Ian Churcher

Lead-oriented synthesis: a new opportunity for synthetic chemistry.

Channa K. Hattotuwagama, A. Nadin, I. Churcher, 2012, Angewandte Chemie.

Organic synthesis provides opportunities to transform drug discovery

Anthony Wood, Andrew W. Thomas, David M. Wilson, 2018, Nature Chemistry.

Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks

Adam Nelson, Frank von Delft, Daniel J Foley, 2017, Chemistry.

Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry

Channa K. Hattotuwagama, Ian Churcher, Alan John Nadin, 2012 .

The Novel γ Secretase Inhibitor N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) Reduces Amyloid Plaque Deposition without Evidence of Notch-Related Pathology in the Tg2576 Mouse

Timothy Harrison, J. Atack, T. Rosahl, 2007, Journal of Pharmacology and Experimental Therapeutics.

Catalytic in vivo protein knockdown by small-molecule PROTACs.

I. E. Smith, Marcus Bantscheff, Kristoffer Famm, 2015, Nature chemical biology.

A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids.

Adam Nelson, Daniel J Foley, S. Marsden, 2015, Chemical communications.

A unified lead-oriented synthesis of over fifty molecular scaffolds.

Adam Nelson, Mark Dow, David House, 2015, Organic & biomolecular chemistry.