J. Valderrama

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Targeting Akt as strategy to kill cancer cells using 3-substituted 5-anilinobenzo[c]isoxazolequinones: A preliminary study.

J. Benites, G. Muccioli, J. Valderrama, 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Synthesis and antiproliferative evaluation of new isomeric ellipticine quinones

C. Theoduloz, J. Valderrama, J. A. Ibacache, 2014 .

In vivo inhibition of tumor progression by 5 hydroxy-1,4-naphthoquinone (juglone) and 2-(4-hydroxyanilino)-1,4-naphthoquinone (Q7) in combination with ascorbate.

J. Benites, P. Calderon, R. Pedrosa, 2016, Biochemical and biophysical research communications.

Biological Evaluation of 3-Acyl-2-Arylamino-1,4-Naphthoquinones as Inhibitors of Hsp90 Chaperoning Function

J. Benites, J. Verrax, P. Calderon, 2012 .

Biological evaluation of 3-acyl-2-arylamino-1,4-naphthoquinones as inhibitors of Hsp90 chaperoning function.

J. Benites, J. Verrax, R. Pedrosa, 2012, Current topics in medicinal chemistry.

Aminopyrimidoisoquinolinequinone (APIQ) redox cycling is potentiated by ascorbate and induces oxidative stress leading to necrotic-like cancer cell death

J. Verrax, P. Calderon, J. Valderrama, 2012, Investigational New Drugs.

Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents.

J. Benites, J. Verrax, P. Calderon, 2010, European journal of medicinal chemistry.

Antiproliferative effects of phenylaminonaphthoquinones are increased by ascorbate and associated with the appearance of a senescent phenotype in human bladder cancer cells.

C. Glorieux, J. Verrax, B. Sid, 2013, Biochemical and biophysical research communications.

Inhibition of human topoisomerase I and activation of caspase-3 by aza-angucyclinones and arylaminopyrimido[4,5-c]isoquinoline-7,10-quinones.

Enrique González, Jaime A. Rodríguez, J. Valderrama, 2012, International journal of molecular medicine.

Inhibition of Escherichia coli and Bacillus subtilis FtsZ Polymerization and Bacillus subtilis Growth by Dihydroxynaphtyl Aryl Ketones

J. Benites, O. Monasterio, R. Lagos, 2019, Front. Microbiol..

Antifungal Activity and In Silico Studies on 2-Acylated Benzo- and Naphthohydroquinones

J. Benites, P. Calderon, Felipe Salas, 2022, Molecules.

Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells.

C. Glorieux, J. Verrax, B. Sid, 2012, Biochemical and biophysical research communications.

In Vitro Inhibition of Hsp90 Protein by Benzothiazoloquinazolinequinones Is Enhanced in The Presence of Ascorbate. A Preliminary In Vivo Antiproliferative Study

J. Benites, G. Muccioli, J. Valderrama, 2020, Molecules.

Studies on Quinones. Part. 33.1 Synthetic Approach to Podands Containing Quinone Fragments

R. Tapia, J. Valderrama, H. Leiva, 2000 .

Studies on quinones. Part 41: synthesis and cytotoxicity of isoquinoline-containing polycyclic quinones.

G. Schmeda-Hirschmann, C. Theoduloz, Jaime A. Rodríguez, 2006, Bioorganic & medicinal chemistry.

Synthesis of 3-Carboxycoumarins from O-Methoxybenzylidene Meldrum's Acid Derivatives

R. Tapia, J. Valderrama, V. Armstrong, 1988 .

Synthesis of 4(1H)-Quinolones by Thermolysis of Arylaminomethylene Meldrum's Acid Derivatives

R. Tapia, J. Valderrama, R. Cassis, 1985 .

New Synthesis of Uracil and 2-Thiouracil

R. Tapia, J. Valderrama, R. Cassis, 1984 .

Studies on quinones. Part 32. Regioselective synthesis of benz[b]phenantridines related to phenantroviridone☆

J. Valderrama, M. F. González, C. Valderrama, 1999 .

Synthesis, Half-Wave Potentials and Antiproliferative Activity of 1-Aryl-substituted Aminoisoquinolinequinones

