P. Kotian

发表

Synthesis of pyrrolo[3,2-d]pyrimidines (9-deazaguanines) by reductive cyclodeamination reactions

D. A. Walsh, J. Montgomery, A. J. Elliott, 1996 .

Comparison of the Anti-Influenza Virus Activity of RWJ-270201 with Those of Oseltamivir and Zanamivir

J. Montgomery, K. Andries, A. Dehghani, 2001, Antimicrobial Agents and Chemotherapy.

Synthesis and nicotinic acetylcholine receptor binding properties of exo-2-(2'-fluoro-5'-pyridinyl)-7-azabicyclo-[2.2.1]heptane: a new positron emission tomography ligand for nicotinic receptors.

N. Volkow, J. Fowler, M. Kuhar, 1997, Journal of medicinal chemistry.

BCX4430, a Novel Nucleoside Analog, Effectively Treats Yellow Fever in a Hamster Model

D. Smee, W. Sheridan, Y. Babu, 2014, Antimicrobial Agents and Chemotherapy.

Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores.

Y. Babu, S. Bantia, P. Kotian, 2009, Bioorganic & medicinal chemistry.

Influenza Neuraminidase Inhibitors as Antiviral Agents

Y. Babu, P. Kotian, P. Chand, 2006 .

Probing the S2 site of factor VIIa to generate potent and selective inhibitors: the structure of BCX-3607 in complex with tissue factor-factor VIIa.

Y. Babu, S. Bantia, P. Kotian, 2007, Acta crystallographica. Section D, Biological crystallography.

The antithrombotic and anti-inflammatory effects of BCX-3607, a small molecule tissue factor/factor VIIa inhibitor.

H. Prydz, Y. Babu, S. Bantia, 2006, Thrombosis research.

Synthesis of (+) and (−) Epibatidine

F. Carroll, P. Kotian, 1995 .

A Practical Large-Scale Synthesis of (3R,4R)-4-(Hydroxymethyl)pyrrolidin-3-ol via Asymmetric 1,3-Dipolar Cycloaddition

P. Kotian, Y. El-Kattan, P. Chand, 2005 .

Synthesis and inhibitory activity of benzoic acid and pyridine derivatives on influenza neuraminidase.

Pooran Chand, D. A. Walsh, Pravin L Kotian, 2005, Bioorganic & medicinal chemistry.

Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity.

A J Elliott, A Dehghani, J. Montgomery, 2001, Journal of medicinal chemistry.

Discovery and optimization of orally bioavailable and potent plasma Kallikrein inhibitors bearing a quaternary carbon.

K. Polach, Y. Babu, P. Kotian, 2022, Bioorganic & medicinal chemistry.

An efficient stereoselective synthesis of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol from (S)-diethylmalate

P. Kotian, P. Chand, 2005 .

Synthetic approaches to imino sugar (2R,3R,4S)-2-(hydroxymethyl)-4-methylpyrrolidine-3,4-diol from naturally occurring sugar and amino acid

Ajit K. Ghosh, Y. Babu, P. Kotian, 2011 .

Synthesis of (+) and (‐) Epibatidine.

F. Carroll, P. Kotian, 1995 .

Synthesis of 9-[1-(Substituted)-3-(phosphonomethoxy)propyl]adenine Derivatives as Possible Antiviral Agents

Ajit K. Ghosh, Y. Babu, P. Kotian, 2005, Nucleosides, nucleotides & nucleic acids.

Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives.

Ali Dehghani, Pooran Chand, Scott Rowland, 2004, Journal of medicinal chemistry.

Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo.

Pooran Chand, Pravin L Kotian, Shanta Bantia, 2005, Bioorganic & medicinal chemistry.

Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.

K. Polach, Y. Babu, P. Kotian, 2022, Bioorganic & medicinal chemistry.

Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE).

K. Polach, Y. Babu, P. Kotian, 2021, Journal of medicinal chemistry.

Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase.

P. Alzari, P. Bonnet, K. Douglas, 2007, Bioorganic & medicinal chemistry.

Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design.

W G Laver, D. A. Walsh, W. G. Laver, 1997, Journal of medicinal chemistry.

