M. Zappalà

发表

Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives.

Angela Rao, Maria Zappalà, Pietro Monforte, 2002, Farmaco.

Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening.

A. Bitto, D. Altavilla, E. Novellino, 2016, European journal of medicinal chemistry.

Immunoproteasome‐selective and non‐selective inhibitors: A promising approach for the treatment of multiple myeloma

A. Allegra, C. Musolino, V. Innao, 2017, Pharmacology & therapeutics.

Peptidyl Vinyl Ketones Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment.

U. Hellmich, T. Schirmeister, S. Cosconati, 2020, ChemMedChem.

Development of Novel Benzodiazepine‐Based Peptidomimetics as Inhibitors of Rhodesain from Trypanosoma brucei rhodesiense

T. Schirmeister, S. Cosconati, M. Zappalà, 2020, ChemMedChem.

Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

T. Schirmeister, M. D. Di Francesco, E. Nizi, 2008, Journal of medicinal chemistry.

Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.

E. De Clercq, C. Pannecouque, J. Balzarini, 2001, Bioorganic & medicinal chemistry letters.

Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.

E. De Clercq, C. Pannecouque, J. Balzarini, 2002, Journal of Medicinal Chemistry.

Azirino[1, 2-d][1, 4]benzodiazepine derivatives and related 1,4-benzodiazepines as anticonvulsant agents in DBA/2 mice.

G. De Sarro, A. De Sarro, A. Chimirri, 1996, General pharmacology.

Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines.

A. Chimirri, M. Zappalà, S. Grasso, 1993, General pharmacology.

Development of Novel Peptidomimetics Containing a Vinyl Sulfone Moiety as Proteasome Inhibitors

T. Schirmeister, M. Zappalà, R. Ettari, 2011, ChemMedChem.

Peptide‐Based Proteasome Inhibitors in Anticancer Drug Design

M. Zappalà, R. Ettari, S. Grasso, 2014, Medicinal research reviews.

Synthesis and antitumor activity of 1,3-benzodioxole derivatives.

M. Zappalà, S. Grasso, N. Micale, 2002, Farmaco.

Optimization strategy of novel peptide-based Michael acceptors for the treatment of Human African Trypanosomiasis.

U. Hellmich, T. Schirmeister, S. Cosconati, 2019, Journal of medicinal chemistry.

Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats

G. Sarro, A. Sarro, M. Zappalà, 1997, Naunyn-Schmiedeberg's Archives of Pharmacology.

7‐Chloro‐1‐(2,6‐difluorophenyl)‐1H,3H‐thiazolo[3,4‐a]benzimidazole and 1‐(2,6‐difluorophenyl)‐6‐methyl‐1H,3H‐thiazolo[3,4‐a]benzimidazole

R. Scopelliti, A. Rao, M. Zappalà, 2001 .

Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors

T. Schirmeister, S. Cosconati, M. Zappalà, 2016, Journal of enzyme inhibition and medicinal chemistry.

Preparation and physico-chemical study of inclusion complexes between idebenone and modifiedβ-cyclodextrins

G. Cavallaro, M. Fresta, G. Cavallaro, 1996 .

Synthesis and Cytotoxicity of Diarylpentanoids against Sensitive CCRF‐CEM and Multidrug‐Resistant CEM/ADR5000 Leukemia Cells

T. Efferth, T. Schirmeister, M. Zappalà, 2021, Chemistry & biodiversity.

Selective induction of apoptosis in multidrug resistant HL60R cells by the thiazolobenzoimidazole derivative 1-(2,6-difluorophenyl)-1H,3H-thiazolo [3,4-a] benzimidazole (TBZ).

