B. Murphy

发表

Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance.

T. Kwok, K. Laderoute, R. Sutherland, 1991, British Journal of Cancer.

The ribosome as affinity matrix': efficient purification scheme for translation factors.

H. Aoki, M. Ganoza, B. Murphy, 1996, Biochimie.

Regulation of gene expression at the translational level. The rescue factor reverses thermosensitive protein synthesis in N4316, a conditionally-lethal mutant of Escherichia coli defective in translation.

M. Ganoza, D. Knauber, B. Murphy, 1989, European journal of biochemistry.

The metal-responsive transcription factor-1 contributes to HIF-1 activation during hypoxic stress.

K. Laderoute, T. Dalton, B. Murphy, 2005, Biochemical and biophysical research communications.

Molecular Mechanism of Convergent Regulation of Brain Na+ Channels by Protein Kinase C and Protein Kinase A Anchored to AKAP-15

W. Catterall, F. Yu, T. Scheuer, 2002, Molecular and Cellular Neuroscience.

cAMP-dependent phosphorylation of two sites in the alpha subunit of the cardiac sodium channel.

W. Catterall, J. Rogers, B. Murphy, 1996, The Journal of biological chemistry.

The metal-responsive transcription factor-1 protein is elevated in human tumors

K. Laderoute, Z. Haroon, L. Sambucetti, 2010, Cancer biology & therapy.

Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1α

T. Kimura, G. Andrews, B. Murphy, 2008, Molecular Cancer Research.

Mechanism of hepatobiliary toxicity of the LPA1 antagonist BMS-986020 developed to treat idiopathic pulmonary fibrosis: Contrasts with BMS-986234 and BMS-986278.

Myrtle A. Davis, L. Lehman-Mckeeman, L. Sivaraman, 2022, Toxicology and applied pharmacology.

Subcellular localization of ornithine decarboxylase in liver of control and growth-hormone-treated rats.

M. Brosnan, B. Murphy, 1976, The Biochemical journal.

Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen

K. Laderoute, R. Sutherland, B. Murphy, 1992, International journal of cancer.

The redox-sensitive human antioxidant responsive element induces gene expression under low oxygen conditions.

K. Laderoute, R. Sutherland, J. Calaoagan, 1998, Carcinogenesis.

The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells.

K. Laderoute, R. Sutherland, S. Short, 1991, British Journal of Cancer.

Multifunctional Epidermal Sensor SystemsEpidermal Electronics Multifunctional Epidermal Sensor Systems with Ultrathin Encapsulation PackagingUltraThin Encapsulation Packaging for Health MonitoringMultifunctional Epidermal Sensor Systems

John A. Wright, Yonggang Huang, J. Rogers, 2016 .

Body Weight Regulation by Selective MC4 Receptor Agonists and Antagonists

N. Ling, Beth A. Fleck, M. Joppa, 2003, Annals of the New York Academy of Sciences.

NF-κB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells

M. Gassmann, W. Schaffner, M. Hottiger, 2005, Biological chemistry.

Dihydropyridine binding to the L-type Ca2+ channel in rabbit heart sarcolemma and skeletal muscle transverse-tubules: role of disulfide, sulfhydryl and phosphate groups.

B. Murphy, B. Tuana, A. W. Washkurak, 1990, Biochimica et biophysica acta.

Lysophosphatidic Acid Receptor Antagonism Protects against Diabetic Nephropathy in a Type 2 Diabetic Model.

R. Harris, A. Fogo, Ming-Zhi Zhang, 2017, Journal of the American Society of Nephrology : JASN.

Aryl piperazine melanocortin MC4 receptor agonists.

Teresa Y. Phillips, B. Dyck, M. Cismowski, 2003, Bioorganic & medicinal chemistry letters.

Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists

P. Distefano, J. Hixon, K. Longo, 2009, Journal of Pharmacology and Experimental Therapeutics.

Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.

David S. Nirschl, Kimberly A. Foster, David S Nirschl, 2017, Journal of medicinal chemistry.

Biochemical analysis of L-type calcium channels from skeletal and cardiac muscle.

B. Murphy, B. Tuana, 1990, Canadian journal of physiology and pharmacology.

Hypoxic coordinate regulation of mitochondrial enzymes in mammalian cells.

