S. Maddaford

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A comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of anthranilamide derivatives that are multidrug resistance modulators.

Lakshmi P Kotra, L. Kotra, R. Gaudreault, 2006, Journal of medicinal chemistry.

In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2).

R. Gaudreault, P. Labrie, S. Maddaford, 2006, Bioorganic & medicinal chemistry.

TOTAL SYNTHESIS OF (+)-XESTOQUINONE USING AN ASYMMETRIC PALLADIUM-CATALYZED POLYENE CYCLIZATION

S. Maddaford, W. Cristofoli, B. A. Keay, 1996 .

An asymmetric diels-alder cycloaddition to alpha-hydroxy-alpha-phenyl-orthoquinodimethane

S. Boulet, S. Maddaford, J. Charlton, 1993 .

Chapter 2 Advancements in the Development of Nitric Oxide Synthase Inhibitors

S. Maddaford, S. Rakhit, J. Ramnauth, 2009 .

Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.

F. Porreca, S. Maddaford, S. Rakhit, 2011, Journal of medicinal chemistry.

3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.

F. Porreca, S. Maddaford, S. Rakhit, 2011, Bioorganic & medicinal chemistry letters.

NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with μ-Opioid Agonist Activity.

S. Maddaford, S. Rakhit, B. Green, 2012, ACS medicinal chemistry letters.

Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.

S. Maddaford, S. Rakhit, J. Ramnauth, 2007, Bioorganic & medicinal chemistry letters.

Identification of a novel non-carbohydrate molecule that binds to the ribosomal A-site RNA.

Kevin B. Turner, Philip E. Johnson, D. Fabris, 2004, Bioorganic & Medicinal Chemistry Letters.

Stereoselective C-glycoside formation by a rhodium(I)-catalyzed 1,4-addition of arylboronic acids to acetylated enones derived from glycals.

S. Maddaford, S. Rakhit, J. Ramnauth, 2001, Organic letters.

A Modified in Situ Suzuki Cross-Coupling of Haloarenes for the Preparation of C2-Symmetric Biaryls

S. Maddaford, B. A. Keay, N. Andersen, 1996 .

A Modified in situ Suzuki Cross-Coupling of Haloarenes for the Preparation of C2-Symmetric Biaryls.

S. Maddaford, B. A. Keay, N. Andersen, 1997 .

Scope and Limitations of the Palladium-Catalyzed Cross-Coupling Reaction of in situ Generated Organoboranes with Aryl and Vinyl Halides

S. Maddaford, B. A. Keay, 1994 .

Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.

F. Porreca, S. Maddaford, S. Rakhit, 2012, Journal of Medicinal Chemistry.

Palladium(II) acetate catalyzed stereoselective C-glycosidation of peracetylated glycals with arylboronic acids.

S. Maddaford, S. Rakhit, J. Ramnauth, 2001, Organic letters.

1996 Merck Frosst Award Lecture Synthetic Adventures Along a Rocky Mountain Road

Noel S. Wilson, J. Nieman, S. Maddaford, 1997 .

A general asymmetric synthesis of (-)-.alpha.-dimethylretrodendrin and its diastereomers

S. Maddaford, J. Charlton, 1993 .

Stereoselective C-glycoside formation by a rhodium(I)-catalyzed 1,4-addition of arylboronic acids to acetylated enones derived from glycals.

S. Maddaford, S. Rakhit, J. Ramnauth, 2001, Organic letters.

A medicinal chemistry perspective on structure-based drug design and development.

S. Maddaford, Shawn P Maddaford, Shawn P. Maddaford, 2012, Methods in molecular biology.

First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.

F. Porreca, S. Maddaford, S. Rakhit, 2012, Journal of medicinal chemistry.

Synthesis of Functionalized Naphthalenes from Substituted 1-Methoxybenzocyclobutenes.

S. Maddaford, B. A. Keay, N. Andersen, 1996, The Journal of organic chemistry.

Synthesis of Functionalized Naphthalenes from Substituted 1‐ Methoxybenzocyclobutenes.

S. Maddaford, B. A. Keay, N. Andersen, 1996 .

The mechanism of stereoselectivity in the cycloaddition reactions of α−hydroxy−ortho−quinodimethanes with the fumarate of methyl lactate and mandelate

S. Maddaford, J. Charlton, 1993 .

Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers.

D. Dodick, G. Dussor, F. Porreca, 2010, Brain : a journal of neurology.

Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine.

F. Porreca, S. Maddaford, S. Rakhit, 2012, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.

F. Porreca, M. De Felice, S. Maddaford, 2011, Journal of medicinal chemistry.