Y. Imai

发表

Increase of serum high density lipoprotein with progression and regression of aortic lipid deposition in rats.

A. Kakinuma, A. Shino, Y. Imai, 1979, Atherosclerosis.

Induction of aortic lipid deposition in a high-response (ExHC) rat fed a diet containing cholesterol and cholic acid.

Z. Suzuoki, A. Shino, Y. Imai, 1977, Atherosclerosis.

Replacement of Thr-303 of P450 2E1 with serine modifies the regioselectivity of its fatty acid hydroxylase activity.

M. Komori, Y. Imai, M. Kusunose, 1993, Journal of biochemistry.

Conversion of P-450 to P-420 by neutral salts and some other reagents.

Y. Imai, R. Sato, Ryuichiro Sato, 1967, European journal of biochemistry.

The roles of cytochrome b5 in a reconstituted N-demethylase system containing cytochrome P-450.

Y. Imai, R. Sato, Ryo Sato, 1977, Biochemical and biophysical research communications.

Multiple forms of cytochrome P-450 purified from liver microsomes of phenobarbital- and 3-methylcholanthrene-pretreated rabbits. I. Resolution, purificaton, and molecular properties.

Y. Imai, R. Sato, C. Hashimoto-Yutsudo, 1980, Journal of biochemistry.

The roles of cytochrome b5 in reconstituted monooxygenase systems containing various forms of hepatic microsomal cytochrome P-450.

Y. Imai, 1981, Journal of biochemistry.

Purification and characterization of cytochrome P-450 with high affinity for 7-alkoxycoumarins.

M. Komori, Y. Imai, R. Sato, 1984, Journal of biochemistry.

A function of cytochrome b5 in fatty acid desaturation by rat liver microsomes.

N. Oshino, Y. Imai, R. Sato, 1971, Journal of Biochemistry (Tokyo).

Purification of bovine soluble guanylate cyclase and ADP-ribosylation on its small subunit by bacterial toxins.

T. Kitagawa, Y. Imai, S. Tsuyama, 1997, Journal of biochemistry.

Rate-limiting step in the reconstituted microsomal drug hydroxylase system.

T. Iyanagi, Y. Imai, R. Sato, 1977, Journal of biochemistry.

Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity.

H. Yamazaki, M. Foroozesh, T. Shimada, 2008, Chemical research in toxicology.

Circular dichroism spectra of purified cytochromes P-450 from rabbit liver microsomes.

T. Nozawa, Y. Imai, M. Hatano, 1979, Biochimica et biophysica acta.

Substrate interaction with hydroxylase system in liver microsomes.

Y. Imai, R. Sato, R. Sato, 1966, Biochemical and biophysical research communications.

Evidence for biochemically different types of vesicles in the hepatic microsomal fraction.

A. Ito, Y. Imai, R. Sato, 1966, Journal of biochemistry.

Role of phospholipids in reconstituted cytochrome P450 3A form and mechanism of their activation of catalytic activity.

S. Imaoka, Y. Funae, Y. Imai, 1992, Biochemistry.

Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes

H. Yamazaki, T. Shimada, F. Guengerich, 1996 .

Interaction between NADPH-cytochrome P-450 reductase and cytochrome P-450 in the membrane of phosphatidylcholine vesicles.

T. Iyanagi, H. Taniguchi, Y. Imai, 1979, Biochimica et biophysica acta.

Substrate binding site of microsomal cytochrome P-450 directly faces membrane lipids.

H. Taniguchi, Y. Imai, R. Sato, 1984, Biochemical and biophysical research communications.

Purification of a substrate complex of cytochrome P-450 from liver microsomes of 3-methylcholanthrene-treated rabbits.

Y. Imai, C. Hashimoto, 1976, Biochemical and biophysical research communications.

The use of 8-aminooctyl sepharose for the separation of some components of the hepatic microsomal electron transfer system.

