W. Keck

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Gene expression changes triggered by exposure of Haemophilus influenzae to novobiocin or ciprofloxacin: combined transcription and translation analysis.

W Keck, C. Gray, H. Gmuender, 2001, Genome research.

Mini-review F-actin Bundles Are Derivatives of Microvilli: What Does This Tell Us about How Bundles Might Form? the Fruit Fly Bristle, a Thorn in Our Side Address Correspondence To

D. DeRosier, L. G. Tilney, W. Keck, 2022 .

Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress

M. Ackermann, U. Jenal, D. Ritz, 2009, Molecular microbiology.

Penicillin‐binding protein 4 of Escherichia coli: molecular cloning of the dacB gene, controlled overexpression, and alterations in murein composition

W. Keck, B. Korat, H. Mottl, 1991, Molecular microbiology.

Deletion of an additional domain located between SXXK and SXN active-site fingerprints in penicillin-binding protein 4 from Escherichia coli

J. Wierenga, W. Keck, H. Mottl, 1992, Journal of bacteriology.

Possible role of Escherichia coli penicillin-binding protein 6 in stabilization of stationary-phase peptidoglycan

M. P. van der Linden, W. Keck, L. de Haan, 1992, Journal of bacteriology.

Cytoplasmic high-level expression of a soluble, enzymatically active form of the Escherichia coli penicillin-binding protein 5 and purification by dye chromatography.

M. P. van der Linden, W. Keck, H. Mottl, 1992, European journal of biochemistry.

The monofunctional glycosyltransferase of Escherichia coli is a member of a new class of peptidoglycan‐synthesising enzymes

D. Stüber, M. Di Berardino, W. Keck, 1996, FEBS letters.

Acquisition of Five High-MrPenicillin-Binding Protein Variants during Transfer of High-Level β-Lactam Resistance from Streptococcus mitis toStreptococcus pneumoniae

L. Gutmann, M. P. van der Linden, R. Hakenbeck, 1998, Journal of bacteriology.

C. Gray, M. Meyer, H. Langen, 2001 .

Use of Genomics To Identify Bacterial Undecaprenyl Pyrophosphate Synthetase: Cloning, Expression, and Characterization of the Essential uppS Gene

M. Fountoulakis, M. Stieger, C. Apfel, 1999, Journal of bacteriology.

C. Gray, M. Meyer, H. Langen, 2001, Proteomics.

G(Anh)MTetra, a natural bacterial cell wall breakdown product, induces interleukin-1 beta and interleukin-6 expression in human monocytes. A study of the molecular mechanisms involved in inflammatory cytokine expression.

E. Vellenga, W. Keck, W. Dokter, 1994, The Journal of biological chemistry.

Analysis of penicillin-binding sites with a micro method — The binding site of PBP 5 from Escherichia coli

U. Schwarz, B. Glauner, W. Keck, 1984 .

Properties and crystallization of a genetically engineered, water-soluble derivative of penicillin-binding protein 5 of Escherichia coli K12.

J. Ghuysen, U. Schwarz, P. Charlier, 1988, European journal of biochemistry.

Identification of CSPa Clients Reveals aR ole in Dynamin 1R egulation

S. Chandra, C. Colangelo, S. Ginsberg, 2012 .

Enzymatic preparation of 1,6-anhydro-muropeptides by immobilized murein hydrolases from Escherichia coli fused to staphylococcal protein A

W. Keck, A. V. Leeuwen, H. Engel, 1992, Applied Microbiology and Biotechnology.

Two different species of murein transglycosylase in Escherichia coli

H. Mett, U. Schwarz, W. Keck, 1980, Journal of bacteriology.

Possible RoleofEscherichia coli Penicillin-Bindi ng Protein 6 inStabilization ofStationary-Phase Peptidoglycan

W. Keck, 1992 .

Acyltransferase activities of the high-molecular-mass essential penicillin-binding proteins.

B. Spratt, G. Piras, M. Galleni, 1991, The Biochemical journal.

GENE TARGETING IN HEMOSTASIS . PLASMINOGEN

W. Keck, 2002 .

In vivo cell division gene product interactions in Escherichia coli K-12

U. Schwarz, L. Ferreira, W. Keck, 1987, Journal of bacteriology.

Penicillin-binding protein 2x of Streptococcus pneumoniae. Expression in Escherichia coli and purification of a soluble enzymatically active derivative.

