S. Halazy

发表

Fluorophosphonate derivatives of N9-benzylguanine as potent, slow-binding multisubstrate analogue inhibitors of purine nucleoside phosphorylase

S. Halazy, A. Ehrhard, A. Eggenspiller, 1996 .

Inhibitors of the Ras signal transduction pathway as potential antitumour agents.

B. Hill, S. Halazy, D. Perrin, 1996, Journal of enzyme inhibition.

Enzymatic phosphorylation and pyrophosphorylation of 2',3'-dideoxyadenosine-5'-monophosphate, a key metabolite in the pathway for activation of the anti-HIV (human immunodeficiency virus) agent 2',3'-dideoxyinosine.

J. Balzarini, S. Halazy, J. Navé, 1994, Biochemical pharmacology.

Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine

B. Hill, S. Halazy, D. Bonnet, 1996 .

3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation.

B. Antonsson, Agnès Bombrun, S. Halazy, 2003, Journal of medicinal chemistry.

Designing heterocyclic selective kinase inhibitors: from concept to new drug candidates

S. Halazy, 2006 .

Section Review: Cardiovascular & Renal: Squalene epoxidase inhibitors

J. Gotteland, S. Halazy, 1996 .

Studies Towards the Synthesis of the Saturated and Unsaturated Carbocyclic Methylene Phosphonate Analogs of Dideoxyadenosine

S. Halazy, D. Wolff-Kugel, 1993 .

Synthesis, antiviral activity and enzymatic phosphorylation of 9-phosphonopentenyl derivatives of guanine.

M. Kenny, S. Tyms, F. Piriou, 1995, Antiviral research.

Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors.

P. Pauwels, C. Palmier, P. Chopin, 1998, Bioorganic & medicinal chemistry letters.

Short and stereoselective synthesis of ?-functionalized E-?,?-difluoroallylphosphonates

S. Halazy, Vronique Gross-Bergs, 1992 .

9-(DIFLUOROPHOSPHONOALKYL)GUANINES AS A NEW CLASS OF MULTISUBSTRATE ANALOGUE INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE

S. Halazy, A. Ehrhard, C. Danzin, 1991 .

Selenium-stabilized carbocations. Formation of 2-(phenylseleno)allyl cations and their reactions with furan, pyrrole, and thiophene

L. Hevesi, S. Halazy, 1983 .

Studies on the synthesis of the antitumor agent CC-1065. Synthesis of PDE I and PDE II, inhibitors of cyclic adenosine-3',5'-monophosphate phosphodiesterase using the 3,3'-bipyrrole strategy

P. Carter, S. Halazy, S. Fitzjohn, 1987 .

Synthetic routes to cyclopropylidenecarbinols and to cyclopropylidienes

A. Krief, S. Halazy, 1981 .

New reactions of 1-seleno-1-vinyl cyclopropanes

A. Krief, S. Halazy, 1981 .

A new general route to olefins from selenides

A. Krief, S. Halazy, 1980 .

Original syntheses of epoxides involving organoselenium intermediates

D. Ende, A. Krief, S. Halazy, 1989 .

New rearrangement of the adducts formed from allenes and benzeneselenenyl halides

L. Hevesi, S. Halazy, 1983 .

STUDIES ON THE ANTITUMOR AGENT CC-1065. 1-PHENYLSULFONYL-1,3-BUTADIENE. AN ELECTROPHILIC EQUIVALENT TO 1,3-BUTADIENE FOR THE SYNTHESIS OF 3,3′-BIPYRROLES.

S. Halazy, P. Magnus, 1984 .

Studies on the antitumor agent CC-1065: 1-phenylsulfonyl-1,3-butadiene ― An electrophilic equivalent to 1,3-butadiene for the synthesis of 3,31-bipyrroles

S. Halazy, P. Magnus, 1984 .

Design and synthesis of new hypocholesterolemic organosilanes with antioxidant properties

D. Junquéro, J. Gotteland, P. Oms, 1996 .

Efficient regioselective syntheses of α and β cuparenones. A new approach for the construction of the cyclopentane ring

A. Krief, S. Halazy, F. Zutterman, 1983 .

Regioselective syntheses of polyalkyleted cyclopentanones

A. Krief, S. Halazy, 1982 .

α-Selenocyclobutyllithium as a 2-lithio-1,3-diene equivalent. regioselective (100%) synthesis of ipsenol

A. Krief, S. Halazy, 1980 .

Discovery and development of a new class of potent, selective, orally active oxytocin receptor antagonists.

C. Giachetti, M. Schwarz, A. Scheer, 2005, Journal of medicinal chemistry.

5-O-Carboxymethyl piperazide derivatives of serotonin: a new class of potent and selective 5-HT1D receptor agonists

P. Pauwels, C. Palmier, J. Valentin, 1995 .

Studies on the antitumor agent CC-1065 : Regiospecific introduction of the oxygen functionality for the synthesis of the B/C component of CC-1065.

S. Halazy, P. Magnus, 1985 .

Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors.

