R. Mumford

发表

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

K. O. Elliston, Jayne Chin, J. Weidner, 1992, Nature.

IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.

J. Weidner, K. Hogquist, D. Chaplin, 1991, Journal of immunology.

Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease.

J. Weidner, I. Singer, D. Kawka, 1996, Gastroenterology.

Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists.

B. Muñoz, M. F. Gardner, Bowei Wang, 2010, Bioorganic & medicinal chemistry letters.

N-isonicotinoyl-(L)-4-aminophenylalanine derivatives as tight binding VLA-4 antagonists.

W. Hagmann, Kashmira Shah, R. Mumford, 2003, Bioorganic & medicinal chemistry letters.

N-Tetrahydrofuroyl-(L)-phenylalanine derivatives as potent VLA-4 antagonists.

M. Maccoss, S. D. de Laszlo, Bing Li, 2002, Bioorganic & medicinal chemistry letters.

N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists.

W. Hagmann, T. Kamenecka, R. Mumford, 2002, Bioorganic & medicinal chemistry letters.

Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists.

M. Maccoss, W. Hagmann, John A. Schmidt, 2002, Bioorganic & medicinal chemistry letters.

The discovery of sulfonylated dipeptides as potent VLA-4 antagonists.

M. Maccoss, S. D. de Laszlo, J. Fenyk-Melody, 2001, Bioorganic & medicinal chemistry letters.

Amidines as amide bond replacements in VLA-4 antagonists.

M. Maccoss, S. D. de Laszlo, W. Hagmann, 2004, Bioorganic & medicinal chemistry letters.

A Small Molecule α4β1/α4β7 Antagonist Differentiates between the Low-Affinity States of α4β1 and α4β7: Characterization of Divalent Cation Dependence

S. D. de Laszlo, P. Detmers, C. Raab, 2003, Journal of Pharmacology and Experimental Therapeutics.

Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.

M. Maccoss, W. Hagmann, K. Lyons, 2002, Bioorganic & medicinal chemistry letters.

α4β7/α4β1Dual Integrin Antagonists Block α4β7-Dependent Adhesion under Shear Flow

S. E. D. Laszlo, B. Pikounis, P. Detmers, 2002 .

Specific and dual antagonists of α4β1 and α4β7 integrins

M. Maccoss, W. Hagmann, L. Lin, 2002 .

The discovery of acylated beta-amino acids as potent and orally bioavailable VLA-4 antagonists.

M. Maccoss, S. D. de Laszlo, J. Fenyk-Melody, 2002, Bioorganic & medicinal chemistry letters.

Dual Integrin Antagonists Block 4 7-Dependent Adhesion under Shear Flow

S. E. D. Laszlo, B. Pikounis, P. Detmers, 2002 .

Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients

J. Weidner, I. McInnes, F. Liew, 1996, The Journal of experimental medicine.

Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis.

J. Weidner, J. Mudgett, M. Lark, 1997, Osteoarthritis and cartilage.

Carboxyl-terminal tripeptidyl hydrolysis of substance P by purified rabbit lung angiotensin-converting enzyme and the potentiation of substance P activity in vivo by captopril and MK-422.

N. Thornberry, A. Patchett, H. Bull, 1984, Molecular pharmacology.

A specific proteinase 3 activity footprint in α1-antitrypsin deficiency

R. Stockley, N. Hopkinson, E. Sapey, 2019, ERJ Open Research.

The Relationship of the Fibrinogen Cleavage Biomarker Aα-Val360 With Disease Severity and Activity in α1-Antitrypsin Deficiency.

R. Stockley, A. Pillai, R. Mumford, 2015, Chest.

The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo

A. Dirksen, R. Stockley, E. Piitulainen, 2011, Thorax.

Evidence that the insulin-like activities of concanavalin A and insulin are mediated by a common insulin receptor linked effector system.

P. Vicario, R. Mumford, H. Katzen, 1981, Biochemistry.

The role of H2O2 formation in the insulin-like and insulin antagonistic effects on fat cells of omega-aminoalkyl glycosides.

R. Mumford, M. Cascieri, H. Katzen, 1979, Archives of biochemistry and biophysics.

Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits.

A. Ford-hutchinson, R. Zamboni, D. Nicholson, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase

K. R. Thompson, W. Hagmann, A. Maycock, 1986, Nature.

N-aryl-prolyl-dipeptides as potent antagonists of VLA-4.