D. A. Clayton, E. Robin, R. Wong, 1984, Science.

Metallothionein IIA is up-regulated by hypoxia in human A431 squamous carcinoma cells.

R. Chin, K. Laderoute, R. Sutherland, 1994, Cancer research.

Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin.

M. Varia, J. Raleigh, S. Chou, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Identification of Benz(othi)azepine-binding Regions within L-type Calcium Channel α1 Subunits*

W. Catterall, S. D. Kimball, R. Kraus, 1996, The Journal of Biological Chemistry.

Phosphorylation of a conserved protein kinase C site is required for modulation of Na+ currents in transfected Chinese hamster ovary cells.

T. Scheuer, W. Catterall, B. Murphy, 1992, Biophysical journal.

Subcellular distribution and isolation of the Ca2+ antagonist receptor associated with the voltage regulated Ca2+ channel from rabbit heart muscle

B. Murphy, B. Tuana, Q. Yi, 1987, Molecular and Cellular Biochemistry.

Enhancement of transforming growth factor-alpha synthesis in multicellular tumour spheroids of A431 squamous carcinoma cells.

K. Laderoute, R. Sutherland, S. Short, 1992, British Journal of Cancer.

Theidentification ofhemeoxygenase as a majorhypoxic stress protein in Chinese hamster ovarycells

K. Laderoute, R. Sutherland, S. Short, 1991 .

Isosteric N‐Arylpiperazine Replacements in a Series of Dihydropyridine NPY1 Receptor Antagonists.

D. Longhi, I. Antal-Zimanyi, H. Wong, 2005 .

Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.

C. Chu, S. Jusuf, Yanou Yang, 2021, Journal of medicinal chemistry.

Discovery and optimization of (R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR).

R. Stoffel, S. Gerritz, D. Gordon, 2008, Bioorganic & medicinal chemistry letters.

(D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues.

W. Humphreys, R. Seethala, P. Sleph, 2008, Bioorganic & medicinal chemistry letters.

A 60 kDa polypeptide of skeletal-muscle sarcoplasmic reticulum is a calmodulin-dependent protein kinase that associates with and phosphorylates several membrane proteins.

J. Doucet, C. Pratt, J. Leddy, 1993, The Biochemical journal.

Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor.

E. Janovitz, D. Longhi, Christine S. Huang, 2016, Journal of Medicinal Chemistry.

Role of corticotropin-releasing factor (CRF) receptors in the anorexic syndrome induced by CRF.

N. Ling, D. Grigoriadis, M. Joppa, 2000, The Journal of pharmacology and experimental therapeutics.

Differential profile of CRF receptor distribution in the rat stomach and duodenum assessed by newly developed CRF receptor antibodies

Y. Taché, E. Chatzaki, D. Grigoriadis, 2003, Journal of neurochemistry.

Tetrazole based amides as growth hormone secretagogues.

R. Seethala, G. Grover, P. Sleph, 2008, Bioorganic & medicinal chemistry letters.

Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues.

R. Stoffel, K. Dickinson, R. Seethala, 2005, Bioorganic & medicinal chemistry letters.

Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues.

K. Dickinson, R. Seethala, G. Grover, 2007, Bioorganic & medicinal chemistry letters.

Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1.

W. Schaffner, K. Laderoute, N. Huynh, 2001, Cancer research.

Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.

W. Humphreys, K. Dickinson, R. Seethala, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).

W. Humphreys, K. Dickinson, R. Seethala, 2007, Journal of medicinal chemistry.

Ultra performance liquid chromatography: tomorrow's HPLC technology today

Brian J. Murphy, Michael E. Swartz, M. Swartz, 2004 .

Specific phosphorylation of a site in the full-length form of the alpha 1 subunit of the cardiac L-type calcium channel by adenosine 3',5'-cyclic monophosphate-dependent protein kinase.

J. Hell, W. Catterall, M. Takahashi, 1996, Biochemistry.

New frontiers in chromatography

M. Swartz, B. Murphy, 2005 .

Increase in tissue inhibitor of metalloproteinase-2 (TIMP-2) levels and inhibition of MMP-2 activity in a metastatic breast cancer cell line by an anti-invasive small molecule SR13179.

N. Zaveri, B. Murphy, N. Waleh, 2010, Cancer letters.

Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup.

R. Sridhar, D. Longhi, Christine S. Huang, 2015, Bioorganic & medicinal chemistry letters.

Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.

