C. Kam

发表

Mechanism-based isocoumarin inhibitors for trypsin and blood coagulation serine proteases: new anticoagulants.

K. Fujikawa, J. Powers, C. Kam, 1988, Biochemistry.

Endocytic delivery of intramolecularly quenched substrates and inhibitors to the intracellular yeast Kex2 protease1.

L. Juliano, A. Henkel, J. Powers, 1999, The Biochemical journal.

Oxyanion-mediated inhibition of serine proteases.

C. Mura, L. Williams, K. Jude, 1998, Biochemistry.

The 2.2 .ANG. resolution x-ray crystal structure of the complex of trypsin inhibited by 4-chloro-3-ethoxy-7-guanidinoisocoumarin: a proposed model of the thrombin-inhibitor complex

W. Bode, E. Meyer, R. Radhakrishnan, 1990 .

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

R. Aebersold, R. Aebersold, R. Aebersold, 1992, The Journal of experimental medicine.

Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates.

J. Harper, J. Volanakis, J. Powers, 1987, The Journal of biological chemistry.

Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them.

J. Lieberman, J. Powers, P. Beresford, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C).

J. Powers, C. Kam, D. Thiele, 2004, Archives of biochemistry and biophysics.

Serine and Cysteine Proteases in Sulfur Mustard-Exposed Hairless Mouse Skin: Enzymatic Activity and Inhibition Profiles

C. Kam, P. Robert, C. P. James, 2000 .

Structural study of porcine pancreatic elastase complexed with 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin as a nonreactivatable doubly covalent enzyme-inhibitor complex.

E. Meyer, J. Powers, C. Kam, 1991, Biochemistry.

Proteinase 3: substrate specificity and possible pathogenetic effect of Wegener's granulomatosis autoantibodies (c-ANCA) by dysregulation of the enzyme.

C. Hack, R. Goldschmeding, J. Kerrigan, 1993, Advances in experimental medicine and biology.

Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin.

J. Powers, J. Oleksyszyn, C. Kam, 1990, Biochemistry.

Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates.

M. Smyth, J. Powers, J. M. Kelly, 2004, Archives of biochemistry and biophysics.

Purification and characterization of lymphocyte chymase I, a granzyme implicated in perforin-mediated lysis.

J. Powers, C. Kam, D. Hudig, 1998, Journal of immunology.

Perforin-Mediated Lysis Chymase I, a Granzyme Implicated in Purification and Characterization of Lymphocyte

J. Powers, C. Kam, D. Hudig, 1998 .

Purification and Characterization of Lymphocyte Chymase I , a Granzyme Implicated in Perforin-Mediated Lysis 1

J. Powers, C. Kam, D. Hudig, 1998 .

Localization, implications for function, and gene expression of chymotrypsin-like proteinases of cytotoxic RNK-16 lymphocytes.

J. Powers, C. Kam, D. Hudig, 1988, Biochimica et biophysica acta.

Lymphocyte granule-mediated cytolysis requires serine protease activity.

J. Powers, C. Kam, D. Hudig, 1987, Biochemical and biophysical research communications.

Determination of proteinase 3—α1‐antitrypsin complexes in inflammatory fluids

A. Sonnenberg, C. Hack, R. Goldschmeding, 1992 .

Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system.

J. Lieberman, J. Powers, C. Huang, 1998, Biochemical and biophysical research communications.

Substrate and inhibitor studies on proteinase 3

R. Goldschmeding, J. Kerrigan, K. Dolman, 1992, FEBS letters.

Mammalian tissue trypsin-like enzymes: substrate specificity and inhibitory potency of substituted isocoumarin mechanism-based inhibitors, benzamidine derivatives, and arginine fluoroalkyl ketone transition-state inhibitors.

W. Simmons, J. Powers, C. Kam, 1995, Archives of biochemistry and biophysics.

The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors.

J. Powers, C. Kam, D. Hudig, 1991, Journal of immunology.

Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors.

J. Powers, C. Kam, D. Hudig, 2000, Biochimica et biophysica acta.

Human Leukocyte Elastase and Porcine Pancreatic Elastase

J. Powers, N. Nishino, P. M. Tuhy, 2001 .

A serine proteinase inactivator inhibits chondrocyte-mediated cartilage proteoglycan breakdown occurring in response to proinflammatory cytokines.

R. Feltell, J. Kerrigan, J. Powers, 1998, Archives of Biochemistry and Biophysics.

Inhibition of thermolysin and carboxypeptidase A by phosphoramidates.

J. Powers, N. Nishino, C M Kam, 1979, Biochemistry.

Synthetic Substrates and Inhibitors of Thrombin

J. Powers, C. Kam, 1992 .

Peptide thioester substrates for serine peptidases and metalloendopeptidases.

J. Powers, C. Kam, 1995, Methods in enzymology.

Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models.

F. L. Suddath, L. Williams, J. Powers, 1996, Biochemistry.

Dipeptide phosphonates as inhibitors of dipeptidyl peptidase IV.

J. Powers, J. Oleksyszyn, R. Smith, 1994, Journal of medicinal chemistry.

Novel amidine-containing peptidyl phosphonates as irreversible inhibitors for blood coagulation and related serine proteases.

J. Powers, J. Oleksyszyn, C M Kam, 1994, Journal of medicinal chemistry.

Mechanism-based isocoumarin inhibitors for blood coagulation serine proteases. Effect of the 7-substituent in 7-amino-4-chloro-3-(isothioureidoalkoxy)isocoumarins on inhibitory and anticoagulant potency.

