Luc Demange

发表

A straightforward and versatile FeCl3 catalyzed Friedel–Crafts C-glycosylation process. Application to the synthesis of new functionalized C-nucleosides

R. Benhida, K. Bougrin, H. Tachallait, 2019, New Journal of Chemistry.

Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives

R. Benhida, K. Bougrin, Hamid Marzag, 2016, Molecules.

Disruption of phactr-1 pathway triggers pro-inflammatory and pro-atherogenic factors: New insights in atherosclerosis development.

O. Hermine, Wang-Qing Liu, C. Garbay, 2015, Biochimie.

Synthesis and evaluation of new potent inhibitors of CK1 and CDK5, two kinases involved in Alzheimer’s disease

L. Meijer, O. Lozach, H. Galons, 2013, Medicinal Chemistry Research.

Several Human Cyclin-Dependent Kinase Inhibitors, Structurally Related to Roscovitine, As New Anti-Malarial Agents

L. Meijer, J. Le bras, O. Lozach, 2014, Molecules.

Synthesis of 6-Pyridylaminopurines

L. Meijer, O. Lozach, S. Bouaziz, 2008 .

Synthesis of 6‐Pyridylaminopurines.

L. Meijer, O. Lozach, S. Bouaziz, 2008 .

New Peptides Structurally Related to VEGF-A165 Exon-7 and -8 Encoded Domains Antagonize Its Binding to NRP-1 and VEGF-R1

O. Hermine, Wang-Qing Liu, C. Garbay, 2015, International Journal of Peptide Research and Therapeutics.

Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model.

M. Montès, J. Boucher, O. Hermine, 2014, Cancer letters.

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds.

G. Pagès, R. Benhida, M. Dufies, 2020, Bioorganic chemistry.

The epimerization of peptide aldehydes—a systematic study

A. Moulin, Jean Martinez, J. Fehrentz, 2006, Journal of peptide science : an official publication of the European Peptide Society.

The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist

A. Moulin, Jean Martinez, J. Fehrentz, 2012, Amino Acids.

Recent Advances in Age-Related Macular Degeneration Therapies

R. Benhida, S. Baillif, Luc Demange, 2022, Molecules.

New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations.

V. Locatelli, A. Torsello, A. Moulin, 2008, Journal of medicinal chemistry.

Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: on the significance of the orientation and substitution at position 3.

A. Moulin, Jean Martinez, J. Fehrentz, 2008, Bioorganic & medicinal chemistry letters.

Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations.

V. Locatelli, A. Torsello, A. Heitz, 2007, Journal of medicinal chemistry.

Synthesis and pharmacological in vitro and in vivo evaluations of novel triazole derivatives as ligands of the ghrelin receptor. 1.

V. Locatelli, A. Torsello, A. Heitz, 2007, Journal of medicinal chemistry.

Modular synthesis of new C-aryl-nucleosides and their anti-CML activity.

G. Robert, P. Auberger, R. Benhida, 2018, Bioorganic & medicinal chemistry letters.

Anorexigenic and electrophysiological actions of novel ghrelin receptor (GHS-R1A) antagonists in rats.

A. Moulin, Jean Martinez, J. Fehrentz, 2009, European journal of pharmacology.

Concise synthesis and antibacterial evaluation of novel 3‐(1,4‐disubstituted‐1,2,3‐triazolyl)uridine nucleosides

R. Benhida, Y. Bakri, A. Bouyahya, 2018, Archiv der Pharmazie.

Practical synthesis of Boc and Fmoc protected 4-fluoro and 4-difluoroprolines from trans-4-hydroxyproline

A. Ménez, Luc Demange, C. Dugave, 1998 .

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

R. Benhida, K. Bougrin, Hamid Marzag, 2016, Molecules.

Ultrasound-assisted facile one-pot sequential synthesis of novel sulfonamide-isoxazoles using cerium (IV) ammonium nitrate (CAN) as an efficient oxidant in aqueous medium.

R. Benhida, S. Alaoui, K. Bougrin, 2018, Ultrasonics sonochemistry.

Cis-trans isomerization of organic molecules and biomolecules: implications and applications.

Christophe Dugave, Luc Demange, Luc Demange, 2003, Chemical reviews.

Synthesis and anti-cancer activities of new sulfonamides 4-substituted-triazolyl nucleosides.

G. Pagès, G. Robert, P. Auberger, 2017, Bioorganic & medicinal chemistry letters.

Solvent-Free Regioselective Synthesis of Novel Isoxazoline and Pyrazoline N-Substituted Saccharin Derivatives Under Microwave Irradiation

E. Álvarez, R. Benhida, S. Alaoui, 2016, Chemistry of Heterocyclic Compounds.

Synthesis of optically pure N-Boc-protected (2R,3R)- and (2R,3S)-3-fluoroprolines

A. Ménez, Luc Demange, J. Cluzeau, 2001 .

Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories.