Y. Imai, 1976, Journal of biochemistry.

An affinity column method for partial purification of cytochrome P-450 from phenobarbital-induced rabbit liver microsomes.

Y. Imai, R. Sato, 1974, Journal of biochemistry.

Evidence for two forms of P-450 hemoprotein in microsomal membranes.

Y. Imai, R. Sato, R. Sato, 1966, Biochemical and biophysical research communications.

Genetic studies on induced and spontaneous hypercholesterolemia in rats.

Y. Imai, H. Matsumura, 1973, Atherosclerosis.

Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes.

H. Yamazaki, T. Shimada, F. Guengerich, 1996, Archives of biochemistry and biophysics.

Lipopolysaccharide-binding protein of Bombyx mori participates in a hemocyte-mediated defense reaction against gram-negative bacteria.

R. Sato, M. Imamura, K. Yaoi, 1999, Journal of insect physiology.

Site of biosynthesis of cytochrome P450 in hepatocytes of phenobarbital treated rats.

Y. Fujii‐Kuriyama, M. Negishi, Y. Tashiro, 1976, Biochemical and biophysical research communications.

Site-directed mutagenesis of the conserved threonine (Thr243) of the distal helix of fungal cytochrome P450nor.

H. Shoun, Y. Shiro, Y. Imai, 1998, Biochemistry.

Modulation of Tryptophan Hydroxylase Activity by Phospholipids: Stimulation Followed by Inactivation

Y. Imai, Y. Imai, T. Yamauchi, 1989, Journal of neurochemistry.

Biological studies of AT-308. 1. Hypocholesterolemic effect of 1,2,4-oxadiazole derivatives in rats.

Y. Imai, K. Shimamoto, 1973, Atherosclerosis.

Biological studies of AT-308. 2. Hypocholesterolemic effect of AT-308, a new derivative of 1,2,4-oxadiazole, in rats.

Y. Imai, H. Matsumura, K. Shimamoto, 1973, Atherosclerosis.

Biological studies of cholestane-3β,5α,6β-triol and its derivatives: Part 1. Hypocholesterolemic effects in rabbits, chickensd rats on atherogenic diets

Y. Imai, T. Kobayashi, T. Matsukawa, 1967 .

Biological studies of cholestane-3β,5α,6β-triol and its derivatives

T. Matsuo, Y. Imai, K. Nishikawa, 1967 .

Resonance Raman studies of hepatic microsomal cytochromes P-450: evidence for strong pi basicity of the fifth ligand in the reduced and carbonyl complex forms.

Y. Ozaki, Y. Kyōgoku, T. Kitagawa, 1978, Biochemistry.

Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits.

M. Komori, Y. Imai, R. Sato, 1988, Biochemistry.

Further purification, characterization and salt activation of acyl-CoA synthetase from Escherichia coli.

L. Suzuki, Y. Imai, K. Kameda, 1985, Biochimica et biophysica acta.

Resonance Raman study on mutant cytochrome P-450 obtained by site-directed mutagenesis.

T. Egawa, T. Kitagawa, T. Ogura, 1990, Biochimica et biophysica acta.

Purification and characterization of recombinant human prostacyclin synthase.

V. Ullrich, C. Yokoyama, T. Tanabe, 2004, Journal of biochemistry.

2-AMINO-4-PHENYLTHIAZOLE DERIVATIVES AS ANTI-ATHEROGENIC AGENTS

T. Sohda, Y. Imai, Y. Kawamatsu, 1981 .

Hepatic mitochondrial cytochrome P-450: isolation and functional characterization.

K. Okuda, Y. Imai, R. Sato, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine.

Y. Kondo, H. Hojo, T. Endo, 1990, Journal of pharmacobio-dynamics.

Serum and tissue lipids and glomerulonephritis in the spontaneously hypercholesterolemic (SHC) rat, with a note on the effects of gonadectomy.

