C. Edge

发表

An approach to improving multiple alignments of protein sequences using predicted secondary structure.

M J Sternberg, M. Sternberg, A. J. Jennings, 2001, Protein engineering.

Accelerating molecular discovery through data and physical sciences: Applications to peptide-membrane interactions.

Ritesh Krishna, Anna Paola Carrieri, Edward O. Pyzer-Knapp, 2018, The Journal of chemical physics.

Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry

C. Chung, B. Bax, C. Edge, 2017, Acta crystallographica. Section D, Structural biology.

Using 3D Structural Information in Computational Design

A. Davis, C. Edge, 2017 .

Fluorescent-Based Assays and RapidFire Mass Spectrometry Lead Discovery for Microsomal Prostaglandin E Synthase Using a Combination of High-Throughput

Melanie V. Leveridge, Stuart M. Baddeley, Benjamin R Bellenie, 2012 .

5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction enables efficacy.

Zehong Wan, A. Reith, F. D. Tattersall, 2019, Bioorganic & medicinal chemistry letters.

Ab initio calculations on 4H-pyran-4-one and its sulphur analogues

C. Thomson, C. Edge, 1985 .

Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort

W. P. Smith, R. Shaw, A. Hackshaw, 2019, British Journal of Cancer.

Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.

Z. Ni, P. Rowland, S. Baker, 2010, Bioorganic & medicinal chemistry letters.

Latonduine analogues restore F508del-CFTR trafficking through the modulation of PARP-3 and PARP-16 activity.

Andersen, David Y. Thomas, G. Carlile, 2016 .

Inhibition of glyoxalase I in vitro by coumarin and coumarin derivatives

C. Thomson, C. Edge, R. Brandt, 2009 .

Structure-directed discovery of an inhibitor of the binding of HIV GP120 to the CD4 receptor

R. Hertzberg, R. Sweet, A. Truneh, 1993 .

Theoretical studies of the electrostatic potential of some enzyme inhibitors using computer graphics techniques

C. Thomson, C. Edge, D. Higgins, 1988 .

Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors.

Zehong Wan, A. Reith, P. Bamborough, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols.

J. Arch, C. Edge, J. Tedder, 1991, Journal of medicinal chemistry.

Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy

S. T. A. Shah, M. Caffrey, A. Pautsch, 2014, Crystal growth & design.

Molecular dynamics simulation of the hydrocarbon region of a biomembrane using a reduced representation model

Jonathan W. Essex, Colin M. Edge, Lewis Whitehead, 2001, J. Comput. Chem..

Decorating Self-Assembled Peptide Cages with Proteins.

R. Sessions, D. Woolfson, Jordan M Fletcher, 2017, ACS nano.

Latonduine Analogs Restore F508del–Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity

David Y. Thomas, G. Carlile, R. Solari, 2016, Molecular Pharmacology.

New Insights into the Catalytic Mechanism of Aldose Reductase: A QM/MM Study

T. Tuttle, C. Edge, Marie-Pierre Dréanic, 2017, ACS omega.

Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors.

Zehong Wan, A. Reith, Xiao Ding, 2018, Bioorganic & medicinal chemistry letters.

First global analysis of the GSK database of small molecule crystal structures

J. Cole, Leen Kalash, R. Copley, 2021, CrystEngComm.

“Particle Informatics”: Advancing Our Understanding of Particle Properties through Digital Design

Kevin J. Roberts, Ian J. Bruno, Robert B. Hammond, 2019, Crystal Growth & Design.

A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease Using RapidFire Mass Spectrometry

Melanie V. Leveridge, A. Reith, A. Nadin, 2016, Journal of biomolecular screening.

Neuron-specific localisation of the TR3 death receptor in Alzheimer's disease

S. J. Newman, P. Maycox, B. Crook, 2000, Brain Research.

Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort

W. P. Smith, R. Shaw, A. Hackshaw, 2019, British Journal of Cancer.

Latonduine Analogs Restore F508del–Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity

David Y. Thomas, G. Carlile, R. Solari, 2016, Molecular Pharmacology.

The Analysis of Molecular Dynamics Simulations by the Hilbert-Huang Transform

Martin T. Swain, Adrian P. Wiley, J. Essex, 2005 .

Lead Discovery for Microsomal Prostaglandin E Synthase Using a Combination of High-Throughput Fluorescent-Based Assays and RapidFire Mass Spectrometry

Melanie V. Leveridge, Stuart M. Baddeley, Benjamin R Bellenie, 2012, Journal of biomolecular screening.