J. Benites, C. Theoduloz, G. Muccioli, 2014, Molecules.

Synthesis and in Vitro Antiproliferative Activity of New Phenylaminoisoquinolinequinones against Cancer Cell Lines

C. Theoduloz, J. Valderrama, V. Arancibia, 2013, Molecules.

Synthesis and in Vitro Cytotoxic Evaluation of Aminoquinones Structurally Related to Marine Isoquinolinequinones

C. Theoduloz, J. Valderrama, V. Delgado, 2012, Molecules.

Studies on quinones. Part 47. Synthesis of novel phenylaminophenanthridinequinones as potential antitumor agents.

J. Benites, C. Theoduloz, Jaime A. Rodríguez, 2011, European journal of medicinal chemistry.

Studies on quinones. Part 45: novel 7-aminoisoquinoline-5,8-quinone derivatives with antitumor properties on cancer cell lines.

C. Theoduloz, Jaime A. Rodríguez, J. Valderrama, 2009, Bioorganic & medicinal chemistry.

Studies on quinones. Part 44: Novel angucyclinone N-heterocyclic analogues endowed with antitumoral activity.

C. Theoduloz, Jaime A. Rodríguez, J. Valderrama, 2008, Bioorganic & medicinal chemistry.

Gastroprotective effect and cytotoxicity of labdeneamides with amino acids.

G. Schmeda-Hirschmann, C. Theoduloz, Jaime A. Rodríguez, 2011, Planta medica.

Studies on quinones. Part 40: Synthesis and cytotoxicity evaluation of anthraquinone epoxides and isomerization products *

G. Schmeda-Hirschmann, C. Theoduloz, Jaime A. Rodríguez, 2006 .

Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones.

C. Theoduloz, Jaime A. Rodríguez, J. Valderrama, 2008, Bioorganic & medicinal chemistry.

Epoxidation of quinones with urea hydrogen peroxide

J. Valderrama, M. F. González, C. Torres, 2003 .

Synthesis and in vitro antiprotozoal activity of thiophene ring-containing quinones.

A. Rojas de Arias, A. Fournet, J. Valderrama, 1999, Chemical & pharmaceutical bulletin.

Regioselectivity in the Diels-Alder reaction of 8,8-dimethylnaphthalene-1,4,5(8H)-trione with 2,4-hexadien-1-ol

R. Araya-Maturana, B. Cassels, J. Valderrama, 1999 .

Kinetic study of the acid-catalyzed rearrangement of 4-acetyl-3,3-dimethyl-5-hydroxy-2-morpholino-2,3-dihydrobenzo[b]furan

J. Valcárcel, José G. Santos, J. Valderrama, 1983 .

Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone

C. Theoduloz, J. Valderrama, O. Espinoza, 2009 .

Synthesis and antiprotozoal activity of naphthofuranquinones and naphthothiophenequinones containing a fused thiazole ring.

R. Tapia, J. Valderrama, N. Walchshofer, 2003, Bioorganic & medicinal chemistry.

Studies on quinones. Part 37. Synthesis and biological activity of o-aminoester functionalised benzo- and naphtho[2,3-b]thiophenequinones.

R. Mahieux, E. Estrabaud, A. Fournet, 2002, Chemical & pharmaceutical bulletin.

Studies on quinones. Part 25. Synthetic approaches to 6,9-dioxygenated-benzazepinones†

H. Pessoa‐Mahana, R. Tapia, J. Valderrama, 1993 .

Studies on quinones. Part 23. Synthesis of azepinones fused to quinone systems

H. Pessoa‐Mahana, R. Tapia, J. Valderrama, 1992 .

Studies on Quinones. Part 22.' Synthesis of 1-Benzazepine-6,9-Quinone Derivatives

R. Tapia, J. Valderrama, Hernari Pcssoa-Mahana, 1992 .

Studies on Quinones. Part 38: synthesis and leishmanicidal activity of sesquiterpene 1,4-Quinones.

