I. Aldana

发表

Studies on Log Po/w of Quinoxaline di-N-Oxides: A Comparison of RP-HPLC Experimental and Predictive Approaches

J. Platts, A. Monge, E. Moreno, 2011, Molecules.

Anti-leishmanial and structure-activity relationship of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives.

M. Sauvain, R. Villar, E. Vicente, 2008, Memorias do Instituto Oswaldo Cruz.

Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies.

A. Monge, I. Aldana, S. Pérez-Silanes, 2012, European journal of medicinal chemistry.

Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors.

L. Meijer, A. Monge, I. Aldana, 2002, Bioorganic & medicinal chemistry.

Selective activity against Mycobacteriumtuberculosis of new quinoxaline 1,4-di-N-oxides.

L. M. Lima, R. Villar, E. Vicente, 2009, Bioorganic & medicinal chemistry.

In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.

S. Franzblau, A. Lenaerts, R. Villar, 2008, The Journal of antimicrobial chemotherapy.

Efficacy of Quinoxaline-2-Carboxylate 1,4-Di-N-Oxide Derivatives in Experimental Tuberculosis

S. Franzblau, A. Lenaerts, R. Villar, 2008, Antimicrobial Agents and Chemotherapy.

Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action.

F. Nicoletti, F. Levy, G. Battaglia, 2011, Journal of medicinal chemistry.

Synthesis of new 2-acetyl and 2-benzoyl quinoxaline 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents.

A. Monge, I. Aldana, B. Zarranz, 2003, European journal of medicinal chemistry.

New 1-Aryl-3-Substituted Propanol Derivatives as Antimalarial Agents

R. García-Sánchez, A. Martínez-Fernández, A. Monge, 2009, Molecules.

A novel class of cardiotonic agents: synthesis and biological evaluation of pyridazino[4,5-b]indoles with cyclic AMP phosphodiesterases inhibiting properties.

A. Monge, M. Font, I. Aldana, 1993, Journal of pharmaceutical sciences.

New Indole and Triazino[5,4‐b]indol‐4‐one Derivatives: Synthesis and Studies as Inotropics and Inhibitors of Blood Platelet Aggregation

A. Monge, M. Font, I. Aldana, 1992, Archiv der Pharmazie.

Synthesis of 3‐amino‐5H‐1,2,3‐triazino[5,4‐b]indol‐4‐one. New compounds with blood platelet antiaggregation activity

A. Monge, I. Aldana, E. Fernández‐Álvarez, 1991 .

Building a MCHR1 homology model provides insight into the receptor-antagonist contacts that are important for the development of new anti-obesity agents.

Anna K. Schrey, R. Kühne, A. Monge, 2010, Bioorganic & medicinal chemistry.

New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities

A. Monge, I. Aldana, S. Pérez-Silanes, 2013, Molecules.

Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives

A. Monge, I. Aldana, S. Pérez-Silanes, 2012, Molecules.

A new NPY-antagonist strongly stimulates apoptosis and lipolysis on white adipocytes in an obesity model.

A. Martí, J. Martínez, J. Margareto, 2000, Life sciences.

Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues.

K. Gates, U. Sarkar, R. Villar, 2007, Journal of medicinal chemistry.

Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates.

N. Romeiro, L. M. Lima, E. Barreiro, 2009, Bioorganic & medicinal chemistry.

Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay.

J. Nicolas, J. Boutin, P. Chomarat, 2005, Cellular signalling.

Synthesis and evaluation of new arylsulfonamidomethylcyclohexyl derivatives as human neuropeptide Y Y5 receptor antagonists for the treatment of obesity.

A. Monge, I. Aldana, Silvia Galiano, 2004, European journal of medicinal chemistry.

In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1 , 4-diN-oxide

S. Franzblau, A. Lenaerts, R. Villar, 2008 .

Synthesis of new oxazolidine, oxazolidin-2-one and perhydro-1,4-oxazine derivatives of arylethanolamine as potential beta3-adrenoceptor agonists

A. Monge, A. Rivero, H. Cerecetto, 1995 .

Combining NMR and molecular modelling in a drug delivery context: investigation of the multi-mode inclusion of a new NPY-5 antagonist bromobenzenesulfonamide into beta-cyclodextrin.