D. Junquéro, J. Gotteland, A. Delhon, 1998, Bioorganic & medicinal chemistry letters.

Carbocyclic phosphonate analogs of 2′,3′-dideoxyadenosine-5′-monophosphate as substrates of 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetate

S. Halazy, J. Navé, D. Wolff-Kugel, 1992 .

Synthesis and reactivity of α-lithio α-trimethylsilyl cyclopropanes and related derivatives

A. Krief, S. Halazy, W. Dumont, 1982 .

Allylselenides possessing a terminal double bond first regioselective synthesis and reactions

A. Krief, S. Halazy, W. Dumont, 1983 .

Synthesis of 1-phenylseleno-1-vinyl and 1-methylseleno-1-vinyl cyclopropanes by formal dehydration of β-hydroxycyclopropyl selenides

A. Krief, S. Halazy, 1981 .

Regio and stereoselective synthesis of 1-methylseleno-1-vinyl and 1-phenylseleno-1-vinyl cyclopropanes

A. Krief, S. Halazy, 1981 .

α-Selenocyclobutyllithium as a 2-lithio-1,3-diene equivalent. regioselective (100%) synthesis of ipsenol

A. Krief, S. Halazy, 1980 .

Regiospecific synthesis of alkylidene cyclopropanes

A. Krief, S. Halazy, 1980 .

Cyclopropanone diselenoketals interesting building blocks in organic synthesis

A. Krief, S. Halazy, J. Lucchetti, 1978 .

(Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors.

J. Désiré, D. Junquéro, J. Gotteland, 1995, Journal of medicinal chemistry.

Ortho- and para-(difluoromethyl)aryl-β-D-glucosides : a new class of enzyme-activated irreversible inhibitors of β-glucosidases

Charles Danzin, S. Halazy, V. Berges, 1990 .

Synthesis and evaluation of new 6-deoxy-6-fluorinated glucosides as inhibitors of yeast α-glucosidase

S. Halazy, A. Ehrhard, C. Danzin, 1992 .

Phosphonate derivatives of N9-benzylguanine: a new class of potent purine nucleoside phosphorylase inhibitors

S. Halazy, A. Ehrhard, A. Eggenspiller, 1992 .

Synthesis and Antiviral Properties of New Cycloalkanol Derivatives of Guanine

M. Kenny, S. Halazy, A. Eggenspiller, 1992 .

9-(Difluorophosphonoalkyl)guanines as a New Class of Multisubstrate Analogue Inhibitors of Purine Nucleoside Phosphorylase.

S. Halazy, A. Ehrhard, C. Danzin, 1991 .

9-(Phosphonoalkyl)guanine derivatives as substrates or inhibitors of guanylate kinase.

S. Halazy, J. Navé, A. Eschbach, 1992, Archives of biochemistry and biophysics.

Design, synthesis, and biological activity of novel, potent, and selective (benzoylaminomethyl)thiophene sulfonamide inhibitors of c-Jun-N-terminal kinase.

Wolfgang H. B. Sauer, M. Camps, Xuliang Jiang, 2004, Journal of medicinal chemistry.

Signal Transduction: An Exciting Field of Investigation for Small Molecule Drug Discovery

S. Halazy, 2003, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry.

In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties

L. Cavarec, I. Chumakov, C. Giachetti, 2008, European Neuropsychopharmacology.

Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses.

P. Pauwels, F. Colpaert, S. Halazy, 1999, Brain research. Molecular brain research.

Dimerization of 8-OH-DPAT increases activity at serotonin 5-HT1A receptors

P. Pauwels, S. Halazy, D. Dupuis, 1998, Naunyn-Schmiedeberg's Archives of Pharmacology.

Dimers of 5HT1 ligands preferentially bind to 5HT1B/1D receptor subtypes.

P. Pauwels, C. Jorand-Lebrun, S. Halazy, 1998, Bioorganic & medicinal chemistry letters.

Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist.

P. Pauwels, P. Chopin, J. Valentin, 1998, Bioorganic & medicinal chemistry letters.

Arylpiperazide derivatives of phenylpiperazines as a new class of potent and selective 5-HT1B receptor antagonists

P. Pauwels, C. Palmier, P. Chopin, 1997 .

Synthesis, binding affinity and intrinsic activity of new anilide derivatives of serotonin at human 5-HT1D receptors

P. Pauwels, C. Palmier, J. Valentin, 1997 .

F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine.

P. Pauwels, C. Palmier, F. Colpaert, 1999, The Journal of pharmacology and experimental therapeutics.

Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.

Jean-Pierre Gotteland, Anthony Nichols, Serge Halazy, 2005, Journal of medicinal chemistry.

GLEPP1/Protein-tyrosine Phosphatase ϕ Inhibitors Block Chemotaxis in Vitro and in Vivo and Improve Murine Ulcerative Colitis

M. Shipp, C. Rommel, M. Camps, 2009, Journal of Biological Chemistry.

Design and synthesis of new potential photoaffinity labels for mammalian squalene epoxidase

J. Gotteland, S. Halazy, C. Dax, 1997 .

Design and Synthesis of New Potential Photoaffinity Labels for Mammalian Squalene Epoxidase.

J. Gotteland, S. Halazy, C. Dax, 1997 .

G-protein coupled receptors bivalent ligands and drug design

S. Halazy, 1999 .

5-HT1B/1D antagonists and depression

C. Jorand-Lebrun, S. Halazy, M. Lamothe, 1997 .

Review Central & Peripheral Nervous Systems 5-HT1B/1D antagonists and depression

C. Jorand-Lebrun, S. Halazy, M. Lamothe, 1997 .

Serotonin dimers: application of the bivalent ligand approach to the design of new potent and selective 5-HT(1B/1D) agonists.

P. Pauwels, C. Palmier, J. Valentin, 1996, Journal of medicinal chemistry.

Synthesis and serotonergic activity of arylpiperazide derivatives of serotonin: potent agonists for 5-HT1D receptors.

P. Pauwels, C. Palmier, J. Valentin, 1995, Journal of medicinal chemistry.

1,1-Difluoroalkyl glucosides: a new class of enzyme-activated irreversible inhibitors of .alpha.-glucosidases

Charles Danzin, S. Halazy, A. Ehrhard, 1989 .