M. Lee-Rueckert

发表

LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis

D. Gómez-Coronado, M. Jauhiainen, J. Metso, 2020, Circulation research.

Enhanced vascular permeability facilitates entry of plasma HDL and promotes macrophage-reverse cholesterol transport from skin in mice

M. Jauhiainen, P. Kovanen, Pirkka-Pekka Laurila, 2015, Journal of Lipid Research.

Phytosterol-mediated inhibition of intestinal cholesterol absorption in mice is independent of liver X receptor.

M. Motilva, A. Valledor, P. Kovanen, 2017, Molecular nutrition & food research.

Mast cell-dependent proteolytic modification of HDL particles during anaphylactic shock in the mouse reduces their ability to induce cholesterol efflux from macrophage foam cells ex vivo.

M. Jauhiainen, J. Metso, P. Kovanen, 2010, Atherosclerosis.

Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells[S]

M. Jauhiainen, J. Metso, P. Kovanen, 2012, Journal of Lipid Research.

Acidic Extracellular Environments Strongly Impair ABCA1-Mediated Cholesterol Efflux From Human Macrophage Foam Cells

M. Jauhiainen, P. Kovanen, J. Lappalainen, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Acute Psychological Stress Accelerates Reverse Cholesterol Transport via Corticosterone-Dependent Inhibition of Intestinal Cholesterol Absorption

M. Jauhiainen, J. Metso, N. Rotllan, 2012, Circulation research.

Mast cell proteases: physiological tools to study functional significance of high density lipoproteins in the initiation of reverse cholesterol transport.

P. Kovanen, M. Lee-Rueckert, 2006, Atherosclerosis.

Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr192 and compromises its cardioprotective activity[S]

M. Baumann, M. Jauhiainen, P. Kovanen, 2018, Journal of Lipid Research.

Extracellular modifications of HDL in vivo and the emerging concept of proteolytic inactivation of pre&bgr;-HDL

P. Kovanen, M. Lee-Rueckert, 2011, Current opinion in lipidology.

Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells Published, JLR Papers in Press, May 10, 2006.

M. Jauhiainen, J. Metso, C. Ehnholm, 2006, Journal of Lipid Research.

Mast Cell Activation In Vivo Impairs the Macrophage Reverse Cholesterol Transport Pathway in the Mouse

M. Jauhiainen, J. Metso, N. Rotllan, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Acidic extracellular pH promotes accumulation of free cholesterol in human monocyte-derived macrophages via inhibition of ACAT1 activity.

P. Kovanen, T. Nordström, K. Öörni, 2020, Atherosclerosis.

Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase Published, JLR Papers in Press, November 8, 2007.

M. Jauhiainen, J. Metso, P. Kovanen, 2008, Journal of Lipid Research.

Neutrophil proteinase 3 - An LDL- and HDL-proteolyzing enzyme with a potential to contribute to cholesterol accumulation in human atherosclerotic lesions.

M. Baumann, M. Jauhiainen, M. Mäyränpää, 2022, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties

M. Jauhiainen, J. Metso, P. Kovanen, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Abstract 5865: High-density Lipoproteins (HDL) Are Present In Stenotic Aortic Valves And May Protect Them Against Calcification

P. Kovanen, M. Kupari, M. Lee-Rueckert, 2008 .

The neutral protease chymase degrades apolipoprotein E from high-density lipoproteins

A. von Eckardstein, P. Kovanen, M. Lee-Rueckert, 2008, Clinical chemistry and laboratory medicine.

Altered HDL Remodeling and Functionality in Familial Hypercholesterolemia.

M. Jauhiainen, J. Metso, P. Kovanen, 2018, Journal of the American College of Cardiology.

The mast cell as a pluripotent HDL-modifying effector in atherogenesis: from in vitro to in vivo significance

P. Kovanen, M. Lee-Rueckert, 2015, Current opinion in lipidology.

Quantification of In Vitro Macrophage Cholesterol Efflux and In Vivo Macrophage-Specific Reverse Cholesterol Transport.

F. Blanco-Vaca, J. Julve, J. Escolà-Gil, 2015, Methods in molecular biology.

Acidification of the intimal fluid: the perfect storm for atherogenesis

P. Kovanen, K. Öörni, M. Lee-Rueckert, 2015, Journal of Lipid Research.

Lipid-Laden Macrophages and Inflammation in Atherosclerosis and Cancer: An Integrative View

P. Kovanen, J. Lappalainen, J. Escolà-Gil, 2022, Frontiers in Cardiovascular Medicine.

HDL functionality in reverse cholesterol transport--Challenges in translating data emerging from mouse models to human disease.

P. Kovanen, J. Escolà-Gil, M. Lee-Rueckert, 2016, Biochimica et biophysica acta.

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health

T. Lehtimäki, L. Peltonen, V. Salomaa, 2016, Science Translational Medicine.

Molecular insights into the mechanisms underlying the cholesterol-lowering effects of phytosterols.

M. Farràs, J. Escolà-Gil, L. Cedó, 2019, Current medicinal chemistry.

The role of the gut in reverse cholesterol transport--focus on the enterocyte.

P. Kovanen, F. Blanco-Vaca, J. Escolà-Gil, 2013, Progress in lipid research.

High-density lipoproteins (HDL) are present in stenotic aortic valves and may interfere with the mechanisms of valvular calcification.

M. Jauhiainen, P. Kovanen, M. Kupari, 2011, Atherosclerosis.

A Unique Protease-sensitive High Density Lipoprotein Particle Containing the Apolipoprotein A-IMilano Dimer Effectively Promotes ATP-binding Cassette A1-mediated Cell Cholesterol Efflux*

G. Franceschini, C. Sirtori, E. Favari, 2007, Journal of Biological Chemistry.

Chronic intermittent psychological stress promotes macrophage reverse cholesterol transport by impairing bile acid absorption in mice

P. Kovanen, H. Gylling, F. Blanco-Vaca, 2015, Physiological reports.

Cholesterol loading suppresses the atheroinflammatory gene polarization of human macrophages induced by colony stimulating factors

M. Jauhiainen, P. Kovanen, J. Lappalainen, 2021, Scientific Reports.

Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDLs⃞ Published, JLR Papers in Press, March 19, 2007.

L. Peltonen, M. Taskinen, M. Jauhiainen, 2007, Journal of Lipid Research.

USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages

M. Taskinen, M. Jauhiainen, J. Metso, 2018, Lipids in Health and Disease.

Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport in vivo.

M. Urpi-Sardà, C. Andrés-Lacueva, F. Blanco-Vaca, 2013, Translational research : the journal of laboratory and clinical medicine.

Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation.

P. Kovanen, J. Lappalainen, R. D. da Silva, 2016, Atherosclerosis.

Obesity-induced changes in cancer cells and their microenvironment: mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism.

N. Rotllan, P. Kovanen, V. Llorente‐Cortés, 2023, Seminars in cancer biology.

Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture

Petri T. Kovanen, Seppo Ylä-Herttuala, Juha Hernesniemi, 2016, Journal of neuropathology and experimental neurology.

The impact of gender and serum estradiol levels on HDL‐mediated reverse cholesterol transport

M. Jauhiainen, J. Metso, P. Kovanen, 2013, European journal of clinical investigation.