D. Paolino, S. Guccione, A. Monge, 2004, Bioorganic & medicinal chemistry.

3-Trifluoromethylquinoxaline N,N'-dioxides as anti-trypanosomatid agents. Identification of optimal anti-T. cruzi agents and mechanism of action studies.

A. López de Cerain, Diego Benítez, A. Monge, 2011, Journal of medicinal chemistry.

New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents.

R. Villar, A. Monge, E. Moreno, 2010, Bioorganic & medicinal chemistry.

Synthesis of new 2-acetyl and 2-benzoyl quinoxaline 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents.

A. Monge, I. Aldana, B. Zarranz, 2003, European journal of medicinal chemistry.

Novel series of substituted biphenylmethyl urea derivatives as MCH-R1 antagonists for the treatment of obesity.

A. Monge, I. Aldana, G. Rivera, 2007, Bioorganic & medicinal chemistry.

Synthesis of new quinoxaline-2-carboxylate 1,4-dioxide derivatives as anti-Mycobacterium tuberculosis agents.

A. Monge, I. Aldana, B. Zarranz, 2005, Journal of medicinal chemistry.

Synthesis and anticancer activity evaluation of new 2-alkylcarbonyl and 2-benzoyl-3-trifluoromethyl-quinoxaline 1,4-di-N-oxide derivatives.

A. Monge, I. Aldana, B. Zarranz, 2004, Bioorganic & medicinal chemistry.

Quinoxaline N,N'-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi. Structure-activity relationships.

H. Cerecetto, I. Aldana, M. A. Ortega, 2004, Bioorganic & medicinal chemistry letters.

Unexpected Reduction of Ethyl 3-Phenylquinoxaline-2-carboxylate 1,4-Di-N-oxide Derivatives by Amines†

L. M. Lima, E. Vicente, A. Monge, 2007, Molecules.

Synthesis and structure-activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents.

L. M. Lima, R. Villar, E. Vicente, 2008, European journal of medicinal chemistry.

Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues.

D. Hadjipavlou-Litina, E. Pontiki, R. Villar, 2007, Bioorganic & medicinal chemistry letters.

Antihypertensive agents: pyridazino (4,5-b)indole derivatives.

M. Font, I. Aldana, P. Parrado, 1982, Journal of pharmaceutical sciences.

Synthesis of some new derivatives of 4-hydrazino-5H-pyridazino[4,5-b]indole

I. Aldana, A. Monge-Vega, E. Ferández-Alvarez, 1981 .

The synthesis of 11H-1,2,4-triazolo[4,3-b]pyridazino[4,5-b]indoles,11H-tetrazolo[4,5-b]pyridazino[4,5-b]indoles and 1,2,4-triazolo[3,4-f]-1,2,4-triazino[4,5-a]indoles

M. Rabbani, I. Aldana, E. Fernández‐Álvarez, 1980 .

New hydrazine and hydrazide quinoxaline 1,4-di-N-oxide derivatives: In silico ADMET, antiplasmodial and antileishmanial activity.

I. Aldana, E. Deharo, Miguel Quiliano, 2017, Bioorganic & medicinal chemistry letters.

Trypanocidal properties, structure-activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives.

M. Zimic, M. Verástegui, A. Monge, 2011, Experimental parasitology.

Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives.

A. Monge, E. Moreno, Enrique Torres, 2003, European journal of medicinal chemistry.

Heterocyclic-2-carboxylic Acid (3-Cyano-1,4-di-N-oxidequinoxalin-2-yl)amide Derivatives as Hits for the Development of Neglected Disease Drugs

R. Villar, Diego Benítez, A. Monge, 2009, Molecules.

Structure-activity relationship of new antimalarial 1-aryl-3-susbtituted propanol derivatives: Synthesis, preliminary toxicity profiling, parasite life cycle stage studies, target exploration, and targeted delivery.