Y. Imai, H. Matsumura, K. Oka, 1977, Atherosclerosis.

Growth inhibition of melanoma cells by N-protected dopa derivatives.

Y. Imai, T. Kasuga, K. Fujita, 1987, Biochemical pharmacology.

Circular dichroism of cytochrome cc' and cytochrome c'.

Y. Imai, T. Horio, K. Hamaguchi, 1969, Journal of biochemistry.

Reduction of tertiary amine N-oxide by purified cytochrome P-450.

R. Kato, K. Iwasaki, Y. Imai, 1977, Biochemical and biophysical research communications.

Solubilization of aromatic hydroxylase system of liver microsomes and requirement of lipid-like factor.

Y. Imai, R. Sato, 1960, Biochimica et biophysica acta.

Spectrophotometric examination of exogenous-ligand complexes of ferric cytochrome P-450. Characterization of the axial ligand trans to thiolate in the native ferric low-spin form.

Y. Imai, Y. Yoshida, C. Hashimoto-Yutsudo, 1982, Journal of biochemistry.

Selective inhibition of T-cell-dependent immune responses by bisbenzylisoquinoline alkaloids in vivo.

Y. Kondo, H. Hojo, Y. Hashimoto, 1992, International journal of immunopharmacology.

Partial purification and some spectral properties of hepatic microsomal cytochrome P-450.

Y. Imai, R. Sato, H. Satake, 1973, Drug metabolism and disposition: the biological fate of chemicals.

Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes.

N. Oshino, Y. Imai, R. Sato, 1966, Biochimica et biophysica acta.

Studies on the substrate interactions with P-450 in drug hydroxylation by liver microsomes.

Y. Imai, R. Sato, 1967, Journal of biochemistry.

A gel-electrophoretically homogeneous preparation of cytochrome P-450 from liver microsomes of phenobarbital-pretreated rabbits.

Y. Imai, R. Sato, Ryo Sato, 1974, Biochemical and biophysical research communications.

Anomalous spectral interactions of reduced P-450 with ethyl isocyanide and other lipophilic ligands.

Y. Imai, R. Sato, 1967, Journal of biochemistry.

Formation rates of the two ethyl isocyanide compounds of liver cytochrome P-450 at low temperatures.

H. S. Mason, Y. Imai, 1971, The Journal of biological chemistry.

Part 1. HYPOCHOLESTEROLEMIC EFFECT OF 1,2,4-ox.4DIAzoLE DERIVATIVES IN RATS

Y. Imai, K. Shimamoto, 1973 .

Importance of an acetone-soluble fraction in aromatic hydroxylation by liver microsomes.

Y. Imai, R. Sato, 1959, Biochimica et biophysica acta.

Activation and inhibition of microsomal hydroxylation by ethyl isocyanide.

Y. Imai, R. Sato, 1966, Biochemical and biophysical research communications.

Role of the electron transfer system in microsomal drug monooxygenase reaction catalyzed by cytochrome P-450.

H. Taniguchi, Y. Imai, R. Sato, 1984, Archives of biochemistry and biophysics.

Isolation and characterization of the multiple charge isoforms of acyl-CoA synthetase from Escherichia coli.

Y. Imai, K. Kameda, 1985, Biochimica et biophysica acta.

Studies on the lipogenesis in animal tissues under pathological conditions. I. The formation of unsaturated fatty acid in diabetic and fasted rats.

Y. Imai, 1961, Journal of biochemistry.

Biosynthesis of myo-inositol in the rat.

Y. Imai, 1963, Journal of biochemistry.

Effects of GTP on bound nitric oxide of soluble guanylate cyclase probed by resonance Raman spectroscopy.

T. Kitagawa, T. Ogura, Y. Imai, 1997, Biochemistry.

Reconstituted O-dealkylase systems containing various forms of liver microsomal cytochrome P-450.

Y. Imai, 1979, Journal of biochemistry.

Comparison of heme environment at the putative distal region of P-450s utilizing their external and internal nitrogenous ligand bound forms.