N. D’alessandro, A. Chimirri, M. Tolomeo, 1998, European journal of cancer.

Drug combination studies of PS-1 and quercetin against rhodesain of Trypanosoma brucei rhodesiense

A. Allegra, M. Zappalà, R. Ettari, 2021, Natural product research.

A physico-chemical study on the interaction between papaverine and natural and modified β-cyclodextrins

C. A. Ventura, G. Mazzone, G. Puglisi, 1998 .

Design and NMR conformational analysis in solution of β5i-selective inhibitors of immunoproteasome

A. Allegra, A. Rotondo, M. Zappalà, 2020 .

Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense

T. Schirmeister, Marta Bogacz, M. Zappalà, 2022, International journal of molecular sciences.

Development of novel 1,4-benzodiazepine-based Michael acceptors as antitrypanosomal agents.

T. Schirmeister, S. Cosconati, M. Zappalà, 2016, Bioorganic & medicinal chemistry letters.

Synthesis of benzothiazole derivatives and their biological evaluation as anticancer agents

A. Schimmer, M. Zappalà, S. Grasso, 2012, Medicinal Chemistry Research.

5H-[1,2,4]Oxadiazolo[5,4-d][1,5]benzothiazepines as anticonvulsant agents in DBA/2 mice

R. Gitto, A. Chimirri, G. Sarro, 1995 .

Anticonvulsant activity of pyrrolo[1',2':1,2]imidazo[4,5-b]pyridines, pyrrolo[2',1':2,3]imidazo[4,5-c] pyridines and pyrrolo[2,1-f]purines in DBA/2 mice.

G. De Sarro, A. De Sarro, A. Chimirri, 1994, General pharmacology.

Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors

Christin Müller, J. Ziebuhr, S. Di Maro, 2022, European Journal of Medicinal Chemistry.

Synthesis and stereochemistry of novel [1,2,4]oxadiazolo[4,5‐a][1,5]benzodiazepine derivatives

R. Ottanà, A. Chimirri, M. Zappalà, 1990 .

Thieno [3,4-b] [1,4] diazepines : synthesis and stereochemistry

R. Gitto, A. Chimirri, M. Zappalà, 1992 .

Annelated 1,5-Benzothiazepines

R. Gitto, A. Chimirri, A. Monforte, 1995 .

Synthesis and structural characteristics of novel 5H-thiazolo[2,3-d][1,5]benzothiazepine derivatives

R. Scopelliti, R. Gitto, A. Chimirri, 1997 .

Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors.

T. Schirmeister, S. Giofrè, M. Zappalà, 2011, European journal of medicinal chemistry.

Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents.

A. Chishti, Ajay Kumar, A. Kozikowski, 2006, Journal of medicinal chemistry.

Pyrrolo[1',2':1,2]imidazo[4,5-b]pyridines, pyrrolo- [2',1':2,3]imidazo[4,5-c]pyridines and pyrrolo[2,1-f]purines as potential benzodiazepine ligands.

G. Genchi, A. Chimirri, P. Monforte, 1993, Farmaco.

Synthesis of New Potential HIV-1 Integrase Inhibitors

Z. Debyser, M. Witvrouw, S. Ferro, 2004 .

Synthesis and in vitro anti-HIV activity of novel delta 2-1,2,4-oxadiazoline derivatives.

A. Carotti, A. Chimirri, A. Monforte, 1994, Farmaco.

Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.

M. Baraldi, G. De Sarro, A. De Sarro, 2000, Journal of medicinal chemistry.

Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones.

G. De Sarro, A. De Sarro, R. Gitto, 2000, Journal of medicinal chemistry.

Synthesis and anti-hIV activity of 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole structurally-related 1,2-substituted benzimidazoles.

E. De Clercq, C. Pannecouque, A. Chimirri, 2002, Farmaco.

Synthesis and Biological Activity of Novel 1H,3H-Thiazolo[3,4-a]Benzimidazoles: Non-nucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors

E. De Clercq, C. Pannecouque, J. Balzarini, 1999, Antiviral chemistry & chemotherapy.

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.

Myriam Witvrouw, Zeger Debyser, Angela Rao, 2005, Journal of medicinal chemistry.

Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents.

Jan Balzarini, Angela Rao, Maria Zappalà, 2004, Farmaco.

Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]quinazolines.

