D. Tondi

发表

Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase.

B K Shoichet, B. Shoichet, S. Ghelli, 1999, Chemistry & biology.

In silico identification and experimental validation of hits active against KPC-2 β-lactamase

R. Brenk, L. Cendron, J. Blázquez, 2018, PloS one.

Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.

R. Stroud, J. Finer-Moore, T. A. Fritz, 2001, Chemistry & biology.

Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases

Maria Paola Costi, F. Spyrakis, S. Cross, 2017, Scientific Reports.

4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-β-Lactamases

F. Spyrakis, L. Cendron, E. Gianquinto, 2020, Pharmaceuticals.

X-ray Crystallography Deciphers the Activity of Broad-Spectrum Boronic Acid β-Lactamase Inhibitors.

Maria Paola Costi, L. Cendron, G. Celenza, 2019, ACS medicinal chemistry letters.

In Silico Identification and Experimental Validation of Novel KPC-2 β-lactamase Inhibitors

R. Brenk, L. Cendron, J. Blázquez, 2018, bioRxiv.

The inhibition of extended spectrum β-lactamases: hits and leads.

Maria Paola Costi, F. Spyrakis, S. Cross, 2014, Current medicinal chemistry.

Nanobodies targeting LexA autocleavage disclose a novel suppression strategy of SOS-response pathway.

L. Van Melderen, E. Pardon, J. Steyaert, 2022, Structure.

Protocetraric and Salazinic Acids as Potential Inhibitors of SARS-CoV-2 3CL Protease: Biochemical, Cytotoxic, and Computational Characterization of Depsidones as Slow-Binding Inactivators

G. Amicosante, N. Franceschini, G. Celenza, 2022, Pharmaceuticals.

Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth.

Maria Paola Costi, M. Mor, G. Ponterini, 2018, Journal of medicinal chemistry.

Targeting the Class A Carbapenemase GES-5 via Virtual Screening

R. Brenk, L. Cendron, G. Celenza, 2020, Biomolecules.

Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?

F. Spyrakis, L. Lazzarato, E. Gianquinto, 2020, Antibiotics.

SOS response in bacteria: Inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein.

L. Cendron, M. Nicoletti, F. Brisdelli, 2017, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Separation, structural determination and biological evaluation of the thymidylate synthase inhibitor 3,3-Di-(4′-hydroxyphenyl)-6(7)-chloro-1-oxo-1H,3H-naphtho[1,8-cd]pyran

G. Celentano, S. Ghelli, M. Costi, 1999 .

Phenylboronic Acid Derivatives as Validated Leads Active in Clinical Strains Overexpressing KPC‐2: A Step against Bacterial Resistance

A. Oliver, L. Cendron, Mattia Vicario, 2018, ChemMedChem.

Ten Years with New Delhi Metallo-β-lactamase-1 (NDM-1): From Structural Insights to Inhibitor Design.

F. Spyrakis, L. Cendron, E. Gianquinto, 2018, ACS infectious diseases.

Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases

F. Spyrakis, S. Cross, G. Cruciani, 2020, Scientific Reports.

Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling.

D. Anderson, T. Kuntzweiler, D. Colombo, 1998, Journal of medicinal chemistry.

Novel Targets and Mechanisms in Antimicrobial Drug Discovery

D. Tondi, 2021, Antibiotics.

Thymidylate synthase structure, function and implication in drug discovery.

Maria Paola Costi, D. Barlocco, D Barlocco, 2005, Current medicinal chemistry.

Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase

Maria Paola Costi, B. Shoichet, E. Caselli, 2001 .

Structure-Based Optimization of a Non-β-lactam Lead Results in Inhibitors That Do Not Up-Regulate β-Lactamase Expression in Cell Culture

Maria Paola Costi, Donatella Tondi, Richard Bonnet, 2005 .

Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy.

Giuseppe Cannazza, Maria Paola Costi, Donatella Tondi, 2007, Journal of medicinal chemistry.

Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors.

Brian K. Shoichet, Maria Paola Costi, Donatella Tondi, 2010, Bioorganic & medicinal chemistry letters.

Structure-based design and in-parallel synthesis of inhibitors of AmpC L-lactamase

B. Shoichet, E. Caselli, M. Negri, 2001 .

Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture.

Maria Paola Costi, Donatella Tondi, Richard Bonnet, 2005, Journal of the American Chemical Society.

Phenylboronic Acids Probing Molecular Recognition against Class A and Class C β-lactamases

L. Cendron, Mattia Vicario, J. Blázquez, 2019, Antibiotics.

Structure-based design and solid phase synthesis of novel AmpC b-lactamase inhibitors

B. Shoichet, E. Caselli, M. Costi, 2001 .

Constrained Dansyl Derivatives Reveal Bacterial Specificity of Highly Conserved Thymidylate Synthases

Maria Paola Costi, S. Ghelli, D. Tondi, 2008, Chembiochem : a European journal of chemical biology.

ortho-Halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity.

Maria Paola Costi, G. Rastelli, A. Gelain, 2003, Bioorganic & medicinal chemistry.

Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition.

R. Stroud, D. Santi, S. Ghelli, 1999, Journal of medicinal chemistry.

Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.

Maria Paola Costi, S. Ghelli, D. Tondi, 2005, Journal of medicinal chemistry.

Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative

Maria Paola Costi, B. Shoichet, R. Bonnet, 2014, Journal of medicinal chemistry.

Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

Maria Paola Costi, Daniela Cardinale, Giambattista Guaitoli, 2011, Proceedings of the National Academy of Sciences.

First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase

Donatella Tondi, Paolo Benedetti, Massimo Baroni, 2019, Journal of Computer-Aided Molecular Design.

Structure-Based Virtual Screening for the Discovery of Novel Inhibitors of New Delhi Metallo-β-lactamase-1.

F. Spyrakis, S. Cross, L. Cendron, 2018, ACS medicinal chemistry letters.

Structure-based studies on species-specific inhibition of thymidylate synthase.

Maria Paola Costi, R. Stroud, D. Barlocco, 2002, Biochimica et biophysica acta.

Design, synthesis and biological evaluation of non-covalent AmpC β-lactamases inhibitors

Maria Paola Costi, L. Costantino, J. Blázquez, 2017, Medicinal Chemistry Research.

Structure-Based Optimization of 1,2,4-Triazole-3-Thione Derivatives: Improving Inhibition of NDM-/VIM-Type Metallo-β-Lactamases and Synergistic Activity on Resistant Bacteria

F. Spyrakis, L. Lazzarato, Filippo Vascon, 2023, Pharmaceuticals.

The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.

S. Mangani, M. Costi, P. Linciano, 2023, European journal of medicinal chemistry.

Constrained Dansyl Derivatives Reveal Bacterial Specificity of Highly Conserved Thymidylate Synthases

Maria Paola Costi, S. Ghelli, D. Tondi, 2008, Chembiochem : a European journal of chemical biology.

A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors

Maria Paola Costi, S. Ghelli, D. Tondi, 2004 .