M. Maccoss, S. D. de Laszlo, Bing Li, 2002, Bioorganic & medicinal chemistry letters.

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

Brian K. Kobilka, Jeffrey L. Benovic, Henrik G. Dohlman, 1986, Nature.

Purification of a membrane-bound metalloendopeptidase from porcine kidney that degrades peptide hormones.

A. Strauss, R. Mumford, M. Zimmerman, 1981, Proceedings of the National Academy of Sciences of the United States of America.

A zinc metalloendopeptidase associated with dog pancreatic membranes.

J. Powers, N. Nishino, A. Strauss, 1980, The Journal of biological chemistry.

Formation of polymorphonuclear leukocyte elastase: alpha 1 proteinase inhibitor complex and A alpha (1-21) fibrinopeptide in human blood stimulated with the calcium ionophore A23187. A model to characterize inhibitors of polymorphonuclear leukocyte elastase.

W. Hanlon, R. Mumford, J. Humes, 1995, Biochemical pharmacology.

rTNFa Facilitates Human Polymorphonuclear Leukocyte Adherence to Fibrinogen Matrices With Mobilization of Specific and Tertiary but Not Azurophilic Granule Markers

W. Hanlon, J. Stolk, R. Mumford, 2005 .

Deficiency of steroid β-glucosidase in Gaucher disease

R. Labow, J. Kanfer, S. Raghavan, 1975 .

The ﬁbrinogen cleavage product A a -Val 360 , a speciﬁc marker of neutrophil elastase activity in vivo

A. Dirksen, R. Stockley, E. Piitulainen, 2022 .

The Course of AαVal541 as a Proteinase 3 Specific Neo-Epitope after Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients

P. Hiemstra, J. Stolk, D. Moes, 2021, International journal of molecular sciences.

Direct Assay of Aα(1–21), a PMN Elastase‐Specific Cleavage Product of Fibrinogen, in the Chimpanzee

W. Hanlon, J. Doherty, R. Mumford, 1991, Annals of the New York Academy of Sciences.

Inhibition of neutrophil elastase in CF sputum by L-658,758.

M. E. Wohl, J. Brain, R. Mumford, 1997, The Journal of pharmacology and experimental therapeutics.

A comparison of alpha 1-proteinase inhibitor methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone and specific beta-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster.

W. Hagmann, J. Doherty, R. Mumford, 1990, The American review of respiratory disease.

Protease activities present in wheat germ and rabbit reticulocyte lysates.

A. Strauss, R. Mumford, C. Pickett, 1981, Biochemical and biophysical research communications.

Cell-mediated Catabolism of Aggrecan

J. Weidner, M. Lark, J. Kimura, 1995, The Journal of Biological Chemistry.

Enkephalinase: selective peptide inhibitors.

S. Charleson, R. Mumford, M. Zimmerman, 1981, Life sciences.

The Discovery and Biologic Properties of Cephalosporin‐Based Inhibitors of PMN Elastase

M. Navia, W. Hanlon, E. Opas, 1991, Annals of the New York Academy of Sciences.

Pharmacological profile of the substituted beta‐lactam L‐659,286: A member of a new class of human PMN elastase inhibitors

L. Schaeffer, W. Hagmann, A. Maycock, 1989, Journal of cellular biochemistry.

Development of C5a receptor antagonists. Differential loss of functional responses.

H. Rosen, Z. Konteatis, P. Fischer, 1994, Journal of immunology.

Carboxyl terminus of inducible nitric oxide synthase. Contribution to NADPH binding and enzymatic activity.

K. O. Elliston, M. Baum, J. Weidner, 1994, The Journal of biological chemistry.

Proteoglycan-degrading activity of human stromelysin-1 and leukocyte elastase in rabbit joints. Quantitation of proteoglycan and a stromelysin-induced HABR fragment of aggrecan in synovial fluid and cartilage.

W. Hagmann, J. Hale, R. Mumford, 1996, Connective tissue research.

Isolation and characterization of glucosylsphingosine from Gaucher's spleen.

J. Kanfer, S. Raghavan, R. Mumford, 1974, Journal of lipid research.

Recent observations on Gaucher's disease.

R. Labow, J. Kanfer, R. Mumford, 1976, Advances in experimental medicine and biology.

Purification of beta-glucosidase activities from bovine spleen by affinity chromatography.