J. Frère, M. Jamin, R. Lurz, 1992, European journal of biochemistry.

In vivo crystal formation in Escherichia coli of an over-expressed soluble form of penicillin-binding protein 5.

K. Sjollema, M. P. van der Linden, J. Vonck, 1992, FEMS microbiology letters.

Isolation and Characterization of a cDNA Clone Encoding the 60-kD Component of the Human SS-A/Ro Ribdnucleoprotein Autoantigen

K. Sullivan, E. Ben-Chetrit, E. Tan, 2013 .

G(AnH)MTetra, a naturally occurring 1,6-anhydro muramyl dipeptide, induces granulocyte colony-stimulating factor expression in human monocytes: a molecular analysis

E. Vellenga, A. Mulder, W. Keck, 1994, Infection and immunity.

Peptidoglycan as a Barrier to Transenvelope Transport Summary

W. Keck, A. Dijkstra, 2017 .

GENE TARGETING IN HEMOSTASIS . TISSUE FACTOR PATHWAY INHIBITOR

W. Keck, N. Hall, 2002 .

Oriented fragmentation of Escherichia coli sacculi by sonication

R. Verwer, E. Beachey, W. Keck, 1980, Journal of bacteriology.

Escherichia coli murein-DD-endopeptidase insensitive to beta-lactam antibiotics

U. Schwarz, W. Keck, W. Keck, 1979, Journal of bacteriology.

Mosaic Genes and Mosaic Chromosomes: Intra- and Interspecies Genomic Variation of Streptococcus pneumoniae

R. Hakenbeck, A. de Saizieu, W. Keck, 2001, Infection and Immunity.

Phosphoenolpyruvate-dependent mannitol phosphotransferase system of Escherichia coli: overexpression, purification, and characterization of the enzymatically active C-terminal domain of enzyme IImtl equivalent to enzyme IIImtl.

G. Robillard, R. van Weeghel, W. Keck, 1991, Biochemistry.

Regulated high-level expression of the mannitol permease of the phosphoenolpyruvate-dependent sugar phosphotransferase system in Escherichia coli.

R. van Weeghel, W. Keck, G. Robillard, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Sequences of the active-site peptides of three of the high-Mr penicillin-binding proteins of Escherichia coli K-12.

B. Spratt, U. Schwarz, B. Glauner, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Dynamic Imaging of Protein-Protein Interaction in Living Cells using Exogenous and Endogenous FRET Pairs

A. Periasamy, W. Keck, 2015 .

Details of mannitol transport in Escherichia coli elucidated by site-specific mutagenesis and complementation of phosphorylation site mutants of the phosphoenolpyruvate-dependent mannitol-specific phosphotransferase system.

G. Robillard, R. van Weeghel, W. Keck, 1991, Biochemistry.

Crystallization of the soluble lytic transglycosylase from Escherichia coli K12.

B. Dijkstra, H. Rozeboom, W. Keck, 1990, Journal of molecular biology.

Purification and characterization of N-acetylmuramyl-L-alanine amidase from human plasma using monoclonal antibodies.

M. Melief, W. Keck, M. Hoijer, 1996, Biochimica et biophysica acta.

Enzyme Digestion Study and Sucrose Density Gradient Ultracentrifugation

W. Keck, Y. Takasaki, Diane Fishwild, 2003 .

Microarray-Based Identification of a NovelStreptococcus pneumoniae Regulon Controlled by an Autoinduced Peptide

K. Amrein, A. de Saizieu, R. Lange, 2000, Journal of bacteriology.

GENE TARGETING IN HEMOSTASIS : PROTEIN C

W. Keck, 2002 .

Investigations of the Mode of Action and Resistance Development of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections

P. Caspers, D. Ritz, S. Schroeder, 2013, Antimicrobial Agents and Chemotherapy.

Cadazolid , a New Antibiotic for the Treatment of Clostridium difficile Infections : 1 Investigations on the Mode of Action and Resistance Development

P. Caspers, D. Ritz, S. Schroeder, 2013 .

Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.

