S. Laufs

发表

Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns.

A. Hotz-Wagenblatt, W. Zeller, S. Fruehauf, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Long-term episomal transgene expression from mitotically stable integration-deficient lentiviral vectors.

Rafael J. Yáñez-Muñoz, G. Dickson, J. Bode, 2014, Human gene therapy.

Differences in functional activity and antigen expression of granulocytes primed in vivo with filgrastim, lenograstim, or pegfilgrastim

A. Ho, A. Benner, F. Wenz, 2007, Transfusion.

Urokinase-Receptor (u-PAR)–An Essential Player in Multiple Games of Cancer: A Review on Its Role in Tumor Progression, Invasion, Metastasis, Proliferation/dormancy, Clinical Outcome and Minimal Residual Disease

H. Allgayer, S. Laufs, J. Schumacher, 2006, Cell cycle.

Look who's talking: deregulated signaling in colorectal cancer.

H. Allgayer, B. Korn, A. Benner, 2012, Cancer genomics & proteomics.

Reconstitution of a metabolic pathway with triple‐cistronic IRES‐containing retroviral vectors for correction of tetrahydrobiopterin deficiency

S. H. Kim, N. Blau, B. Thöny, 2000, The journal of gene medicine.

Transfer of drug resistance genes in hematopoietic progenitors for chemoprotection: is it still an option?

E. Buss, W. Zeller, S. Fruehauf, 2003, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Suicide gene therapy of sarcoma cell lines using recombinant adeno-associated virus 2 vectors

F. Wenz, U. Hengge, S. Fruehauf, 2004, Cancer Gene Therapy.

Unrestricted somatic stem cells: interaction with CD34+ cells in vitro and in vivo, expression of homing genes and exclusion of tumorigenic potential.

H. Allgayer, F. Wenz, W. Zeller, 2011, Cytotherapy.

CXCR4 Expression and Treatment with SDF-1α or Plerixafor Modulate Proliferation and Chemosensitivity of Colon Cancer Cells.

D. Heckmann, H. Allgayer, F. Wenz, 2013, Translational oncology.

The CXCR4 antagonist AMD3100 releases a subset of G-CSF-primed peripheral blood progenitor cells with specific gene expression characteristics.

H. Goldschmidt, A. Ho, W. Zeller, 2006, Experimental hematology.

Nuclear localization of tetrahydrobiopterin biosynthetic enzymes.

N. Blau, B. Thöny, D. Heerklotz, 2004, Biochimica et biophysica acta.

Characterization of Human Mesothelioma Cell Lines as Tumor Models for Suicide Gene Therapy

A. Jauch, F. Wenz, S. Fruehauf, 2008, Oncology Research and Treatment.

A combination of granulocyte-colony-stimulating factor (G-CSF) and plerixafor mobilizes more primitive peripheral blood progenitor cells than G-CSF alone: results of a European phase II study.

H. Goldschmidt, A. Ho, F. Wenz, 2009, Cytotherapy.

Cross‐resistance of imatinib mesylate and 17‐aag in imatinib‐resistant cells that overexpress bcr‐abl

J. Melo, W. Zeller, J. Topaly, 2003, British journal of haematology.

Development and optimization of a real-time quantitative PCR-based method for the titration of AAV-2 vector stocks.

F. Wenz, U. Hengge, J. Topaly, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

Pseudotyped recombinant adeno-associated viral vectors mediate efficient gene transfer into primary human CD34(+) peripheral blood progenitor cells.

L. Sellner, F. Wenz, J. Kleinschmidt, 2010, Cytotherapy.

Gene Therapy for Sarcoma

N. Kröger, S. Hegewisch-Becker, U. Hengge, 2002, Cells Tissues Organs.

Retroviral MDR1 gene transfer into marrow-engrafting human peripheral blood progenitor cells results in preferential transgene expression in the immature myeloid compartment rather than in mature myeloid progeny in vivo.

E. Buss, S. Naundorf, W. Zeller, 2006, Cytotherapy.

Generation of efficient human blood progenitor-targeted recombinant adeno-associated viral vectors (AAV) by applying an AAV random peptide library on primary human hematopoietic progenitor cells.

L. Sellner, F. Wenz, J. Kleinschmidt, 2008, Experimental hematology.

Multidrug resistance 1 gene transfer can confer chemoprotection to human peripheral blood progenitor cells engrafted in immunodeficient mice.