J. Benites, A. Fournet, É. Prina, 2003, Bioorganic & medicinal chemistry.

Hetero-annulation reaction between 2-acylnaphthoquinones and 2-aminobenzothiazoles. A new synthetic route to antiproliferative benzo[g]benzothiazolo[2,3-b]quinazoline-7,12-quinones

J. Benites, P. Calderon, G. Muccioli, 2015 .

Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines.

J. Benites, L. Rojo, M. Pedro, 2008, Bioorganic & medicinal chemistry.

SYNTHESIS OF 2,2-DIMETHYL-3, 4-EPOXY-2 H -NAPHTHO[2,3-b]PYRAN-5, 10-DIONE

R. Tapia, J. Valderrama, C. Lizama, 2001 .

Studies on Quinones. XX. synthesis of 2-acetonylpyranonaphthoqoinones

R. Tapia, J. Valderrama, B. C. Saitz, 1990 .

Green Synthesis and Electrochemical Properties of Mono- and Dimers Derived from Phenylaminoisoquinolinequinones

F. J. Recio, J. Valderrama, César A Zúñiga, 2019, Molecules.

Solvent-Free Synthesis of 6-Arylbenzimidazo[1,2-c]quinazolines under Microwave Irradiation.

R. Salazar, R. Araya-Maturana, H. Pessoa‐Mahana, 2004 .

Solvent-Free Synthesis of 6-Arylbenzimidazo[1,2-c]quinazolines under Microwave Irradiation

R. Salazar, R. Araya-Maturana, H. Pessoa‐Mahana, 2004 .

Access to Quinazolines from 2‐Nitrobenzaldehyde and Arylamines.

H. Pessoa‐Mahana, R. Tapia, J. Valderrama, 1999 .

Studies on quinones. Part 46. Synthesis and in vitro antitumor evaluation of aminopyrimidoisoquinolinequinones.

P. Calderon, C. Theoduloz, Jaime A. Rodríguez, 2010, European journal of medicinal chemistry.

Dienone–phenol rearrangement mechanism of 8,8-dimethyl- and 6,8,8-trimethyl-naphthalene-1,4,5(8H)-triones in acetic anhydride solution

José G. Santos, J. Valderrama, C. Goycoolea, 1988 .

Dienone-phenol rearrangement of naphthalenetriones. A route to 10-acetoxy5,6,7,8-tetra hydrophenanthrene-1,4-diones

R. Tapia, J. Valderrama, R. Cassis, 1987 .

Studies on quinones. XV. A convenient entry into thetetrahydrophenanthrene-1,4-quinone system utilizing the dienone-phenol rearrangement of spiro [cyclopentanenaphthalene]triones

R. Tapia, J. Valderrama, R. Cassis, 1985 .

Design and synthesis of angucyclinone AB-pyrido[2,3-d] pyrimidine analogues

J. Valderrama, D. Vásquez, 2008 .

Studies on quinones. VIII. The application of michael adducts from 2‐hydroxy‐1,4‐naphthoquinones for the preparation of dihydronaphthopyrandiones

R. Tapia, J. Valderrama, R. Cassis, 1982 .

A Diels–Alder strategy towards a benzonaphthopyranoquinone

R. Tapia, J. Valderrama, H. Fillion, 2001 .

Synthesis of 3,4-dihydro-4-hydroxy-9-methoxy-2H-naphtho[2,3-b]thiopyranoquinone

P. R. Jenkins, J. Fawcett, D. Russell, 1997 .

Synthesis of 3,4-Dihydro-4-Hydroxy-2,2-Dimethyl-2H-1-Benzopyran-5 8-Dione. A Potential Key Intermediate for the Preparation of Naphtho[2,3-b]Pyranoquinones

R. Tapia, J. Valderrama, M. Paredes, 1992 .

New 2-Acetyl-3-aminophenyl-1,4-naphthoquinones: Synthesis and In Vitro Antiproliferative Activities on Breast and Prostate Human Cancer Cells