A. Monforte, P. Monforte, M. Zappalà, 2000, European journal of medicinal chemistry.

Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats

G. De Sarro, A. De Sarro, A. Sarro, 1995, Antimicrobial agents and chemotherapy.

1-aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents.

F. Menniti, G. De Sarro, C. De Micheli, 2003, Bioorganic & medicinal chemistry letters.

Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: identification of the 1-(4-amino-3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent.

A. Cagnotto, T. Mennini, M. Zappalà, 2008, Bioorganic & medicinal chemistry.

Microwave-induced synthesis of benzimidazole and thiazolidinone derivatives as HIV-1 RT inhibitors

S. Ferro, A. Chimirri, A. Rao, 2004 .

2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2004, Antiviral research.

Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones.

Angela Rao, Maria Zappalà, Pietro Monforte, 2003, Farmaco.

1‐Aryl‐6,7‐methylenedioxy‐3H‐quinazolin‐4‐ones as Anticonvulsant Agents.

F. Menniti, G. Sarro, M. Zappalà, 2004 .

Anti-HIV agents: design and discovery of new potent RT inhibitors.

E. De Clercq, L. De Luca, M. Barreca, 2003, Farmaco.

Anti-HIV agents. V. Synthesis, structure and in vitro anti-HIV activity of novel 1H,3H-naphtho[2',3':4,5]imidazo[1,2-c]thiazoles.

R. Scopelliti, A. Chimirri, A. Rao, 1997, Farmaco.

Synthesis of benzothiazole derivatives and their biological evaluation as anticancer agents

A. Schimmer, M. Zappalà, S. Grasso, 2011, Medicinal Chemistry Research.

Synthesis and Structural Features of New Cyclofunctionalized Benzimidazoles

A. Chimirri, A. Rao, A. Monforte, 2000 .

Synthesis of Novel 3‐(Alkylcarbamoyl)‐2‐aryl‐1,2‐dihydro‐6,7‐(methylenedioxy)‐3H‐quinazolin‐4‐ones as Anticonvulsant Agents

M. Zappalà, S. Grasso, G. Zuccalà, 2006, Chemistry & biodiversity.

Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors.

M. Leippe, T. Schirmeister, C. Gelhaus, 2010, Bioorganic & medicinal chemistry.

Synthesis and anti‐HIV Activity of 1‐(2,6‐Difluorophenyl)‐1H,3H‐thiazolo[3,4‐a]benzimidazole Structurally‐Related 1,2‐Substituted Benzimidazoles.

C. Pannecouque, E. Clercq, A. Chimirri, 2003 .

Synthesis, Structure and in Vitro Anti-Human Immunodeficiency virus Activity of Novel 3-Methyl-1H,3H-Thiazolo[3,4-a]Benzimidazoles

E. De Clercq, C. Pannecouque, M. Witvrouw, 1998, Antiviral chemistry & chemotherapy.

Structural Features and Anti-Human Immunodeficiency Virus (HIV) Activity of the Isomers of 1-(2′,6′-Difluorophenyl)-1H,3H-Thiazolo[3,4-a]Benzimidazole, a Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor

E. De Clercq, J. Balzarini, M. Witvrouw, 1997 .

Anti-HIV agents. IV. Synthesis and in vitro anti-HIV activity of novel 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazoles.

R. Scopelliti, A. Chimirri, A. Monforte, 1996, Farmaco.

Anti-HIV agents II. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles.

A. Chimirri, A. Monforte, P. Monforte, 1991, Farmaco.

Synthesis and cytotoxic activity of 1,3-benzodioxole derivatives. Note II.

M. Zappalà, S. Grasso, N. Micale, 2003, Farmaco.

Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.

Jan Balzarini, Angela Rao, Maria Zappalà, 2005, Journal of medicinal chemistry.