M. Komori, Y. Imai, T. Fukuda, 1994, Biochimica et biophysica acta.

Protein-protein and lipid-protein interactions in a reconstituted cytochrome P-450 dependent microsomal monooxygenase.

H. Taniguchi, Y. Imai, R. Sato, 1987, Biochemistry.

Covalent binding of polychlorinated biphenyls to proteins by reconstituted monooxygenase system containing cytochrome P-450.

T. Shimada, Y. Imai, R. Sato, 1981, Chemico-biological interactions.

Microheterogeneity in the major phenobarbital-inducible forms of rabbit liver microsomal cytochrome P-450 as revealed by nucleotide sequencing of cloned cDNAs.

S. Tsunasawa, M. Komori, Y. Imai, 1988, Biochemistry.

Unique Heme Environment at the Putative Distal Region of Hydrogen Peroxide-Dependent Fatty Acid α-Hydroxylase from Sphingomonas paucimobilis (Peroxygenase P450SPα)

Y. Imai, E. Kusunose, I. Matsunaga, 2000 .

Quantitative Thermogenesis of Brown Fat in Hibernation and Cold Adaptation

Y. Imai, B. Horwitz, R. Smith, 1968 .

Hypocholesterolemic effect of alisol A-24-monoacetate and its related compounds in rats.

Y. Imai, H. Matsumura, Y. Aramaki, 1970, Japanese journal of pharmacology.

Distribution of lipids in subcellular fractions of fatty livers. I. Lipids in liver cell fractions of rats fed a high fat and cholesterol diet.

Y. Imai, Y. Takasugi, 1966, Journal of biochemistry.

Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (ω-1)-hydroxylase and testosterone 16α-hydroxylase)

Y. Imai, Masahiko Nakamura, 1989 .

The importance of threonine‐301 from cytochromes P‐450 (laurate (ω‐1)‐hydroxylase and testosterone 16α‐hydroxylase) in substrate binding as demonstrated by site‐directed mutagenesis

Y. Imai, Masahiko Nakamura, 1988 .

Elucidation of the Differences between the 430- and 455-nm Absorbing Forms of P450-Isocyanide Adducts by Resonance Raman Spectroscopy*

T. Egawa, S. Ogo, T. Kitagawa, 2001, The Journal of Biological Chemistry.

Absorption spectral studies on heme ligand interactions of P-450nor.

H. Shoun, K. Nakahara, Y. Imai, 1997, Biochimica et biophysica acta.

Structure-Function Relationships of Cytochrome P-450 Laurate (ω-1)-Hydroxylase

T. Uno, H. Yokota, Y. Imai, 1989 .

Multiple forms of cytochrome P-450 purified from liver microsomes of phenobarbital- and 3-methylcholanthrene-pretreated rabbits. II. Spectral properties.

Y. Imai, R. Sato, C. Hashimoto-Yutsudo, 1980, Journal of biochemistry.

Magnetic circular dichroism studies of hepatic microsomal cytochrome P-450.

T. Nozawa, Y. Imai, M. Hatano, 1975, Biochemistry.

PROTEIN-PROTEIN AND LIPID-PROTEIN INTERACTIONS IN A RECONSTITUTED LIVER MICROSOMAL MONOOXYGENASE SYSTEM

H. Taniguchi, Y. Imai, R. Sato, 1980 .

Studies on the microsomal mixed function oxidase system: redox properties of detergent-solubilized NADPH-cytochrome P-450 reductase.

T. Iyanagi, H. S. Mason, Y. Imai, 1978, Biochemistry.

Metabolism of 4-methyl-5-β-hydroxyethylthiazole-S35 in rats.