J. Benites, Felipe Salas, G. Muccioli, 2020, Oxidative medicine and cellular longevity.

Reaction of spiroanthracenones with DDQ: a one-pot synthesis of benz[a]anthraquinones

R. Tapia, J. Valderrama, C. Pessoa-Mahana, 1994 .

Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents

R. Tapia, J. Valderrama, C. Salas, 2002 .

Access to New Cytotoxic Quinone-Amino Acid Conjugates Linked through A Vinylic Spacer from 2-Acylnaphthoquinones and Methyl 3-Aminocrotonate

J. Benites, C. Theoduloz, J. Valderrama, 2017, Molecules.

Synthetic approaches and in vitro cytotoxic evaluation of 2-acyl-3-(3,4,5-trimethoxyanilino)-1,4-naphthoquinones

J. Benites, P. Calderon, G. Muccioli, 2017 .

Eco-Friendly Synthesis and Antiproliferative Evaluation of Some Oxygen Substituted Diaryl Ketones

J. Benites, G. Muccioli, J. Valderrama, 2013, Molecules.

The solar-chemical photo-Friedel–Crafts heteroacylation of 1,4-quinones

J. Benites, J. Valderrama, David Ríos, 2011 .

Studies on Quinones. IX. Synthesis of Isochroman-5, 8-Diones

R. Tapia, J. Valderrama, J. C. Vega, 1982 .

Regiochemical control in the amination reaction of phenanthridine-7,10-quinones

J. Valderrama, J. A. Ibacache, 2009 .

Design and synthesis of angucyclinone 5-aza analogues

J. Valderrama, D. Vásquez, M. F. González, 2006 .

Studies on quinones. Part 39: Synthesis and leishmanicidal activity of acylchloroquinones and hydroquinones.

A. Fournet, É. Prina, C. Zamorano, 2005, Bioorganic & medicinal chemistry.

Studies on quinones. Part 35: Access to antiprotozoal active euryfurylquinones and hydroquinones

J. Benites, A. Fournet, É. Prina, 2002 .

STUDIES ON QUINONES. PART 36.1 SYNTHESIS AND TRYPANOCIDAL ACTIVITY OF 2-ALKOXYCARBONYLBENZO[b]THIOPHENE-4,7-QUINONES

A. Rojas de Arias, H. Pessoa‐Mahana, J. Valderrama, 2002 .

Studies on quinones. Part 34: The reaction of styrene with activated 1,4-benzoquinones: access to potential antiprotozoal pyranobenzoquinones ☆

R. Tapia, J. Valderrama, J. Miret, 2001 .

Studies on Quinones. Part 30. Synthesis of Benzo[b]thiophene-4, 7-Quinones

J. Valderrama, C. Valderrama, 1997 .

Synthesis Of 1-Benzazepines as Precursors of 1-Benzazepinediones

H. Pessoa‐Mahana, J. Valderrama, 2000 .

On the Reaction of 2-Alkanoylnaphthohydroquinones with Hydroxylamine: Access to Cytotoxic 2-(Hydroxyamino)-1,4-naphthoquinone and Their 3-(Hydroxyimino)alkyl Analogous

J. Benites, P. Calderon, G. Muccioli, 2022, Journal of Chemistry.

Synthesis of a Pyrrolo[1,4]Benzodiazepinequinone

C. Centella, R. Tapia, J. Valderrama, 1999 .

Nitric Acid on Silica Gel: A Useful Nitrating Reagent for Activated Aromatic Compounds

R. Tapia, J. Valderrama, Glenda Torres, 1986 .

A facile synthesis of the pyranonaphthazarin system

C. Saitz, R. Tapia, J. Valderrama, 1992 .

Studies on Quinones. XVIII1. Synthesis of Diels-Alder Adducts of Activated Quinones with (E)-1-trimethylsilyloxybuta-1,3-diene

J. Valderrama, M. Paredes, F. Fariña, 1989 .

Synthesis of 2H-Naphtho[2,3-b]-thiopyranoquinones and Density Functional Study for the Diels-Alder Reaction of a Benzothiopyranoquinone