An Efficient Synthesis Of Acyclic N7- and N9-Adenine Nucleosides Via Alkylation With Secondary Carbon Electrophiles to Introduce Versatile Functional Groups At the C-1 Position of Acyclic Moiety

Ajit K. Ghosh, Y. Babu, S. Bantia, 2006, Nucleosides, nucleotides & nucleic acids.

Synthesis of 9-[1-(Substituted)-2-(Phosphonomethoxy)Ethyl]Adenine Derivatives as Possible Antiviral Agents

Ajit K. Ghosh, Y. Babu, S. Bantia, 2005, Nucleosides, nucleotides & nucleic acids.

Synthesis of 9-[1-(1-Hydroxyethyl)-3-(Phosphonomethoxy)Propyl] Adenine and Prodrug as Possible Antiviral Agents

Ajit K. Ghosh, Y. Babu, P. Kotian, 2005, Nucleosides, nucleotides & nucleic acids.

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

Gianluca Pegoraro, Sina Bavari, Travis K. Warren, 2014, Nature.

BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

S. Bavari, R. Panchal, W. Sheridan, 2016, Journal of Infection and Public Health.

Synthesis of N6-Substituted 9-[3-(Phosphonomethoxy)Propyl]Adenine Derivatives As Possible Antiviral Agents

Ajit K. Ghosh, Y. Babu, S. Bantia, 2005, Nucleosides, nucleotides & nucleic acids.

BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.

A J Elliott, A Dehghani, J. Montgomery, 2000, Journal of medicinal chemistry.

Synthesis, Ligand Binding, and Quantitative Structure−Activity Relationship Study of 3β-(4‘-Substituted phenyl)-2β-heterocyclic Tropanes: Evidence for an Electrostatic Interaction at the 2β-Position

M. Kuhar, S. Mascarella, F. Carroll, 1996 .

Synthesis and Ligand Binding Study of 3β-(4′-Substituted phenyl)- 2β-(heterocyclic)tropanes.

M. Kuhar, S. Mascarella, F. Carroll, 1995 .

Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes.

M. Kuhar, S. Mascarella, F. Carroll, 1995, Journal of medicinal chemistry.

Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter.

M. Kuhar, F. Carroll, A. Dehghani, 1995, Journal of medicinal chemistry.

3b-(4'-Chlorophenyl)tropan-2b-carboxamides and Cocaine Amide Analogues: New High Affinity and Selective Compounds for the Dopamine Transporter

M. Kuhar, F. Carroll, A. Lewin, 1992 .

BCX-4161, a Small Molecule and Orally Bioavailable Plasma Kallikrein Inhibitor for the Treatment of Hereditary Angioedema

Y. Babu, S. Bantia, P. Kotian, 2013 .

Discovery of highly potent small molecule kallikrein inhibitors.

A. Dehghani, Y. Babu, S. Bantia, 2006, Medicinal chemistry (Shariqah (United Arab Emirates)).

Preclinical Characterization of BCX9930, a Potent Oral Complement Factor D Inhibitor, Targeting Alternative Pathway-Mediated Diseases Including Paroxysmal Nocturnal Hemoglobinuria (PNH)

Y. Babu, P. Kotian, Xilin Chen, 2020 .

Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes--a novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies.

Y. Babu, P. Morris, S. Bantia, 2010, International immunopharmacology.

Oseltamivir and Zanamivir Activity of RWJ-270201 with Those of Comparison of the Anti-Influenza Virus

J. Montgomery, K. Andries, A. Dehghani, 2001 .

Synthesis of novel azasugar-containing 2'β-C-Me 9-deaza nucleosides as potential anti-hepatitis C virus agents

K. Polach, Y. Babu, S. Bantia, 2022, Nucleosides, nucleotides & nucleic acids.

BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

S. Bavari, R. Panchal, W. Sheridan, 2016, Journal of Infection and Public Health.

An Efficient Synthesis of a Novel Broad-spectrum Nucleoside Analogue BCX4430 Triphosphate

K. Polach, Z. Dang, Y. Babu, 2022, Tetrahedron Letters.

Introduction of an Isopropyl Group at the Gamma Position of a Hydrindenone Derivative

P. Kotian, D. Caine, 1994 .

Discovery of highly potent small molecule kallikrein inhibitors.

A. Dehghani, Y. Babu, S. Bantia, 2006, Medicinal chemistry (Shariqah (United Arab Emirates)).