J. A. Vega

发表

Novel IBX‐Mediated Processes for the Synthesis of Amino Sugars and Libraries Thereof

K. Nicolaou, P. Baran, Y. Zhong, 2000 .

Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, J. M. Alonso, G. Macdonald, 2012, Journal of medicinal chemistry.

Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, G. Macdonald, G. Tresadern, 2010, ACS chemical neuroscience.

Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.

María Lourdes Linares, G. Macdonald, G. Tresadern, 2010, Bioorganic & medicinal chemistry letters.

Continuous Flow α-Arylation of N,N-Dialkylhydrazones under Visible-Light Photoredox Catalysis.

F. Delgado, J. M. Alonso, J. A. Vega, 2017, Organic letters.

Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors.

J. Spurlino, F. Delgado, Ó. Delgado, 2011, Bioorganic & medicinal chemistry letters.

A new approach to the synthesis of 2-aminoimidazo[1,2-a]pyridine derivatives through microwave-assisted N-alkylation of 2-halopyridines

C. Hamdouchi, J. Alvarez-Builla, J. A. Vega, 1999 .

Imidazo[1,2-a]pyridines: orally active positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, Sergio A Alonso de Diego, J. M. Alonso, 2012, Journal of medicinal chemistry.

A General Synthesis of α‐Trifluoromethylstyrenes through Palladium‐Catalyzed Cross‐Couplings with 1,1,1‐Trifluoroacetone Tosylhydrazone

C. Valdés, J. A. Vega, A. A. Trabanco, 2014 .

Iodine(V) reagents in organic synthesis. Part 3. New routes to heterocyclic compounds via o-iodoxybenzoic acid-mediated cyclizations: generality, scope, and mechanism.

K. Nicolaou, S. Barluenga, P. Baran, 2002, Journal of the American Chemical Society.

Synthesis and reactivity of N-alkyl-2-oxoalkanesulfonamides

J. Vaquero, J. Alvarez-Builla, J. A. Vega, 1998 .

Diazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders.

J. Bartolomé-Nebreda, F. Delgado, Carlos M Martínez-Viturro, 2020, Journal of medicinal chemistry.

Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.

Sergio A Alonso de Diego, Michiel Van Gool, G. Macdonald, 2019, ACS medicinal chemistry letters.

A microwave synthesis of the cis and trans isomers of 3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one: The influence of solvent and power output on the diastereoselectivity

J. Alvarez-Builla, J. A. Vega, J. J. Vaquero, 1996 .

Short synthesis and anti-rhinoviral activity of imidazo[1,2-a]pyridines: the effect of acyl groups at 3-position.

C. Hamdouchi, B. Heinz, J. Alvarez-Builla, 1999, Bioorganic & medicinal chemistry letters.

Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).

María Lourdes Linares, G. Macdonald, M. Somers, 2016, Journal of medicinal chemistry.

Simple approach to the synthesis of novel tricyclic BACE1 inhibitor warhead through β-lactam opening

Hassen Bel Abed, J. A. Vega, H. Gijsen, 2015 .

Fluorous-tagged carbamates for the pd-catalyzed amination of aryl halides.

J. A. Vega, A. A. Trabanco, M. A. Fernández, 2007, The Journal of organic chemistry.

N-Bridged 5,6-bicyclic pyridines: Recent applications in central nervous system disorders.

F. Delgado, Ó. Delgado, J. A. Vega, 2015, European journal of medicinal chemistry.

Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor.

María Lourdes Linares, A. Megens, G. Macdonald, 2012, Journal of medicinal chemistry.

Scaffold Hopping to Imidazo[1,2-a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor

María Lourdes Linares, G. Tresadern, H. Lavreysen, 2021, ACS omega.

Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1H-benzimidazol-2-ones as mGlu2 Receptor PAMs.

María Lourdes Linares, G. Tresadern, H. Lavreysen, 2019, ACS medicinal chemistry letters.

Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.

María Lourdes Linares, J. M. Alonso, G. Macdonald, 2014, Journal of medicinal chemistry.

Improved method for the synthesis of N-methyl-2-oxoalkanesulfonamides.

J. Vaquero, J. Alvarez-Builla, J. A. Vega, 1992 .

Imidazo[1,2-a]pyridines: orally active positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, J. M. Alonso, G. Macdonald, 2012, Journal of medicinal chemistry.