P. R. Jenkins, F. Zuloaga, J. Fawcett, 2000 .

Approach to the Synthesis of 1,5-Diazaanthraquinones by Diels-Alder Reactions of Quinoline-5,8-diones

R. Tapia, J. Valderrama, Carmina Quintanar, 1996 .

Synthesis of naphtho[2,3-b]pyranoquinones and its aza-analogues from a useful benzopyranoquinone intermediate

R. Tapia, J. Valderrama, Carmina Quintanar, 1994 .

Studies on quinones. XII. Cycloketalization of michael adducts from hydroxyquinones

R. Tapia, J. Valderrama, R. Cassis, 1984 .

Studies on Quinones. XIX. Improved Synthesis of 2-Nitro-1,4-benzoquinone and its Reaction with Nucleophiles

R. Tapia, J. Valderrama, V. Polgatti, 1990 .

Half-Wave Potentials and In Vitro Cytotoxic Evaluation of 3-Acylated 2,5-Bis(phenylamino)-1,4-benzoquinones on Cancer Cells

J. Benites, G. Muccioli, J. Valderrama, 2019, Molecules.

DIELS-ALDER REACTIONS OF 1-DIMETHYLAMINO-1-AZA-1,3-DIENES WITH BENZO[b]THIOPHENE-4,7-QUINONES

J. Valderrama, L. Cardenas, 2003 .

Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones.

J. Verrax, P. Calderon, C. Theoduloz, 2009, Bioorganic & medicinal chemistry letters.

Molecular chaperone Hsp90 as a target for oxidant-based anticancer therapies.

C. Glorieux, J. Verrax, P. Calderon, 2011, Current medicinal chemistry.

A Simple Synthesis of Ethyl 5-(1,4-Cyclohexadiene-3,6-dione-1-yl)-3,5-dihydroxy Pentanoate

C. Saitz, R. Tapia, J. Valderrama, 1994 .

Studies on quinones. Part 21. Regioselective synthesis of tetracyclic quinones related to rabelomycin

R. Araya-Maturana, R. Tapia, J. Valderrama, 1991 .

Inhibition of cancer cell growth and migration by dihydroxynaphthyl aryl ketones

J. Benites, P. Calderon, O. Monasterio, 2016, Molecular & Cellular Toxicology.

Redox-active quinones and ascorbate: an innovative cancer therapy that exploits the vulnerability of cancer cells to oxidative stress.

C. Glorieux, J. Verrax, P. Calderon, 2011, Anti-cancer agents in medicinal chemistry.

Perkin communications. Acid-catalysed rearrangement of the Diels–Alder adducts of activated quinones

J. Valderrama, M. Paredes, F. Fariña, 1990 .

Regiospecific Michael reaction of (+)-euryfuran with activated 1,4-benzoquinones

J. Benites, J. Valderrama, M. Preite, 2000 .

Synthesis and Cytotoxic Activity on Human Cancer Cells of Novel Isoquinolinequinone–Amino Acid Derivatives

J. Benites, C. Theoduloz, G. Muccioli, 2016, Molecules.

Synthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j]phenanthridine- and Benzo[g]pyrimido[4,5-c]isoquinolinequinones

J. Benites, C. Theoduloz, Cristina Theoduloz, 2012, Molecules.

DNA Damage and Inhibition of Akt Pathway in MCF-7 Cells and Ehrlich Tumor in Mice Treated with 1,4-Naphthoquinones in Combination with Ascorbate

J. Benites, R. Pedrosa, J. Valderrama, 2015, Oxidative medicine and cellular longevity.

Synthesis and in vitro antiproliferative evaluation of 3-acyl-2-arylamino-1,4-naphthoquinones

J. Benites, C. Theoduloz, J. Valderrama, 2014, Medicinal Chemistry Research.

In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones

J. Benites, P. Calderon, H. Toledo, 2018, Oxidative medicine and cellular longevity.

An in vitro comparative study with furyl-1,4-quinones endowed with anticancer activities

J. Benites, H. Taper, J. Valderrama, 2011, Investigational New Drugs.

Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta

J. Benites, L. Sobrevia, F. Pardo, 2016, Oxidative medicine and cellular longevity.

Oxidative phenylamination of 5-substituted 1-hydroxynaphthalenes to N-phenyl-1,4-naphthoquinone monoimines by air and light “on water”

J. Benites, L. Espinoza, J. Valderrama, 2014, Beilstein journal of organic chemistry.

Part 1: Effect of vitamin C on the biological activity of two euryfurylbenzoquinones on TLT, a murine hepatoma cell line.

