J. Czech

发表

Inhibition of thrombin by derivatives of the dipeptide aspartic acid-amidinophenylalanine

G. Dickneite, W. Stüber, E. Paques, 1994 .

Pharmacological characterization of a new 4-amidinophenyl-alanine thrombin-inhibitor (CRC 220).

E. Weinmann, G. Dickneite, W. Stüber, 1995, Thrombosis research.

Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.

Hans Matter, Volker Laux, Armin Bauer, 2005, Journal of medicinal chemistry.

Prodrugs of anthracyclines for use in antibody-directed enzyme prodrug therapy.

C. Monneret, J. Florent, F. Tillequin, 1998, Journal of medicinal chemistry.

Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis.

M. Dreyer, Friedemann Schmidt, Tilo Weiss, 2021, Journal of medicinal chemistry.

Activation of Adenosine Monophosphateâ•flActivated Protein Kinase Reduces the Onset of Dietâ•’Induced Hepatocellular Carcinoma in Mice

B. Viollet, A. Kannt, D. Schmoll, 2020 .

Novel factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of P4 substituents in combination with a neutral P1 ligand.

H. Matter, H. Schreuder, V. Laux, 2004, Bioorganic & medicinal chemistry letters.

Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand.

H. Matter, H. Schreuder, V. Laux, 2004, Bioorganic & medicinal chemistry letters.

Probing Factor Xa Protein-Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands.

H. Matter, P. Lindemann, Svenja Herziger, 2022, Journal of medicinal chemistry.

Antibodies as Carriers of Cytotoxicity

K. Bosslet, C. Kolar, D. Hoffmann, 1992 .

Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors.

M. Dreyer, Friedemann Schmidt, Tilo Weiss, 2015, ACS medicinal chemistry letters.

Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin.

A. Evers, H. Schreuder, M. Kurz, 2015, Journal of medicinal chemistry.

Synthesis and characterisation of novel thrombin inhibitors based on 4-amidinophenylalanine.

G. Dickneite, W. Stüber, R. Koschinsky, 1995, Journal of enzyme inhibition.

Identification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone.

G. Hessler, A. Evers, Tilo Weiss, 2012, Journal of medicinal chemistry.

Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents.

H. Matter, H. Schreuder, V. Laux, 2004, Bioorganic & medicinal chemistry letters.

Combination of Antibiotic Treatment with the Thrombin Inhibitor Recombinant Hirudin for the Therapy of Experimental Klebsiella pneumoniae Sepsis

G. Dickneite, J. Czech, Gerhard Dickneite, 1994, Thrombosis and Haemostasis.

Formation of fibrin monomers in experimental disseminated intravascular coagulation and its inhibition by recombinant hirudin.

G. Dickneite, J. Czech, H. Keuper, 1994, Circulatory shock.

The RESOLUTE consortium: unlocking SLC transporters for drug discovery

D. Kell, G. Superti-Furga, R. Everley, 2020, Nature Reviews Drug Discovery.

A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders

H. Schreuder, A. Kannt, R. Elvert, 2018, Scientific Reports.

Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (ADEPT) : A phenol nitrogen mustard carbamate

C. Monneret, J. Florent, M. Gerken, 1997 .

The antiproliferative effect of malononitrilamides (MNAs) on vascular smooth muscle cells is antagonized by exogenous uridine

J. Czech, H. Schorlemmer, R. Kurrle, 1999, Inflammation Research.

Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa)

H. Schreuder, M. Kurz, A. Bauer, 2016, Scientific Reports.

Activation of Adenosine Monophosphate—Activated Protein Kinase Reduces the Onset of Diet‐Induced Hepatocellular Carcinoma in Mice

B. Viollet, A. Kannt, D. Schmoll, 2020, Hepatology communications.

Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes.

Hans Matter, Armin Bauer, Marc Nazaré, 2012, Angewandte Chemie.

Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275.

E. Sausville, M. Stetler-Stevenson, P. Worland, 1992, Journal of the National Cancer Institute.

Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).

A. Evers, H. Schreuder, M. Follmann, 2016, Journal of medicinal chemistry.

Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa.

H. Matter, H. Schreuder, M. Lorenz, 2004, Analytical biochemistry.