A. Tanaka

发表

Crystal Structure of the RUN Domain of the RAP2-interacting Protein x*

Y. Hayashizaki, T. Kigawa, S. Yokoyama, 2006, Journal of Biological Chemistry.

Solution structure of the zinc finger HIT domain in protein FON

S. Sugano, T. Umehara, T. Kigawa, 2005, Protein science : a publication of the Protein Society.

Solution structure of the GUCT domain from human RNA helicase II/Guβ reveals the RRM fold, but implausible RNA interactions

Peter Güntert, Satoru Watanabe, Naoya Tochio, 2009, Proteins.

Structure of the human Tim44 C-terminal domain in complex with pentaethylene glycol: ligand-bound form.

S. Sugano, S. Yokoyama, T. Terada, 2007, Acta crystallographica. Section D, Biological crystallography.

Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles.

T. Umehara, M. Shirouzu, T. Honma, 2022, ACS medicinal chemistry letters.

Solution structure of the major DNA-binding domain of Arabidopsis thaliana ethylene-insensitive3-like3.

Kazuo Shinozaki, Motoaki Seki, Eiko Seki, 2005, Journal of molecular biology.

Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold.

S. Sugano, S. Yokoyama, M. Shirouzu, 2008, Journal of molecular biology.

Structural basis for the dual RNA-recognition modes of human Tra2-β RRM

Sumio Sugano, Peter Güntert, Satoru Watanabe, 2010, Nucleic acids research.

Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1.

S. Yokoyama, Masayuki Yamamoto, K. I. Tong, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.

M. Shirouzu, T. Honma, Hitomi Yuki, 2017, Bioorganic & medicinal chemistry.

Solution Structure of an Arabidopsis WRKY DNA Binding Domainw⃞

K. Shinozaki, T. Kigawa, S. Yokoyama, 2005, The Plant Cell Online.

Structure of the trypanosome cyanide-insensitive alternative oxidase

T. Honma, H. Saimoto, T. Aoki, 2013, Proceedings of the National Academy of Sciences.

Crystal structure analysis of the PHD domain of the transcription co-activator Pygopus.

Y. Hayashizaki, T. Umehara, T. Kigawa, 2007, Journal of molecular biology.

Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures.

S. Yokoyama, M. Shirouzu, T. Honma, 2012, Bioorganic & medicinal chemistry.

Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei

P. Michels, T. Honma, Tomohiro Sato, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies.

Y. Urade, M. Shirouzu, K. Inaka, 2018, Bioorganic & medicinal chemistry.

Purification, crystallization and preliminary X-ray diffraction analysis of the histone chaperone cia1 from fission yeast.

T. Umehara, M. Horikoshi, S. Yokoyama, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo

Satoshi Tanaka, Shigeyuki Yokoyama, Hiroshi Kajita, 2013, Science Translational Medicine.

The ubiquinone synthesis pathway is a promising drug target for Chagas disease

M. Shirouzu, T. Honma, K. Kita, 2021, PloS one.

Critical importance of the de novo pyrimidine biosynthesis pathway for Trypanosoma cruzi growth in the mammalian host cell cytoplasm.

T. Aoki, M. Inoue, K. Kita, 2012, Biochemical and biophysical research communications.

Crystallization and preliminary X-ray analysis of aspartate transcarbamoylase from the parasitic protist Trypanosoma cruzi.

T. Honma, T. Aoki, S. Matsuoka, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells.

S. Yokoyama, T. Usui, H. Osada, 2006, Toxicology letters.

Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi.

T. Fujimura, C. Fan, T. Aoki, 2012, Biochemical and biophysical research communications.

Two-Colored Fluorescence Correlation Spectroscopy Screening for LC3-P62 Interaction Inhibitors

S. Yokoyama, F. Inagaki, N. Noda, 2013, Journal of biomolecular screening.

Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase from Trypanosoma brucei brucei.

T. Honma, T. Aoki, A. Moore, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Trypanosoma brucei gambiense glycerol kinase.