Falcipain‐2 inhibitors

M. Zappalà, R. Ettari, S. Grasso, 2010, Medicinal research reviews.

Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain‐2 Inhibitors

T. Schirmeister, E. Nizi, M. Zappalà, 2008, ChemMedChem.

Annelated 1,5-Benzodiazepines. Part 1. Three, Four, and Five membered Rings

R. Gitto, A. Chimirri, A. Monforte, 1993 .

Annelated 1,5-Benzodiazepines. Part II. Six Membered Rings

R. Gitto, A. Chimirri, A. Monforte, 1993 .

Enantioselective recognition of 2,3-benzodiazepin-4-one derivatives with anticonvulsant activity on several polysaccharide chiral stationary phases.

S. Alcaro, P. Ficarra, R. Ficarra, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Efficient 3D Database Screening for Novel HIV-1 IN Inhibitors

Myriam Witvrouw, Zeger Debyser, M. Letizia Barreca, 2004, J. Chem. Inf. Model..

Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors.

M. Leippe, T. Schirmeister, A. Evers, 2009, Bioorganic & medicinal chemistry.

Synthesis and Cytotoxic Activity of 1,3-Benzodioxole Derivatives. Part 2.

M. Zappalà, S. Grasso, N. Micale, 2003 .

Quinolones potentiate cefazolin-induced seizures in DBA/2 mice

G. De Sarro, A. De Sarro, A. Chimirri, 1993, Antimicrobial Agents and Chemotherapy.

A SIMPLE AND EFFICIENT SYNTHESIS OF GYKI 52466 AND GYKI 52895

C. De Micheli, M. Zappalà, S. Grasso, 2002 .

Synthesis and anticonvulsant properties of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-ones.

G. De Sarro, G. Trimarchi, A. De Sarro, 1989, Journal of medicinal chemistry.

Synthesis, Biological Activity, Pharmacokinetic Properties and Molecular Modelling Studies of Novel 1H,3H-Oxazolo[3,4-a]Benzimidazoles: Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

E. De Clercq, C. Pannecouque, G. De Sarro, 2001, Antiviral chemistry & chemotherapy.

Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain‐2 Inhibitors

Maria Zappalà, Giovanni Grazioso, Tanja Schirmeister, 2012, ChemMedChem.

Glutamate binding-site ligands of NMDA receptors.

M. Zappalà, R. Ettari, S. Grasso, 2011, Current medicinal chemistry.

AMPA receptor antagonists

R. Gitto, A. Chimirri, M. Zappalà, 1999 .

Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain

T. Schirmeister, S. Cosconati, Marta Bogacz, 2022, ACS medicinal chemistry letters.

Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents

E. Novellino, A. Lavecchia, T. Schirmeister, 2014, ChemMedChem.

Anti-HIV agents. I: Synthesis and in vitro anti-HIV evaluation of novel 1H,3H-thiazolo[3,4-a]benzimidazoles.

A. Chimirri, A. Monforte, P. Monforte, 1991, Farmaco.

Structural features and anti-human immunodeficiency virus (HIV) activity of the isomers of 1-(2',6'-difluorophenyl)-l H,3H-thiazo lo(3,4-a)benzimidazole, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor

J. Balzarini, A. Chimirri, P. Monforte, 1997 .

Non-covalent immunoproteasome inhibitors induce cell cycle arrest in multiple myeloma MM.1R cells

A. Bitto, N. Irrera, D. Altavilla, 2019, Journal of enzyme inhibition and medicinal chemistry.

The beautiful “Trionfo d’Amore” attributed to Botticelli: a chemical characterisation by proton-induced X-ray emission and micro-Raman spectroscopy

Marina Bicchieri, M. Nardone, Armida Sodo, 2001 .

Synthesis and anticonvulsant properties of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-one derivatives.

G. De Sarro, A. De Sarro, R. Gitto, 2001, Farmaco.

Synthesis and structure-activity relationships of 2,3-benzodiazepines as AMPA receptor antagonists.

C. De Micheli, M. Zappalà, S. Grasso, 2001, Mini reviews in medicinal chemistry.

Enantioseparation, absolute configuration determination, and anticonvulsant activity of (+/-)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-one.

G. De Sarro, P. Ficarra, M. Zappalà, 2007, Chirality.

Synthesis, chiral resolution, and enantiopharmacology of a potent 2,3-benzodiazepine derivative as noncompetitive AMPA receptor antagonist.

