assisted substitution reactions of allylic acetates and allylic alcohols

W. H. Pearson, J. Schkeryantz, 1992 .

Intramolecular azide-diene cycloadditions. An approach to fused bicyclic 3-pyrrolines based on a one-pot nitrene-diene cycloaddition equivalent.

Y. Poon, B. Dixon, W. H. Pearson, 1987 .

Generation of synthetic equivalents of RCH(Li)NH2 for the synthesis of primary amines. Tin-lithium exchange on carbamate-protected (.alpha.-aminoalkyl)stannanes

W. H. Pearson, A. Lindbeck, 1989 .

Stereochemical effects in the ozonolysis of (E)- and (Z)-1-ethoxypropene

R. L. Kuczkowski, W. H. Pearson, B. Wojciechowski, 1989 .

Double allylation reactions of (2-azaallyl)stannanes: synthesis of N,N-bis(3-butenyl)amines and their conversion to 2,3,6,7-tetrahydroazepines via ring-closing metathesis.

W. H. Pearson, A. Aponick, 2001, Organic letters.

An improved method for the preparation of pyrrolidines by the cycloaddition of nonstabilized 2-azaallyl anions with alkenes

W. H. Pearson, M. Postich, W. Pearson, 1992 .

Generation of 2-azaallyl anions by the transmetalation of N-(trialkylstannyl)methanimines. Pyrrolidine synthesis by [3 + 2] cycloadditions with alkenes

W. H. Pearson, M. Postich, Daniel P. Szura, 1992 .

SYNTHESIS OF AMINES BY TEH INTERMOLECULAR SCHMIDT REACTION OF ALIPHATIC AZIDES WITH CARBOCATIONS

W. H. Pearson, W. Fang, 1995 .

Total Synthesis of (.+-.)-Quinolizidine 217A.

H. Suga, W. H. Pearson, 2010 .

Application of the 2‐Azaallyl Anion Cycloaddition Method to an Enantioselective Total Synthesis of (+)‐Coccinine.

B. Lian, W. H. Pearson, 1998 .

Fluorous affinity purification of oligonucleotides.

A. Sercel, D. Berry, W. H. Pearson, 2005, The Journal of organic chemistry.

Synthesis and Mannosidase Inhibitory Activity of 3‐Benzyloxymethyl Analogues of Swainsonine.

W. H. Pearson, Luyi Guo, 2002 .

An intramolecular, Schmidt reaction of an alkyl azide with a carbocation. The generation and rearrangement of a conformationally restricted secondary aminodiazonium ion.

W. H. Pearson, J. Schkeryantz, W. Pearson, 1992 .

2-(3-Pyrrolin-1-yl)-1,4-naphthoquinones: Photoactivated Alkylating Agents

W. H. Pearson, A. Aponick, Amber L. Dietz, 2008 .

Pyrrolo-dC and pyrrolo-C: fluorescent analogs of cytidine and 2′-deoxycytidine for the study of oligonucleotides ☆

A. Sercel, D. Berry, J. B. Randolph, 2004 .

Cycloadditions of nonstabilized 2-azaallyllithiums with cycloheptatriene.

J. Kampf, W. H. Pearson, Douglas Mans, 2002, Organic letters.

Transmetallation of n-(trialkylstannyl)methylimines. A new method for the generation and cycloaddition of 2-azaallyl anions.

W. Harter, W. H. Pearson, Daniel P. Szura, 1988 .

Sulfur participation in solvolysis involving four-membered ring intermediates

W. Kenan, W. H. Pearson, E. Eliel, 1980 .

Cycloadditions of 2-azaallyllithium species with conjugated polyenes.

J. Kampf, W. H. Pearson, Douglas Mans, 2004, The Journal of organic chemistry.

Reactions of Azides with Electrophiles: New Methods for the Generation of Cationic 2-Azabutadienes. Synthesis of 1,2,3,4-Tetrahydroquinolines and 1,2 Dihydroquinolines via a Hetero Diels-Alder Reaction

W. H. Pearson, W. Fang, 1997 .

Infection increases activity via Toll dependent and independent mechanisms in Drosophila melanogaster

Giorgio F. Gilestro, E. Beckwith, Marc S. Dionne, 2021, bioRxiv.

Synthesis of (.+-.)-.gamma.-lycorane by the intramolecular cycloaddition of an azide with an .omega.-chloroalkene

W. H. Pearson, J. Schkeryantz, 1992 .

Approach to 6a-Epipretazettine and 6a-Epiprecriwelline via an Intramolecular 2-Azaallyl Anion Cycloaddition Reaction

W. H. Pearson, M. Postich, 1994 .

Intramolecular 2-azaallyl anion cycloadditions. Application to the synthesis of fused bicyclic pyrrolidines

M. Walters, W. H. Pearson, K. Oswell, 1986 .

Synthesis and Mannosidase Inhibitory Activity of 6- and 7-Substituted Analogues of Swainsonine.

E. Hembre, W. H. Pearson, 2002 .

Synthesis of Tetrahydroxyquinolizidines: Ring-Expanded Analogs of the Mannosidase Inhibitor Swainsonine

E. Hembre, W. H. Pearson, 1996 .