C. Baum, W. Zeller, S. Fruehauf, 2002, Human gene therapy.

Efficient gene transfer with pseudotyped recombinant adeno-associated viral vectors into human chronic myelogenous leukemia cells

L. Sellner, F. Wenz, J. Kleinschmidt, 2011, Leukemia & lymphoma.

Recombinant adeno-associated virus 2-mediated transfer of the human superoxide-dismutase gene does not confer radioresistance on HeLa cervical carcinoma cells.

F. Wenz, S. Fruehauf, C. Herskind, 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Protection of hematopoietic cells from chemotherapy-induced toxicity by multidrug resistance-I gene transfer followed by analysis of retroviral insertion sites into the human genome

E. Buss, S. Naundorf, W. Zeller, 2003 .

Retrovirus‐Mediated Double Transduction of the GTPCH and PTPS Genes Allows 6‐Pyruvoyltetrahydropterin Synthase‐Deficient Human Fibroblasts to Synthesize and Release Tetrahydrobiopterin

N. Blau, B. Thöny, S. Laufs, 1998, Journal of neurochemistry.

Retroviral transfer of the human multidrug resistance-1 gene in human mobilized peripheral blood progenitor cells engrafting in NOD / SCID mice can confer chemoprotection

E. Buss, B. Schiedlmeier, C. Baum, 2002 .

of Colon Cancer Induced Gene Expression , Invasion and Chemosensitivity − α SDF-1 The Disparate Twins : A Comparative Study of CXCR 4 and CXCR 7 in

D. Heckmann, H. Allgayer, J. Sleeman, 2014 .

The Disparate Twins: A Comparative Study of CXCR4 and CXCR7 in SDF-1α–Induced Gene Expression, Invasion and Chemosensitivity of Colon Cancer

D. Heckmann, H. Allgayer, J. H. Leupold, 2013, Clinical Cancer Research.

Impact of raltegravir on HIV-1 RNA and DNA forms following initiation of antiretroviral therapy in treatment-naive patients.

L. Kaderali, M. Bickel, Manfred Schmidt, 2014, The Journal of antimicrobial chemotherapy.

High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies

C. von Kalle, H. Glimm, F. Wenz, 2015, Molecular therapy. Methods & clinical development.

Clonal inventory screens uncover monoclonality following serial transplantation of MGMT P140K-transduced stem cells and dose-intense chemotherapy.

C. von Kalle, H. Allgayer, I. Roeder, 2011, Human gene therapy.

Retroviral vectors for gene therapy.

C. von Kalle, S. Laufs, P. Maier, 2010, Future microbiology.

Analysis of self-inactivating lentiviral vector integration sites and flanking gene expression in human peripheral blood progenitor cells after alkylator chemotherapy.

H. Allgayer, F. Wenz, M. Zucknick, 2010, Human gene therapy.

Safety Analysis in Retroviral Gene Therapy: Identifying Virus Integration Sites in Gene-Modified Cells

W. Zeller, S. Fruehauf, S. Laufs, 2010 .

QuickMap: a public tool for large-scale gene therapy vector insertion site mapping and analysis

G Opelz, A Hotz-Wagenblatt, S Fruehauf, 2009, Gene Therapy.

Lentiviral vector integration sites in human NOD/SCID repopulating cells

Stefan Fruehauf, Agnes Hotz-Wagenblatt, Guillermo Guenechea, 2006, The journal of gene medicine.

Rapid detection of retroviral vector integration sites in colony-forming human peripheral blood progenitor cells using PCR with arbitrary primers

W. Zeller, S. Fruehauf, B. Gentner, 2003, Gene Therapy.

Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O6-methylguanine-DNA methyltransferaseP140K

S Fruehauf, F Wenz, F. Wenz, 2010, Gene Therapy.

Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles.