Wolfgang Keck, Christopher Kohl, Daniel Ritz, 2013, Journal of medicinal chemistry.

Role of Autofluorescence in Flow Cytometric Analysis of Escherichia coli Treated with Bactericidal Antibiotics

U. Jenal, D. Ritz, W. Keck, 2013, Journal of bacteriology.

Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation

W. Keck, 2016 .

Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development

M. Page, H. Locher, B. Takács, 2001, Antimicrobial Agents and Chemotherapy.

Peptide Deformylase as an Antibacterial Drug Target: Assays for Detection of Its Inhibition in Escherichia coli Cell Homogenates and Intact Cells

M. Page, S. Evers, C. Apfel, 2001, Antimicrobial Agents and Chemotherapy.

Effect of pyrimido[1,6-a]benzimidazoles, quinolones, and Ca2+ on the DNA gyrase-mediated cleavage reaction

K. Kuratli, W. Keck, H. Gmünder, 1995, Antimicrobial agents and chemotherapy.

Peptidoglycan as a barrier to transenvelope transport

W Keck, A J Dijkstra, W. Keck, 1996, Journal of bacteriology.

Arrangement of glycan chains in the sacculus of Escherichia coli

R. Verwer, U. Schwarz, N. Nanninga, 1978, Journal of bacteriology.

Cloning and characterization of mepA, the structural gene of the penicillin‐insensitive murein endopeptidase from Escherichia coli

W. Keck, M. Huber, E. Goodell, 1990, Molecular microbiology.

Exoenzymatic activity of transglycosylase isolated from Escherichia coli.

M. de Pedro, U. Schwarz, E. Beachey, 1981, European journal of biochemistry.

Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.

L. Prade, D. Ritz, R. Lange, 2012, Bioorganic & medicinal chemistry letters.

Genome-wide transcriptional analysis of bacterial genomes: applications in antibacterial drug discovery

C. Gray, H. Gmuender, A. D. Saizieu, 1999, Nature Genetics.

Identification of new members of the lytic transglycosylase family in Haemophilus influenzae and Escherichia coli.

W. Keck, A. Dijkstra, 1996, Microbial drug resistance.

Murein-metabolizing enzymes from Escherichia coli: existence of a second lytic transglycosylase

L. V. van Wijngaarden, W. Keck, H. Engel, 1992, Journal of bacteriology.

Crystal structure of Escherichia coli lytic transglycosylase Slt35 reveals a lysozyme-like catalytic domain with an EF-hand.

K. H. Kalk, B. Dijkstra, E. J. van Asselt, 1999, Structure.

Doughnut-shaped structure of a bacterial muramidase revealed by X-ray crystallography

K. H. Kalk, B. Dijkstra, H. Rozeboom, 1994, Nature.

University of Groningen Crystal structure of Escherichia coli lytic transglycosylase Slt35 reveals a lysozyme-like catalytic domain with an EF-hand Asselt,

K. H. Kalk, B. Dijkstra, B. Takács, 1999 .

The lytic transglycosylase family of Escherichia coli

M. Haiker, W. Keck, 1997 .

Purification of penicillin-binding protein 4 of Escherichia coli as a soluble protein by dye-affinity chromatography.

W. Keck, H. Mottl, 1991, European journal of biochemistry.

Cloning and controlled overexpression of the gene encoding the 35 kDa soluble lytic transglycosylase from Escherichia coli

Francis Hermann, W. Keck, A. Dijkstra, 1995, FEBS letters.

Murein-metabolizing enzymes from Escherichia coli: sequence analysis and controlled overexpression of the slt gene, which encodes the soluble lytic transglycosylase

B. Kazemier, W. Keck, H. Engel, 1991, Journal of bacteriology.

The a-Dystroglycan-b-Dystroglycan Complex

J. Leszyk, J. Fallon, W. Keck, 1995 .

Using NMR Spectroscopy and Computational Chemistry to Confirm the Structure of Novel Antibiotic Nocamycin O

W. Keck, Stephanie Lewis, 2021 .

Infections: In Vitro and in Vivo Antibacterial Evaluation

D. Ritz, A. Klenk, C. Kelly, 2013 .

Localization of penicillin-binding protein 1b in Escherichia coli: immunoelectron microscopy and immunotransfer studies

M. Bayer, W. Keck, M. H. Bayer, 1990, Journal of bacteriology.

A modified vector for the controlled high-level overproduction of staphylococcal protein A fusion proteins in the periplasm of Escherichia coli.