D. Wright, A. Vettorazzi, A. López de Cerain, 2018, European journal of medicinal chemistry.

Synthesis and Antimalarial Activity of New 3-Arylquinoxaline-2-carbonitrile Derivatives

M. Sauvain, A. Monge, I. Aldana, 2005, Arzneimittelforschung.

1-Hydrazino-4-(3,5-dimethyl-1-pyrazolyl)-5H-pyridazino[4,5-b]indole. A new antihypertensive agent

A. Monge, M. Font, I. Aldana, 1991 .

Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents

A. Monge, I. Aldana, S. Pérez-Silanes, 2014, Molecules.

Antiplasmodial structure-activity relationship of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives.

M. Sauvain, E. Vicente, A. Monge, 2008, Experimental parasitology.

Derivados de 1,4-di-N-óxido de quinoxalina y enfermedades olvidadas

R. Villar, I. Aldana, B. Solano, 2007 .

New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterium tuberculosis agents.

A. Monge, E. Moreno, Enrique Torres, 2011, Bioorganic & medicinal chemistry letters.

1,4-Di-N-oxide quinoxaline-2-carboxamide: Cyclic voltammetry and relationship between electrochemical behavior, structure and anti-tuberculosis activity

A. Monge, E. Moreno, Enrique Torres, 2011 .

Substitutions of Fluorine Atoms and Phenoxy Groups in the Synthesis of Quinoxaline 1,4-di-N-oxide Derivatives†

R. Villar, E. Vicente, A. Monge, 2007, Molecules.

Novel antimalarial chloroquine- and primaquine-quinoxaline 1,4-di-N-oxide hybrids: Design, synthesis, Plasmodium life cycle stage profile, and preliminary toxicity studies.

A. Vettorazzi, L. Corcuera, D. Mazier, 2018, European journal of medicinal chemistry.

Synthesis and Biological Evaluation of New Quinoxaline Derivatives as Antioxidant and Anti‐Inflammatory Agents

D. Hadjipavlou-Litina, E. Pontiki, R. Villar, 2011, Chemical biology & drug design.

Primaquine–quinoxaline 1,4-di-N-oxide hybrids with action on the exo-erythrocytic forms of Plasmodium induce their effect by the production of reactive oxygen species

I. Aldana, Miguel Quiliano, Silvia Galiano, 2019, Malaria Journal.

Synthesis and Antiplasmodial Activity of 3-Furyl and 3-Thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives †

R. Villar, E. Vicente, A. Monge, 2008, Molecules.

Comparative use of solvent-free KF-A12O3 and K2CO3 in acetone in the synthesis of quinoxaline 1,4-dioxide derivatives designed as antimalarial drug candidates

L. M. Lima, A. Marin, E. Vicente, 2005 .

Quinoxaline 1,4-di-N-oxide and the potential for treating tuberculosis.

R. Villar, E. Vicente, R. Goldman, 2011, Infectious disorders drug targets.

Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives

L. M. Lima, M. Sauvain, A. Monge, 2006 .

Synthesis and Structure—Activity Relationship of 3-Phenylquinoxaline 1,4-Di-N-oxide Derivatives as Antimalarial Agents.

I. Aldana, 2009 .

Comparative Use of Solvent‐Free KF‐Al2O3 and K2CO3 in Acetone in the Synthesis of Quinoxaline 1,4‐Dioxide Derivatives Designed as Antimalarial Drug Candidates.

L. M. Lima, A. Marin, E. Vicente, 2006 .

Anti-malarial activity of some 7-chloro-2-quinoxalinecarbonitrile-1,4-di-N-oxide derivatives.

A. Giménez, A. Monge, I. Aldana, 2003, Die Pharmazie.

Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives.

A. Monge, I. Aldana, B. Zarranz, 2003, Bioorganic & medicinal chemistry.

Anti-Mycobacterium tuberculosis Agents Derived from Quinoxaline-2-carbonitrile and Quinoxaline-2-carbonitrile 1,4-di-N-oxide

A. Monge, I. Aldana, M. A. Ortega, 2002, Arzneimittelforschung.

Antimycobacterial activity of new quinoxaline-2-carbonitrile and quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives.

I. Tirapu, A. Monge, I. Aldana, 2001, Die Pharmazie.

Cyclic Voltammetric Study of Some Anti-Chagas-Active 1,4-Dioxidoquinoxalin-2-yl Ketone Derivatives

A. Monge, Enrique Torres, I. Aldana, 2013 .

Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents.