K. Behnia, N. Murugesan, Z. Gu, 2013, Journal of medicinal chemistry.

Functional Co-expression of the 1 and Type IIA Subunits of Sodium Channels in a Mammalian Cell Line (*)

W. Catterall, T. Scheuer, D. Ragsdale, 1995, The Journal of Biological Chemistry.

Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase.

Ming Li, W. Catterall, M. Li, 1993, Science.

A phosphorylation site in the Na+ channel required for modulation by protein kinase C.

W. Catterall, T. Scheuer, W. Catterall, 1991, Science.

Physical and functional sensitivity of zinc finger transcription factors to redox change

K. Webster, D. J. Discher, N. Bishopric, 1996, Molecular and cellular biology.

Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit.

W. Catterall, J. Striessnig, B. Murphy, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Dihydropyridine receptor of L-type Ca 2 + channels : Identification of binding domains for [ 3 H ] ( + )-PN 200-11 O and [ 3 H ] azidopine within the al subunit JORG STRIESSNIG

W. Catterall, B. Murphy, 2022 .

Regulation of malignant progression by the hypoxia-sensitive transcription factors HIF-1alpha and MTF-1.

B. Murphy, 2004, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Regulation of tissue-specific glycolytic isozyme genes: coordinate response to oxygen availability in myogenic cells

K. Webster, B. Murphy, 1988 .

Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1.

A. Giaccia, K. Webster, D. J. Discher, 1999, Cancer research.

Phosphorylation of purified rat brain Na+ channel reconstituted into phospholipid vesicles by protein kinase C.

W. Catterall, B. Murphy, W. A. Catterall, 1992, The Journal of biological chemistry.

Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line.

T. Scheuer, W. Catterall, D. Ragsdale, 1995, The Journal of biological chemistry.

Transcriptional analysis of Bacillus subtilis rRNA-tRNA operons. I. The tRNA gene cluster of rrnB has an internal promoter.

C. Green, B. Murphy, B. Vold, 1988, The Journal of biological chemistry.

Selective down-regulation of integrin receptors in spheroids of squamous cell carcinoma.

R. Kramer, R. Sutherland, J. Gallo, 1994, Cancer research.

FunctionalAnchoringof the cAMP-DependentProteinKinase

John D. Scott, B. Murphy, John D. Scott, 1998 .

Factor-1 Hypoxia in Fibroblasts : A Central Role for Metal Transcription Placenta Growth Factor Gene Expression Is Induced by Updated Version

W. Schaffner, K. Laderoute, N. Huynh, 2001 .

Factor-1 Involves Metal Response Elements and Metal Transcription Activation of Metallothionein Gene Expression by Hypoxia

K. Webster, D. J. Discher, K. Laderoute, 1999 .

Oxygen regulated 80 kDa protein and glucose regulated 78 kDa protein are identical

K. Laderoute, R. Sutherland, HaroldC. Smith, 1991, Molecular and Cellular Biochemistry.

Identification of the sites of selective phosphorylation and dephosphorylation of the rat brain Na+ channel alpha subunit by cAMP-dependent protein kinase and phosphoprotein phosphatases.

S. Rossie, K. De Jongh, W. Catterall, 1993, The Journal of biological chemistry.

The purified Ca2+ antagonist receptor from skeletal muscle: subunit structure, photoaffinity labeling and endogenous protein kinase activity

B. Murphy, B. Tuana, Q. Yi, 1989, Molecular and Cellular Biochemistry.

A calmodulin dependent protein kinase activity associated with rabbit heart sarcolemma

B. Murphy, B. Tuana, Christina Schwarzkopf, 1987, Molecular and Cellular Biochemistry.

cAMP-dependent Phosphorylation of Two Sites in the α Subunit of the Cardiac Sodium Channel*

W. Catterall, J. Rogers, B. Murphy, 1996, The Journal of Biological Chemistry.

Primary Structure and Function of an A Kinase Anchoring Protein Associated with Calcium Channels

J. Yates, W. Catterall, L. Hays, 1998, Neuron.

AKAP15 Anchors cAMP-dependent Protein Kinase to Brain Sodium Channels*

W. Catterall, Peter C. Gray, B. Murphy, 1998, The Journal of Biological Chemistry.

Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues.