P. Michels, T. Honma, T. Aoki, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

An Arabidopsis SBP‐domain fragment with a disrupted C‐terminal zinc‐binding site retains its tertiary structure

K. Shinozaki, T. Kigawa, S. Yokoyama, 2006, FEBS letters.

1H, 13C, and 15N resonance assignments and solution structures of the KH domain of human ribosome binding factor A, mtRbfA, involved in mitochondrial ribosome biogenesis

P. Güntert, T. Kigawa, S. Yokoyama, 2022, Biomolecular NMR Assignments.

Curved EFC/F-BAR-Domain Dimers Are Joined End to End into a Filament for Membrane Invagination in Endocytosis

Sumio Sugano, Masaki Yamamoto, Shigeyuki Yokoyama, 2007, Cell.

Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target.

P. Michels, T. Honma, T. Aoki, 2013, Journal of biochemistry.

AfsR recruits RNA polymerase to the afsS promoter: a model for transcriptional activation by SARPs.

S. Horinouchi, Y. Ohnishi, A. Tanaka, 2007, Journal of molecular biology.

Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2

T. Umehara, K. Matsuno, M. Shirouzu, 2022, ACS medicinal chemistry letters.

Amyloid beta cleavage by ANA‐TA9, a synthetic peptide from the ANA/BTG3 Box A region

M. Saito, A. Matsuda, T. Sakane, 2021, Alzheimer's & dementia.

Synthesis and aldose reductase-inhibitory activity of imidazopyrroloquinoline esters.

E. Niki, T. Tanimoto, A. Tanaka, 1996, Chemical & pharmaceutical bulletin.

Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound.

S. Yokoyama, H. Nakano, T. Nagano, 2012, Journal of medicinal chemistry.

Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography.

S. Yamamoto, T. Yamada, M. Orita, 2001, Journal of medicinal chemistry.

Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions.

S. Yokoyama, H. Osada, Y. Kondoh, 2006, Chemistry, an Asian journal.

Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor.

S. Yokoyama, M. Shirouzu, T. Honma, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva.

K. Miyazono, M. Shirouzu, T. Honma, 2021, Bioorganic & medicinal chemistry letters.

Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches

K. Miyazono, S. Yokoyama, M. Shirouzu, 2020, ACS omega.

Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).

K. Miyazono, S. Yokoyama, M. Shirouzu, 2019, Chemical & pharmaceutical bulletin.

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

K. Matsuda, S. Yokoyama, M. Shirouzu, 2013, Nature.

RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing

P. Güntert, M. Hagiwara, S. Yokoyama, 2014, Nature Structural &Molecular Biology.

Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP.

S. Sugano, P. Güntert, S. Yokoyama, 2006, Structure.

The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition

Y. Hayashizaki, P. Güntert, T. Kigawa, 2008, Nucleic acids research.

The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma.

Y. Matsuo, Kazuo Sato, T. Nagase, 2004, Structure.

Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2

T. Kigawa, S. Yokoyama, Satoru Watanabe, 2010, Journal of Structural and Functional Genomics.

Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome.

Yoshihide Hayashizaki, Masami Horikoshi, Shigeyuki Yokoyama, 2007, Structure.

A novel zinc-binding motif revealed by solution structures of DNA-binding domains of Arabidopsis SBP-family transcription factors.

Kazuo Shinozaki, Motoaki Seki, Eiko Seki, 2004, Journal of molecular biology.

Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator.

S. Sugano, T. Kigawa, S. Yokoyama, 2009, Journal of structural biology.

Insights from Pim1 structure for anti-cancer drug design

Naoko Ogawa, Hitomi Yuki, Akiko Tanaka, 2012, Expert opinion on drug discovery.

Crystal structures of the S6K1 kinase domain in complexes with inhibitors

S. Yokoyama, M. Shirouzu, T. Honma, 2014, Journal of Structural and Functional Genomics.

Solution Structure of the B3 DNA Binding Domain of the Arabidopsis Cold-Responsive Transcription Factor RAV1w⃞

Kazuo Shinozaki, Motoaki Seki, Eiko Seki, 2004, The Plant Cell Online.

The Open Form Inducer Approach for Structure-Based Drug Design

T. Honma, S. Matsuoka, M. Inoue, 2016, PloS one.

Prediction of Ligand-Induced Structural Polymorphism of Receptor Interaction Sites Using Machine Learning

Hitomi Yuki, Teruki Honma, Daisuke Takaya, 2013, J. Chem. Inf. Model..

A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide.

S. Yokoyama, T. Honma, T. Nagano, 2012, Journal of molecular biology.

Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode.