Z. Suzuoki, A. Kobata, Y. Imai, 1960 .

Hypotensive Effect of N-Ethoxycarbonyl-3-morpholinosydnonimine(SIN-10) in Carbon Tetrachloride-Treated Rats

Y. Imai, K. Hirano, H. Matsumura, 1975 .

Different mechanisms of regioselection of fatty acid hydroxylation by laurate (omega-1)-hydroxylating P450s, P450 2C2 and P450 2E1.

M. Komori, Y. Imai, M. Kusunose, 1994, Journal of Biochemistry (Tokyo).

Characterization of rabbit liver cytochrome P-450 (laurate omega-1 hydroxylase) synthesized in transformed yeast cells.

Y. Imai, 1988, Journal of biochemistry.

BIOLOGIC STUDIES OF CHOLESTANE-3β,5α,6β-TRIOL AND ITS DERIVATIVES. III. THE METABOLIC FATE AND METABOLITES OF CHOLESTANE-3β,5α,6β-TRIOL IN ANIMALS

T. Matsuo, Y. Imai, S. Kikuchi, 1968 .

Further studies on chimeric P450 2C2/2C14 having testosterone 16 beta-hydroxylase activity which is absent in the parental P450s.

T. Uno, Y. Imai, 1992, Journal of biochemistry.

Identification of regions functioning in substrate interaction of rabbit liver cytochrome P-450 (laurate (omega-1)-hydroxylase).

T. Uno, Y. Imai, 1989, Journal of biochemistry.

Changes in the profiles of rodent plasma lipoproteins and apolipoproteins after cholesterol feeding.

Y. Imai, T. Kitazaki, M. Tsuda, 1983, Journal of biochemistry.

Replacing the carboxy-terminal 28 residues of rabbit liver P-450 (laurate (ω-1)-hydroxylase) with those of P-450 (testosterone 16α-hydroxylase) produces a new stereospecific hydroxylase activity

T. Uno, H. Yokota, Y. Imai, 1990 .

Dual effect of ethyl isocyanide on drug hydroxylation by liver microsomes.

Y. Imai, R. Sato, 1968, Journal of biochemistry.

Three spectrally different states of cytochromes cc' and c' and their interconversion.

Y. Imai, T. Horio, R. Sato, 1969, Journal of biochemistry.

Interaction of polycyclic hydrocarbons with cytochrome P-450. III. Effects of hydrocarbon binding on the interaction of some ligands with P-448(1) heme.

Y. Imai, 1982, Journal of biochemistry.

Interaction of polycyclic hydrocarbons with cytochrome P-450. I. Specific binding of various hydrocarbons to P-448(1).

Y. Imai, 1982, Journal of biochemistry.

Fungal P450nor: expression in Escherichia coli and site-directed mutageneses at the putative distal region.

K. Tsuruta, H. Shoun, Y. Imai, 1997, Archives of Biochemistry and Biophysics.

S24 PROTEIN ENGINEERING IN STUDIES ON METABOLISH OF TOXIC SUBSTANCES

Y. Imai, 1988 .

Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells.

Y. Imai, 1987, Journal of biochemistry.

Nitrogenous ligation at the sixth coordination position of the Thr-301 to Lys-mutated P450IIC2 heme iron.

Y. Imai, M. Nakamura, 1991, Journal of biochemistry.

Spectral interactions of protoheme with ethyl isocyanide and some other ligands in enutral pH region.

Y. Imai, R. Sato, 1968, Journal of biochemistry.

Effect of ionic strength on the ethyl isocyanide difference spectrum of reduced P-450 in liver microsomes.

Y. Imai, R. Sato, 1968, Journal of biochemistry.

Changes in plasma lipids and abnormal lipoproteins in a patient with drug-induced cholestatic hepatitis.

Y. Imai, Y. Kondo, F. Matuzaki, 1991, Japanese journal of medicine.

Induction by phenobarbital of hepatic microsomal drug-metabolizing enzyme system in partially hepatectomized rats.

Y. Imai, R. Sato, Y. Hino, 1974, Journal of biochemistry.