F. L. Suddath, J. Kerrigan, J. Powers, 1994, Journal of medicinal chemistry.

Reaction of azapeptides with human leukocyte elastase and porcine pancreatic elastase. New inhibitors and active site titrants.

J. Powers, N. Nishino, P. M. Tuhy, 1984, The Journal of biological chemistry.

Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency.

J. Kerrigan, J. Powers, J. Oleksyszyn, 1995, Journal of medicinal chemistry.

Mechanism-based isocoumarin inhibitors for trypsin-like serine proteases involved in blood coagulation

J. Powers, C. Kam, J. C. Copher, 1987 .

Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase.

U Winkler, D. Johnson, J. Powers, 1998, Journal of medicinal chemistry.

Proteases--structures, mechanism and inhibitors.

J. Powers, J. Oleksyszyn, C. Kam, 1993, Agents and actions. Supplements.

Biotinylated isocoumarins, new inhibitors and reagents for detection, localization, and isolation of serine proteases.

J. Powers, C. Kam, D. Hudig, 1993, Bioconjugate chemistry.

Reaction of azapeptides with chymotrypsin-like enzymes. New inhibitors and active site titrants for chymotrypsin A alpha, subtilisin BPN', subtilisin Carlsberg, and human leukocyte cathepsin G.

J. Powers, P. M. Tuhy, C. Kam, 1984, The Journal of biological chemistry.

Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase I.

J. Powers, C. Kam, D. Hudig, 2001, International immunopharmacology.

Dipeptidyl peptidase I: importance of progranzyme activation sequences, other dipeptide sequences, and the N-terminal amino group of synthetic substrates for enzyme activity.

J. Powers, C. Kam, D. Hudig, 2002, Archives of biochemistry and biophysics.

Michaelis complexes of porcine pancreatic elastase with 7‐[(alkylcarbamoyl)amino]‐4‐chloro‐3‐ethoxyisocoumarins: Translational sampling of inhibitor position and kinetic measurements

F. L. Suddath, J. Powers, C. Kam, 1992, Proteins.

Synthetic Mechanism-Based and Transition-State Inhibitors for Human Neutrophil Elastase

E. Meyer, J. Powers, J. Oleksyszyn, 1992 .

Comparison of tritiation efficiency using3H3+ and3H2+ ion beams

J. Powers, B. Richardson, C. Kam, 1984 .

Serine Protease Control of Lymphocyte-Mediated Cytolysis

J. Powers, C. Kam, D. Redelman, 1993 .

The Human Cytotoxic T Cell Granule Serine Protease Granzyme H Has Chymotrypsin-like (Chymase) Activity and Is Taken Up into Cytoplasmic Vesicles Reminiscent of Granzyme B-containing Endosomes*

James C. Powers, J. Trapani, J. Powers, 1999, The Journal of Biological Chemistry.

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.

J. Tschopp, M. Poe, J. Powers, 1991, Biochemistry.

Inhibition of thrombin by arginine-containing peptide chloromethyl ketones and bis chloromethyl ketone-albumin conjugates.

J. Powers, C. Kam, S. Odake, 1995, Journal of enzyme inhibition.

Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia.

J. Trapani, T. Sayers, H. Young, 1992, The Journal of biological chemistry.

Selective isocoumarin serine protease inhibitors block RNK-16 lymphocyte granule-mediated cytolysis.

J. Powers, C. Kam, D. Hudig, 1989, Molecular immunology.

Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes).

M. Orłowski, R. Kohanski, A. Eleuteri, 1997, Biochemistry.

Isocoumarin inhibitors of serine peptidases.

J. Powers, C. Kam, 1994, Methods in enzymology.

Cutaneous protease activity in the mouse ear vesicant model †

J. Powers, C. Kam, R. Casillas, 2000, Journal of applied toxicology : JAT.

BACILLUS THURINGIENSIS CRY GENE AND PROTEIN

C. Kam, 2017 .

Mechanism‐based isocoumarin inhibitors for serine proteases: Use of active site structure and substrate specificity in inhibitor design

J. Powers, C. Kam, Maria A. Hernandez, 1989, Journal of cellular biochemistry.

In vivo determination of the anticoagulant effect of a substituted isocoumarin (ACITIC).

D. Ku, A. Lumsden, J. Powers, 1990, Thrombosis research.

The synthesis of arginylfluoroalkanes, their inhibition of trypsin and blood-coagulation serine proteinases and their anticoagulant activity.

J. Powers, C. Kam, T. Ueda, 1990, The Biochemical journal.

Cytotoxic T-lymphocyte serine proteases: Substrate and inhibitor studies with granzymes A and B, and human Q31 chymase

J. Tschopp, M. Poe, J. Powers, 1992 .

Synthetic substrates and inhibitors for serine proteases from lymphocytes, mast cells, semen, and blood.

J. Powers, C. Kam, D. Hudig, 1992, Agents and actions. Supplements.

Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system.

J. Lieberman, J. Powers, C. Huang, 1998, Biochemical and biophysical research communications.

Substrate specificity and inhibitors of a capillary injury-related protease from sheep lung lymph.

M. Orłowski, J. Powers, J. Ayala, 1989, Archives of biochemistry and biophysics.