W. Humphreys, K. Dickinson, R. Seethala, 2008, Bioorganic & medicinal chemistry letters.

BMS-986327 as a novel PET imaging agent for assessment of LPA1 receptors in IPF

Joonyoung Kim, W. Hayes, P. Chow, 2019, Rare ILD/DPLD.

BMS-986278, an LPA1 Receptor Antagonist for Idiopathic Pulmonary Fibrosis: Preclinical Assessments of Potential Hepatobiliary Toxicity

B. Murphy, K. Chadwick, M. Graziano, 2019, D17. TOWARDS THE NEXT IPF THERAPIES.

Modification of a discontinuous and highly porous sodium dodecyl sulfate-polyacrylamide gel system for minigel electrophoresis.

J. Doucet, B. Murphy, B. Tuana, 1990, Analytical biochemistry.

Sites of Selective cAMP-dependent Phosphorylation of the L-type Calcium Channel α1 Subunit from Intact Rabbit Skeletal Muscle Myotubes (*)

W. Catterall, B. Murphy, E. Rotman, 1995, The Journal of Biological Chemistry.

A Highly Porous Sodium Dodecyl Sulfate-Polyacrylamide Gel System

J. Doucet, B. Murphy, B. Tuana, 1993 .

Enhancement of heme oxygenase expression and activity in A431 squamous carcinoma multicellular tumor spheroids.

D. Stevenson, K. Laderoute, R. Sutherland, 1993, Cancer research.

Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor.

Beth A. Fleck, Joe A. Tran, A. Foster, 2004, Bioorganic & medicinal chemistry letters.

A screening library for peptide activated G-protein coupled receptors. 1. The test set.

J. Saunders, J. Williams, B. Murphy, 2004, Journal of medicinal chemistry.

Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT2C Receptor Agonists.

Kimberly A. Foster, A. Azzará, J. Robl, 2017, Journal of medicinal chemistry.

A novel peroxisome proliferator-activated receptor delta antagonist, SR13904, has anti-proliferative activity in human cancer cells

K. Laderoute, J. Calaoagan, N. Zaveri, 2009, Cancer biology & therapy.

Identification of a 15-kDa cAMP-dependent Protein Kinase-anchoring Protein Associated with Skeletal Muscle L-type Calcium Channels*

W. Catterall, B. Murphy, Victoria C. Tibbs, 1997, The Journal of Biological Chemistry.

Two major antigens of heart sarcolemma are Ca2(+)-binding glycoproteins that copurify with the dihydropyridine receptor.

R. Sunahara, G. Pierce, B. Murphy, 1991, Biochimica et biophysica acta.

Enhancement of transforming growth factor-a . synthesis in multicellular tumour spheroids of A 431 squamous carcinoma cells

K. Laderoute, R. Sutherland, S. Short, 2022 .

Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate.

J. Barrish, E. Janovitz, D. Longhi, 2014, Journal of medicinal chemistry.

Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies.

S. Radhakrishnan, D. Longhi, Christine S. Huang, 2015, Bioorganic & medicinal chemistry letters.

Functional Anchoring of the cAMP-Dependent Protein Kinase.

J. Scott, B. Murphy, John D. Scott, 1998, Trends in cardiovascular medicine.

cAMP-DEPENDENT PHOSPHORYLATION OF THE L-TYPE CALCIUM CHANNEL: BIOCHEMICAL CHARACTERIZATION AND PHYSIOLOGICAL REGULATION

W. Catterall, A. Sculptoreanu, T. Scheuer, 1995 .

Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists

P. Distefano, J. Hixon, K. Longo, 2009, Journal of Pharmacology and Experimental Therapeutics.

The Identification of Phosphorylation Sites in Large Membrane Proteins Following Their Isolation by SDS-PAGE

B. Murphy, K. Jongh, E. Rotman, 1993 .

Pharmacological Characterization of GPCR Agonists, Antagonists, Allosteric Modulators and Biased Ligands from HTS Hits to Lead Optimization

Zhuyin Li, C. Sum, M. Cvijic, 2019 .

Tumor Hypoxia and Heterogeneity: Challenges and Opportunities for the Future.

Sutherland, R. Sutherland, Murphy, 1996, Seminars in radiation oncology.

Phosphorylation and the Identification of a Protein Kinase: Activity Associated with the Dihydropyridine Receptor Isolated from Rabbit Heart and Skeletal Muscle a

B. Murphy, B. Tuana, 1989 .