F. Menniti, G. De Sarro, G. Roda, 2006, Journal of medicinal chemistry.

New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists.

F. Menniti, G. De Sarro, C. De Micheli, 2006, Bioorganic & medicinal chemistry letters.

Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents.

F. Menniti, G. De Sarro, M. Zappalà, 2005, Farmaco.

Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists.

F. Menniti, C. Costagli, A. Galli, 2003, Bioorganic & medicinal chemistry letters.

ChemInform Abstract: Synthesis and Structure-Activity Relationships of 2,3-Benzodiazepines as AMPA Receptor Antagonists.

M. Zappalà, S. Grasso, N. Micale, 2002 .

Development of novel N-3-bromoisoxazolin-5-yl substituted 2,3-benzodiazepines as noncompetitive AMPAR antagonists.

M. Zappalà, R. Ettari, S. Grasso, 2017, Bioorganic & medicinal chemistry.

Compounds with potential anti-tumor activity. VII: Synthesis and anti-tumor activity of 1-aryl-N,N'-di(1,3,4-thiadiazol-2-yl)methylenediamines

A. Chimirri, P. Monforte, M. Zappalà, 1989 .

Anticonvulsant Activity and Plasma Level of 2,3-Benzodiazepin-4-ones (CFMs) in Genetically Epilepsy-Prone Rats

R. Gitto, A. Chimirri, G. Sarro, 1999, Pharmacology Biochemistry and Behavior.

Determination of 2,3-benzodiazepine derivatives in rat plasma by high-performance liquid chromatography.

G. De Sarro, R. Gitto, A. Chimirri, 1999, Journal of chromatography. A.

Relationship Between Anticonvulsant Activity and Plasma Level of Some 2,3-Benzodiazepines in Genetically Epilepsy-Prone Rats

R. Gitto, A. Chimirri, G. Sarro, 1998, Pharmacology Biochemistry and Behavior.

3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists.

A. Constanti, V. Libri, G. De Sarro, 1998, Journal of medicinal chemistry.

1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.

A. Constanti, V. Libri, G. De Sarro, 1997, Journal of medicinal chemistry.

Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3‐Benzodiazepine‐Derived Noncompetitive AMPA Receptor Antagonist

T. Mennini, P. Ficarra, M. Zappalà, 2009, ChemMedChem.

New 7,8‐Ethylenedioxy‐2,3‐benzodiazepines as Noncompetitive AMPA Receptor Antagonists.

F. Menniti, G. Sarro, M. Zappalà, 2006 .

Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists.

M. Baraldi, G. Puia, G. De Sarro, 1999, Journal of medicinal chemistry.

7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists.

G. De Sarro, A. De Sarro, R. Gitto, 1998, Bioorganic & medicinal chemistry letters.

Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agents.

G. Puia, G. De Sarro, C. De Micheli, 2004, Bioorganic & medicinal chemistry.

Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters.

G. De Sarro, L. Toma, A. De Sarro, 2002, Journal of medicinal chemistry.

Synthesis and anticonvulsant activity of novel and potent 1-aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-ones.

M. Baraldi, G. Puia, G. De Sarro, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists.

G. De Sarro, A. De Sarro, R. Gitto, 1999, Farmaco.

Aminopyrazinyl derivatives: synthesis and evaluation of antiinflammatory and related activities.

R. Ottanà, M. Vigorita, M. Zappalà, 1994, Farmaco.

Compounds with Potential Antitumor Activity. Part 7. Synthesis and Antitumor Activity of 1‐Aryl‐N,N′‐di(1,3,4‐thiadiazol‐2‐yl)methylenediamines.

A. Chimirri, A. Monforte, P. Monforte, 1989 .

Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation.