H. Hennies, M. Zenke, T. Šarić, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib

M. Sperandio, F. Wenz, G. Calandra, 2009, Leukemia & lymphoma.

Retroviral Integration Sites Correlate with Expressed Genes in Hematopoietic Stem Cells

C. Schwager, A. Ho, Jonathon Blake, 2005, Stem cells.

Retroviral vector insertions in T-lymphocytes used for suicide gene therapy occur in gene groups with specific molecular functions

A. Zander, A. Ho, A. Hotz-Wagenblatt, 2006, Bone Marrow Transplantation.

MDR1 Gene Transfer Using a Lentiviral SIN Vector Confers Radioprotection to Human CD34+ Hematopoietic Progenitor Cells

F. Wenz, S. Fruehauf, C. Herskind, 2008, Radiation research.

Genetic Vaccines and Therapy

A. Jauch, R. Lockey, L. Sellner, 2008 .

Autographa californicaNuclear Polyhedrosis Virusp143Gene Product Is a DNA-Binding Protein☆

E. Carstens, A. Lu, S. Laufs, 1997 .

Overexpression of MDR1 Using a Retroviral Vector Differentially Regulates Genes Involved in Detoxification and Apoptosis and Confers Radioprotection

Stefan Fruehauf, Li Li, Christopher Baum, 2006, Radiation research.

Enhanced complement resistance in drug‐selected P‐glycoprotein expressing multi‐drug‐resistant ovarian carcinoma cells

Z. Fishelson, S. Fruehauf, M. Kirschfink, 2009, Clinical and experimental immunology.

Viral Determinants of Integration Site Preferences of Simian Immunodeficiency Virus-Based Vectors

K. Überla, W. Zeller, S. Kuate, 2006, Journal of Virology.

Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells.

A. Jauch, A. Ho, A. Benner, 2003, Blood.

Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL – Inhibition of P-glycoprotein function by 17-AAG

S Fruehauf, A. Jauch, J. Melo, 2005, Leukemia.

Susceptibility of mesothelioma cell lines to adeno-associated virus 2 vector-based suicide gene therapy.

A. Jauch, F. Wenz, W. Zeller, 2004, Lung cancer.

Prospects and RISC score of viral gene therapy for sarcoma

W. Zeller, S. Fruehauf, M. Veldwijk, 2003, Expert opinion on biological therapy.

Transplantation of human hematopoietic progenitor cells transduced with a retroviral vector containing the human multidrug-resistance-1 gene for myeloprotective gene therapy.

C. Baum, S. Fruehauf, S. Laufs, 2002, Transplantation proceedings.

Dokumentation und Evaluation der Weiterbildung Contents of Forthcoming Issues · Themenvorschau

W. Zeller, S. Paepke, C. Camcı, 2016 .

Clonal Analysis of Individual Marrow‐Repopulating Cells after Experimental Peripheral Blood Progenitor Cell Transplantation

E. Buss, S. Naundorf, J. Topaly, 2004, Stem cells.

A Lentiviral CXCR4 Overexpression and Knockdown Model in Colorectal Cancer Cell Lines Reveals Plerixafor-Dependent Suppression of SDF-1α-Induced Migration and Invasion

D. Heckmann, H. Allgayer, F. Wenz, 2011, Oncology Research and Treatment.

Normal-Tissue Radioprotection by Overexpression of the Copper-Zinc and Manganese Superoxide Dismutase Genes

L. Sellner, F. Wenz, A. Radujkovic, 2009, Strahlentherapie und Onkologie.

Dominant negative allele (N47D) in a compound heterozygote for a variant of 6‐pyruvoyltetrahydropterin synthase deficiency causing transient hyperphenylalaninemia

N. Blau, B. Thöny, S. Laufs, 1999, Human Mutation.

F2A sequence linking MGMTP140K and MDR1 in a bicistronic lentiviral vector enables efficient chemoprotection of haematopoietic stem cells

D. Heckmann, H. Allgayer, F. Wenz, 2012, Cancer Gene Therapy.

Urokinase-receptor (u-PAR)

H. Allgayer, S. Laufs, J. Schumacher, 2006 .

Application of a haematopoetic progenitor cell-targeted adeno-associated viral (AAV) vector established by selection of an AAV random peptide library on a leukaemia cell line

A. Jauch, L. Sellner, F. Wenz, 2008, Genetic Vaccines and Therapy.

Multiple Displacement Amplification Enables Large-Scale Clonal Analysis following Retroviral Gene Therapy

H. Allgayer, F. Wenz, W. Zeller, 2007, Journal of Virology.

Characterization of Human Mesothelioma Cell Lines as Tumor Models for Suicide Gene Therapy

A. Jauch, F. Wenz, S. Fruehauf, 2008, Oncology Research and Treatment.

Cold spots in hot spots: transcription start sites of active genes are spared from HIV vector integration

M. Gisslén, L. Else, A. Yilmaz, 2009, AIDS.