J. Byrd, J. Kanfer, S. Raghavan, 1974, Analytical biochemistry.

Deficiency of glucosylsphingosine: -Glucosidase in Gaucher disease

J. Kanfer, S. Raghavan, R. Mumford, 1973 .

HYDROLYTIC AND TRANSGLUCOLYTIC ACTIVITIES OF A PARTIALLY PURIFIED CALF BRAIN β‐GLUCOSIDASE

J. Kanfer, S. Raghavan, R. Mumford, 1976, Journal of neurochemistry.

Hydrolytic and transglucosylation activities of a purified calf spleen beta-glucosidase.

J. Kanfer, S. Raghavan, R. Mumford, 1975, Biochimica et biophysica acta.

Synthesis of glucosylceramide by purified calf spleen β-glucosidase

J. Kanfer, S. Raghavan, R. Mumford, 1974 .

Discovery of N-{N-[(3-cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(L)-prolyl}-4-[(3',5'-dichloroisonicotinoyl) amino]-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4.

P. Davies, M. Maccoss, C. Raab, 2009, Journal of medicinal chemistry.

VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis.

J. Weidner, T. Glant, M. Lark, 1995, The Journal of clinical investigation.

Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis

N. Boéchat, W. Rom, J. Weidner, 1996, The Journal of experimental medicine.

Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.

S. Venkatraman, B. Muñoz, Bowei Wang, 2009, Bioorganic & medicinal chemistry letters.

Influence of acid surrogates toward potency of VLA-4 antagonist.

S. Venkatraman, B. Muñoz, Merryl D. Cramer, 2005, Bioorganic & medicinal chemistry letters.

N-Tetrahydrofuroyl-(L)-phenylalanine derivatives as potent VLA-4 antagonists.

M. Maccoss, S. D. de Laszlo, W. Hagmann, 2002, Bioorganic & medicinal chemistry letters.

Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase.

M. Maccoss, S. Grant, R. Chabin, 2005, Bioorganic & medicinal chemistry letters.

Arylsulfatases A and B in metachromatic leukodystrophy and Maroteaux-Lamy syndrome: studies with 4-methylumelliferyl sulfate.

E. Kolodny, R. Mumford, 1976, Advances in Experimental Medicine and Biology.

Human leukocyte acid hydrolases: characterization of eleven lysosomal enzymes and study of reaction conditions for their automated analysis.

E. Kolodny, R. Mumford, Edwin H. Kolodny, 1976, Clinica chimica acta; international journal of clinical chemistry.

Potency of antileukoprotease and alpha 1-antitrypsin to inhibit degradation of fibrinogen by adherent polymorphonuclear leukocytes from normal subjects and patients with chronic granulomatous disease.

W. Hanlon, J. Stolk, J. Dijkman, 1992, American journal of respiratory cell and molecular biology.

The discovery of small molecule carbamates as potent dual α4β1/α4β7 integrin antagonists

M. Maccoss, W. Hagmann, K. Lyons, 2002 .

Constraining the amide bond in N-sulfonylated dipeptide VLA-4 antagonists.

W. Hagmann, John A. Schmidt, R. Mumford, 2008, Bioorganic & medicinal chemistry letters.

Expression and Immunoaffinity Purification of Human Inducible Nitric-oxide Synthase

M. MacCoss, P. Griffin, J. Weidner, 1996, The Journal of Biological Chemistry.

Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.

Terry D. Lee, C. Nathan, A. Ding, 1992, Science.

The Gaucher mouse.

J. Kanfer, S. Raghavan, R. Mumford, 1975, Biochemical and biophysical research communications.

Small Molecule Inhibitor of Neutrophil Elastase Restores Impaired Production of Human Myeloid Cells Observed in Severe Congenital Neutropenia.

R. Abagyan, M. Totrov, D. Dale, 2007 .

The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading

M. Lark, I. Singer, D. Kawka, 1987, The Journal of cell biology.

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.

J. Weidner, L. Lohmander, M. Lark, 1997, The Journal of clinical investigation.

Purification of α- and β-galactosidases by affinity chromatography

J. Kanfer, R. Mumford, G. Petrovich, 1973 .

Inhibition of porcine kidney "enkephalinase" by substituted-N-carboxymethyl dipeptides.