E. Novellino, Valeria La Pietra, L. Marinelli, 2015, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of Papain‐Family Cathepsin L‐Like Cysteine Protease Inhibitors Containing a 1,4‐Benzodiazepine Scaffold as Antiprotozoal Agents

T. Schirmeister, N. Capodicasa, A. Pinto, 2014, ChemMedChem.

Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis

U. Hellmich, T. Schirmeister, S. Cosconati, 2022, Molecules.

Dual Inhibition of Parasitic Targets: a Valuable Strategy to Treat Malaria and Neglected Tropical Diseases.

M. Zappalà, R. Ettari, S. Previti, 2021, Current medicinal chemistry.

Immunoproteasome and Non-Covalent Inhibition: Exploration by Advanced Molecular Dynamics and Docking Methods

M. Tutone, M. Zappalà, R. Ettari, 2021, Molecules.

G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives.

F. Da Settimo, S. Taliani, M. Zappalà, 2016, Journal of medicinal chemistry.

NMR characterization and conformational analysis of a potent papain-family cathepsin L-like cysteine protease inhibitor with different behaviour in polar and apolar media

A. Rotondo, M. Zappalà, R. Ettari, 2014 .

Monoclonal Antibodies: The Greatest Resource to Treat Multiple Myeloma

A. Allegra, M. Zappalà, R. Ettari, 2023, International journal of molecular sciences.

Determination of new 2,3-benzodiazepines in rat plasma using high-performance liquid chromatography with ultraviolet detection.

G. De Sarro, A. Chimirri, M. Zappalà, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Microwave-assisted synthesis of benzimidazole and thiazolidinone derivatives as HIV-1 RT inhibitors

S. Ferro, A. Chimirri, A. Rao, 2006 .

Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors.

E. Novellino, A. Lavecchia, T. Schirmeister, 2014, European journal of medicinal chemistry.

Identification of a new series of amides as non-covalent proteasome inhibitors.

E. Novellino, A. Lavecchia, T. Schirmeister, 2014, European journal of medicinal chemistry.

Development of peptidomimetic boronates as proteasome inhibitors.

E. Novellino, A. Lavecchia, T. Schirmeister, 2013, European journal of medicinal chemistry.

Conservation of Acid Paper: Studies Carried out in the Chemistry Laboratory of the Istituto Centrale per la Patologia del Libro

M. Zappalà, 1997 .

NMR conformational analysis in solution of a potent class of cysteine proteases inhibitors

A. Rotondo, M. Zappalà, R. Ettari, 2015, Structural Chemistry.

A Simple, One-Pot Synthesis of Novel 1 H , 3 H -Thiazolo-[3,4- a ]benzimidazoles

A. Chimirri, P. Monforte, M. Zappalà, 1988 .

Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.

M. Leippe, T. Schirmeister, M. D. Di Francesco, 2009, Journal of medicinal chemistry.

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

J. Gut, P. Rosenthal, U. Hellmich, 2017, Journal of medicinal chemistry.

Influence of amino acid size at the P3 position of N-Cbz-tripeptide Michael acceptors targeting falcipain-2 and rhodesain for the treatment of malaria and human african trypanosomiasis.

T. Schirmeister, J. Legac, Marta Bogacz, 2023, Bioorganic chemistry (Print).

Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening

T. Schirmeister, S. Cosconati, A. Messere, 2021, J. Chem. Inf. Model..

Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain.

M. Leippe, T. Schirmeister, A. Evers, 2010, European journal of medicinal chemistry.

Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense.

U. Hellmich, T. Schirmeister, S. Cosconati, 2022, European journal of medicinal chemistry.

Falcipain-2 and falcipain-3 inhibitors as promising antimalarial agents.

M. Zappalà, R. Ettari, S. Previti, 2020, Current medicinal chemistry.

The Inhibition of Cysteine Proteases Rhodesain and TbCatB: A Valuable Approach to Treat Human African Trypanosomiasis.

L. Tamborini, M. Zappalà, R. Ettari, 2016, Mini reviews in medicinal chemistry.

Development of Novel Amides as Noncovalent Inhibitors of Immunoproteasomes

A. Bitto, E. Novellino, A. Lavecchia, 2019, ChemMedChem.

High-performance liquid chromatographic determination of new 2,3-benzodiazepines.