Y. Hayashizaki, P. Güntert, T. Kigawa, 2008, Biochemistry.

The NMR solution structures of the five constituent cold-shock domains (CSD) of the human UNR (upstream of N-ras) protein

O. Ohara, T. Kigawa, S. Yokoyama, 2010, Journal of Structural and Functional Genomics.

The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain.

Y. Hayashizaki, T. Kigawa, S. Yokoyama, 2006, Journal of molecular biology.

Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3

S. Sugano, P. Güntert, T. Kigawa, 2009, Nucleic acids research.

Solution structure of the antifreeze‐like domain of human sialic acid synthase

Yoko Ito, S. Sugano, P. Güntert, 2006, Protein science : a publication of the Protein Society.

Solution Structure of the B 3 DNA Binding Domain of the Arabidopsis Cold-Responsive Transcription Factor RAV 1

K. Shinozaki, T. Kigawa, M. Seki, 2004 .

Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain*

Shigeyuki Yokoyama, Takashi Umehara, Keiko Ozato, 2010, The Journal of Biological Chemistry.

Crystal Structure of the Human BRD2 Bromodomain

Masami Horikoshi, Shigeyuki Yokoyama, Takashi Umehara, 2006, Journal of Biological Chemistry.

1H, 13C and 15N resonance assignments and solution structures of the two RRM domains of Matrin-3

P. Güntert, T. Kigawa, S. Yokoyama, 2021, Biomolecular NMR Assignments.

Solution structure of the SWIRM domain of human histone demethylase LSD1.

Satoru Watanabe, Eiko Seki, Naoya Tochio, 2006, Structure.

Structural and functional differences of SWIRM domain subtypes.

Y. Hayashizaki, O. Ohara, T. Umehara, 2007, Journal of molecular biology.

Structural and functional characterization of the NHR1 domain of the Drosophila neuralized E3 ligase in the notch signaling pathway.

O. Ohara, P. Güntert, T. Kigawa, 2009, Journal of molecular biology.

Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.

S. Yokoyama, T. Honma, D. Takaya, 2020, Journal of molecular graphics & modelling.

Solution structure of the Src homology 2 domain from␣the human feline sarcoma oncogene Fes

Sumio Sugano, Peter Güntert, Seizo Koshiba, 2005, Journal of biomolecular NMR.

Solution structure of the kinase‐associated domain 1 of mouse microtubule‐associated protein/microtubule affinity‐regulating kinase 3

Y. Hayashizaki, T. Kigawa, S. Yokoyama, 2006, Protein science : a publication of the Protein Society.

Solution structure of the PWWP domain of the hepatoma‐derived growth factor family

Y. Hayashizaki, P. Güntert, T. Kigawa, 2005, Protein science : a publication of the Protein Society.

Solution structure of the rhodanese homology domain At4g01050(175–295) from Arabidopsis thaliana

Kazuo Shinozaki, Peter Güntert, Motoaki Seki, 2005, Protein science : a publication of the Protein Society.

Application of Support Vector Machine to Three-Dimensional Shape-Based Virtual Screening Using Comprehensive Three-Dimensional Molecular Shape Overlay with Known Inhibitors

Hitomi Yuki, Teruki Honma, Daisuke Takaya, 2012, J. Chem. Inf. Model..

Purification, crystallization and preliminary X-ray diffraction study of human ribosomal protein L10 core domain.

S. Sugano, S. Yokoyama, M. Shirouzu, 2007, Acta Crystallographica. Section F : Structural Biology and Crystallization Communications.

Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase

Masayuki Inoue, Teruki Honma, Akiko Tanaka, 2014, Molecular microbiology.

Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase.

T. Honma, M. Inoue, K. Kita, 2017, Bioorganic & medicinal chemistry.

Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.

S. Yokoyama, M. Shirouzu, A. Tanaka, 2014, Acta crystallographica. Section D, Biological crystallography.

NMR solution structures of actin depolymerizing factor homology domains

Y. Hayashizaki, T. Kigawa, S. Yokoyama, 2009, Protein science : a publication of the Protein Society.

A fluorescence correlation spectroscopy-based assay for fragment screening of slowly inhibiting protein-peptide interaction inhibitors.

S. Yokoyama, T. Honma, T. Nagano, 2010, Analytical biochemistry.

Solution structure of an atypical WW domain in a novel β‐clam‐like dimeric form

Peter Güntert, Satoru Watanabe, Naoya Tochio, 2007 .