J. Springer, J. Hirshfield, A. Patchett, 1982, Biochemical and biophysical research communications.

Calmodulin is a subunit of nitric oxide synthase from macrophages

C. Nathan, T. Lee, K. Swiderek, 1992, The Journal of experimental medicine.

Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease

M. Sporn, Y. Vodovotz, K. Flanders, 1996, The Journal of experimental medicine.

Effects of VLA-4 antagonists in rat whole embryo culture.

W. Hagmann, L. Lin, John A. Schmidt, 2002, Teratology.

A&agr;-Val360: a marker of neutrophil elastase and COPD disease activity

R. Stockley, R. Mumford, R. Carter, 2012, European Respiratory Journal.

PROCESSING OF PRE‐PROALBUMIN AND PRE‐PLACENTAL LACTOGEN *

A. Alberts, R. Mumford, M. Zimmerman, 1980, Annals of the New York Academy of Sciences.

Characterization of an endopeptidase involved in pre-protein processing.

A. Alberts, A. Strauss, R. Mumford, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Proteinase activities of the golden hamster eggs and cells of the cumulus oophorus.

R. Mumford, J. Hartmann, M. Zimmerman, 1981, Developmental biology.

PROTEASE ACTIVITIES PRESENT IN DOG PANCREATIC MEMBRANES THAT PROCESS HUMAN PRE‐PLACENTAL LACTOGEN

A. Alberts, J. Powers, N. Nishino, 1980, Annals of the New York Academy of Sciences.

Ozone-induced changes in corn pollen

R. Mumford, H. Lipke, W. Feder, 1972 .

Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1.

A. Whitty, B. Dolinski, C. Raab, 2002, Biochemistry.

Precursor processing in the biosynthesis of proteins

D. Steiner, R. Mumford, M. Zimmerman, 1980 .

Characterization of alpha(4)beta(1) (CD49d/CD29) on equine leukocytes: potential utility of a potent alpha(4)beta(1) (CD49d/CD29) receptor antagonist in the treatment of equine heaves (recurrent airway obstruction).

D. Thompson, P. Prasit, D. Nicholson, 2009, Veterinary immunology and immunopathology.

Immunohistochemical localization of types 1 and 2 5alpha-reductase in human scalp.

D. Thiboutot, D. Whiting, G. Harris, 1999, British Journal of Dermatology.

A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence.

S. D. de Laszlo, P. Detmers, C. Raab, 2003, The Journal of pharmacology and experimental therapeutics.

Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists.

M. Maccoss, W. Hagmann, K. Lyons, 2002, Bioorganic & medicinal chemistry letters.

Highly constrained bicyclic VLA-4 antagonists.

M. Maccoss, Gail Forrest, W. Hagmann, 2007, Bioorganic & medicinal chemistry letters.

Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.

M. Maccoss, W. Hagmann, K. Lyons, 2002, Bioorganic & Medicinal Chemistry Letters.

Adhesion under Shear Flow

S. E. D. Laszlo, B. Pikounis, P. Detmers, 2002 .

Synthetic segments of the mammalian beta AR are preferentially recognized by cAMP-dependent protein kinase and protein kinase C.

C. Strader, E. Slater, R. Mumford, 1987, Biochemical and biophysical research communications.

PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors.

M. Lark, W. Hagmann, A. Maycock, 1991, Archives of biochemistry and biophysics.

Immunohistochemical localization of types 1 and 2 5α‐reductase in human scalp

Harris, J. Flanagan, D. Thiboutot, 1999, The British journal of dermatology.

N-(arylacetyl)-biphenylalanines as potent VLA-4 antagonists.

Bing Li, M. Maccoss, S. D. de Laszlo, 2002, Bioorganic & medicinal chemistry letters.

The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo

A. Dirksen, R. Stockley, E. Piitulainen, 2011, Thorax.

Effect of intravenous alpha-1-antitrypsin augmentation therapy on proteinase-3-generated AaVal541 in deficient patients

P. Hiemstra, J. Stolk, R. Mumford, 2021, Airway pharmacology and treatment.

The Relationship of the Fibrinogen Cleavage Biomarker Aα-Val360 With Disease Severity and Activity in α1-Antitrypsin Deficiency.

R. Stockley, A. Pillai, R. Mumford, 2015, Chest.

N-(3-phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists.

S. D. de Laszlo, W. Hagmann, T. Kamenecka, 2003, Bioorganic & medicinal chemistry letters.

Radiochemical decomposition of N-14CH3 labeled sphingomyelin (II)

J. Kanfer, R. Mumford, G. Petrovich, 1973 .