W. Keck, H. Mottl, H. Engel, 1992, Protein expression and purification.

Bacterial targets and antibiotics: genome-based drug discovery

W. Keck, C. Gray, C. P. Gray, 1999, Cellular and Molecular Life Sciences CMLS.

In the presence of subunit A inhibitors DNA gyrase cleaves DNA fragments as short as 20 bp at specific sites.

K. Kuratli, W. Keck, H. Gmünder, 1997, Nucleic acids research.

Overexpression, purification, and characterization of UDP-N-acetylmuramyl:L-alanine ligase from Escherichia coli

W. Keck, M. Gubler, Y. Appoldt, 1996, Journal of bacteriology.

Rapid screening of a large number of immobilized textile dyes for the purification of proteins: use of penicillin-binding protein 4 of Escherichia coli as a model enzyme.

W. Keck, H. Mottl, 1992, Protein expression and purification.

Novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram positive activity and improved safety profile.

D. Ritz, H. Locher, P. Seiler, 2015, Journal of medicinal chemistry.

In Vitro and In Vivo Antibacterial Evaluation of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections

D. Ritz, A. Klenk, C. Kelly, 2013, Antimicrobial Agents and Chemotherapy.

Cytoplasmic phosphorylating domain of the mannitol-specific transport protein of the phosphoenolpyruvate-dependent phosphotransferase system in Escherichia coli: overexpression, purification, and functional complementation with the mannitol binding domain.

W Keck, G. Robillard, R. van Weeghel, 1991, Biochemistry.

Penicillin-binding protein 4 of Escherichia coli shows a novel type of primary structure among penicillin-interacting proteins.

P. Terpstra, W. Keck, H. Mottl, 1991, FEMS microbiology letters.

Engineering and overexpression of periplasmic forms of the penicillin-binding protein 3 of Escherichia coli.

J. Ghuysen, J. V. Van Beeumen, H. Hara, 1994, The Biochemical journal.

Bacterial transcript imaging by hybridization of total RNA to oligonucleotide arrays

Antoine de Saizieu, Wolfgang Keck, Jan Mous, 1998, Nature Biotechnology.

Control of the activity of the soluble lytic transglycosylase by the stringent response in Escherichia coli.

L. Ferreira, J. Höltje, W. Keck, 1990, FEMS microbiology letters.

Domain organization and molecular characterization of 13 two-component systems identified by genome sequencing of Streptococcus pneumoniae.

P. Caspers, K. Amrein, M. Stieger, 1999, Gene.

Molecular cloning, overexpression and mapping of the slt gene encoding the soluble lytic transglycosylase of Escherichia coli

W. Keck, A. Betzner, 1989, Molecular and General Genetics MGG.

Genomic Strategies in Antibacterial Drug Discovery

C. Gray, W. Keck, 2003 .

Murein-Metabolizing EnzymesfromEscherichia coli: Existence ofaSecondLytic Transglycosylase

W. Keck, H. Engel, 1992 .

Investigations of the Mode of Action and Resistance Development of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections

P. Caspers, D. Ritz, S. Schroeder, 2013, Antimicrobial Agents and Chemotherapy.

Insights into native epitopes of proliferating cell nuclear antigen using recombinant DNA protein products

K. Sullivan, R. Houghten, E. Tan, 1990, The Journal of experimental medicine.

Arrangement ofGlycan Chains intheSacculus of Escherichia coli

R. Verwer, N. Nanninga, W. Keck, 1978 .

Strategies towards a better understanding of antibiotic action: Folate pathway inhibition in Haemophilus influenzae as an example

C. Gray, M. Meyer, M. Fountoulakis, 1998, Electrophoresis.

Murein-metabolizing enzymes from Escherichia coli: existence of a second lytic transglycosylase

W. Keck, H. Engel, A. J. Smink, 1992, Journal of Bacteriology.