A. Monge, H. Cerecetto, Enrique Torres, 2013, European journal of medicinal chemistry.

Alsinol, an arylamino alcohol derivative active against Plasmodium, Babesia, Trypanosoma, and Leishmania: past and new outcomes

D. Stien, J. Sorres, V. Eparvier, 2020, Parasitology Research.

Antihypertensive and vasodilator effect of A-80b, a new pyridazino indole derivative.

A. Monge, M. Font, I. Aldana, 1992, European journal of pharmacology.

ImmunoPEGliposomes for the targeted delivery of novel lipophilic drugs to red blood cells in a falciparum malaria murine model.

X. Fernàndez-Busquets, P. Gomes, I. Aldana, 2017, Biomaterials.

Benzo[1, 2‐c]1, 2, 5‐oxadiazole N‐Oxide Derivatives as Potential Antitrypanosomal Drugs. Structure‐Activity Relationships. Part II

A. Denicola, G. Seoane, A. Monge, 2002, Archiv der Pharmazie.

New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands

D. Caignard, P. Delagrange, A. Monge, 2012, Molecules.

New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities.

M. Zimic, A. Monge, I. Aldana, 2011, Bioorganic & medicinal chemistry letters.

Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure-activity relationships.

M. Zimic, A. Monge, I. Aldana, 2011, Experimental parasitology.

Determination of a new hypoxia selective agent from 2-quinoxalinecarbonitrile 1,4-di-N-oxides in plasma by high performance liquid chromatography.

E. González-Peñas, A. Monge, C. Dios-Vieítez, 1997, Arzneimittel-Forschung.

Physico-chemical properties and stability of the new hypoxia-selective agent 7-chloro-3-[[N,N-dimethylamino)propyl]amino]-2-quinoxalinecarbonitrile 1,4-di-N-oxide hydrochloride.

A. Monge, I. Aldana, C. Bachiller, 1997, Arzneimittel-Forschung.

Benzo[1,2‐c]1,2,5‐oxadiazole N‐Oxide Derivatives as Potential Antitrypanosomal Drugs. Structure—Activity Relationships. Part 2.

A. Denicola, G. Seoane, A. Monge, 2002 .

Synthesis and evaluation of new hydrazide derivatives as neuropeptide Y Y5 receptor antagonists for the treatment of obesity.

A. Monge, I. Aldana, Silvia Galiano, 2004, Bioorganic & medicinal chemistry.

Synthesis of new thiophene and benzo[b]thiophene hydrazide derivatives as human NPY Y(5) antagonists.

A. Monge, I. Aldana, Silvia Galiano, 2004, Bioorganic & medicinal chemistry letters.

New 5H-pyridazino[4,5-b]indole derivatives. Synthesis and studies as inhibitors of blood platelet aggregation and inotropics.

A. Monge, M. Font, I. Aldana, 1991, Journal of medicinal chemistry.

Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration

B. Dunn, D. Wright, A. Vettorazzi, 2016, International journal for parasitology. Drugs and drug resistance.

New 5H‐Pyridazino(4,5‐b)indole Derivatives. Synthesis and Studies as Inhibitors of Blood Platelet Aggregation and Inotropics.

A. Monge, M. Font, I. Aldana, 1992 .

Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity.

Virgilio Bocanegra-García, Nuria Cirauqui, A. Monge, 2008, Current medicinal chemistry.

New quinoxaline 1,4-di-N-oxide derivatives: Trypanosomaticidal activities and enzyme docking simulation

M. Zimic, M. Verástegui, A. Monge, 2011 .

Novel Human Neuropeptide Y Y5 Receptor Antagonists for the Treatment of Obesity

A. Monge, I. Aldana, Silvia Galiano, 2005, Arzneimittelforschung.

New Amide Derivatives as Melanin-concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity

A. Monge, I. Aldana, S. Pérez-Silanes, 2008, Arzneimittel-Forschung (Drug Research).

The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine.

I. Aldana, E. Deharo, Miguel Quiliano, 2012, Memorias do Instituto Oswaldo Cruz.