G. De Sarro, R. Gitto, A. Chimirri, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Development of isoquinolinone derivatives as immunoproteasome inhibitors.

N. Iraci, M. Zappalà, R. Ettari, 2021, Bioorganic & medicinal chemistry letters.

Immunoproteasome-Selective Inhibitors: A Promising Strategy to Treat Hematologic Malignancies, Autoimmune and Inflammatory Diseases.

A. Bitto, M. Zappalà, R. Ettari, 2016, Current Medicinal Chemistry.

Anti-HIV agents. III. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]imidazo[4,5-b]pyridines.

A. Chimirri, P. Monforte, M. Zappalà, 1994, Farmaco.

Blunting Neuroinflammation by Targeting the Immunoproteasome with Novel Amide Derivatives

A. Bitto, N. Irrera, M. Zappalà, 2023, International journal of molecular sciences.

Virtual Screening Strategy and In Vitro Tests to Identify New Inhibitors of the Immunoproteasome

M. Tutone, Ugo Perricone, M. Zappalà, 2023, International Journal of Molecular Sciences.

Identification of 2-thioxoimidazolidin-4-one derivatives as novel noncovalent proteasome and immunoproteasome inhibitors.

A. Bitto, R. Maccari, R. Ottanà, 2017, Bioorganic & medicinal chemistry letters.

4,5-Dihydro-7,8-dimethoxy-1-phenyl-3H-2,3-benzodiazepin-4-one.

R. Gitto, A. Rotondo, M. Zappalà, 2001, Acta crystallographica. Section C, Crystal structure communications.

Synthesis and Structural Features of 11H-Tetrazolo〔1,5-c〕〔2,3〕benzodiazepines

R. Gitto, A. Chimirri, F. Bevacqua, 1999 .

1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.

A. Constanti, V. Libri, G. De Sarro, 1997, Journal of Medicinal Chemistry.

Chromatographic determination of 7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones in rat plasma: relationship to their anticonvulsant activity.

G. De Sarro, M. Zappalà, S. Grasso, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Synthesis and antitumor activity evaluation of Delta2-1,2,4-oxadiazoline derivatives.

A. Chimirri, A. Rao, A. Monforte, 1996, Il Farmaco.

Drug Synergism: Studies of Combination of RK-52 and Curcumin against Rhodesain of Trypanosoma brucei rhodesiense.

A. Allegra, T. Schirmeister, M. Zappalà, 2020, ACS medicinal chemistry letters.

Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense

A. Allegra, T. Schirmeister, M. Zappalà, 2023, International journal of molecular sciences.

Synthesis and characterization in solid and solution of trans-dichloro-1-(2', 6'-difluorophenyl)-1H,3H-thiazolo [3,4-a]-benzimidazole(tri-n-propyl-phosphine)-palladium(II)": a palladium(II) complex of a ligand with anti-HIV properties.

A. Giannetto, M. Cusumano, M. Zappalà, 1997, Journal of inorganic biochemistry.

Synthesis and antitumor activity evaluation of Delta2-1,2,4-oxadiazoline derivatives.

A. Chimirri, A. Rao, A. Monforte, 1996, Farmaco.

Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain‐2 Inhibitors

T. Schirmeister, E. Nizi, M. Zappalà, 2008, ChemMedChem.

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

J. Gut, P. Rosenthal, U. Hellmich, 2017, Journal of medicinal chemistry.

Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.

Jan Balzarini, Laura De Luca, Maria Zappalà, 2002, Journal of medicinal chemistry.

Synthesis and Stereochemistry of Novel (1,2,4)Oxadiazolo(4,5-a)(1,5)benzodiazepine Derivatives.

R. Ottanà, A. Chimirri, M. Zappalà, 1990 .

Identification of Dual Inhibitors Targeting Main Protease (Mpro) and Cathepsin L as Potential Anti-SARS-CoV-2 Agents

S. Cosconati, M. Zappalà, R. Ettari, 2024, ACS Medicinal Chemistry Letters.