R. Benhida, Luc Demange, C. Ronco, 2017, MedChemComm.

New CXCR1/CXCR2 inhibitors represent an effective treatment for kidney or head and neck cancers sensitive or refractory to reference treatments

M. Montès, G. Pagès, P. Auberger, 2019, Theranostics.

ATM, ATR, CHK1, CHK2 and WEE1 inhibitors in cancer and cancer stem cells.

R. Benhida, Luc Demange, C. Ronco, 2017, MedChemComm.

Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.

P. Greengard, L. Meijer, M. Flajolet, 2008, Journal of medicinal chemistry.

Targeting the Major Groove of the Palindromic d(GGCGCC)2 Sequence by Oligopeptide Derivatives of Anthraquinone Intercalators

Krystel El Hage, N. Gresh, J. Piquemal, 2022, J. Chem. Inf. Model..

Synthesis, 3D-structure and stability analyses of NRPa-308, a new promising anti-cancer agent.

G. Pagès, R. Benhida, O. Hermine, 2019, Bioorganic & medicinal chemistry letters.

Interaction of human cyclophilin hCyp‐18 with short peptides suggests the existence of two functionally independent subsites

M. Moutiez, Luc Demange, C. Dugave, 2001, FEBS letters.

Synthesis of phosphinic alanyl-proline surrogates Alaψ(PO2R-CH)Pro as potential inhibitors of the human cyclophilin hCyp-18

Luc Demange, C. Dugave, 2001 .

Synthesis of pseudopeptides containing aza-phenylalanine surrogates of the Phe-pNA motif: Influence on the binding to the human cyclophilin hCyp-18

Luc Demange, C. Dugave, 2004, Letters in Peptide Science.

NRPa-308, a new neuropilin-1 antagonist, exerts in vitro anti-angiogenic and anti-proliferative effects and in vivo anti-cancer effects in a mouse xenograft model.

M. Montès, G. Pagès, R. Benhida, 2018, Cancer letters.

Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.

L. Meijer, N. Gresh, O. Lozach, 2013, Bioorganic & medicinal chemistry letters.

The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist

A. Moulin, Jean Martinez, J. Fehrentz, 2013, Amino Acids.

A sweet origin for the key congocidine precursor 4-acetamidopyrrole-2-carboxylate.

G. Challis, Lijiang Song, H. Galons, 2012, Angewandte Chemie.

Conformational analysis of a polyconjugated protein-binding ligand by joint quantum chemistry and polarizable molecular mechanics. Addressing the issues of anisotropy, conjugation, polarization, and multipole transferability

N. Gresh, J. Piquemal, C. Garbay, 2014, Journal of Molecular Modeling.

Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma

M. Montès, G. Pagès, Nathalie Lagarde, 2020, Journal of experimental & clinical cancer research : CR.

New Peptides Structurally Related to VEGF-A165 Exon-7 and -8 Encoded Domains Antagonize Its Binding to NRP-1 and VEGF-R1

O. Hermine, Wang-Qing Liu, C. Garbay, 2015, International Journal of Peptide Research and Therapeutics.

Synthesis and structure-activity relationship of non-peptidic antagonists of neuropilin-1 receptor.

M. Montès, N. Gresh, J. Piquemal, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of new potent inhibitors of CK1 and CDK5, two kinases involved in Alzheimer’s disease

L. Meijer, O. Lozach, H. Galons, 2013, Medicinal Chemistry Research.

Cyanoguanidine as a versatile, eco-friendly and inexpensive reagent for the synthesis of 2-aminobenzoxazoles and 2-guanidinobenzoxazoles

R. Benhida, Luc Demange, C. Ronco, 2018 .

Synthesis and evaluation of Glypsi(PO(2)R-N)Pro-containing pseudopeptides as novel inhibitors of the human cyclophilin hCyp-18.

M. Moutiez, Luc Demange, C. Dugave, 2002, Journal of medicinal chemistry.

cis—trans Isomerization of Organic Molecules and Biomolecules: Implications and Applications

Luc Demange, C. Dugave, 2003 .

Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.

P. Greengard, L. Meijer, M. Flajolet, 2008, Journal of medicinal chemistry.

Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories.

R. Benhida, Luc Demange, C. Ronco, 2017, MedChemComm.

Ultrasound-assisted facile one-pot sequential synthesis of novel sulfonamide-isoxazoles using cerium (IV) ammonium nitrate (CAN) as an efficient oxidant in aqueous medium.

R. Benhida, S. Alaoui, K. Bougrin, 2018, Ultrasonics sonochemistry.