J. Benites, L. Rojo, P. Calderon, 2008, European journal of medicinal chemistry.

DETERMINATION OF PARTITION COEFFICIENT OF BENZO[b]THIOPHENES BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

J. Valderrama, V. Arancibia, C. Valderrama, 2005 .

Kinetic studies on the rearrangement of Diels–Alder adducts of activated benzoquinones with (E)-1-trimethylsiloxybuta-1,3-diene

P. Robert, José G. Santos, J. Valderrama, 1993 .

Discovery of New 2-Phenylamino-3-acyl-1,4-naphthoquinones as Inhibitors of Cancer Cells Proliferation: Searching for Intra-Cellular Targets Playing a Role in Cancer Cells Survival

J. Benites, J. Valderrama, P. Buc Calderon, 2023, Molecules.

STUDIES ON QUINONES. XI. SYNTHESIS OF QUINONES FROM HYDROQUINONES BY USING MANGANESE DIOXIDE AND ACID-IMPREGNATED MANGANESE DIOXIDE

J. Valderrama, R. Cassis, 1983 .

Studies on Quinones. XI. Synthesis of Quinones from Hydroquinones by Using Manganese Dioxide and Acid-Impregnated Manganese Dioxide1

J. Valderrama, R. Cassis, 1983 .

Synthesis and in vitro antiproliferative evaluation of 3-acyl-2-arylamino-1,4-naphthoquinones

J. Benites, C. Theoduloz, J. Valderrama, 2014, Medicinal Chemistry Research.

Studies on quinones. XIII. Synthesis and reactivity in acid medium of cyclic O,N‐ketals derived from acylbenzoquinones and enamines

R. Tapia, J. Valderrama, R. Cassis, 1984 .

Studies on quinones. Part 27. Diels–Alder reaction of 8,8-dimethylnaphthalene-1,4,5(8H)-trione

F. Zuloaga, R. Araya-Maturana, J. Valderrama, 1993 .

Studies on quinones. 24. Rearrangement of Diels-Alder adducts of activated quinones under acidic conditions☆

J. Valderrama, M. Paredes, F. Fariña, 1992 .

Studies on quinones. XIV1. Oxidative demethylation of hydroquinones dimethylethers with nitric acid- impregnated manganese dioxide

R. Tapia, J. Valderrama, B. Errazuriz, 1985 .

Studies on quinones. VII. Synthesis of some benzo[b]thiophene‐4,7‐diones

R. Tapia, J. Valderrama, J. C. Vega, 1981 .

The Reaction of 2-Acetyl-1,4-benzoquinone with Alcohols. A Convenient Synthesis of 2-Acetyl-3-alkoxy-1,4-benzoquinones

J. Valderrama, F. Fariña, 1971 .

ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES

J. Benites, C. Theoduloz, G. Muccioli, 2016 .

Inhibition of cancer cell growth and migration by dihydroxynaphthyl aryl ketones

J. Benites, P. Calderon, O. Monasterio, 2016, Molecular & Cellular Toxicology.

Part 2: influence of 2-euryfuryl-1,4-naphthoquinone and its peri-hydroxy derivatives on both cell death and metabolism of TLT cells, a murine hepatoma cell line. modulation of cytotoxicity by vitamin C.

J. Benites, H. Taper, J. Valderrama, 2009, Chemical & pharmaceutical bulletin.

CRYSTAL STRUCTURE OF (1,4-DIHYDROXYNAPHTHALEN-2-YL) (4'-METHOXYPHENYL) METHANONE

J. Benites, J. Valderrama, I. Brito, 2016 .