Structural basis for controlling the dimerization and stability of the WW domains of an atypical subfamily

T. Kigawa, S. Yokoyama, Satoru Watanabe, 2008, Protein science : a publication of the Protein Society.

Solution structure of the cysteine‐rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily

P. Güntert, T. Kigawa, S. Yokoyama, 2009, Protein science : a publication of the Protein Society.

JAL-TA9 Inhibits Aggregation of Hprp180-192 through the Cleavage Reaction

M. Saito, T. Sakane, A. Tanaka, 2020 .

Chemical structure and biological activity relationship of bacterial cell walls and muramyl peptides.

A. Tanaka, M. Tsujimoto, S. Nagao, 1986, Federation proceedings.

Solution structure of the C‐terminal DUF1000 domain of the human thioredoxin‐like 1 protein

S. Sugano, T. Kigawa, S. Yokoyama, 2010, Proteins.

Solution structure of the RWD domain of the mouse GCN2 protein

K. Kinoshita, J. Kawai, Piero Carninci, 2004, Protein science : a publication of the Protein Society.

A Fluorescent-Based High-Throughput Screening Assay for Small Molecules That Inhibit the Interaction of MdmX with p53

T. Kigawa, S. Yokoyama, T. Honma, 2013, Journal of biomolecular screening.

Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state.

S. Sugano, S. Yokoyama, M. Shirouzu, 2010, Acta crystallographica. Section D, Biological crystallography.

Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase.

T. Honma, H. Saimoto, A. Moore, 2019, Biochimica et biophysica acta. Bioenergetics.

Crystallization of the archaeal transcription termination factor NusA: a significant decrease in twinning under microgravity conditions.

S. Sano, Y. Bessho, T. Umehara, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structure of the C-terminal Phosphotyrosine Interaction Domain of Fe65L1 Complexed with the Cytoplasmic Tail of Amyloid Precursor Protein Reveals a Novel Peptide Binding Mode*

Y. Hayashizaki, T. Kigawa, S. Yokoyama, 2008, Journal of Biological Chemistry.

Structural basis for the recognition between the regulatory particles Nas6 and Rpt3 of the yeast 26S proteasome.

Masami Horikoshi, Shigeyuki Yokoyama, Takashi Umehara, 2007, Biochemical and biophysical research communications.

Purification, crystallization and preliminary X-ray diffraction analysis of the non-ATPase subunit Nas6 in complex with the ATPase subunit Rpt3 of the 26S proteasome from Saccharomyces cerevisiae.

T. Umehara, M. Horikoshi, S. Yokoyama, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Purification, crystallization and preliminary X-ray diffraction of the C-terminal bromodomain from human BRD2.

T. Umehara, S. Yokoyama, B. Padmanabhan, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Letter to the Editor: NMR assignment of the hypothetical ENTH-VHS domain At3g16270 from Arabidopsis thaliana

Kazuo Shinozaki, Peter Güntert, Motoaki Seki, 2004, Journal of biomolecular NMR.

Letter to the Editor: NMR assignment of the hypothetical rhodanese domain At4g01050 from Arabidopsis thaliana

Kazuo Shinozaki, Peter Güntert, Motoaki Seki, 2004, Journal of biomolecular NMR.

Contribution of structural biology to clinically validated target proteins.

S. Yokoyama, Sotaro Shibayama, A. Tanaka, 2008, Drug discovery today.

1H, 13C and 15N resonance assignment of the YTH domain of YTHDC2

P. Güntert, T. Kigawa, S. Yokoyama, 2020, Biomolecular NMR Assignments.

Crystal structure of the N-terminal RecA-like domain of a DEAD-box RNA helicase, the Dugesia japonica vasa-like gene B protein.

T. Kigawa, S. Yokoyama, Y. Muto, 2005, Journal of structural biology.

Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound.

S. Yokoyama, H. Nakano, T. Nagano, 2012, Journal of medicinal chemistry.

Structure of the UNC5H2 death domain.

Y. Hayashizaki, T. Kigawa, S. Yokoyama, 2006, Acta crystallographica. Section D, Biological crystallography.

Solution structure of the RNA binding domain in the human muscleblind‐like protein 2

P. Güntert, T. Kigawa, S. Yokoyama, 2009, Protein science : a publication of the Protein Society.